CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: diflubenzuron
Accession: CHEBI:34703
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Definition: A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.
Synonyms: exact_synonym: N-[(4-chlorophenyl)carbamoyl]-2,6-difluorobenzamide
related_synonym: 1-(4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea; 1-(p-chlorophenyl)-3-(2,6-difluorobenzoyl)urea; Formula=C14H9ClF2N2O2; InChI=1S/C14H9ClF2N2O2/c15-8-4-6-9(7-5-8)18-14(21)19-13(20)12-10(16)2-1-3-11(12)17/h1-7H,(H2,18,19,20,21); InChIKey=QQQYTWIFVNKMRW-UHFFFAOYSA-N; N-(4-Chlorophenylcarbamoyl)-2,6-difluorobenzamide; N-{[(4-chlorophenyl)amino]carbonyl}-2,6-difluorobenzamide; SMILES=Fc1cccc(F)c1C(=O)NC(=O)Nc1ccc(Cl)cc1; difluron
xref: Beilstein:2162461; CAS:35367-38-5; HMDB:HMDB0031778; KEGG:C14427; KEGG:D07829
xref_mesh: MESH:D004132
xref: PMID:19835689; PMID:20954045; PMID:22782793; PMID:8510122; PPDB:234; Wikipedia:Diflubenzuron
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
Diflubenzuron results in increased expression of CYP1A1 protein
CTD
PMID:8812189
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects binding
ISO
Diflubenzuron binds to CYP1A2 protein
CTD
PMID:32278787
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Diflubenzuron results in increased expression of CYP3A23-3A1 protein
CTD
PMID:8812189
NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
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Cyp3a62
cytochrome P450, family 3, subfamily a, polypeptide 62
affects binding
ISO
Diflubenzuron binds to CYP3A4 protein
CTD
PMID:32278787
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Diflubenzuron results in increased activity of NR1I2 protein
CTD
PMID:16565514
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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