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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dichlorvos
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Accession:CHEBI:34690 term browser browse the term
Definition:An alkenyl phosphate that is the 2,2-dichloroethenyl ester of dimethyl phosphate.
Synonyms:related_synonym: 2,2-Dichloroethenyl dimethyl phosphate;   DDVP;   Dimethyl 2,2-dichlorovinyl phosphate;   Formula=C4H7Cl2O4P;   InChI=1S/C4H7Cl2O4P/c1-8-11(7,9-2)10-3-4(5)6/h3H,1-2H3;   InChIKey=OEBRKCOSUFCWJD-UHFFFAOYSA-N;   Phosphoric acid, 2,2-dichloroethenyl dimethyl ester;   Phosphoric acid, 2,2-dichlorovinyl dimethyl ester;   SMILES=COP(=O)(OC)OC=C(Cl)Cl
 xref: Beilstein:1709141;   CAS:62-73-7;   HMDB:HMDB0033956;   KEGG:C14430;   KEGG:D03791
 xref_mesh: MESH:D004006
 xref: MetaCyc:CPD-10185;   PMID:24021659;   PMID:24231740;   PMID:24374570;   PPDB:220;   Reaxys:1709141;   Wikipedia:Dichlorvos


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dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
decreases expression
decreases activity
decreases response to substance
increases acylation
increases phosphorylation
EXP
ISO
[Carbaryl co-treated with Dichlorvos] results in decreased activity of ACHE protein; [crotoxyphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Dichlorvos results in increased phosphorylation of ACHE protein] inhibits the reaction [thioflavin T binds to ACHE protein]; [malaoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Mevinphos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Paraoxon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Parathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Phosphamidon co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein; [Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]
Dichlorvos results in decreased expression of ACHE protein
1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [Dichlorvos co-treated with Monocrotophos] results in increased activity of ACHE protein; [Monocrotophos co-treated with Dichlorvos] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; [sodium arsenite co-treated with Dichlorvos co-treated with Monocrotophos] results in decreased activity of ACHE protein; [sodium arsenite co-treated with Dichlorvos] results in decreased activity of ACHE protein; Dichlorvos inhibits the reaction [sodium arsenite results in increased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]
ACHE protein results in decreased susceptibility to Dichlorvos
Dichlorvos results in increased acylation of ACHE protein
Dichlorvos metabolite results in decreased activity of ACHE protein; Dichlorvos results in decreased activity of ACHE protein
[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; Atropine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; coumarin inhibits the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Dichlorvos binds to and results in decreased activity of ACHE protein; Dichlorvos promotes the reaction [malaoxon results in decreased activity of ACHE protein]; Gallamine Triethiodide affects the reaction [Dichlorvos results in increased acylation of ACHE protein]; Gallamine Triethiodide promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; Propidium promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Tubocurarine promotes the reaction [Dichlorvos results in increased phosphorylation of ACHE protein]
CTD PMID:119426 PMID:235931 PMID:473212 PMID:475593 PMID:597376 PMID:1258061 PMID:1494302 PMID:1609424 PMID:1855619 PMID:2086312 PMID:2537085 PMID:3247000 PMID:3945941 PMID:4859365 PMID:6933967 PMID:7150809 PMID:7218377 PMID:7234437 PMID:7713347 PMID:8231460 PMID:8359835 PMID:8579882 PMID:8783813 PMID:9268605 PMID:9515941 PMID:9586870 PMID:10421444 PMID:10975133 PMID:12018594 PMID:14631503 PMID:15033007 PMID:15679473 PMID:15793557 PMID:15979224 PMID:16036766 PMID:16193528 PMID:16598855 PMID:16978018 PMID:17188317 PMID:17722737 PMID:18070496 PMID:18423506 PMID:19100812 PMID:19631781 PMID:20026515 PMID:20396698 PMID:20412842 PMID:21251949 PMID:21349312 PMID:21673941 PMID:21767560 PMID:22209767 PMID:22783142 PMID:23220589 PMID:25082528 PMID:25895260 PMID:26814074 PMID:27899289 PMID:30625376 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects localization
multiple interactions
ISO Dichlorvos affects the localization of AIFM1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Dichlorvos affects the localization of AIFM1 protein]
CTD PMID:24231740 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO Dichlorvos results in increased expression of AKR7A3 mRNA CTD PMID:21813463 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G ALB albumin affects binding EXP Dichlorvos binds to ALB protein CTD PMID:15525694 PMID:17188226 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO Dichlorvos results in increased expression of ALDH1A1 mRNA CTD PMID:21813463 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G ANXA2 annexin A2 increases expression ISO Dichlorvos results in increased expression of ANXA2 mRNA CTD PMID:21813463 NCBI chr15:60,347,151...60,398,025
