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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dimethoate
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Accession:CHEBI:34714 term browser browse the term
Definition:A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.
Synonyms:exact_synonym: O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] phosphorodithioate
 related_synonym: 2-Dimethoxyphosphinothioylthio-N-methylacetamide;   Formula=C5H12NO3PS2;   InChI=1S/C5H12NO3PS2/c1-6-5(7)4-12-10(11,8-2)9-3/h4H2,1-3H3,(H,6,7);   InChIKey=MCWXGJITAZMZEV-UHFFFAOYSA-N;   O,O-dimethyl S-[2-(methylamino)-2-oxoethyl] dithiophosphate;   Phosphamide;   Phosphorodithioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester;   SMILES=CNC(=O)CSP(=S)(OC)OC
 xref: CAS:60-51-5;   KEGG:C14326;   LINCS:LSM-24992
 xref_mesh: MESH:D004117
 xref: PMID:11054639;   PMID:15803959;   PPDB:244;   Pesticides:dimethoate;   Reaxys:1785339;   Wikipedia:Dimethoate


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dimethoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
affects activity
decreases expression
multiple interactions
ISO
EXP
Dimethoate results in decreased activity of ACHE protein
Dimethoate affects the activity of ACHE protein
Dimethoate results in decreased expression of ACHE protein
Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]
pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]
CTD PMID:3247000 PMID:15033006 PMID:16112538 PMID:16112789 PMID:16701032 PMID:16833148 PMID:17997881 PMID:18070496 PMID:19793545 PMID:19917271 PMID:25082528 PMID:25967365 PMID:26482405 PMID:26769589 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases phosphorylation ISO Dimethoate results in decreased phosphorylation of AKT2 protein CTD PMID:23994500 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Alb albumin increases response to substance
multiple interactions
ISO ALB protein results in increased susceptibility to Dimethoate
ALB protein promotes the reaction [Zinc Oxide binds to Dimethoate]
CTD PMID:27441385 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Dimethoate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO
EXP
Dimethoate results in decreased activity of BCHE protein CTD PMID:19793545 PMID:24052565 PMID:26482405 PMID:27441385 PMID:30243730 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
increases expression
EXP
ISO
[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Dimethoate results in increased activity of CAT protein]
Ascorbic Acid inhibits the reaction [Dimethoate results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Dimethoate results in increased activity of CAT protein]
Dimethoate results in increased expression of CAT protein
CTD PMID:11834209 PMID:16112789 PMID:20077558 PMID:22034174 PMID:26482405 PMID:26769589 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Dimethoate results in increased expression of CCL2 mRNA CTD PMID:23397585 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cd86 CD86 molecule increases expression ISO Dimethoate results in increased expression of CD86 protein CTD PMID:23994500 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP Dimethoate results in decreased expression of CHRM1 mRNA; Dimethoate results in decreased expression of CHRM1 protein CTD PMID:14694657 PMID:15033006 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP Dimethoate results in decreased expression of CHRM2 mRNA; Dimethoate results in decreased expression of CHRM2 protein CTD PMID:14694657 PMID:15033006 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases expression
decreases expression
ISO
EXP
Dimethoate results in increased expression of CHRM3 mRNA
Dimethoate results in decreased expression of CHRM3 mRNA
CTD PMID:15033005 PMID:15033006 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Cnst consortin, connexin sorting protein increases expression ISO Dimethoate results in increased expression of CNST mRNA CTD PMID:23397585 NCBI chr13:97,838,325...97,915,131
Ensembl chr13:97,838,361...97,913,082
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression
multiple interactions
ISO Dimethoate results in increased expression of CXCL10 mRNA
Estradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of CXCL10 mRNA]]
CTD PMID:23943137 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression
multiple interactions
ISO
EXP
Dimethoate results in decreased activity of CYP11A1 protein
Dimethoate results in decreased expression of CYP11A1 mRNA
Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of CYP11A1 mRNA]
CTD PMID:11054639 PMID:26769589 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO Dimethoate results in increased expression of CYP19A1 mRNA CTD PMID:23943137 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 increases expression EXP Dimethoate results in increased expression of CYP2D1 mRNA CTD PMID:25967365 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Esr1 estrogen receptor 1 decreases activity
increases expression
ISO Dimethoate results in decreased activity of ESR1 protein
Dimethoate results in increased expression of ESR1 protein
