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Term:domoic acid
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Accession:CHEBI:34727 term browser browse the term
Definition:An L-proline derivative produced by the diatomic algal genus of Pseudo-nitzschia and other related species that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is an analogue of kainic acid and is the neurotoxin associated with amnesic shellfish poisoning (ASP).
Synonyms:exact_synonym: (3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)-L-proline
 related_synonym: Formula=C15H21NO6;   InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1;   InChIKey=VZFRNCSOCOPNDB-AOKDLOFSSA-N;   L-domoic acid;   SMILES=C[C@H](\\C=C\\C=C(\\C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O)C(O)=O
 xref: CAS:14277-97-5 "ChemIDplus";   CAS:14277-97-5 "KEGG COMPOUND";   HMDB:HMDB0033939;   KEGG:C13732
 xref_mesh: MESH:C012301
 xref: PDBeChem:DOQ;   PMID:10223629 "Europe PMC";   PMID:18728725 "Europe PMC";   PMID:20120452 "Europe PMC";   PMID:22406515 "Europe PMC";   PMID:24511141 "Europe PMC";   PMID:24564603 "Europe PMC";   PMID:24638960 "Europe PMC";   PMID:24663110 "Europe PMC";   PMID:28817087 "Europe PMC";   Reaxys:5126272 "Reaxys";   Wikipedia:Domoic_acid

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domoic acid term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:6480464
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:6480464
G Pvalb parvalbumin JBrowse link 7 119,428,657 119,443,674 RGD:6480464
G Wdr35 WD repeat domain 35 JBrowse link 6 34,094,291 34,152,048 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        hapten 2962
          domoic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        amino acid 12315
                                          alpha-amino acid 7422
                                            L-alpha-amino acid 7079
                                              glutamine family amino acid 5338
                                                L-proline 240
                                                  L-proline derivative 223
                                                    domoic acid 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.