Ensembl chr15:60,347,134...60,402,883
JBrowse link
G APEH acylaminoacyl-peptide hydrolase decreases activity EXP
ISO
Dichlorvos results in decreased activity of APEH protein CTD PMID:15888665 PMID:19379766 NCBI chr 3:49,673,102...49,683,971
Ensembl chr 3:49,674,014...49,683,971
JBrowse link
G APP amyloid beta precursor protein increases secretion EXP
ISO
Dichlorvos results in increased secretion of APP protein alternative form
Dichlorvos results in increased secretion of APP protein modified form
CTD PMID:7605915 PMID:8624119 PMID:11526466 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AR androgen receptor multiple interactions EXP Dichlorvos promotes the reaction [Metribolone results in increased activity of AR protein] CTD PMID:17219378 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
increases expression
ISO TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of ATM mRNA]
Dichlorvos results in increased expression of ATM mRNA; Dichlorvos results in increased expression of ATM protein
CTD PMID:24369695 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO Dichlorvos results in increased expression of BAX protein CTD PMID:22817663 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCHE butyrylcholinesterase multiple interactions
decreases expression
decreases activity
EXP
ISO
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Dichlorvos binds to and results in decreased activity of BCHE protein; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; Tiapamil Hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]
Dichlorvos results in decreased expression of BCHE protein
diacetylmonoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; Magnesium Sulfate promotes the reaction [Dichlorvos results in decreased activity of BCHE protein]
[bacoside A co-treated with Plant Preparations] inhibits the reaction [Dichlorvos results in decreased expression of BCHE protein]; Dichlorvos binds to and results in decreased activity of BCHE protein
CTD PMID:235931 PMID:423703 PMID:1276991 PMID:4631366 PMID:7150809 PMID:12190811 PMID:12828128 PMID:16036766 PMID:16193528 PMID:16598855 PMID:17698511 PMID:19504058 PMID:20229498 PMID:20395308 PMID:21673941 PMID:21767560 PMID:22209767 PMID:27899289 NCBI chr 3:165,772,904...165,837,423
Ensembl chr 3:165,772,904...165,837,462
JBrowse link
G BTG2 BTG anti-proliferation factor 2 increases expression ISO Dichlorvos results in increased expression of BTG2 mRNA CTD PMID:21813463 NCBI chr 1:203,305,519...203,309,602
Ensembl chr 1:203,305,491...203,309,602
JBrowse link
G CASP1 caspase 1 increases expression ISO Dichlorvos results in increased expression of CASP1 mRNA CTD PMID:23053939 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 increases activity
increases cleavage
increases expression
decreases expression
multiple interactions
EXP
ISO
Dichlorvos results in increased activity of CASP3 protein
Dichlorvos results in increased cleavage of CASP3 protein
Dichlorvos results in increased expression of CASP3 mRNA
Dichlorvos results in decreased expression of CASP3 mRNA
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; [Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]; Dichlorvos results in increased cleavage of and results in increased activity of CASP3 protein; TEMPOL-H inhibits the reaction [Dichlorvos results in increased cleavage of CASP3 protein]
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Dichlorvos results in increased activity of CASP3 protein]
CTD PMID:16973328 PMID:17681413 PMID:17850875 PMID:19815060 PMID:21784090 PMID:22817663 PMID:24369695 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity
ISO [Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dichlorvos results in increased activity of CASP9 protein] CTD PMID:16973328 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
increases activity
decreases activity
ISO [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; coenzyme Q10 inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]
Dichlorvos results in increased activity of CAT protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]
CTD PMID:1587340 PMID:20302853 PMID:22034174 PMID:22224058 PMID:22751200 PMID:25891459 PMID:26814074 PMID:27180203 PMID:29143438 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDC25A cell division cycle 25A multiple interactions
increases expression
ISO TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDC25A protein]
Dichlorvos results in increased expression of CDC25A mRNA; Dichlorvos results in increased expression of CDC25A protein
CTD PMID:24369695 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Dichlorvos results in increased expression of CDKN1A mRNA; Dichlorvos results in increased expression of CDKN1A protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDKN1A mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CDKN1A protein]
