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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:cumene
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Accession:CHEBI:34656 term browser browse the term
Definition:An alkylbenzene that is benzene carrying an isopropyl group.
Synonyms:related_synonym: (propan-2-yl)benzene;   1-Methylethyl-Benzene;   2-Phenylpropane;   Formula=C9H12;   InChI=1S/C9H12/c1-8(2)9-6-4-3-5-7-9/h3-8H,1-2H3;   InChIKey=RWGFKTVRMDUZSP-UHFFFAOYSA-N;   Isopropylbenzene;   SMILES=CC(C)c1ccccc1
 xref: Beilstein:1236613;   CAS:98-82-8;   HMDB:HMDB0034029;   KEGG:C14396
 xref_mesh: MESH:C015763
 xref: MetaCyc:CPD0-2360;   PMID:19340095;   PMID:24441387;   Patent:KR20140001929;   Reaxys:1236613;   Wikipedia:Cumene


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cumene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap12 A-kinase anchoring protein 12 decreases expression ISO cumene results in decreased expression of AKAP12 mRNA CTD PMID:18648096 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Areg amphiregulin multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of AREG mRNA CTD PMID:18648096 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Cadm1 cell adhesion molecule 1 decreases expression ISO cumene results in decreased expression of CADM1 mRNA CTD PMID:18648096 NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722
JBrowse link
G Cav1 caveolin 1 decreases expression ISO cumene results in decreased expression of CAV1 mRNA CTD PMID:18648096 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CCN1 mRNA CTD PMID:18648096 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of CCND1 mRNA CTD PMID:18648096 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh5 cadherin 5 decreases expression ISO cumene results in decreased expression of CDH5 mRNA CTD PMID:18648096 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D decreases expression ISO cumene results in decreased expression of CDKN2D mRNA CTD PMID:18648096
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CEBPD mRNA CTD PMID:18648096 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CKS1B mRNA CTD PMID:18648096 NCBI chr 2:188,740,564...188,745,144
Ensembl chr 2:188,740,573...188,745,144
JBrowse link
G Clu clusterin increases expression
multiple interactions
ISO cumene results in increased expression of CLU mRNA
KRAS gene mutant form promotes the reaction [cumene results in increased expression of CLU mRNA]
CTD PMID:18648096 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of DLC1 mRNA CTD PMID:18648096 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO cumene results in decreased expression of DUSP1 mRNA CTD PMID:18648096 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp14 dual specificity phosphatase 14 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP14 mRNA CTD PMID:18648096 NCBI chr10:71,363,688...71,383,602
Ensembl chr10:71,363,688...71,383,602
JBrowse link
G Dusp3 dual specificity phosphatase 3 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP3 mRNA CTD PMID:18648096 NCBI chr10:89,904,578...89,918,296
Ensembl chr10:89,904,560...89,918,427
JBrowse link
G Dusp4 dual specificity phosphatase 4 decreases expression ISO cumene results in decreased expression of DUSP4 mRNA CTD PMID:18648096 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Eno1 enolase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENO1 mRNA CTD PMID:18648096 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENPP2 mRNA CTD PMID:18648096 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of EPCAM mRNA CTD PMID:18648096 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Ereg epiregulin multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of EREG mRNA CTD PMID:18648096 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression
increases expression
ISO cumene results in decreased expression of ETS1 mRNA
cumene results in increased expression of ETS1 mRNA
CTD PMID:18648096 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Fhl1 four and a half LIM domains 1 decreases expression ISO cumene results in decreased expression of FHL1 mRNA CTD PMID:18648096 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of GPER1 mRNA CTD PMID:18648096 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO cumene results in decreased expression of GPX3 mRNA CTD PMID:18648096 NCBI chr10:40,247,436...40,255,423
Ensembl chr10:40,247,436...40,255,422
JBrowse link
G Gsn gelsolin decreases expression ISO cumene results in decreased expression of GSN mRNA CTD PMID:18648096 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects localization
decreases activity
ISO cumene affects the localization of GSTP1 protein
cumene results in decreased activity of GSTP1 protein
CTD PMID:18409811 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of IGFBP4 mRNA CTD PMID:18648096 NCBI chr10:86,950,555...86,962,563
Ensembl chr10:86,950,557...86,962,578
JBrowse link
G Klf5 Kruppel-like factor 5 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of KLF5 mRNA CTD PMID:18648096 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of CCN1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of CEBPD mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of CKS1B mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of DLC1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP14 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of DUSP3 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENO1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of ENPP2 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of EPCAM mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of GPER1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of IGFBP4 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT18 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT8 