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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:debrisoquin
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Accession:CHEBI:34665 term browser browse the term
Definition:A carboxamidine that has formula C10H13N3.
Synonyms:exact_synonym: 3,4-dihydroisoquinoline-2(1H)-carboximidamide
 related_synonym: Debrisochinum;   Formula=C10H13N3;   InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12);   InChIKey=JWPGJSVJDAJRLW-UHFFFAOYSA-N;   Isocaramidine;   SMILES=NC(=N)N1CCc2ccccc2C1;   debrisoquina;   debrisoquine;   debrisoquinum
 xref: Beilstein:1427619;   CAS:1131-64-2;   DrugBank:DB04840;   Drug_Central:788;   KEGG:C13650
 xref_mesh: MESH:D003647
 xref: Patent:BE629007;   Patent:US3157573;   Wikipedia:Debrisoquine



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debrisoquin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases response to substance
decreases metabolic processing
increases abundance
affects metabolic processing
increases hydroxylation
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]
CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin
CYP2D6 protein affects the metabolism of Debrisoquin; CYP2D6 protein polymorphism affects the metabolism of Debrisoquin
CYP2D6 protein results in increased hydroxylation of Debrisoquin
CYP2D6 protein results in increased metabolism of Debrisoquin
CTD PMID:3577206 PMID:6603386 PMID:8946814 PMID:11673748 PMID:11823760 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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  CHEBI ontology 19860
    role 19832
      biological role 19830
        pharmacological role 19069
          neurotransmitter agent 16750
            adrenergic agent 9181
              debrisoquin 1
                N-hydroxydebrisoquine O-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            organic molecule 19692
                              organic cyclic compound 19503
                                organic heterocyclic compound 18875
                                  organonitrogen heterocyclic compound 18156
                                    isoquinolines 533
                                      debrisoquin 1
                                        N-hydroxydebrisoquine O-glucuronide 0
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