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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chlorpyrifos-methyl
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Accession:CHEBI:34632 term browser browse the term
Definition:An organic thiophosphate that is O,O-dimethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Synonyms:exact_synonym: O,O-dimethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate
 related_synonym: Chloropyriphos-methyl;   Chlorpyrifos O,O-dimethyl analog;   Formula=C7H7Cl3NO3PS;   InChI=1S/C7H7Cl3NO3PS/c1-12-15(16,13-2)14-7-5(9)3-4(8)6(10)11-7/h3H,1-2H3;   InChIKey=HRBKVYFZANMGRE-UHFFFAOYSA-N;   Methyl chlorpyriphos;   O,O-dimethyl O-(3,5,6-trichloropyridin-2-yl) thiophosphate;   Phosphorothioic acid, O,O-dimethyl O-(3,5,6-trichloro-2-pyridinyl) ester;   Phosphorothioic acid, O,O-dimethyl O-(3,5,6-trichloro-2-pyridyl) ester;   SMILES=COP(=S)(OC)Oc1nc(Cl)c(Cl)cc1Cl;   Trichlormethylfos;   o,o-Dimethyl-o-(3,5,6-trichloro-2-pyridyl)phosphorothioate
 xref: Beilstein:1541078;   CAS:5598-13-0;   KEGG:C14520
 xref_mesh: MESH:C007031
 xref: PPDB:155;   Pesticides:chlorpyrifos-methyl;   Reaxys:1541078


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chlorpyrifos-methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
multiple interactions		 ISO chlorpyrifos-methyl affects the activity of ABCB1 protein
chlorpyrifos-methyl affects the reaction [ABCB1 protein results in increased transport of calcein AM]		 CTD PMID:21783720 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions		 EXP chlorpyrifos-methyl results in decreased activity of ACHE protein
Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of ACHE protein]		 CTD PMID:34425170 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of AHR protein CTD PMID:23436777 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 ISO chlorpyrifos-methyl binds to AR protein
chlorpyrifos-methyl binds to and results in increased activity of AR protein		 CTD PMID:23436777 PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 EXP Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of BCHE protein] CTD PMID:34425170 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP chlorpyrifos-methyl results in decreased activity of CAT protein
Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of CAT protein]		 CTD PMID:34425170 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cnr1 cannabinoid receptor 1 decreases activity
multiple interactions		 ISO chlorpyrifos-methyl results in decreased activity of CNR1 protein
chlorpyrifos-methyl inhibits the reaction [CP 55244 binds to CNR1 protein]		 CTD PMID:12243867 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of ESR1 protein CTD PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of ESR2 protein CTD PMID:33049310 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases methylation
increases methylation		 ISO chlorpyrifos-methyl results in decreased methylation of H19 gene
chlorpyrifos-methyl results in increased methylation of H19 gene		 CTD PMID:23125134 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO chlorpyrifos-methyl results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO chlorpyrifos-methyl binds to and results in increased activity of PPARG protein CTD PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO chlorpyrifos-methyl inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO chlorpyrifos-methyl binds to and results in decreased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO chlorpyrifos-methyl metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
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  CHEBI ontology 19811
    role 19818
      application 19630
        agrochemical 16259
          chlorpyrifos-methyl 16
Path 2
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  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      chalcogen 19515
                        oxygen atom 19520
                          oxygen molecular entity 19490
                            hydroxides 19300
                              oxoacid 18725
                                pnictogen oxoacid 13221
                                  phosphorus oxoacid 12413
                                    phosphoric acids 11427
                                      phosphoric acid 11417
                                        phosphoric acid derivative 11226
                                          phosphate 11225
                                            organic phosphate 11225
                                              organic thiophosphate 8611
                                                chlorpyrifos-methyl 16
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