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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromodichloromethane
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Accession:CHEBI:34591 term browser browse the term
Definition:A halomethane that is dichloromethane in which oneof the hydrogens has been replaced by a bromine atom. It occurs as a contaminant in drinking water.
Synonyms:exact_synonym: bromo(dichloro)methane
 related_synonym: CHBrCl2;   Formula=CHBrCl2;   InChI=1S/CHBrCl2/c2-1(3)4/h1H;   InChIKey=FMWLUWPQPKEARP-UHFFFAOYSA-N;   SMILES=[H]C(Cl)(Cl)Br;   dichlorobromomethane;   dichloromonobromomethane;   monobromodichloromethane
 xref: Beilstein:1697005;   CAS:75-27-4;   Gmelin:25941;   KEGG:C14708
 xref_mesh: MESH:C025191
 xref: PMID:23446885;   PMID:24001804;   PMID:24647036;   Reaxys:1697005;   Wikipedia:Bromodichloromethane


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bromodichloromethane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B3gat1 beta-1,3-glucuronyltransferase 1 multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of B3GAT1 protein CTD PMID:24211274 NCBI chr 8:27,777,024...27,804,368
Ensembl chr 8:27,777,179...27,804,515
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; LEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form] CTD PMID:24211274 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of CCL2 protein] CTD PMID:23438451 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP bromodichloromethane results in increased expression of CCND1 mRNA CTD PMID:24001804 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO [Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA; gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA] CTD PMID:23438451 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases methylation
EXP bromodichloromethane results in decreased expression of CDH1 mRNA; bromodichloromethane results in decreased expression of CDH1 protein
bromodichloromethane results in increased methylation of CDH1 gene
CTD PMID:24001804 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
decreases expression
increases expression
affects metabolic processing
multiple interactions
ISO
EXP
CYP1A2 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in decreased expression of CYP1A2 protein
bromodichloromethane results in increased expression of CYP1A2 protein
CYP1A2 protein affects the metabolism of bromodichloromethane
isosafrole inhibits the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]; Tetrachlorodibenzodioxin promotes the reaction [CYP1A2 protein affects the metabolism of bromodichloromethane]
CTD PMID:11295256, PMID:12062927, PMID:12076521 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
increases metabolic processing
decreases expression
EXP bromodichloromethane results in increased expression of CYP2B1 protein
CYP2B1 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in decreased expression of CYP2B1 protein
CTD PMID:11295256, PMID:12076521 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases metabolic processing EXP CYP2B2 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases response to substance
increases metabolic processing
increases expression
EXP
ISO
CYP2E1 protein results in increased metabolism of and results in increased activity of bromodichloromethane
[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CYP2E1 protein; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats]
CYP2E1 gene mutant form results in decreased susceptibility to bromodichloromethane
CYP2E1 protein results in increased metabolism of bromodichloromethane
bromodichloromethane results in increased expression of CYP2E1 protein
CTD PMID:9458004, PMID:11295256, PMID:12076521, PMID:12076522, PMID:18350910, PMID:23438451, PMID:23640861, PMID:24211274 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO bromodichloromethane results in increased expression of GPT CTD PMID:25640707 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases metabolic processing
multiple interactions
ISO
EXP
GSTT1 protein results in increased metabolism of bromodichloromethane
GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]
CTD PMID:12588193, PMID:14998683 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Ifng interferon gamma multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IFNG mRNA] CTD PMID:24211274 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL1B mRNA] CTD PMID:24211274 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; CYP2E1 protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA] CTD PMID:24211274 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP bromodichloromethane results in decreased expression of JUN mRNA CTD PMID:24001804 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lep leptin increases expression
multiple interactions
decreases response to substance
ISO bromodichloromethane results in increased expression of LEP mRNA
bromodichloromethane promotes the reaction [Dietary Fats results in increased expression of LEP mRNA]; LEP protein affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; LEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEP protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane]
LEP gene mutant form results in decreased susceptibility to bromodichloromethane
CTD PMID:23438451, PMID:23640861, PMID:24211274 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor multiple interactions ISO LEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEPR protein results in decreased susceptibility to [Dietary Fats co-treated with bromodichloromethane] CTD PMID:23438451 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lhb luteinizing hormone subunit beta decreases secretion EXP bromodichloromethane results in decreased secretion of LHB protein CTD PMID:14657523, PMID:17344021 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases methylation
increases expression
decreases expression
ISO
EXP
bromodichloromethane results in decreased methylation of MYC promoter
bromodichloromethane results in increased expression of MYC mRNA
bromodichloromethane results in decreased expression of MYC mRNA
CTD PMID:11099637, PMID:24001804 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions ISO [Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein; LEP protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein]; LEPR protein affects the reaction [[Dietary Fats co-treated with bromodichloromethane] affects the localization of NCF2 protein] CTD PMID:23438451 NCBI chr13:70,226,441...70,259,019
Ensembl chr13:70,226,647...70,257,576
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO
EXP
bromodichloromethane results in increased expression of PCNA protein CTD PMID:8717228, PMID:11099637 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Prf1 perforin 1 multiple interactions ISO [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; [PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats] CTD PMID:24211274 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382
JBrowse link
G Rag2 recombination activating 2 multiple interactions ISO [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of CASP3 protein modified form]; [PRF1 protein co-treated with RAG2 protein] affects the reaction [[bromodichloromethane co-treated with Dietary Fats] results in increased expression of IL2 mRNA]; [PRF1 protein co-treated with RAG2 protein] affects the susceptibility to [bromodichloromethane co-treated with Dietary Fats] CTD PMID:24211274 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Dietary Fats co-treated with bromodichloromethane] results in increased expression of TNF protein CTD PMID:23438451 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
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  CHEBI ontology 19787
    role 19734
      application 19393
        reagent 17168
          bromodichloromethane 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  halohydrocarbon 13937
                                    haloalkane 11657
                                      halomethane 9949
                                        bromodichloromethane 25
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