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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:domoic acid
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Accession:CHEBI:34727 term browser browse the term
Definition:An L-proline derivative that is L-proline substituted by a carboxymethyl group at position 3 and a 6-carboxyhepta-2,4-dien-2-yl group at position 4. It is produced by the diatomic algal Pseudo-nitzschia. It is an analogue of kainic acid and a neurotoxin which causes amnesic shellfish poisoning (ASP).
Synonyms:exact_synonym: (3S,4S)-4-[(2Z,4E,6R)-6-carboxyhepta-2,4-dien-2-yl]-3-(carboxymethyl)-L-proline
 related_synonym: Formula=C15H21NO6;   InChI=1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1;   InChIKey=VZFRNCSOCOPNDB-AOKDLOFSSA-N;   L-domoic acid;   SMILES=C[C@H](\\C=C\\C=C(\\C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O)C(O)=O
 xref: CAS:14277-97-5;   DrugBank:DB02852;   FooDB:FDB012146;   HMDB:HMDB0033939;   KEGG:C13732;   KNApSAcK:C00034487
 xref_mesh: MESH:C012301
 xref: PDBeChem:DOQ;   PMID:10223629;   PMID:1264348;   PMID:18728725;   PMID:20120452;   PMID:22406515;   PMID:24511141;   PMID:24564603;   PMID:24638960;   PMID:24663110;   PMID:28817087;   PMID:32302120;   PMID:32512724;   PMID:32891664;   PMID:33153112;   PMID:33193520;   PMID:33218768;   PMID:33347336;   PMID:33517972;   PMID:33524817;   PMID:33530611;   Reaxys:5126272;   Wikipedia:Domoic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:167470


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domoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
increases localization		 ISO domoic acid results in increased expression of BAX mRNA
Carbachol inhibits the reaction [domoic acid results in increased localization of BAX protein]		 CTD PMID:18293405 PMID:19200344 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO domoic acid affects the expression of BCL2 mRNA CTD PMID:18293405 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO Carbachol inhibits the reaction [domoic acid results in increased activity of CASP3 protein] CTD PMID:19200344 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO domoic acid results in increased expression of GCLC mRNA; domoic acid results in increased expression of GCLC protein CTD PMID:23315585 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
affects response to substance
decreases response to substance		 ISO domoic acid results in increased expression of GCLM mRNA; domoic acid results in increased expression of GCLM protein
GCLM affects the susceptibility to domoic acid
[GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to 2,3-dimethoxy-1,4-naphthoquinone; [GCLM protein results in decreased susceptibility to domoic acid] which results in decreased susceptibility to Hydrogen Peroxide; GCLM protein results in decreased susceptibility to domoic acid; GCLM results in decreased susceptibility to domoic acid		 CTD PMID:17804861 PMID:19200344 PMID:23315585 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 increases phosphorylation EXP domoic acid results in increased phosphorylation of GRIA1 protein CTD PMID:19564213 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Pvalb parvalbumin increases expression ISO domoic acid results in increased expression of PVALB protein CTD PMID:26797589 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561 		JBrowse link
G Wdr35 WD repeat domain 35 increases expression
multiple interactions		 EXP domoic acid results in increased expression of WDR35 mRNA; domoic acid results in increased expression of WDR35 protein
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline inhibits the reaction [domoic acid results in increased expression of WDR35 protein]; Edaravone inhibits the reaction [domoic acid results in increased expression of WDR35 protein]		 CTD PMID:23289926 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        hapten 3058
          domoic acid 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino acid 16057
                                          alpha-amino acid 13932
                                            L-alpha-amino acid 12141
                                              glutamine family amino acid 10325
                                                L-proline 299
                                                  L-proline derivative 275
                                                    domoic acid 8
paths to the root