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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:dichloroacetyl chloride
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Accession:CHEBI:34688 term browser browse the term
Definition:The acyl chloride obtained by displacement of the hydroxy group of dichloroacetic acid by chloride.
Synonyms:related_synonym: 2,2-Dichloroacetyl chloride;   CHCl2COCl;   Chlorure de dichloracetyle;   Dichloracetyl chloride;   Dichloroacetic acid chloride;   Dichloroethanoyl chloride;   Formula=C2HCl3O;   InChI=1S/C2HCl3O/c3-1(4)2(5)6/h1H;   InChIKey=FBCCMZVIWNDFMO-UHFFFAOYSA-N;   SMILES=ClC(Cl)C(Cl)=O;   alpha,alpha-dichloroacetyl chloride
 xref: Beilstein:1209426;   CAS:79-36-7;   Gmelin:430743;   KEGG:C14867
 xref_mesh: MESH:C053063
 xref: PMID:9130009


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dichloroacetyl chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions
increases expression
ISO 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of CASP3 mRNA] CTD PMID:32073640 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Hmox1 heme oxygenase 1 decreases expression
multiple interactions
ISO 2,2-dichloroacetyl chloride results in decreased expression of HMOX1 mRNA; 2,2-dichloroacetyl chloride results in decreased expression of HMOX1 protein
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of HMOX1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of HMOX1 protein]
CTD PMID:32073640 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
increases expression
ISO 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein]
2,2-dichloroacetyl chloride results in increased expression of KEAP1 mRNA; 2,2-dichloroacetyl chloride results in increased expression of KEAP1 protein
CTD PMID:32073640 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
ISO 2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 mRNA; 2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 protein
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in decreased expression of NFE2L2 protein]
CTD PMID:32073640 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
ISO 2,2-dichloroacetyl chloride results in increased expression of NOS2 mRNA; 2,2-dichloroacetyl chloride results in increased expression of NOS2 protein
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of NOS2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of NOS2 protein]
CTD PMID:32073640 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of RELA mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of RELA protein]
2,2-dichloroacetyl chloride results in increased expression of RELA mRNA; 2,2-dichloroacetyl chloride results in increased expression of RELA protein; 2,2-dichloroacetyl chloride results in increased expression of RELA protein modified form
CTD PMID:32073640 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO 2,2-dichloroacetyl chloride results in increased expression of TNF mRNA; 2,2-dichloroacetyl chloride results in increased expression of TNF protein
2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF protein]
CTD PMID:32073640 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        hapten 3018
          dichloroacetyl chloride 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic group 18613
                              organic divalent group 18604
                                organodiyl group 18604
                                  carbonyl group 18521
                                    carbonyl compound 18521
                                      carboxylic acid 18196
                                        monocarboxylic acid 17604
                                          acetic acid 10857
                                            dichloroacetic acid 992
                                              dichloroacetyl chloride 7
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