CTD PMID:21813463 PMID:24369695 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CES2 carboxylesterase 2 increases expression ISO Dichlorvos results in increased expression of CES2 mRNA CTD PMID:21813463 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096
JBrowse link
G CHAT choline O-acetyltransferase increases activity ISO Dichlorvos results in increased activity of CHAT protein CTD PMID:17722737 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,665,104
Ensembl chr10:49,609,095...49,665,104
JBrowse link
G CHEK2 checkpoint kinase 2 multiple interactions
increases expression
ISO TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CHEK2 mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of CHEK2 protein]
Dichlorvos results in increased expression of CHEK2 mRNA; Dichlorvos results in increased expression of CHEK2 protein
CTD PMID:24369695 NCBI chr22:28,687,743...28,741,866
Ensembl chr22:28,687,743...28,742,422
JBrowse link
G CHRM1 cholinergic receptor muscarinic 1 decreases expression ISO Dichlorvos results in decreased expression of CHRM1 protein CTD PMID:19100812 NCBI chr11:62,908,675...62,921,861
Ensembl chr11:62,908,679...62,921,807
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 decreases expression ISO Dichlorvos results in decreased expression of CHRM2 protein CTD PMID:19100812 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,669...137,020,255
Ensembl chr 7:136,868,669...137,020,255
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 decreases expression ISO Dichlorvos results in decreased expression of CHRM3 protein CTD PMID:19100812 NCBI chr 1:239,386,565...239,915,450
Ensembl chr 1:239,386,565...239,915,452
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 NCBI chr20:63,343,223...63,375,471
Ensembl chr20:63,343,223...63,378,401
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Dichlorvos inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:15733544 NCBI chr 1:154,567,778...154,584,708
Ensembl chr 1:154,567,778...154,580,013
JBrowse link
G CNR1 cannabinoid receptor 1 multiple interactions
decreases activity
ISO Dichlorvos inhibits the reaction [CP 55244 binds to CNR1 protein]
Dichlorvos results in decreased activity of CNR1 protein
CTD PMID:12243867 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,359
Ensembl chr 6:88,139,864...88,166,359
JBrowse link
G CREB1 cAMP responsive element binding protein 1 decreases phosphorylation ISO Dichlorvos results in decreased phosphorylation of CREB1 protein CTD PMID:19100812 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CYBB cytochrome b-245 beta chain increases expression ISO Dichlorvos results in increased expression of CYBB mRNA; Dichlorvos results in increased expression of CYBB protein CTD PMID:21964614 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions
ISO Dichlorvos affects the localization of CYCS protein
10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide inhibits the reaction [Dichlorvos affects the localization of CYCS protein]
CTD PMID:17850875 PMID:21784090 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G DBH dopamine beta-hydroxylase increases activity
multiple interactions
ISO Dichlorvos results in increased activity of DBH protein
Nimodipine inhibits the reaction [Dichlorvos results in increased activity of DBH protein]
CTD PMID:12186780 NCBI chr 9:133,636,363...133,659,329
Ensembl chr 9:133,636,363...133,659,329
JBrowse link
G DLG2 discs large MAGUK scaffold protein 2 affects response to substance EXP DLG2 gene SNP affects the susceptibility to Dichlorvos CTD PMID:25622337 NCBI chr11:83,455,009...85,628,535
Ensembl chr11:83,455,012...85,627,922
JBrowse link
G DRD2 dopamine receptor D2 decreases activity
multiple interactions
ISO Dichlorvos results in decreased activity of DRD2 protein
Nimodipine inhibits the reaction [Dichlorvos results in decreased activity of DRD2 protein]
CTD PMID:12186780 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G ESR1 estrogen receptor 1 decreases activity EXP Dichlorvos results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G FAS Fas cell surface death receptor decreases expression ISO Dichlorvos results in decreased expression of FAS protein CTD PMID:15369847 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand decreases expression ISO Dichlorvos results in decreased expression of FASL protein CTD PMID:15369847 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G GABRD gamma-aminobutyric acid type A receptor subunit delta decreases expression ISO Dichlorvos results in decreased expression of GABRD mRNA CTD PMID:19146868 NCBI chr 1:2,019,345...2,030,758
Ensembl chr 1:2,019,329...2,030,758
JBrowse link
G GCK glucokinase decreases activity
increases expression
ISO Dichlorvos results in decreased activity of GCK protein
Dichlorvos results in increased expression of GCK mRNA
CTD PMID:16153661 NCBI chr 7:44,143,213...44,189,439
Ensembl chr 7:44,143,213...44,198,170
JBrowse link
