CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: clavulone II
Accession: CHEBI:34643
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Definition: A clavulone that has formula C25H34O7.
Synonyms: exact_synonym: methyl (4R,5E,7E,14Z)-4,12-bis(acetyloxy)-9-oxo-12alpha-prosta-5,7,10,14-tetraen-1-oate
related_synonym: Formula=C25H34O7; InChI=1S/C25H34O7/c1-5-6-7-8-9-10-17-25(32-20(3)27)18-16-23(28)22(25)13-11-12-21(31-19(2)26)14-15-24(29)30-4/h9-13,16,18,21H,5-8,14-15,17H2,1-4H3/b10-9-,12-11+,22-13-/t21-,25-/m0/s1; InChIKey=QXSYLWTUKSQQCP-VZCZYXORSA-N; SMILES=CCCCC\\C=C/C[C@]1(OC(C)=O)C=CC(=O)/C1=C/C=C/[C@@H](CCC(=O)OC)OC(C)=O
xref: Beilstein:3658162; CAS:85700-43-2; KEGG:C13812; LIPID_MAPS_instance:LMFA03120002
xref_mesh: MESH:C057741
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
clavulone II results in increased expression of BAX protein
CTD
PMID:15920677
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bid
BH3 interacting domain death agonist
increases cleavage
ISO
clavulone II results in increased cleavage of BID protein
CTD
PMID:15920677
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
G
Casp3
caspase 3
increases activity
ISO
clavulone II results in increased activity of CASP3 protein
CTD
PMID:15920677
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
multiple interactions
ISO
clavulone II results in increased cleavage of and results in increased activity of CASP8 protein
CTD
PMID:15920677
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
multiple interactions
ISO
clavulone II results in increased cleavage of and results in increased activity of CASP9 protein
CTD
PMID:15920677
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccnd1
cyclin D1
decreases expression
ISO
clavulone II results in decreased expression of CCND1 protein
CTD
PMID:15920677
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
clavulone II results in decreased expression of MCL1 protein
CTD
PMID:15920677
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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