Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Droloxifene
go back to main search page
Accession:CHEBI:34731 term browser browse the term
Definition:A stilbenoid that has formula C26H29NO2.
Synonyms:related_synonym: 3-Hydroxytamoxifen;   Formula=C26H29NO2;   InChI=1S/C26H29NO2/c1-4-25(20-9-6-5-7-10-20)26(22-11-8-12-23(28)19-22)21-13-15-24(16-14-21)29-18-17-27(2)3/h5-16,19,28H,4,17-18H2,1-3H3/b26-25+;   InChIKey=ZQZFYGIXNQKOAV-OCEACIFDSA-N;   SMILES=CC\\C(=C(\\c1ccc(OCCN(C)C)cc1)c1cccc(O)c1)c1ccccc1
 xref: CAS:82413-20-5;   HMDB:HMDB0013868;   KEGG:C14296;   KEGG:D03911
 xref_mesh: MESH:C038345


show annotations for term's descendants           Sort by:
 
Droloxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO droloxifene results in decreased activity of CYP1B1 protein CTD PMID:12419016 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO droloxifene results in decreased activity of CYP3A4 protein CTD PMID:12419016 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases activity ISO droloxifene results in decreased activity of CYP3A5 protein CTD PMID:12419016 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Prkce protein kinase C, epsilon affects localization ISO droloxifene affects the localization of PRKCE protein CTD PMID:9714066 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO droloxifene binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression EXP droloxifene results in increased expression of TGFB1 mRNA CTD PMID:15618244 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          carbon atom 19657
            organic molecular entity 19657
              olefinic compound 14850
                stilbenoid 5644
                  Droloxifene 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic aromatic compound 19220
                                  stilbenoid 5644
                                    Droloxifene 6
paths to the root