G GNLY granulysin decreases expression EXP Dichlorvos results in decreased expression of GNLY mRNA; Dichlorvos results in decreased expression of GNLY protein CTD PMID:16002202 NCBI chr 2:85,694,294...85,698,854
Ensembl chr 2:85,685,175...85,698,854
Ensembl chr 2:85,685,175...85,698,854
JBrowse link
G GSR glutathione-disulfide reductase decreases expression
increases activity
decreases activity
multiple interactions
ISO Dichlorvos results in decreased expression of GSR protein
Dichlorvos results in increased activity of GSR protein
Dichlorvos results in decreased activity of GSR protein
[Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; Dichlorvos inhibits the reaction [sodium arsenite results in increased activity of GSR protein]; Plant Extracts inhibits the reaction [Dichlorvos results in decreased activity of GSR protein]; sodium arsenite inhibits the reaction [Dichlorvos results in increased activity of GSR protein]
CTD PMID:18539328 PMID:20302853 PMID:22224058 PMID:22751200 PMID:25895260 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GYS2 glycogen synthase 2 increases activity ISO Dichlorvos results in increased activity of GYS2 protein CTD PMID:222008 NCBI chr12:21,531,527...21,604,858
Ensembl chr12:21,536,107...21,604,847
JBrowse link
G GZMA granzyme A decreases expression EXP Dichlorvos results in decreased expression of GZMA mRNA; Dichlorvos results in decreased expression of GZMA protein CTD PMID:16002202 NCBI chr 5:55,102,646...55,110,252
Ensembl chr 5:55,102,646...55,110,252
JBrowse link
G GZMB granzyme B decreases expression EXP Dichlorvos results in decreased expression of GZMB protein CTD PMID:18063463 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267
JBrowse link
G GZMK granzyme K decreases expression EXP Dichlorvos results in decreased expression of GZMK protein CTD PMID:18063463 NCBI chr 5:55,024,256...55,034,570
Ensembl chr 5:55,024,256...55,034,570
JBrowse link
G HDC histidine decarboxylase increases activity ISO Dichlorvos results in increased activity of HDC protein CTD PMID:119426 NCBI chr15:50,241,945...50,266,049
Ensembl chr15:50,241,947...50,265,965
JBrowse link
G HK1 hexokinase 1 decreases activity ISO Dichlorvos results in decreased activity of HK1 protein CTD PMID:10544956 NCBI chr10:69,269,991...69,401,882
Ensembl chr10:69,269,984...69,401,884
JBrowse link
G HMOX1 heme oxygenase 1 decreases expression
multiple interactions
ISO Dichlorvos results in decreased expression of HMOX1 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of HMOX1 protein]
CTD PMID:26814074 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma decreases expression ISO Dichlorvos results in decreased expression of IFNG protein CTD PMID:19145326 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1B interleukin 1 beta increases expression
increases secretion
ISO Dichlorvos results in increased expression of IL1B mRNA; Dichlorvos results in increased expression of IL1B protein
Dichlorvos results in increased secretion of IL1B protein
CTD PMID:21964614 PMID:22817663 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 decreases response to substance ISO Dichlorvos results in decreased susceptibility to IL2 protein CTD PMID:8349949 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL6 interleukin 6 increases expression ISO Dichlorvos results in increased expression of IL6 mRNA; Dichlorvos results in increased expression of IL6 protein CTD PMID:21964614 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M increases expression
multiple interactions
ISO Dichlorvos results in increased expression of ITGAM mRNA; Dichlorvos results in increased expression of ITGAM protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of ITGAM protein]
CTD PMID:21964614 PMID:22817663 PMID:24369695 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G LCAT lecithin-cholesterol acyltransferase decreases activity
multiple interactions
EXP Dichlorvos results in decreased activity of LCAT protein
Dichlorvos inhibits the reaction [[LCAT protein results in increased metabolism of Lecithins] which results in increased chemical synthesis of Cholesterol Esters]
CTD PMID:4847537 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G LPL lipoprotein lipase decreases activity ISO Dichlorvos results in decreased activity of LPL protein CTD PMID:3196159 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
JBrowse link
G MAOA monoamine oxidase A decreases activity ISO Dichlorvos results in decreased activity of MAOA protein CTD PMID:12018584 NCBI chr  X:43,655,006...43,746,817
Ensembl chr  X:43,654,907...43,746,824
JBrowse link
G MAOB monoamine oxidase B decreases activity ISO Dichlorvos results in decreased activity of MAOB protein CTD PMID:12018584 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions
increases phosphorylation
ISO Nimodipine inhibits the reaction [Dichlorvos results in increased phosphorylation of MAP2 protein] CTD PMID:11282359 PMID:16635102 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,058...209,734,118
