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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Dicyclohexyl phthalate
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Accession:CHEBI:34693 term browser browse the term
Definition:A phthalate ester that has formula C20H26O4.
Synonyms:related_synonym: Formula=C20H26O4;   InChI=1S/C20H26O4/c21-19(23-15-9-3-1-4-10-15)17-13-7-8-14-18(17)20(22)24-16-11-5-2-6-12-16/h7-8,13-16H,1-6,9-12H2;   InChIKey=VOWAEIGWURALJQ-UHFFFAOYSA-N;   SMILES=O=C(OC1CCCCC1)c1ccccc1C(=O)OC1CCCCC1
 xref: CAS:84-61-7;   KEGG:C14529
 xref_mesh: MESH:C036042


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Dicyclohexyl phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO dicyclohexyl phthalate results in increased expression of ABCB1A mRNA CTD PMID:34851150 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP dicyclohexyl phthalate results in decreased phosphorylation of AKT1 protein CTD PMID:30391266 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression EXP dicyclohexyl phthalate results in decreased expression of ALDH2 mRNA CTD PMID:33983380 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Ar androgen receptor multiple interactions ISO dicyclohexyl phthalate inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; dicyclohexyl phthalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:15840436 PMID:28571686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 increases expression EXP dicyclohexyl phthalate results in increased expression of CRHR2 mRNA CTD PMID:15620428 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of CYP11A1 mRNA; dicyclohexyl phthalate results in decreased expression of CYP11A1 protein CTD PMID:30391266 PMID:33983380 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression EXP dicyclohexyl phthalate results in decreased expression of CYP11B1 mRNA CTD PMID:33983380 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP dicyclohexyl phthalate results in decreased expression of CYP11B2 mRNA CTD PMID:33983380 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of CYP17A1 mRNA; dicyclohexyl phthalate results in decreased expression of CYP17A1 protein CTD PMID:30391266 PMID:33983380 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity EXP dicyclohexyl phthalate results in decreased activity of CYP1A1 protein CTD PMID:27432241 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity EXP dicyclohexyl phthalate results in decreased activity of CYP1A2 protein CTD PMID:27432241 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP dicyclohexyl phthalate results in decreased activity of CYP2B1 protein CTD PMID:27432241 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity EXP dicyclohexyl phthalate results in decreased activity of CYP3A62 protein CTD PMID:27432241 NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833 		JBrowse link
G Cyp51 cytochrome P450, family 51 decreases expression EXP dicyclohexyl phthalate results in decreased expression of CYP51 mRNA CTD PMID:33983380 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression EXP dicyclohexyl phthalate results in decreased expression of DHCR7 mRNA CTD PMID:33983380 NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase decreases expression EXP dicyclohexyl phthalate results in decreased expression of EBP mRNA CTD PMID:33983380 NCBI chr  X:14,299,427...14,305,826
Ensembl chr  X:14,299,448...14,305,826 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein; dicyclohexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [dicyclohexyl phthalate binds to and results in increased activity of ESR1 protein] CTD PMID:15840436 PMID:28571686 PMID:28717100 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO dicyclohexyl phthalate binds to and results in decreased activity of ESR2 protein; dicyclohexyl phthalate inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased activity of ESR2 protein]; dicyclohexyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:15840436 PMID:28571686 PMID:28717100 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression EXP dicyclohexyl phthalate results in decreased expression of FDPS mRNA CTD PMID:33983380 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP dicyclohexyl phthalate results in decreased expression of FSHB protein CTD PMID:30391266 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Galr2 galanin receptor 2 decreases expression EXP dicyclohexyl phthalate results in decreased expression of GALR2 mRNA CTD PMID:15620428 NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176 		JBrowse link
G Gba1 glucosylceramidase beta 1 multiple interactions ISO [dicyclohexyl phthalate results in increased activity of NR1I2 protein] which results in increased expression of GBA1 mRNA CTD PMID:34851150 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Grm7 glutamate metabotropic receptor 7 increases expression EXP dicyclohexyl phthalate results in increased expression of GRM7 mRNA CTD PMID:15620428 NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression EXP dicyclohexyl phthalate results in decreased expression of HMGCR mRNA CTD PMID:33983380 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of HMGCS1 mRNA CTD PMID:33983380 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of HSD11B1 mRNA; dicyclohexyl phthalate results in decreased expression of HSD11B1 protein CTD PMID:30391266 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity EXP
ISO		 dicyclohexyl phthalate results in decreased activity of HSD11B2 protein CTD PMID:16184081 PMID:19786001 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP dicyclohexyl phthalate results in decreased expression of HSD17B3 mRNA; dicyclohexyl phthalate results in decreased expression of HSD17B3 protein CTD PMID:30391266 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of HSD3B1 mRNA; dicyclohexyl phthalate results in decreased expression of HSD3B1 protein CTD PMID:30391266 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 decreases expression EXP dicyclohexyl phthalate results in decreased expression of HSD3B3 mRNA CTD PMID:33983380 NCBI chr 2:186,138,044...186,144,024
Ensembl chr 2:186,138,044...186,144,033 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B increases expression EXP dicyclohexyl phthalate results in increased expression of HTR1B mRNA CTD PMID:15620428 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549 		JBrowse link
