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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dichlorvos
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Accession:CHEBI:34690 term browser browse the term
Definition:An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.
Synonyms:related_synonym: 2,2-Dichloroethenyl dimethyl phosphate;   DDVP;   Dimethyl 2,2-dichlorovinyl phosphate;   Formula=C4H7Cl2O4P;   InChI=1S/C4H7Cl2O4P/c1-8-11(7,9-2)10-3-4(5)6/h3H,1-2H3;   InChIKey=OEBRKCOSUFCWJD-UHFFFAOYSA-N;   Phosphoric acid, 2,2-dichloroethenyl dimethyl ester;   Phosphoric acid, 2,2-dichlorovinyl dimethyl ester;   SMILES=COP(=O)(OC)OC=C(Cl)Cl
 xref: Beilstein:1709141;   CAS:62-73-7;   HMDB:HMDB0033956;   KEGG:C14430;   KEGG:D03791
 xref_mesh: MESH:D004006
 xref: MetaCyc:CPD-10185;   PMID:24021659;   PMID:24231740;   PMID:24374570;   PPDB:220;   Reaxys:1709141;   Wikipedia:Dichlorvos


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dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Yt blood group) multiple interactions
decreases expression
decreases activity
decreases response to substance
increases acylation
increases phosphorylation		 EXP
ISO		 [Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; [crotoxyphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [malaoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Paraoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Parathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Phosphamidon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]
Dichlorvos results in decreased expression of ACHE protein
1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos] results in decreased activity of ACHE protein; Dichlorvos inhibits the reaction [sodium arsenite results in increased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]
ACHE protein results in decreased susceptibility to Dichlorvos
Dichlorvos results in increased acylation of ACHE protein
Dichlorvos metabolite results in decreased activity of ACHE protein; Dichlorvos results in decreased activity of ACHE protein
[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Dichlorvos binds to and results in decreased activity of ACHE protein; Dichlorvos promotes the reaction [malaoxon results in decreased activity of ACHE protein]; Gallamine Triethiodide affects the reaction [Dichlorvos results in increased acylation of ACHE protein]; Gallamine Triethiodide promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]		 CTD PMID:119426 PMID:235931 PMID:473212 PMID:475593 PMID:597376 More... NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization
multiple interactions		 ISO Dichlorvos affects the localization of AIFM1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Dichlorvos affects the localization of AIFM1 protein]		 CTD PMID:24231740 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO Dichlorvos results in increased expression of AKR7A3 mRNA CTD PMID:21813463 NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770 		JBrowse link
G ALB albumin affects binding EXP Dichlorvos binds to ALB protein CTD PMID:15525694 PMID:17188226 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO Dichlorvos results in increased expression of ALDH1A1 mRNA CTD PMID:21813463 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G ANXA2 annexin A2 increases expression ISO Dichlorvos results in increased expression of ANXA2 mRNA CTD PMID:21813463 NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883 		JBrowse link
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP
ISO		 Dichlorvos results in decreased activity of APEH protein CTD PMID:15888665 PMID:19379766 NCBI chr 3:49,673,117...49,683,971
Ensembl chr 3:49,674,014...49,683,971 		JBrowse link
G APP amyloid beta precursor protein increases secretion EXP
ISO		 Dichlorvos results in increased secretion of APP protein alternative form
Dichlorvos results in increased secretion of APP protein modified form		 CTD PMID:7605915 PMID:8624119 PMID:11526466 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G AR androgen receptor multiple interactions EXP Dichlorvos promotes the reaction [Metribolone results in increased activity of AR protein] CTD PMID:17219378 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619 		JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
increases expression		 ISO TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of ATM mRNA]
Dichlorvos results in increased expression of ATM mRNA; Dichlorvos results in increased expression of ATM protein		 CTD PMID:24369695 NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,823...108,369,102 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO Dichlorvos results in increased expression of BAX protein CTD PMID:22817663 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCHE butyrylcholinesterase multiple interactions
decreases expression
decreases activity		 EXP
ISO		 [Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Dichlorvos binds to and results in decreased activity of BCHE protein; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]
Dichlorvos results in decreased expression of BCHE protein
diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; Magnesium Sulfate promotes the reaction [Dichlorvos results in decreased activity of BCHE protein]
[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]; Dichlorvos binds to and results in decreased activity of BCHE protein		 CTD PMID:235931 PMID:423703 PMID:1276991 PMID:4631366 PMID:7150809 More... NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462 		JBrowse link
G BTG2 BTG anti-proliferation factor 2 increases expression ISO Dichlorvos results in increased expression of BTG2 mRNA CTD PMID:21813463 NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602 		JBrowse link
G CASP1 caspase 1 increases expression ISO Dichlorvos results in increased expression of CASP1 mRNA CTD PMID:23053939 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 increases activity
increases cleavage
increases expression
decreases expression
multiple interactions		 EXP
ISO		 Dichlorvos results in increased activity of CASP3 protein
Dichlorvos results in increased cleavage of CASP3 protein
Dichlorvos results in increased expression of CASP3 mRNA
Dichlorvos results in decreased expression of CASP3 mRNA
[Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; Dichlorvos results in increased cleavage of and results in increased activity of CASP3 protein; mitoquinone inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased cleavage of CASP3 protein]
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]		 CTD PMID:16973328 PMID:17681413 PMID:17850875 PMID:19815060 PMID:21784090 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity		 ISO [Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP9 protein] CTD PMID:16973328 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
increases activity
decreases activity		 ISO [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]
Dichlorvos results in increased activity of CAT protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]		 CTD PMID:1587340 PMID:20302853 PMID:22034174 PMID:22224058 PMID:22751200 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CDC25A cell division cycle 25A multiple interactions
increases expression		 ISO TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A protein]
Dichlorvos results in increased expression of CDC25A mRNA; Dichlorvos results in increased expression of CDC25A protein		 CTD PMID:24369695 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Dichlorvos results in increased expression of CDKN1A mRNA; Dichlorvos results in increased expression of CDKN1A protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDKN1A mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDKN1A protein]		 CTD PMID:21813463 PMID:24369695 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CES2 carboxylesterase 2 increases expression ISO Dichlorvos results in increased expression of CES2 mRNA CTD PMID:21813463 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G CHAT choline O-acetyltransferase increases activity ISO Dichlorvos results in increased activity of CHAT protein CTD PMID:17722737 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942 		JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
increases expression		 ISO TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CHEK2 mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CHEK2 protein]
Dichlorvos results in increased expression of CHEK2 mRNA; Dichlorvos results in increased expression of CHEK2 protein		 CTD PMID:24369695 NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422 		JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 decreases expression ISO Dichlorvos results in decreased expression of CHRM1 protein CTD PMID:19100812 NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 decreases expression ISO Dichlorvos results in decreased expression of CHRM2 protein CTD PMID:19100812 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255 		JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 decreases expression ISO Dichlorvos results in decreased expression of CHRM3 protein CTD PMID:19100812 NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 NCBI chr20:63,343,223...63,361,349
Ensembl chr20:63,343,223...63,378,401 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 NCBI chr 1:154,567,778...154,580,013
Ensembl chr 1:154,567,778...154,580,013 		JBrowse link
G CNR1 cannabinoid receptor 1 multiple interactions
decreases activity		 ISO Dichlorvos inhibits the reaction [CP 55244 binds to CNR1 protein]
Dichlorvos results in decreased activity of CNR1 protein		 CTD PMID:12243867 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases phosphorylation ISO Dichlorvos results in decreased phosphorylation of CREB1 protein CTD PMID:19100812 NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988 		JBrowse link
G CYBB cytochrome b-245 beta chain increases expression ISO Dichlorvos results in increased expression of CYBB mRNA; Dichlorvos results in increased expression of CYBB protein CTD PMID:21964614 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions		 ISO Dichlorvos affects the localization of CYCS protein