Ensembl chr 2:209,424,058...209,734,118
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase increases expression ISO Dichlorvos results in increased expression of MGMT mRNA CTD PMID:21813463 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G NCEH1 neutral cholesterol ester hydrolase 1 affects expression
decreases activity
ISO Dichlorvos affects the expression of NCEH1 protein modified form
Dichlorvos results in decreased activity of NCEH1 protein
CTD PMID:6245657 PMID:16978018 NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218
JBrowse link
G NEFH neurofilament heavy chain affects expression ISO Dichlorvos affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr22:29,480,218...29,491,390
Ensembl chr22:29,480,218...29,491,390
JBrowse link
G NEFL neurofilament light chain decreases expression ISO Dichlorvos results in decreased expression of NEFL mRNA CTD PMID:19146868 NCBI chr 8:24,950,955...24,956,612
Ensembl chr 8:24,950,955...24,957,110
Ensembl chr 8:24,950,955...24,957,110
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases activity
decreases expression
multiple interactions
EXP
ISO
Dichlorvos results in increased activity of NFE2L2 protein
Dichlorvos results in decreased expression of NFE2L2 mRNA; Dichlorvos results in decreased expression of NFE2L2 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 protein]
CTD PMID:20143881 PMID:25891459 PMID:26814074 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression
multiple interactions
ISO Dichlorvos results in increased expression of NOS2 mRNA; Dichlorvos results in increased expression of NOS2 protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of NOS2 mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of NOS2 protein]
CTD PMID:22817663 PMID:24369695 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 decreases expression
multiple interactions
ISO Dichlorvos results in decreased expression of NQO1 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NQO1 protein]
CTD PMID:26814074 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity
increases cleavage
multiple interactions
ISO Dichlorvos results in increased activity of PARP1 protein
Dichlorvos results in increased cleavage of PARP1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Dichlorvos results in increased activity of PARP1 protein]
CTD PMID:24231740 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PNPLA6 patatin like phospholipase domain containing 6 decreases activity ISO
EXP
Dichlorvos results in decreased activity of PNPLA6 protein CTD PMID:7713347 PMID:9268605 PMID:9586870 PMID:10776595 PMID:11282359 PMID:11705460 NCBI chr19:7,534,164...7,561,767
Ensembl chr19:7,534,004...7,561,764
JBrowse link
G POMC proopiomelanocortin multiple interactions
increases secretion
ISO Dichlorvos inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]
Dichlorvos results in increased secretion of POMC protein modified form
CTD PMID:2993719 PMID:6245657 NCBI chr 2:25,160,860...25,168,580
Ensembl chr 2:25,160,853...25,168,903
JBrowse link
G PON1 paraoxonase 1 multiple interactions
decreases activity
decreases expression
decreases response to substance
ISO 1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; 1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; asoxime chloride inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; Obidoxime Chloride inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]; Trimedoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein]
Dichlorvos results in decreased expression of PON1 mRNA; Dichlorvos results in decreased expression of PON1 protein
PON1 protein inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of ACHE protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of HMOX1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NFE2L2 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of NQO1 protein]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of PON1 mRNA]; PON1 protein inhibits the reaction [Dichlorvos results in decreased expression of PON1 protein]
PON1 protein results in decreased susceptibility to Dichlorvos
CTD PMID:20412842 PMID:25891459 PMID:26814074 PMID:29098328 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PRF1 perforin 1 decreases expression EXP Dichlorvos results in decreased expression of PRF1 mRNA; Dichlorvos results in decreased expression of PRF1 protein CTD PMID:16002202 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit increases expression
multiple interactions
ISO Dichlorvos results in increased expression of PRKDC mRNA; Dichlorvos results in increased expression of PRKDC protein
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of PRKDC mRNA]
CTD PMID:24369695 NCBI chr 8:47,773,111...47,960,136
Ensembl chr 8:47,773,111...47,960,178
Ensembl chr 8:47,773,111...47,960,178
JBrowse link
G PYGB glycogen phosphorylase B increases activity ISO Dichlorvos results in increased activity of PYGB protein CTD PMID:10544956 NCBI chr20:25,248,039...25,298,012
