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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromodichloromethane
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Accession:CHEBI:34591 term browser browse the term
Definition:A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.
Synonyms:exact_synonym: bromo(dichloro)methane
 related_synonym: CHBrCl2;   Formula=CHBrCl2;   InChI=1S/CHBrCl2/c2-1(3)4/h1H;   InChIKey=FMWLUWPQPKEARP-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Br;   dichlorobromomethane;   dichloromonobromomethane;   monobromodichloromethane
 xref: Beilstein:1697005;   CAS:75-27-4;   Gmelin:25941;   KEGG:C14708
 xref_mesh: MESH:C025191
 xref: PMID:23446885;   PMID:24001804;   PMID:24647036;   Reaxys:1697005;   Wikipedia:Bromodichloromethane



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bromodichloromethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat1 beta-1,3-glucuronyltransferase 1 multiple interactions EXP [bromodichloromethane co-treated with Dietary Fats] results in increased expression of B3GAT1 protein CTD PMID:24211274 NCBI chr 9:26,644,813...26,672,646
Ensembl chr 9:26,645,024...26,674,397
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; LEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form] CTD PMID:24211274 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of CCL2 protein] CTD PMID:23438451 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO bromodichloromethane results in increased expression of CCND1 mRNA CTD PMID:24001804 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662
JBrowse link
G Cd68 CD68 antigen multiple interactions EXP [Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA; gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA] CTD PMID:23438451 NCBI chr11:69,555,039...69,556,996
Ensembl chr11:69,555,039...69,556,979
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases methylation
ISO bromodichloromethane results in decreased expression of CDH1 mRNA; bromodichloromethane results in decreased expression of CDH1 protein
bromodichloromethane results in increased methylation of CDH1 gene
CTD PMID:24001804 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases expression
increases expression
affects metabolic processing
multiple interactions
ISO CYP1A2 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in decreased expression of CYP1A2 protein
bromodichloromethane results in increased expression of CYP1A2 protein
CYP1A2 protein affects the metabolism of bromodichloromethane
isosafrole inhibits the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]; Tetrachlorodibenzodioxin promotes the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]
CTD PMID:11295256 PMID:12062927 PMID:12076521 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986
JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 increases metabolic processing ISO CYP2A6 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 increases metabolic processing ISO CYP2B2 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 NCBI chr 7:25,760,813...25,795,622
Ensembl chr 7:25,760,922...25,795,622
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases expression
increases metabolic processing
decreases response to substance
ISO
EXP
CYP2E1 protein results in increased metabolism of and results in increased activity of bromodichloromethane
bromodichloromethane results in increased expression of CYP2E1 protein
CYP2E1 protein results in increased metabolism of bromodichloromethane
CYP2E1 gene mutant form results in decreased susceptibility to bromodichloromethane
[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CYP2E1 protein; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]
CTD PMID:9458004 PMID:11295256 PMID:12076521 PMID:12076522 PMID:18350910 More... NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases expression EXP bromodichloromethane results in increased expression of GPT CTD PMID:25640707 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886
JBrowse link
G Gstt1 glutathione S-transferase, theta 1 increases metabolic processing
multiple interactions
EXP
ISO
GSTT1 protein results in increased metabolism of bromodichloromethane
GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]
CTD PMID:12588193 PMID:14998683 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418
JBrowse link
G Ifng interferon gamma multiple interactions EXP [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA] CTD PMID:24211274 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA] CTD PMID:24211274 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il2 interleukin 2 multiple interactions EXP [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA] CTD PMID:24211274 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108
JBrowse link
G Jun jun proto-oncogene decreases expression ISO bromodichloromethane results in decreased expression of JUN mRNA CTD PMID:24001804 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Lep leptin increases expression
decreases response to substance
multiple interactions
EXP bromodichloromethane results in increased expression of LEP mRNA
LEP gene mutant form results in decreased susceptibility to bromodichloromethane
bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA]; LEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; LEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEP protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]
CTD PMID:23438451 PMID:23640861 PMID:24211274 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lepr leptin receptor multiple interactions EXP LEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEPR protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane] CTD PMID:23438451 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Lhb luteinizing hormone beta decreases secretion ISO bromodichloromethane results in decreased secretion of LHB protein CTD PMID:14657523 PMID:17344021 NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
JBrowse link
G Myc myelocytomatosis oncogene decreases methylation
decreases expression
increases expression
EXP
ISO
bromodichloromethane results in decreased methylation of MYC promoter
bromodichloromethane results in decreased expression of MYC mRNA
bromodichloromethane results in increased expression of MYC mRNA
CTD PMID:11099637 PMID:24001804 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions EXP [Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein; LEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein] CTD PMID:23438451 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP
ISO
bromodichloromethane results in increased expression of PCNA protein CTD PMID:8717228 PMID:11099637 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Prf1 perforin 1 (pore forming protein) multiple interactions EXP [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; [PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats] CTD PMID:24211274 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459
JBrowse link
G Rag2 recombination activating gene 2 multiple interactions EXP [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; [PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats] CTD PMID:24211274 NCBI chr 2:101,455,057...101,462,873
Ensembl chr 2:101,455,063...101,462,874
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Dietary Fats co-treated with bromodichloromethane] results in increased expression of TNF protein CTD PMID:23438451 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link

Term paths to the root
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  CHEBI ontology 22188
    role 22173
      application 21755
        reagent 18783
          bromodichloromethane 25
Path 2
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  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    main group molecular entity 22114
                      s-block molecular entity 21706
                        hydrogen molecular entity 21622
                          hydrides 20748
                            organic hydride 20297
                              organic fundamental parent 20297
                                hydrocarbon 19869
                                  halohydrocarbon 16259
                                    haloalkane 12961
                                      halomethane 10454
                                        bromodichloromethane 25
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