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of LASP1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of MMP14 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of RACK1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of RB1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SDC1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SLC2A1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SOD3 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of SRD5A1 mRNA; [cumene co-treated with KRAS gene mutant form] results in decreased expression of VWF mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of AREG mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of CCND1 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of EREG mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of KLF5 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of LAMTOR2 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein; [cumene co-treated with KRAS gene mutant form] results in increased expression of MIF mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of PTGES mRNA; KRAS gene mutant form promotes the reaction [cumene results in increased expression of CLU mRNA] CTD PMID:18648096 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT18 mRNA CTD PMID:18648096 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of KRT8 mRNA CTD PMID:18648096 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of LAMTOR2 mRNA CTD PMID:18648096 NCBI chr 2:187,911,530...187,914,930
Ensembl chr 2:187,911,533...187,915,596
JBrowse link
G Lasp1 LIM and SH3 protein 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of LASP1 mRNA CTD PMID:18648096 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133
JBrowse link
G Lims2 LIM zinc finger domain containing 2 decreases expression ISO cumene results in decreased expression of LIMS2 mRNA CTD PMID:18648096 NCBI chr18:24,707,951...24,746,159
Ensembl chr18:24,708,115...24,746,159
JBrowse link
G Loxl1 lysyl oxidase-like 1 decreases expression ISO cumene results in decreased expression of LOXL1 mRNA CTD PMID:18648096 NCBI chr 8:63,067,757...63,092,124
Ensembl chr 8:63,067,300...63,092,009
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 mRNA; [cumene co-treated with KRAS gene mutant form] results in increased expression of MAP2K1 protein CTD PMID:18648096 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Mif macrophage migration inhibitory factor multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of MIF mRNA CTD PMID:18648096 NCBI chr20:13,715,219...13,732,980
Ensembl chr20:13,732,198...13,732,859
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of MMP14 mRNA CTD PMID:18648096 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Pdzd2 PDZ domain containing 2 decreases expression ISO cumene results in decreased expression of PDZD2 mRNA CTD PMID:18648096 NCBI chr 2:62,399,748...62,520,448
Ensembl chr 2:62,399,748...62,634,785
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in increased expression of PTGES mRNA CTD PMID:18648096 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO cumene results in decreased expression of PTPRD mRNA CTD PMID:18648096 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
JBrowse link
G Rack1 receptor for activated C kinase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of RACK1 mRNA CTD PMID:18648096 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of RB1 mRNA CTD PMID:18648096 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs decreases expression ISO cumene results in decreased expression of RECK mRNA CTD PMID:18648096 NCBI chr 5:59,348,568...59,415,169
Ensembl chr 5:59,348,639...59,415,135
JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SDC1 mRNA CTD PMID:18648096 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SLC2A1 mRNA CTD PMID:18648096 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SOD3 mRNA CTD PMID:18648096 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of SRD5A1 mRNA CTD PMID:18648096 NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
JBrowse link
G Vwf von Willebrand factor multiple interactions ISO [cumene co-treated with KRAS gene mutant form] results in decreased expression of VWF mRNA CTD PMID:18648096 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
2-isopropylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rxrb retinoid X receptor beta increases activity ISO 2-isopropylphenol results in increased activity of RXRB protein CTD PMID:18207673 NCBI chr20:3,822,673...3,829,138
Ensembl chr20:3,823,042...3,829,140
JBrowse link
2-phenylpropan-2-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thrb thyroid hormone receptor beta multiple interactions ISO 2-phenyl-2-propanol binds to and results in decreased activity of THRB protein CTD PMID:27633901 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
4-isopropylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 4-isopropylphenol inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:27561732 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases glutathionylation ISO CYP2C8 protein results in increased glutathionylation of 4-isopropylphenol CTD PMID:23470418 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of 4-isopropylphenol CTD PMID:23470418 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
ISO 4-isopropylphenol binds to and results in increased activity of ESRRG protein; 4-isopropylphenol inhibits the reaction [afimoxifene binds to and results in decreased activity of ESRRG protein]
4-isopropylphenol binds to ESRRG protein
CTD PMID:27486708 PMID:31127318 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G LOC686683 similar to olfactory receptor 73 multiple interactions ISO 4-isopropylphenol binds to and results in increased activity of OLFR73 protein CTD PMID:21142015 NCBI chr 3:76,186,104...76,187,045
Ensembl chr 3:76,186,104...76,187,045
JBrowse link