Ensembl chr20:25,248,085...25,298,012
JBrowse link
G PYGL glycogen phosphorylase L increases activity ISO Dichlorvos results in increased activity of PYGL protein CTD PMID:222008 NCBI chr14:50,905,217...50,944,483
Ensembl chr14:50,857,891...50,944,483
JBrowse link
G SNCA synuclein alpha multiple interactions
affects localization
ISO coenzyme Q10 inhibits the reaction [Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]]; Dichlorvos promotes the reaction [SNCA protein binds to SNCA protein]
Dichlorvos affects the localization of SNCA protein
CTD PMID:21073741 PMID:21843543 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity
ISO [10-(6'-ubiquinonyl)decyltriphenylphosphonium bromide results in increased expression of SOD2 protein] which results in decreased susceptibility to Dichlorvos; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Dichlorvos results in decreased activity of SOD2 protein] CTD PMID:17850875 PMID:21784090 PMID:24231740 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TAP1 transporter 1, ATP binding cassette subfamily B member increases expression ISO Dichlorvos results in increased expression of TAP1 mRNA CTD PMID:21813463 NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,978
Ensembl chr 6:32,845,209...32,853,978
JBrowse link
G TAT tyrosine aminotransferase multiple interactions
increases expression
ISO [Atropine co-treated with Obidoxime Chloride co-treated with Diazepam] inhibits the reaction [Dichlorvos results in increased expression of TAT protein] CTD PMID:7761789 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
G TF transferrin affects binding EXP
ISO
Dichlorvos binds to TF protein
Dichlorvos binds to TRF protein
CTD PMID:18930948 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TH tyrosine hydroxylase increases activity
multiple interactions
ISO Dichlorvos results in increased activity of TH protein
Nimodipine inhibits the reaction [Dichlorvos results in increased activity of TH protein]
CTD PMID:12186780 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor increases expression
increases secretion
ISO Dichlorvos results in increased expression of TNF mRNA; Dichlorvos results in increased expression of TNF protein
Dichlorvos results in increased secretion of TNF protein
CTD PMID:21964614 PMID:22817663 PMID:23053939 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 decreases expression
multiple interactions
increases expression
ISO Dichlorvos results in decreased expression of TP53 mRNA
TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of TP53 mRNA]; TEMPOL-H inhibits the reaction [Dichlorvos results in increased expression of TP53 protein]
Dichlorvos results in increased expression of TP53 mRNA; Dichlorvos results in increased expression of TP53 protein
CTD PMID:23053939 PMID:24369695 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TUBB tubulin beta class I increases phosphorylation ISO Dichlorvos results in increased phosphorylation of TUBB protein CTD PMID:11282359 PMID:16635102 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,720,352...30,725,426
Ensembl chr 6:30,720,352...30,725,426
JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases activity ISO Dichlorvos results in decreased activity of UGP2 protein CTD PMID:222008 NCBI chr 2:63,840,969...63,891,562
Ensembl chr 2:63,840,940...63,891,562
Ensembl chr 2:63,840,940...63,891,562
JBrowse link
G XAB2 XPA binding protein 2 affects response to substance EXP XAB2 gene SNP affects the susceptibility to Dichlorvos CTD PMID:22102698 NCBI chr19:7,619,525...7,629,545
Ensembl chr19:7,619,525...7,629,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24518
    role 24431
      biological role 24398
        antimicrobial agent 20561
          antibacterial agent 15091
            dichlorvos 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 24518
    subatomic particle 24476
      composite particle 24476
        hadron 24476
          baryon 24476
            nucleon 24476
              atomic nucleus 24476
                atom 24476
                  main group element atom 24334
                    p-block element atom 24334
                      chalcogen 23404
                        oxygen atom 23283
                          oxygen molecular entity 23283
                            hydroxides 22516
                              oxoacid 21620
                                pnictogen oxoacid 10810
                                  phosphorus oxoacid 9595
                                    phosphoric acids 8313
                                      phosphoric acid 8313
                                        phosphoric acid derivative 7984
                                          phosphate 7984
                                            organic phosphate 7983
                                              alkyl phosphate 4360
                                                dialkyl phosphate 3603
                                                  dichlorvos 84
paths to the root