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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:debrisoquin
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Accession:CHEBI:34665 term browser browse the term
Definition:A carboxamidine that has formula C10H13N3.
Synonyms:exact_synonym: 3,4-dihydroisoquinoline-2(1H)-carboximidamide
 related_synonym: Debrisochinum;   Formula=C10H13N3;   InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12);   InChIKey=JWPGJSVJDAJRLW-UHFFFAOYSA-N;   Isocaramidine;   SMILES=NC(=N)N1CCc2ccccc2C1;   debrisoquina;   debrisoquine;   debrisoquinum
 xref: Beilstein:1427619;   CAS:1131-64-2;   DrugBank:DB04840;   Drug_Central:788;   KEGG:C13650
 xref_mesh: MESH:D003647
 xref: Patent:BE629007;   Patent:US3157573;   Wikipedia:Debrisoquine


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debrisoquin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases response to substance
decreases metabolic processing
increases abundance
affects metabolic processing
increases hydroxylation
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]
CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin
CYP2D6 protein affects the metabolism of Debrisoquin; CYP2D6 protein polymorphism affects the metabolism of Debrisoquin
CYP2D6 protein results in increased hydroxylation of Debrisoquin
CYP2D6 protein results in increased metabolism of Debrisoquin
CTD PMID:3577206, PMID:6603386, PMID:8946814, PMID:11673748, PMID:11823760, PMID:12464242, PMID:17470523 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        pharmacological role 18797
          neurotransmitter agent 16425
            adrenergic agent 8935
              debrisoquin 1
                N-hydroxydebrisoquine O-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organonitrogen heterocyclic compound 17461
                                    isoquinolines 426
                                      debrisoquin 1
                                        N-hydroxydebrisoquine O-glucuronide 0
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