CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dicofol
Accession: CHEBI:34692
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Definition: A tertiary alcohol that is DDT in which the benzylic hydrogen has been replaced by a hydroxy group.
Synonyms: exact_synonym: 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol
related_synonym: 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethanol; 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol; 2,2,2-trichloro-1,1-bis(p-chlorophenyl)ethanol; 4,4'-dichloro-alpha-(trichloromethyl)benzhydrol; 4-chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)benzenemethanol; Acarin; DTMC; Formula=C14H9Cl5O; InChI=1S/C14H9Cl5O/c15-11-5-1-9(2-6-11)13(20,14(17,18)19)10-3-7-12(16)8-4-10/h1-8,20H; InChIKey=UOAMTSKGCBMZTC-UHFFFAOYSA-N; Kelthane; Mitigan; SMILES=OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)C(Cl)(Cl)Cl; di-(p-chlorophenyl)trichloromethylcarbinol; p,p-dicofol
xref: Beilstein:1886299; CAS:115-32-2; KEGG:C14301
xref_mesh: MESH:D004010
xref: PPDB:223
G
Alb
albumin
multiple interactions
ISO
Dicofol binds to and affects the folding of ALB protein
CTD
PMID:34656558
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Ar
androgen receptor
affects binding multiple interactions
ISO
Dicofol binds to AR protein Dicofol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [Dicofol results in increased activity of AR protein]
CTD
PMID:15064155 PMID:15253041 PMID:18324785 PMID:21310686
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
Dicofol results in decreased activity of CYP19A1 protein
CTD
PMID:10806373
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP1A1 mRNA; Dicofol results in increased expression of CYP1A1 protein
CTD
PMID:19595748
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
Dicofol results in increased expression of CYP1A2 mRNA
CTD
PMID:19595748
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP2B1 protein
CTD
PMID:19595748
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Dicofol results in increased expression of CYP2B2 protein
CTD
PMID:19595748
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP2E1 protein
CTD
PMID:19595748
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Dicofol results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:19595748
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Dio1
iodothyronine deiodinase 1
decreases activity
ISO
Dicofol results in decreased activity of DIO1 protein
CTD
PMID:29228274
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
G
Esr1
estrogen receptor 1
affects binding increases activity multiple interactions
ISO
Dicofol binds to ESR1 protein Dicofol results in increased activity of ESR1 protein Dicofol binds to and results in increased activity of ESR1 protein
CTD
PMID:10789375 PMID:15064155 PMID:15253041 PMID:16337670 PMID:29162470
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
increases activity
ISO
Dicofol results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Ggt1
gamma-glutamyltransferase 1
increases activity
EXP
Dicofol results in increased activity of GGT1 protein
CTD
PMID:2387028
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
G
Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Dicofol results in increased activity of GPT protein
CTD
PMID:2387028
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Ifnb1
interferon beta 1
multiple interactions
ISO
Dicofol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]
CTD
PMID:18177342
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
G
Iyd
iodotyrosine deiodinase
multiple interactions
ISO
Dicofol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine]
CTD
PMID:33352258
NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Dicofol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]
CTD
PMID:17015962
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Dicofol binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Dicofol results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Prkcb
protein kinase C, beta
multiple interactions increases activity
ISO
Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]; Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein]
CTD
PMID:1724372
NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
G
Ttr
transthyretin
affects binding
EXP
Dicofol binds to TTR protein
CTD
PMID:2043046
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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