CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: bornane-2,3-dione
Accession: CHEBI:34607
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Definition: A bornane monoterpenoid that is bicyclo[2.2.1]heptane substituted by methyl groups at positions 1, 7 and 7 and oxo groups at positions 2 and 3.
Synonyms: exact_synonym: 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-dione
related_synonym: 2,3-bornanedione; Camphorquinone; Formula=C10H14O2; InChI=1S/C10H14O2/c1-9(2)6-4-5-10(9,3)8(12)7(6)11/h6H,4-5H2,1-3H3; InChIKey=VNQXSTWCDUXYEZ-UHFFFAOYSA-N; SMILES=CC1(C)C2CCC1(C)C(=O)C2=O; camphoquinone; camphor quinone; camphoroquinone
xref: Beilstein:1909463; CAS:10373-78-1; CAS:465-29-2; Gmelin:482102; KEGG:C14515; LIPID_MAPS_instance:LMPR0102120030
xref_mesh: MESH:C048339
xref: PMID:24430338; Reaxys:1909463
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Ar
androgen receptor
multiple interactions
ISO
camphoroquinone inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]
CTD
PMID:11985887
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atm
ATM serine/threonine kinase
increases phosphorylation
ISO
camphorquinone results in increased phosphorylation of ATM protein
CTD
PMID:26658076
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Ccnb1
cyclin B1
decreases expression
ISO
camphorquinone results in decreased expression of CCNB1 mRNA; camphorquinone results in decreased expression of CCNB1 protein
CTD
PMID:26658076
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Cdc25c
cell division cycle 25C
decreases expression
ISO
camphorquinone results in decreased expression of CDC25C mRNA; camphorquinone results in decreased expression of CDC25C protein
CTD
PMID:26658076
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdk1
cyclin-dependent kinase 1
decreases expression
ISO
camphorquinone results in decreased expression of CDK1 mRNA; camphorquinone results in decreased expression of CDK1 protein
CTD
PMID:26658076
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of CDKN1A protein] camphorquinone results in increased expression of CDKN1A mRNA; camphorquinone results in increased expression of CDKN1A protein
CTD
PMID:26658076
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Chek2
checkpoint kinase 2
increases phosphorylation
ISO
camphorquinone results in increased phosphorylation of CHEK2 protein
CTD
PMID:26658076
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Dhrs11
dehydrogenase/reductase 11
increases reduction
ISO
DHRS11 protein results in increased reduction of camphorquinone
CTD
PMID:30926317
NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
camphorquinone results in increased expression of GADD45A protein
CTD
PMID:26658076
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [camphorquinone results in increased expression of HMOX1 protein] camphorquinone results in increased expression of HMOX1 mRNA; camphorquinone results in increased expression of HMOX1 protein
CTD
PMID:26658076
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
camphorquinone results in increased phosphorylation of MAPK1 protein
CTD
PMID:26658076
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
camphorquinone results in increased phosphorylation of MAPK3 protein
CTD
PMID:26658076
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression multiple interactions
ISO
camphorquinone results in increased expression of PTGS2 mRNA; camphorquinone results in increased expression of PTGS2 protein U 0126 inhibits the reaction [camphorquinone results in increased expression of PTGS2 protein]
CTD
PMID:26658076
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tp53
tumor protein p53
increases phosphorylation
ISO
camphorquinone results in increased phosphorylation of TP53 protein
CTD
PMID:26658076
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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