cumene hydroperoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase decreases activity
increases activity
multiple interactions
ISO
EXP
cumene hydroperoxide results in decreased activity of CAT protein
cumene hydroperoxide results in increased activity of CAT protein
Iron promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in decreased activity of CAT protein]
CTD PMID:12065085 PMID:12423650 PMID:16928893 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects oxidation EXP CYP2B1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects oxidation EXP CYP2B6 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects oxidation ISO CYP2C19 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects oxidation ISO CYP2C8 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 affects oxidation EXP CYP2D1 protein affects the oxidation of cumene hydroperoxide CTD PMID:17478480 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 multiple interactions ISO [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone; [[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B1; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol; [CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin CTD PMID:19713358 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 multiple interactions
decreases expression
EXP 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]; Vitamin E analog inhibits the reaction [cumene hydroperoxide results in decreased expression of EEF2 protein]
cumene hydroperoxide results in decreased expression of EEF2; cumene hydroperoxide results in decreased expression of EEF2 protein
CTD PMID:16469450 PMID:17510559 PMID:19447174 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 multiple interactions ISO cumene hydroperoxide results in increased phosphorylation of and results in increased activity of FGFR2 protein CTD PMID:12717419 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of G6PD protein CTD PMID:16928893 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO cumene hydroperoxide results in increased expression of GAPDH protein CTD PMID:11295360 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLC mRNA CTD PMID:30547568 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO cumene hydroperoxide results in increased expression of GCLM mRNA CTD PMID:30547568 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases response to substance
increases metabolic processing
increases reduction
ISO GPX1 protein results in decreased susceptibility to cumene hydroperoxide
GPX1 protein results in increased metabolism of cumene hydroperoxide
GPX1 protein results in increased reduction of cumene hydroperoxide
CTD PMID:1740415 PMID:1939125 PMID:8428933 PMID:9126277 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gpx2 glutathione peroxidase 2 increases reduction ISO GPX2 protein results in increased reduction of cumene hydroperoxide CTD PMID:8428933 NCBI chr 6:99,839,960...99,843,245
Ensembl chr 6:99,839,960...99,843,245
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases response to substance ISO GPX4 results in decreased susceptibility to cumene hydroperoxide CTD PMID:18206984 NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP cumene hydroperoxide results in decreased activity of GSR protein CTD PMID:16928893 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 increases metabolic processing
affects metabolic processing
decreases response to substance
ISO
EXP
GSTA1 protein results in increased metabolism of cumene hydroperoxide
GSTA3 protein affects the metabolism of cumene hydroperoxide
GSTA3 protein results in decreased susceptibility to cumene hydroperoxide
CTD PMID:1740415 PMID:1985777 PMID:2768223 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases metabolic processing
increases metabolic processing
ISO GSTA2 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTA2 protein results in increased metabolism of cumene hydroperoxide
CTD PMID:3138230 PMID:15077012 PMID:15128049 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases glutathionylation ISO GSTA3 protein results in increased glutathionylation of cumene hydroperoxide CTD PMID:21876218 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm3 glutathione S-transferase mu 3 decreases metabolic processing
increases metabolic processing
ISO GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide
CTD PMID:15247628 NCBI chr 2:210,685,204...210,688,273
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases metabolic processing
increases metabolic processing
ISO GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide
GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide
CTD PMID:15247628 NCBI chr 2:210,685,338...210,688,133
Ensembl chr 2:210,685,197...210,688,272
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases metabolic processing ISO GSTP1 protein results in increased metabolism of cumene hydroperoxide CTD PMID:2747627 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects oxidation
affects metabolic processing
ISO GSTT1 protein affects the oxidation of cumene hydroperoxide
GSTT1 protein affects the metabolism of cumene hydroperoxide
CTD PMID:9854036 PMID:19664997 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 affects metabolic processing EXP GSTT2 protein affects the metabolism of cumene hydroperoxide CTD PMID:2114406 NCBI chr20:13,760,810...13,764,481
Ensembl chr20:13,760,810...13,764,475
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects metabolic processing ISO GSTZ1 protein affects the metabolism of cumene hydroperoxide CTD PMID:9396740 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Gusb glucuronidase, beta multiple interactions
decreases uptake
