Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chlorpyrifos-methyl
go back to main search page
Accession:CHEBI:34632 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Synonyms:exact_synonym: O,O-dimethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate
 related_synonym: Chloropyriphos-methyl;   Chlorpyrifos O,O-dimethyl analog;   Formula=C7H7Cl3NO3PS;   InChI=1S/C7H7Cl3NO3PS/c1-12-15(16,13-2)14-7-5(9)3-4(8)6(10)11-7/h3H,1-2H3;   InChIKey=HRBKVYFZANMGRE-UHFFFAOYSA-N;   Methyl chlorpyriphos;   O,O-dimethyl O-(3,5,6-trichloropyridin-2-yl) thiophosphate;   Phosphorothioic acid, O,O-dimethyl O-(3,5,6-trichloro-2-pyridinyl) ester;   Phosphorothioic acid, O,O-dimethyl O-(3,5,6-trichloro-2-pyridyl) ester;   SMILES=COP(=S)(OC)Oc1nc(Cl)c(Cl)cc1Cl;   Trichlormethylfos;   o,o-Dimethyl-o-(3,5,6-trichloro-2-pyridyl)phosphorothioate
 xref: Beilstein:1541078;   CAS:5598-13-0;   KEGG:C14520
 xref_mesh: MESH:C007031
 xref: PPDB:155;   Pesticides:chlorpyrifos-methyl;   Reaxys:1541078



show annotations for term's descendants           Sort by:
chlorpyrifos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
multiple interactions
ISO chlorpyrifos-methyl affects the activity of ABCB1 protein
chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]
CTD PMID:21783720 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
EXP chlorpyrifos-methyl results in decreased activity of ACHE protein
Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of ACHE protein]
CTD PMID:34425170 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
ISO chlorpyrifos-methyl binds to AR protein
chlorpyrifos-methyl binds to and results in increased activity of AR protein
CTD PMID:23436777 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
EXP Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of BCHE protein] CTD PMID:34425170 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP chlorpyrifos-methyl results in decreased activity of CAT protein
Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of CAT protein]
CTD PMID:34425170 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases activity
multiple interactions
ISO chlorpyrifos-methyl results in decreased activity of CNR1 protein
chlorpyrifos-methyl inhibits the reaction [CP 55244 binds to CNR1 protein]
CTD PMID:12243867 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases methylation
increases methylation
ISO chlorpyrifos-methyl results in decreased methylation of H19 gene
chlorpyrifos-methyl results in increased methylation of H19 gene
CTD PMID:23125134 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO chlorpyrifos-methyl results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO chlorpyrifos-methyl inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO chlorpyrifos-methyl binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Tp53 tumor protein p53 affects activity ISO chlorpyrifos-methyl metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        agrochemical 16289
          chlorpyrifos-methyl 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      chalcogen 19534
                        oxygen atom 19509
                          oxygen molecular entity 19509
                            hydroxides 19320
                              oxoacid 18744
                                pnictogen oxoacid 13224
                                  phosphorus oxoacid 12429
                                    phosphoric acids 11430
                                      phosphoric acid 11430
                                        phosphoric acid derivative 11239
                                          phosphate 11238
                                            organic phosphate 11238
                                              organic thiophosphate 8622
                                                chlorpyrifos-methyl 16
paths to the root