mitoquinone inhibits the reaction [Dichlorvos affects the localization of CYCS protein]		 CTD PMID:17850875 PMID:21784090 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G DBH dopamine beta-hydroxylase increases activity
multiple interactions		 ISO Dichlorvos results in increased activity of DBH protein
Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein]		 CTD PMID:12186780 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329 		JBrowse link
G DLG2 discs large MAGUK scaffold protein 2 affects response to substance EXP DLG2 gene SNP affects the susceptibility to Dichlorvos CTD PMID:25622337 NCBI chr11:83,455,012...85,628,373
Ensembl chr11:83,455,012...85,628,335 		JBrowse link
G DRD2 dopamine receptor D2 decreases activity
multiple interactions		 ISO Dichlorvos results in decreased activity of DRD2 protein
Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]		 CTD PMID:12186780 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G ESR1 estrogen receptor 1 decreases activity EXP Dichlorvos results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FAS Fas cell surface death receptor decreases expression ISO Dichlorvos results in decreased expression of FAS protein CTD PMID:15369847 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand decreases expression ISO Dichlorvos results in decreased expression of FASL protein CTD PMID:15369847 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GABRD gamma-aminobutyric acid type A receptor subunit delta decreases expression ISO Dichlorvos results in decreased expression of GABRD mRNA CTD PMID:19146868 NCBI chr 1:2,019,345...2,030,758
Ensembl chr 1:2,019,329...2,030,758 		JBrowse link
G GCK glucokinase decreases activity
increases expression		 ISO Dichlorvos results in decreased activity of GCK protein
Dichlorvos results in increased expression of GCK mRNA		 CTD PMID:16153661 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170 		JBrowse link
G GNLY granulysin decreases expression EXP Dichlorvos results in decreased expression of GNLY mRNA; Dichlorvos results in decreased expression of GNLY protein CTD PMID:16002202 NCBI chr 2:85,694,358...85,698,852
Ensembl chr 2:85,685,175...85,698,852 		JBrowse link
G GSR glutathione-disulfide reductase decreases expression
increases activity
decreases activity
multiple interactions		 ISO Dichlorvos results in decreased expression of GSR protein
Dichlorvos results in increased activity of GSR protein
Dichlorvos results in decreased activity of GSR protein
[Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; Dichlorvos inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Plant Extracts inhibits the reaction [Dichlorvos results in decreased activity of GSR protein]; sodium arsenite inhibits the reaction [Dichlorvos results in increased activity of GSR protein]		 CTD PMID:18539328 PMID:20302853 PMID:22224058 PMID:22751200 PMID:25895260 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GYS2 glycogen synthase 2 increases activity ISO Dichlorvos results in increased activity of GYS2 protein CTD PMID:222008 NCBI chr12:21,532,577...21,604,847
Ensembl chr12:21,536,107...21,604,847 		JBrowse link
G GZMA granzyme A decreases expression EXP Dichlorvos results in decreased expression of GZMA mRNA; Dichlorvos results in decreased expression of GZMA protein CTD PMID:16002202 NCBI chr 5:55,102,646...55,110,252
Ensembl chr 5:55,102,646...55,110,252 		JBrowse link
G GZMB granzyme B decreases expression EXP Dichlorvos results in decreased expression of GZMB protein CTD PMID:18063463 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267 		JBrowse link
G GZMK granzyme K decreases expression EXP Dichlorvos results in decreased expression of GZMK protein CTD PMID:18063463 NCBI chr 5:55,024,256...55,034,570
Ensembl chr 5:55,024,256...55,034,570 		JBrowse link
G HDC histidine decarboxylase increases activity ISO Dichlorvos results in increased activity of HDC protein CTD PMID:119426 NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965 		JBrowse link
G HK1 hexokinase 1 decreases activity ISO Dichlorvos results in decreased activity of HK1 protein CTD PMID:10544956 NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884 		JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
multiple interactions		 ISO Dichlorvos results in decreased expression of HMOX1 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of HMOX1 protein]		 CTD PMID:26814074 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G IFNG interferon gamma decreases expression ISO Dichlorvos results in decreased expression of IFNG protein CTD PMID:19145326 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL1B interleukin 1 beta increases expression
increases secretion		 ISO Dichlorvos results in increased expression of IL1B mRNA; Dichlorvos results in increased expression of IL1B protein
Dichlorvos results in increased secretion of IL1B protein		 CTD PMID:21964614 PMID:22817663 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 decreases response to substance ISO Dichlorvos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL6 interleukin 6 increases expression ISO Dichlorvos results in increased expression of IL6 mRNA; Dichlorvos results in increased expression of IL6 protein CTD PMID:21964614 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO INS1 protein inhibits the reaction [Dichlorvos results in increased abundance of Glucose] CTD PMID:222008 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G ITGAM integrin subunit alpha M increases expression