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in decreased uptake of GUSB protein]; alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of GUSB protein] CTD PMID:19135433 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO cumene hydroperoxide results in increased expression of HMOX1 mRNA CTD PMID:30547568 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO cumene hydroperoxide results in increased expression of HSPB1 protein CTD PMID:11295360 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 increases activity EXP cumene hydroperoxide results in increased activity of IDH1 protein CTD PMID:16928893 NCBI chr 9:71,882,108...71,911,645
Ensembl chr 9:71,882,105...71,900,044
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of IL1B protein] CTD PMID:19135433 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide] CTD PMID:19608619 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mb myoglobin affects metabolic processing ISO MB protein mutant form affects the metabolism of cumene hydroperoxide CTD PMID:8855949 NCBI chr 7:118,101,633...118,108,864
Ensembl chr 7:118,101,634...118,108,864
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases response to substance EXP MGST1 results in decreased susceptibility to cumene hydroperoxide CTD PMID:17306223 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [9,10-Dimethyl-1,2-benzanthracene co-treated with cumene hydroperoxide] results in increased activity of MPO protein CTD PMID:14972014 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases response to substance
affects response to substance
multiple interactions
ISO NFE2L2 gene mutant form results in increased susceptibility to cumene hydroperoxide
[NFE2L2 affects the susceptibility to sulforafan] which affects the susceptibility to cumene hydroperoxide
Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to cumene hydroperoxide]]; NFE2L2 protein promotes the reaction [sulforafan results in decreased susceptibility to cumene hydroperoxide]
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]
CTD PMID:19303893 PMID:19608619 PMID:20932822 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased expression of NOS2 protein] CTD PMID:19135433 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO cumene hydroperoxide results in increased expression of NQO1 mRNA CTD PMID:30547568 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity
multiple interactions
ISO cumene hydroperoxide results in increased activity of ODC1 protein
Iron promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]; Iron-Dextran Complex promotes the reaction [cumene hydroperoxide results in increased activity of ODC1 protein]
CTD PMID:12065085 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Ppia peptidylprolyl isomerase A decreases response to substance EXP PPIA protein results in decreased susceptibility to cumene hydroperoxide CTD PMID:17011206 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
JBrowse link
G Prdx1 peroxiredoxin 1 increases expression ISO cumene hydroperoxide results in increased expression of PRDX1 protein CTD PMID:11295360 NCBI chr 5:135,536,413...135,551,986
Ensembl chr 5:135,536,413...135,551,990
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression ISO cumene hydroperoxide results in increased expression of PRDX2 protein CTD PMID:11295360 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression ISO cumene hydroperoxide results in increased expression of PRDX6 protein CTD PMID:11295360 NCBI chr13:79,077,567...79,088,113
Ensembl chr13:79,077,033...79,088,127
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO cumene hydroperoxide results in increased expression of PTGS2 protein
[cumene hydroperoxide results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [cumene hydroperoxide results in increased expression of PTGS2 protein]
CTD PMID:14972014 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sord sorbitol dehydrogenase increases activity EXP cumene hydroperoxide results in increased activity of SORD protein CTD PMID:16928893 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO cumene hydroperoxide results in increased expression of TGFB1 mRNA CTD PMID:8148055 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO alpha-Tocopherol inhibits the reaction [cumene hydroperoxide results in increased secretion of TNF protein] CTD PMID:19135433 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    role 19767
      chemical role 19289
        environmental contaminant 18629
          benzene 5635
            alkylbenzene 3353
              cumene 101
                2-isopropylphenol + 1
                2-phenyl-1,2-propanediol 0
                2-phenylpropan-2-ol 1
                4-isopropylphenol + 5
                cumene hydroperoxide 47
                cuminaldehyde 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    main group molecular entity 19705
                      s-block molecular entity 19458
                        hydrogen molecular entity 19451
                          hydrides 18730
                            organic hydride 18292
                              organic fundamental parent 18292
                                hydrocarbon 18024
                                  cyclic hydrocarbon 17087
                                    monocyclic hydrocarbon 5809
                                      annulene 5635
                                        aromatic annulene 5635
                                          benzene 5635
                                            alkylbenzene 3353
                                              cumene 101
                                                2-isopropylphenol + 1
                                                2-phenyl-1,2-propanediol 0
                                                2-phenylpropan-2-ol 1
                                                4-isopropylphenol + 5
                                                cumene hydroperoxide 47
                                                cuminaldehyde 0
paths to the root