G Inha inhibin subunit alpha decreases expression EXP dicyclohexyl phthalate results in decreased expression of INHA mRNA CTD PMID:33983380 NCBI chr 9:76,994,465...76,997,366
Ensembl chr 9:76,993,589...76,997,248 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of INSIG1 mRNA CTD PMID:33983380 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insl3 insulin-like 3 decreases expression EXP dicyclohexyl phthalate results in decreased expression of INSL3 mRNA CTD PMID:30391266 PMID:33983380 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression EXP dicyclohexyl phthalate results in decreased expression of LDLR mRNA CTD PMID:33983380 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP dicyclohexyl phthalate results in decreased expression of LHCGR mRNA; dicyclohexyl phthalate results in decreased expression of LHCGR protein CTD PMID:15620428 PMID:30391266 PMID:33983380 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation EXP dicyclohexyl phthalate results in decreased phosphorylation of MAPK1 protein CTD PMID:30391266 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation EXP dicyclohexyl phthalate results in decreased phosphorylation of MAPK3 protein CTD PMID:30391266 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to MED1 protein] CTD PMID:34851150 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions ISO dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to MTTP promoter] CTD PMID:34851150 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase decreases expression EXP dicyclohexyl phthalate results in decreased expression of MVD mRNA CTD PMID:33983380 NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971 		JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to NCOA1 protein] CTD PMID:34851150 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO dicyclohexyl phthalate inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:34851150 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO dicyclohexyl phthalate inhibits the reaction [NR1I2 protein binds to NCOR2 protein] CTD PMID:34851150 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Neu3 neuraminidase 3 multiple interactions ISO [dicyclohexyl phthalate results in increased activity of NR1I2 protein] which results in increased expression of NEU3 mRNA CTD PMID:34851150 NCBI chr 1:154,137,732...154,148,879
Ensembl chr 1:154,050,855...154,148,813 		JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions
increases expression		 ISO dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to NPC1L1 promoter]
dicyclohexyl phthalate results in increased expression of NPC1L1 mRNA		 CTD PMID:34851150 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113 		JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of NR0B1 mRNA CTD PMID:33983380 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO dicyclohexyl phthalate binds to and results in increased activity of NR1I2 protein; dicyclohexyl phthalate inhibits the reaction [NR1I2 protein binds to NCOR1 protein]; dicyclohexyl phthalate inhibits the reaction [NR1I2 protein binds to NCOR2 protein]; dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to MED1 protein]; dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to NCOA1 protein]
[dicyclohexyl phthalate results in increased activity of NR1I2 protein] which results in increased expression of GBA1 mRNA; [dicyclohexyl phthalate results in increased activity of NR1I2 protein] which results in increased expression of NEU3 mRNA; dicyclohexyl phthalate binds to and results in increased activity of NR1I2 protein; dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to MTTP promoter]; dicyclohexyl phthalate promotes the reaction [NR1I2 protein binds to NPC1L1 promoter]; NR1I2 affects the reaction [dicyclohexyl phthalate results in increased abundance of Ceramides]		 CTD PMID:34851150 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects binding
increases activity		 ISO dicyclohexyl phthalate binds to NR1I3 protein
dicyclohexyl phthalate results in increased activity of NR1I3 protein		 CTD PMID:25938866 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity ISO dicyclohexyl phthalate results in increased activity of NR3C1 protein CTD PMID:19927138 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases expression EXP dicyclohexyl phthalate results in decreased expression of NSDHL mRNA CTD PMID:33983380 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142 		JBrowse link
G Ptger4 prostaglandin E receptor 4 increases expression EXP dicyclohexyl phthalate results in increased expression of PTGER4 mRNA CTD PMID:15620428 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Ptgfr prostaglandin F receptor decreases expression EXP dicyclohexyl phthalate results in decreased expression of PTGFR mRNA CTD PMID:15620428 NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression EXP dicyclohexyl phthalate results in decreased expression of SCARB1 mRNA; dicyclohexyl phthalate results in decreased expression of SCARB1 protein CTD PMID:30391266 PMID:33983380 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP dicyclohexyl phthalate results in decreased expression of STAR mRNA; dicyclohexyl phthalate results in decreased expression of STAR protein CTD PMID:30391266 PMID:33983380 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression EXP dicyclohexyl phthalate results in decreased expression of TM7SF2 mRNA CTD PMID:33983380 NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270 		JBrowse link
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  CHEBI ontology 19811
    role 19818
      application 19630
        pharmaceutical 19503
          drug 19471
            hormone receptor modulator 18942
              endocrine disruptor 18759
                phthalate ester 8329
                  Dicyclohexyl phthalate 56
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      aromatic carboxylic acid 12571
                                        benzoic acids 12570
                                          benzenedicarboxylic acid 8551
                                            phthalic acid 8312
                                              phthalate ester 8329
                                                Dicyclohexyl phthalate 56
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