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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Bisphenol B
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Accession:CHEBI:34581 term browser browse the term
Definition:A bisphenol that has formula C16H18O2.
Synonyms:related_synonym: 2,2-Bis(4-hydroxyphenyl)butane;   4,4'-(1-Methylpropylidene)bisphenol;   4,4'-Dihydroxy-2,2-diphenylbutane;   Formula=C16H18O2;   InChI=1S/C16H18O2/c1-3-16(2,12-4-8-14(17)9-5-12)13-6-10-15(18)11-7-13/h4-11,17-18H,3H2,1-2H3;   InChIKey=HTVITOHKHWFJKO-UHFFFAOYSA-N;   SMILES=CCC(C)(c1ccc(O)cc1)c1ccc(O)cc1
 xref: CAS:77-40-7;   KEGG:C14225
 xref_mesh: MESH:C492482


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Bisphenol B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO bisphenol B results in increased expression of ABCB1 mRNA CTD PMID:22214767 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agr3 anterior gradient 3, protein disulphide isomerase family member increases expression ISO bisphenol B results in increased expression of AGR3 mRNA CTD PMID:28591870 NCBI chr 6:55,371,738...55,424,233
Ensembl chr 6:55,371,738...55,424,674
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases acetylation EXP bisphenol B results in increased acetylation of AKT1 protein CTD PMID:31332466 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 decreases expression ISO bisphenol B results in decreased expression of ALDH1A3 mRNA CTD PMID:28591870 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Ar androgen receptor decreases activity
increases activity
multiple interactions
ISO bisphenol B results in decreased activity of AR protein
bisphenol B results in increased activity of AR protein
bisphenol B inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bisphenol B inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bisphenol B inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]
CTD PMID:24563381, PMID:27561732, PMID:29392883, PMID:30582956, PMID:30951782 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cat catalase decreases activity EXP bisphenol B results in decreased activity of CAT protein CTD PMID:29940534, PMID:31424294 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases acetylation EXP bisphenol B results in increased acetylation of CREB1 protein CTD PMID:31332466 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Dio1 iodothyronine deiodinase 1 increases expression EXP bisphenol B results in increased expression of DIO1 mRNA CTD PMID:28167136 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases expression EXP bisphenol B results in decreased expression of DIO2 mRNA CTD PMID:28167136 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO bisphenol B results in decreased expression of EPAS1 mRNA CTD PMID:28591870 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
affects binding
increases activity
affects activity
multiple interactions
ISO
EXP
bisphenol B results in decreased expression of ESR1 protein
bisphenol B binds to ESR1 protein
bisphenol B results in increased activity of ESR1 protein
bisphenol B affects the activity of ESR1 protein
bisphenol B binds to and results in decreased activity of ESR1 protein; bisphenol B binds to and results in increased activity of ESR1 protein; bisphenol B inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol B results in increased activity of and affects the localization of ESR1 protein; Fulvestrant inhibits the reaction [bisphenol B results in increased activity of ESR1 protein]
CTD PMID:11750080, PMID:12504345, PMID:21256200, PMID:23611293, PMID:24856822, PMID:25012808, PMID:28591870, PMID:29392883, PMID:30143207, PMID:30582956, PMID:30951782, PMID:31195007, PMID:31388671 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions
ISO bisphenol B results in increased activity of ESR2 protein
bisphenol B inhibits the reaction [Estradiol binds to ESR2 protein]
CTD PMID:30582956, PMID:30951782, PMID:31195007 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO bisphenol B binds to and results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP bisphenol B results in decreased expression of FSHB protein CTD PMID:31424294 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 decreases expression ISO bisphenol B results in decreased expression of GABBR2 mRNA CTD PMID:28591870 NCBI chr 5:62,276,100...62,621,737
Ensembl chr 5:62,276,100...62,621,737
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects binding ISO bisphenol B binds to GPER1 protein CTD PMID:28858478 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO bisphenol B promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]
bisphenol B results in increased expression of GREB1 mRNA
CTD PMID:24856822, PMID:28591870, PMID:31388671 NCBI chr 6:41,932,941...42,002,770
Ensembl chr 6:41,932,244...42,002,819
JBrowse link
G Insl3 insulin-like 3 increases expression ISO bisphenol B results in increased expression of INSL3 protein CTD PMID:28482050 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP bisphenol B results in decreased expression of LHB protein CTD PMID:31424294 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mgp matrix Gla protein increases expression ISO bisphenol B results in increased expression of MGP mRNA CTD PMID:28591870 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Myb MYB proto-oncogene, transcription factor increases expression ISO bisphenol B results in increased expression of MYB mRNA CTD PMID:28591870 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO 4-cumylphenol promotes the reaction [bisphenol B results in increased activity of NR1I2 protein]; bisphenol B inhibits the reaction [TO-901317 binds to NR1I2 protein]; bisphenol B promotes the reaction [4-cumylphenol results in increased activity of NR1I2 protein] CTD PMID:22214767, PMID:30582956, PMID:30951782, PMID:31195007 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions
decreases activity
ISO bisphenol B results in increased activity of NR1I3 protein
bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]
bisphenol B results in decreased activity of NR1I3 protein
CTD PMID:28927721, PMID:30582956, PMID:31195007 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO bisphenol B inhibits the reaction [Dexamethasone binds to NR3C1 protein]; bisphenol B inhibits the reaction [Hydrocortisone binds to NR3C1 protein]; bisphenol B inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:28078411, PMID:30582956, PMID:31195007 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO bisphenol B inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:30951782 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Oga O-GlcNAcase multiple interactions
increases expression
EXP bisphenol B results in increased expression of and results in decreased activity of OGA protein
bisphenol B results in increased expression of OGA mRNA
CTD PMID:31332466 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO bisphenol B results in increased expression of PGR mRNA
bisphenol B inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:28591870, PMID:31195007, PMID:31388671 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO bisphenol B results in decreased expression of PSCA mRNA CTD PMID:28591870 NCBI chr 7:116,090,189...116,091,955
Ensembl chr 7:116,090,189...116,091,955
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO bisphenol B binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression EXP bisphenol B results in decreased expression of THRA mRNA CTD PMID:28167136 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression EXP bisphenol B results in decreased expression of THRB mRNA CTD PMID:28167136 NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO bisphenol B results in increased expression of UGT1A1 mRNA CTD PMID:22214767 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      molecular entity 19767
        polyatomic entity 19677
          heteroatomic molecular entity 19594
            hydroxides 19064
              organic hydroxy compound 18631
                phenols 18111
                  bisphenol 17405
                    Bisphenol B 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    p-block element atom 19655
                      carbon group element atom 19550
                        carbon atom 19539
                          organic molecular entity 19539
                            organic molecule 19461
                              organic cyclic compound 19232
                                organic aromatic compound 19049
                                  phenols 18111
                                    bisphenol 17405
                                      Bisphenol B 32
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.