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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:E-4031
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Accession:CHEBI:34732 term browser browse the term
Definition:A sulfonamide that has formula C21H27N3O3S.
Synonyms:related_synonym: Formula=C21H27N3O3S;   InChI=1S/C21H27N3O3S/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27/h3-9,18,23H,10-15H2,1-2H3;   InChIKey=SRUISGSHWFJION-UHFFFAOYSA-N;   SMILES=Cc1cccc(CCN2CCC(CC2)C(=O)c2ccc(NS(C)(=O)=O)cc2)n1
 xref: CAS:113558-89-7;   KEGG:C13776;   LINCS:LSM-2928
 xref_mesh: MESH:C063968


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E-4031 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP E 4031 inhibits the reaction [Corticosterone inhibits the reaction [CRH protein results in increased secretion of Adrenocorticotropic Hormone]] CTD PMID:18835572 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases response to substance ISO CYP19A1 gene mutant form results in decreased susceptibility to E 4031 CTD PMID:25972195 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 multiple interactions ISO [KCNE2 protein binds to KCNH2 protein] which results in increased susceptibility to E 4031; E 4031 results in decreased activity of [KCNE2 protein binds to KCNH2 protein] CTD PMID:10219239 NCBI chr11:32,434,786...32,447,264
Ensembl chr11:32,440,237...32,447,259
JBrowse link
G Kcnh1 potassium voltage-gated channel subfamily H member 1 affects binding
multiple interactions
ISO E 4031 binds to KCNH1 protein
E 4031 binds to and results in decreased activity of KCNH1 protein
CTD PMID:18471075 PMID:18497958 NCBI chr13:110,920,712...111,232,291
Ensembl chr13:110,920,737...111,232,269
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects localization
affects binding
multiple interactions
decreases activity
increases activity
ISO
EXP
E 4031 affects the localization of KCNH2 protein mutant form
E 4031 binds to KCNH2 protein
[KCNE2 protein binds to KCNH2 protein] which results in increased susceptibility to E 4031; beta-Cyclodextrins analog inhibits the reaction [E 4031 results in decreased activity of KCNH2 protein]; E 4031 binds to and results in decreased activity of KCNH2 protein; E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]; E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 inhibits the reaction [KCNH2 protein results in increased transport of Thallium]; E 4031 inhibits the reaction [Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 results in decreased activity of [KCNE2 protein binds to KCNH2 protein]; E 4031 results in increased glycosylation of and affects the localization of KCNH2 protein mutant form
E 4031 results in increased activity of KCNH2 protein mutant form
E 4031 inhibits the reaction [Progesterone results in decreased localization of KCNH2 protein]
CTD PMID:10219239 PMID:10531299 PMID:11741928 PMID:12070109 PMID:12359267 PMID:14709917 PMID:15272206 PMID:16494862 PMID:16757186 PMID:17513944 PMID:18724381 PMID:19260734 PMID:19583963 PMID:20050851 PMID:21158687 PMID:21525004 PMID:23707769 PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    chemical entity 19883
      atom 19881
        nonmetal atom 19760
          sulfur atom 16325
            sulfur molecular entity 16325
              organosulfur compound 15254
                sulfonamide 3183
                  E-4031 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      chalcogen 19464
                        oxygen atom 19425
                          oxygen molecular entity 19425
                            hydroxides 19147
                              oxoacid 18286
                                chalcogen oxoacid 11505
                                  sulfur oxoacid 11109
                                    sulfonic acid 7352
                                      sulfonic acid derivative 7352
                                        sulfonamide 3183
                                          E-4031 5
paths to the root