multiple interactions		 ISO Dichlorvos results in increased expression of ITGAM mRNA; Dichlorvos results in increased expression of ITGAM protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of ITGAM protein]		 CTD PMID:21964614 PMID:22817663 PMID:24369695 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase decreases activity
multiple interactions		 EXP Dichlorvos results in decreased activity of LCAT protein
Dichlorvos inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]		 CTD PMID:4847537 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131 		JBrowse link
G LPL lipoprotein lipase decreases activity ISO Dichlorvos results in decreased activity of LPL protein CTD PMID:3196159 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MAOA monoamine oxidase A decreases activity ISO Dichlorvos results in decreased activity of MAOA protein CTD PMID:12018584 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,817 		JBrowse link
G MAOB monoamine oxidase B decreases activity ISO Dichlorvos results in decreased activity of MAOB protein CTD PMID:12018584 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450 		JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions
increases phosphorylation		 ISO Nimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein] CTD PMID:11282359 PMID:16635102 NCBI chr 2:209,424,047...209,734,112
Ensembl chr 2:209,424,047...209,734,147 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase increases expression ISO Dichlorvos results in increased expression of MGMT mRNA CTD PMID:21813463 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983 		JBrowse link
G NCEH1 neutral cholesterol ester hydrolase 1 affects expression
decreases activity		 ISO Dichlorvos affects the expression of NCEH1 protein modified form
Dichlorvos results in decreased activity of NCEH1 protein		 CTD PMID:6245657 PMID:16978018 NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218 		JBrowse link
G NEFH neurofilament heavy chain affects expression ISO Dichlorvos affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390 		JBrowse link
G NEFL neurofilament light chain decreases expression ISO Dichlorvos results in decreased expression of NEFL mRNA CTD PMID:19146868 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,956,721 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases activity
decreases expression
multiple interactions		 EXP
ISO		 Dichlorvos results in increased activity of NFE2L2 protein
Dichlorvos results in decreased expression of NFE2L2 mRNA; Dichlorvos results in decreased expression of NFE2L2 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 protein]		 CTD PMID:20143881 PMID:25891459 PMID:26814074 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NOS2 nitric oxide synthase 2 increases expression
multiple interactions		 ISO Dichlorvos results in increased expression of NOS2 mRNA; Dichlorvos results in increased expression of NOS2 protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of NOS2 mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of NOS2 protein]		 CTD PMID:22817663 PMID:24369695 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions		 ISO Dichlorvos results in decreased expression of NQO1 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NQO1 protein]		 CTD PMID:26814074 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity
increases cleavage
multiple interactions		 ISO Dichlorvos results in increased activity of PARP1 protein
Dichlorvos results in increased cleavage of PARP1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Dichlorvos results in increased activity of PARP1 protein]		 CTD PMID:24231740 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PNPLA6 patatin like phospholipase domain containing 6 decreases activity ISO
EXP		 Dichlorvos results in decreased activity of PNPLA6 protein CTD PMID:7713347 PMID:9268605 PMID:9586870 PMID:10776595 PMID:11282359 More... NCBI chr19:7,534,164...7,561,767
Ensembl chr19:7,534,004...7,561,764 		JBrowse link
G POMC proopiomelanocortin multiple interactions
increases secretion		 ISO Dichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]
Dichlorvos results in increased secretion of POMC protein modified form		 CTD PMID:2993719 PMID:6245657 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903 		JBrowse link
G PON1 paraoxonase 1 multiple interactions
decreases activity
decreases expression
decreases response to substance		 ISO 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; asoxime chloride inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]
Dichlorvos results in decreased expression of PON1 mRNA; Dichlorvos results in decreased expression of PON1 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of HMOX1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NQO1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of PON1 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of PON1 protein]
