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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bornane-2,3-dione
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Accession:CHEBI:34607 term browser browse the term
Definition:A bornane monoterpenoid that is bicyclo[2.2.1]heptane substituted by methyl groups at positions 1, 7 and 7 and oxo groups at positions 2 and 3.
Synonyms:exact_synonym: 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione
 related_synonym: 2,3-bornanedione;   Camphorquinone;   Formula=C10H14O2;   InChI=1S/C10H14O2/c1-9(2)6-4-5-10(9,3)8(12)7(6)11/h6H,4-5H2,1-3H3;   InChIKey=VNQXSTWCDUXYEZ-UHFFFAOYSA-N;   SMILES=CC1(C)C2CCC1(C)C(=O)C2=O;   camphoquinone;   camphor quinone;   camphoroquinone
 xref: Beilstein:1909463;   CAS:10373-78-1;   CAS:465-29-2;   Gmelin:482102;   KEGG:C14515;   LIPID_MAPS_instance:LMPR0102120030
 xref_mesh: MESH:C048339
 xref: PMID:24430338;   Reaxys:1909463



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bornane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO camphoroquinone inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:11985887 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
(1S)-bornane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases phosphorylation ISO camphorquinone results in increased phosphorylation of ATM protein CTD PMID:26658076 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO camphorquinone results in decreased expression of CCNB1 mRNA; camphorquinone results in decreased expression of CCNB1 protein CTD PMID:26658076 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO camphorquinone results in decreased expression of CDC25C mRNA; camphorquinone results in decreased expression of CDC25C protein CTD PMID:26658076 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO camphorquinone results in decreased expression of CDK1 mRNA; camphorquinone results in decreased expression of CDK1 protein CTD PMID:26658076 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of CDKN1A protein]
camphorquinone results in increased expression of CDKN1A mRNA; camphorquinone results in increased expression of CDKN1A protein
CTD PMID:26658076 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO camphorquinone results in increased phosphorylation of CHEK2 protein CTD PMID:26658076 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Dhrs11 dehydrogenase/reductase 11 increases reduction ISO DHRS11 protein results in increased reduction of camphorquinone CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO camphorquinone results in increased expression of GADD45A protein CTD PMID:26658076 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of HMOX1 protein]
camphorquinone results in increased expression of HMOX1 mRNA; camphorquinone results in increased expression of HMOX1 protein
CTD PMID:26658076 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO camphorquinone results in increased phosphorylation of MAPK1 protein CTD PMID:26658076 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO camphorquinone results in increased phosphorylation of MAPK3 protein CTD PMID:26658076 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO camphorquinone results in increased expression of PTGS2 mRNA; camphorquinone results in increased expression of PTGS2 protein
U 0126 inhibits the reaction [camphorquinone results in increased expression of PTGS2 protein]
CTD PMID:26658076 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tp53 tumor protein p53 increases phosphorylation ISO camphorquinone results in increased phosphorylation of TP53 protein CTD PMID:26658076 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      molecular entity 19832
        polyatomic entity 19790
          molecule 19695
            cyclic compound 19510
              bicyclic compound 17296
                carbobicyclic compound 5879
                  bornane-2,3-dione 14
                    (1R)-bornane-2,3-dione 0
                    (1S)-bornane-2,3-dione 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    main group molecular entity 19782
                      s-block molecular entity 19620
                        hydrogen molecular entity 19607
                          hydrides 19105
                            organic hydride 18665
                              organic fundamental parent 18665
                                hydrocarbon 18401
                                  terpene 13835
                                    terpenoid 13532
                                      monoterpenoid 2030
                                        bornane monoterpenoid 38
                                          bornane-2,3-dione 14
                                            (1R)-bornane-2,3-dione 0
                                            (1S)-bornane-2,3-dione 13
paths to the root