CTD PMID:22562034 PMID:23943137 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO Dimethoate results in increased expression of ESR2 mRNA CTD PMID:23943137 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Dimethoate results in increased expression of FSHB protein CTD PMID:19579042 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP Dimethoate results in increased activity of G6PDX protein CTD PMID:16112789 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Dimethoate results in increased expression of GFAP mRNA; Dimethoate results in increased expression of GFAP protein CTD PMID:21941777 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gsr glutathione-disulfide reductase increases expression EXP Dimethoate results in increased expression of GSR protein CTD PMID:16112789 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 increases expression ISO Dimethoate results in increased expression of GULP1 mRNA CTD PMID:23397585 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD17B3 mRNA] CTD PMID:26769589 NCBI chr17:1,579,319...1,610,745
Ensembl chr17:1,579,319...1,610,745
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of HSD3B3 mRNA] CTD PMID:26769589 NCBI chr 2:200,756,557...200,762,492
Ensembl chr 2:200,585,748...200,762,492
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein decreases expression ISO Dimethoate results in decreased expression of ID3 mRNA CTD PMID:23397585 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Dimethoate results in decreased secretion of IL10 protein CTD PMID:23994500 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression
ISO Dimethoate results in increased secretion of IL1B protein
Estradiol inhibits the reaction [Dimethoate results in increased expression of IL1B mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL1B mRNA]]
CTD PMID:23943137 PMID:23994500 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO Dimethoate affects the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Estradiol inhibits the reaction [Dimethoate results in increased expression of IL6 mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of IL6 mRNA]] CTD PMID:23891859 PMID:23943137 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Klf9 Kruppel-like factor 9 increases expression ISO Dimethoate results in increased expression of KLF9 mRNA CTD PMID:23397585 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Kmo kynurenine 3-monooxygenase decreases activity EXP Dimethoate results in decreased activity of KMO protein CTD PMID:2119399 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Dimethoate results in decreased activity of KYAT1 protein CTD PMID:2119399 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases expression
multiple interactions
ISO
EXP
Dimethoate results in decreased expression of LHB protein
Dimethoate results in increased expression of LHB protein
rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein]
CTD PMID:19579042 PMID:19726577 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Dimethoate results in decreased phosphorylation of MAPK1 protein CTD PMID:23994500 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Dimethoate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; Dimethoate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pdxk pyridoxal kinase decreases activity EXP
ISO
Dimethoate results in decreased activity of PDXK protein CTD PMID:2119399 PMID:2547861 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Dimethoate results in increased expression of PTGS2 protein
[Dimethoate co-treated with Eicosapentaenoic Acid] results in increased expression of PTGS2 protein; Docosahexaenoic Acids inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]; docosapentaenoic acid inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]
CTD PMID:19579042 PMID:22476691 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Dimethoate results in increased expression of S100B mRNA; Dimethoate results in increased expression of S100B protein CTD PMID:21941777 NCBI chr20:13,130,633...13,142,856
Ensembl chr20:13,130,636...13,142,856
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
increases expression
ISO
EXP
Dimethoate results in decreased expression of STAR mRNA
Dimethoate results in decreased expression of STAR mRNA; Dimethoate results in decreased expression of STAR protein
Acetylcysteine inhibits the reaction [Dimethoate results in decreased expression of STAR mRNA]; Arachidonic Acid inhibits the reaction [Dimethoate results in decreased expression of STAR protein]; Eicosapentaenoic Acid promotes the reaction [Dimethoate results in decreased expression of STAR protein]
Dimethoate results in increased expression of STAR mRNA
CTD PMID:11054639 PMID:19579042 PMID:22476691 PMID:23943137 PMID:26769589 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Dimethoate results in increased expression of TBX3 mRNA CTD PMID:23397585 NCBI chr12:42,479,518...42,494,588
Ensembl chr12:42,480,560...42,492,526
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity ISO Dimethoate results in decreased activity of TDO2 protein CTD PMID:2547861 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tgoln2 trans-golgi network protein 2 increases expression ISO Dimethoate results in increased expression of TGOLN2 mRNA CTD PMID:23397585 NCBI chr 4:100,475,415...100,483,229
Ensembl chr 4:100,475,416...100,483,168
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Dimethoate results in increased expression of TNF mRNA
Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]; fulvestrant inhibits the reaction [Estradiol inhibits the reaction [Dimethoate results in increased expression of TNF mRNA]]
CTD PMID:23891859 PMID:23943137 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        agrochemical 14673
          dimethoate 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                acetamides 12395
                                                  acetamide 5462
                                                    N-methyl-2-sulfanylacetamide 52
                                                      dimethoate 43
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