PON1 protein results in decreased susceptibility to Dichlorvos		 CTD PMID:20412842 PMID:25891459 PMID:26814074 PMID:29098328 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G PRF1 perforin 1 decreases expression EXP Dichlorvos results in decreased expression of PRF1 mRNA; Dichlorvos results in decreased expression of PRF1 protein CTD PMID:16002202 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit increases expression
multiple interactions		 ISO Dichlorvos results in increased expression of PRKDC mRNA; Dichlorvos results in increased expression of PRKDC protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of PRKDC mRNA]		 CTD PMID:24369695 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178 		JBrowse link
G PYGB glycogen phosphorylase B increases activity ISO Dichlorvos results in increased activity of PYGB protein CTD PMID:10544956 NCBI chr20:25,248,085...25,298,012
Ensembl chr20:25,248,085...25,298,012 		JBrowse link
G PYGL glycogen phosphorylase L increases activity ISO Dichlorvos results in increased activity of PYGL protein CTD PMID:222008 NCBI chr14:50,905,217...50,944,483
Ensembl chr14:50,857,891...50,944,483 		JBrowse link
G SNCA synuclein alpha multiple interactions
affects localization		 ISO coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]; Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]
Dichlorvos affects the localization of SNCA protein		 CTD PMID:21073741 PMID:21843543 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity		 ISO [mitoquinone results in increased expression of SOD2 protein] which results in decreased susceptibility to Dichlorvos; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of SOD2 protein] CTD PMID:17850875 PMID:21784090 PMID:24231740 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Dichlorvos results in increased expression of TAP1 mRNA CTD PMID:21813463 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816 		JBrowse link
G TAT tyrosine aminotransferase multiple interactions
increases expression		 ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092 		JBrowse link
G TF transferrin affects binding EXP
ISO		 Dichlorvos binds to TF protein
Dichlorvos binds to TRF protein		 CTD PMID:18930948 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TH tyrosine hydroxylase increases activity
multiple interactions		 ISO Dichlorvos results in increased activity of TH protein
Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]		 CTD PMID:12186780 NCBI chr11:2,163,929...2,171,815
Ensembl chr11:2,163,929...2,171,815 		JBrowse link
G TNF tumor necrosis factor increases expression
increases secretion		 ISO Dichlorvos results in increased expression of TNF mRNA; Dichlorvos results in increased expression of TNF protein
Dichlorvos results in increased secretion of TNF protein		 CTD PMID:21964614 PMID:22817663 PMID:23053939 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 decreases expression
multiple interactions
increases expression		 ISO Dichlorvos results in decreased expression of TP53 mRNA
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of TP53 mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of TP53 protein]
Dichlorvos results in increased expression of TP53 mRNA; Dichlorvos results in increased expression of TP53 protein		 CTD PMID:23053939 PMID:24369695 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TUBB tubulin beta class I increases phosphorylation ISO Dichlorvos results in increased phosphorylation of TUBB protein CTD PMID:11282359 PMID:16635102 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538 		JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases activity ISO Dichlorvos results in decreased activity of UGP2 protein CTD PMID:222008 NCBI chr 2:63,840,969...63,891,560
Ensembl chr 2:63,840,952...63,891,562 		JBrowse link
G XAB2 XPA binding protein 2 affects response to substance EXP XAB2 gene SNP affects the susceptibility to Dichlorvos CTD PMID:22102698 NCBI chr19:7,619,525...7,629,545
Ensembl chr19:7,619,525...7,629,545 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      biological role 25936
        antimicrobial agent 21902
          antibacterial agent 17828
            dichlorvos 85
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      chalcogen 24924
                        oxygen atom 24814
                          oxygen molecular entity 24814
                            hydroxides 24056
                              oxoacid 22984
                                pnictogen oxoacid 13805
                                  phosphorus oxoacid 12864
                                    phosphoric acids 11885
                                      phosphoric acid 11885
                                        phosphoric acid derivative 11686
                                          phosphate 11685
                                            organic phosphate 11685
                                              alkyl phosphate 4389
                                                dialkyl phosphate 3631
                                                  dichlorvos 85
paths to the root