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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:debrisoquin
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Accession:CHEBI:34665 term browser browse the term
Definition:A carboxamidine that has formula C10H13N3.
Synonyms:exact_synonym: 3,4-dihydroisoquinoline-2(1H)-carboximidamide
 related_synonym: Debrisochinum;   Formula=C10H13N3;   InChI=1S/C10H13N3/c11-10(12)13-6-5-8-3-1-2-4-9(8)7-13/h1-4H,5-7H2,(H3,11,12);   InChIKey=JWPGJSVJDAJRLW-UHFFFAOYSA-N;   Isocaramidine;   SMILES=NC(=N)N1CCc2ccccc2C1;   debrisoquina;   debrisoquine;   debrisoquinum
 xref: Beilstein:1427619;   CAS:1131-64-2;   DrugBank:DB04840;   Drug_Central:788;   KEGG:C13650
 xref_mesh: MESH:D003647
 xref: Patent:BE629007;   Patent:US3157573;   Wikipedia:Debrisoquine


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debrisoquin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases response to substance
decreases metabolic processing
increases abundance
affects metabolic processing
increases hydroxylation
increases metabolic processing		 ISO CYP2D6 gene mutant form affects the metabolism of and affects the hydroxylation of Debrisoquin; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in decreased susceptibility to Debrisoquin]; Paroxetine inhibits the reaction [CYP2D6 gene mutant form results in increased abundance of Debrisoquin metabolite]
CYP2D6 gene mutant form results in decreased metabolism of Debrisoquin; CYP2D6 gene polymorphism results in decreased metabolism of Debrisoquin
CYP2D6 protein affects the metabolism of Debrisoquin; CYP2D6 protein polymorphism affects the metabolism of Debrisoquin
CYP2D6 protein results in increased hydroxylation of Debrisoquin
CYP2D6 protein results in increased metabolism of Debrisoquin		 CTD PMID:3577206 PMID:6603386 PMID:8946814 PMID:11673748 PMID:11823760 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19818
    role 19790
      biological role 19788
        pharmacological role 19035
          neurotransmitter agent 16672
            adrenergic agent 9156
              debrisoquin 1
                N-hydroxydebrisoquine O-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19818
    subatomic particle 19816
      composite particle 19816
        hadron 19816
          baryon 19816
            nucleon 19816
              atomic nucleus 19816
                atom 19816
                  main group element atom 19761
                    p-block element atom 19761
                      carbon group element atom 19703
                        carbon atom 19698
                          organic molecular entity 19698
                            organic molecule 19656
                              organic cyclic compound 19461
                                organic heterocyclic compound 18817
                                  organonitrogen heterocyclic compound 18027
                                    isoquinolines 455
                                      debrisoquin 1
                                        N-hydroxydebrisoquine O-glucuronide 0
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