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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dicofol
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Accession:CHEBI:34692 term browser browse the term
Definition:A tertiary alcohol that is DDT in which the benzylic hydrogen has been replaced by a hydroxy group.
Synonyms:exact_synonym: 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol
 related_synonym: 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethanol;   1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol;   2,2,2-trichloro-1,1-bis(p-chlorophenyl)ethanol;   4,4'-dichloro-alpha-(trichloromethyl)benzhydrol;   4-chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)benzenemethanol;   Acarin;   DTMC;   Formula=C14H9Cl5O;   InChI=1S/C14H9Cl5O/c15-11-5-1-9(2-6-11)13(20,14(17,18)19)10-3-7-12(16)8-4-10/h1-8,20H;   InChIKey=UOAMTSKGCBMZTC-UHFFFAOYSA-N;   Kelthane;   Mitigan;   SMILES=OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)C(Cl)(Cl)Cl;   di-(p-chlorophenyl)trichloromethylcarbinol;   p,p-dicofol
 xref: Beilstein:1886299;   CAS:115-32-2;   KEGG:C14301
 xref_mesh: MESH:D004010
 xref: PPDB:223


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dicofol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding
multiple interactions
ISO Dicofol binds to AR protein
Dicofol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [Dicofol results in increased activity of AR protein]
CTD PMID:15064155, PMID:15253041, PMID:18324785, PMID:21310686 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Dicofol results in decreased activity of CYP19A1 protein CTD PMID:10806373 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP1A1 mRNA; Dicofol results in increased expression of CYP1A1 protein CTD PMID:19595748 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Dicofol results in increased expression of CYP1A2 mRNA CTD PMID:19595748 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP2B1 protein CTD PMID:19595748 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Dicofol results in increased expression of CYP2B2 protein CTD PMID:19595748 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP2E1 protein CTD PMID:19595748 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19595748 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Dicofol results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity
ISO Dicofol binds to ESR1 protein
Dicofol binds to and results in increased activity of ESR1 protein
Dicofol results in increased activity of ESR1 protein
CTD PMID:10789375, PMID:15064155, PMID:15253041, PMID:16337670, PMID:29162470 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Dicofol results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity EXP Dicofol results in increased activity of GGT1 protein CTD PMID:2387028 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Dicofol results in increased activity of GPT protein CTD PMID:2387028 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Dicofol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Dicofol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Dicofol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Dicofol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases activity
ISO Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]; Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein] CTD PMID:1724372 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Ttr transthyretin affects binding EXP Dicofol binds to TTR protein CTD PMID:2043046 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        aetiopathogenetic role 18936
          carcinogenic agent 18312
            DDT 524
              dicofol 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                carbocyclic compound 18181
                                  benzenoid aromatic compound 17178
                                    benzenes 16920
                                      chlorobenzenes 12990
                                        monochlorobenzenes 8871
                                          4,4'-dichlorodiphenylmethane 525
                                            DDT 524
                                              dicofol 19
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