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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dicofol
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Accession:CHEBI:34692 term browser browse the term
Definition:A tertiary alcohol that is DDT in which the benzylic hydrogen has been replaced by a hydroxy group.
Synonyms:exact_synonym: 2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol
 related_synonym: 1,1-bis(4-chlorophenyl)-2,2,2-trichloroethanol;   1,1-bis(p-chlorophenyl)-2,2,2-trichloroethanol;   2,2,2-trichloro-1,1-bis(p-chlorophenyl)ethanol;   4,4'-dichloro-alpha-(trichloromethyl)benzhydrol;   4-chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)benzenemethanol;   Acarin;   DTMC;   Formula=C14H9Cl5O;   InChI=1S/C14H9Cl5O/c15-11-5-1-9(2-6-11)13(20,14(17,18)19)10-3-7-12(16)8-4-10/h1-8,20H;   InChIKey=UOAMTSKGCBMZTC-UHFFFAOYSA-N;   Kelthane;   Mitigan;   SMILES=OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)C(Cl)(Cl)Cl;   di-(p-chlorophenyl)trichloromethylcarbinol;   p,p-dicofol
 xref: Beilstein:1886299;   CAS:115-32-2;   KEGG:C14301
 xref_mesh: MESH:D004010
 xref: PPDB:223


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dicofol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding
multiple interactions
ISO Dicofol binds to AR protein
Dicofol inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Dicofol inhibits the reaction [Metribolone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [Dicofol results in increased activity of AR protein]
CTD PMID:15064155 PMID:15253041 PMID:18324785 PMID:21310686 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Dicofol results in decreased activity of CYP19A1 protein CTD PMID:10806373 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP1A1 mRNA; Dicofol results in increased expression of CYP1A1 protein CTD PMID:19595748 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP Dicofol results in increased expression of CYP1A2 mRNA CTD PMID:19595748 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP2B1 protein CTD PMID:19595748 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Dicofol results in increased expression of CYP2B2 protein CTD PMID:19595748 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP2E1 protein CTD PMID:19595748 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Dicofol results in increased expression of CYP3A23-3A1 mRNA CTD PMID:19595748 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Dicofol results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Esr1 estrogen receptor 1 affects binding
multiple interactions
increases activity
ISO Dicofol binds to ESR1 protein
Dicofol binds to and results in increased activity of ESR1 protein
Dicofol results in increased activity of ESR1 protein
CTD PMID:10789375 PMID:15064155 PMID:15253041 PMID:16337670 PMID:29162470 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Dicofol results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 increases activity EXP Dicofol results in increased activity of GGT1 protein CTD PMID:2387028 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Dicofol results in increased activity of GPT protein CTD PMID:2387028 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Dicofol inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Dicofol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Dicofol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Dicofol binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Dicofol results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Prkcb protein kinase C, beta multiple interactions
increases activity
ISO Calcium inhibits the reaction [Dicofol results in increased activity of PRKCB protein]; Phosphatidylserines promotes the reaction [Dicofol results in increased activity of PRKCB protein] CTD PMID:1724372 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Ttr transthyretin affects binding EXP Dicofol binds to TTR protein CTD PMID:2043046 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        aetiopathogenetic role 19035
          carcinogenic agent 18362
            DDT 540
              dicofol 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                carbocyclic compound 18309
                                  benzenoid aromatic compound 17453
                                    benzenes 17233
                                      chlorobenzenes 13608
                                        monochlorobenzenes 9752
                                          4,4'-dichlorodiphenylmethane 541
                                            DDT 540
                                              dicofol 20
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