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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Bisphenol B
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Accession:CHEBI:34581 term browser browse the term
Definition:A bisphenol that has formula C16H18O2.
Synonyms:related_synonym: 2,2-Bis(4-hydroxyphenyl)butane;   4,4'-(1-Methylpropylidene)bisphenol;   4,4'-Dihydroxy-2,2-diphenylbutane;   Formula=C16H18O2;   InChI=1S/C16H18O2/c1-3-16(2,12-4-8-14(17)9-5-12)13-6-10-15(18)11-7-13/h4-11,17-18H,3H2,1-2H3;   InChIKey=HTVITOHKHWFJKO-UHFFFAOYSA-N;   SMILES=CCC(C)(c1ccc(O)cc1)c1ccc(O)cc1
 xref: CAS:77-40-7;   KEGG:C14225
 xref_mesh: MESH:C492482


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Bisphenol B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A increases expression ISO bisphenol B results in increased expression of ABCB1 mRNA CTD PMID:22214767 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Agr3 anterior gradient 3 increases expression ISO bisphenol B results in increased expression of AGR3 mRNA CTD PMID:28591870 NCBI chr12:35,925,621...35,949,737
Ensembl chr12:35,925,620...35,949,736
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases acetylation ISO bisphenol B results in increased acetylation of AKT1 protein CTD PMID:31332466 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 decreases expression ISO bisphenol B results in decreased expression of ALDH1A3 mRNA CTD PMID:28591870 NCBI chr 7:66,390,892...66,427,477
Ensembl chr 7:66,390,890...66,427,517
JBrowse link
G Ar androgen receptor decreases activity
increases activity
multiple interactions
ISO bisphenol B results in decreased activity of AR protein
bisphenol B results in increased activity of AR protein
bisphenol B inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bisphenol B inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bisphenol B inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]
CTD PMID:24563381, PMID:27561732, PMID:29392883, PMID:30582956, PMID:30951782 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Cat catalase decreases activity ISO bisphenol B results in decreased activity of CAT protein CTD PMID:29940534, PMID:31424294 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases acetylation ISO bisphenol B results in increased acetylation of CREB1 protein CTD PMID:31332466 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases expression ISO bisphenol B results in increased expression of CYP3A4 mRNA CTD PMID:22214767 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Dio1 deiodinase, iodothyronine, type I increases expression ISO bisphenol B results in increased expression of DIO1 mRNA CTD PMID:28167136 NCBI chr 4:107,291,465...107,307,168
Ensembl chr 4:107,291,465...107,307,169
JBrowse link
G Dio2 deiodinase, iodothyronine, type II decreases expression ISO bisphenol B results in decreased expression of DIO2 mRNA CTD PMID:28167136 NCBI chr12:90,724,552...90,739,038
Ensembl chr12:90,724,552...90,738,438
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO bisphenol B results in decreased expression of EPAS1 mRNA CTD PMID:28591870 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression
affects binding
increases activity
affects activity
multiple interactions
ISO
EXP
bisphenol B results in decreased expression of ESR1 protein
bisphenol B binds to ESR1 protein
bisphenol B results in increased activity of ESR1 protein
bisphenol B affects the activity of ESR1 protein
bisphenol B binds to and results in decreased activity of ESR1 protein; bisphenol B binds to and results in increased activity of ESR1 protein; bisphenol B inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol B results in increased activity of and affects the localization of ESR1 protein; Fulvestrant inhibits the reaction [bisphenol B results in increased activity of ESR1 protein]
CTD PMID:11750080, PMID:12504345, PMID:21256200, PMID:23611293, PMID:24856822, PMID:25012808, PMID:28591870, PMID:29392883, PMID:30143207, PMID:30582956, PMID:30951782, PMID:31195007, PMID:31388671 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) increases activity
multiple interactions
ISO bisphenol B results in increased activity of ESR2 protein
bisphenol B inhibits the reaction [Estradiol binds to ESR2 protein]
CTD PMID:30582956, PMID:30951782, PMID:31195007 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions ISO bisphenol B binds to and results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr 1:187,608,510...188,214,885
Ensembl chr 1:187,608,791...188,214,885
JBrowse link
G Fshb follicle stimulating hormone beta decreases expression ISO bisphenol B results in decreased expression of FSHB protein CTD PMID:31424294 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656
JBrowse link
G Gabbr2 gamma-aminobutyric acid (GABA) B receptor, 2 decreases expression ISO bisphenol B results in decreased expression of GABBR2 mRNA CTD PMID:28591870 NCBI chr 4:46,662,318...46,991,714
Ensembl chr 4:46,662,305...46,991,873
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects binding ISO bisphenol B binds to GPER1 protein CTD PMID:28858478 NCBI chr 5:139,423,150...139,427,800
Ensembl chr 5:139,423,151...139,427,800
JBrowse link
G Greb1 gene regulated by estrogen in breast cancer protein multiple interactions
increases expression
ISO bisphenol B promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]
bisphenol B results in increased expression of GREB1 mRNA
CTD PMID:24856822, PMID:28591870, PMID:31388671 NCBI chr12:16,670,615...16,801,394
Ensembl chr12:16,670,615...16,800,886
JBrowse link
G Insl3 insulin-like 3 increases expression ISO bisphenol B results in increased expression of INSL3 protein CTD PMID:28482050 NCBI chr 8:71,689,252...71,690,577
Ensembl chr 8:71,689,214...71,690,575
JBrowse link
G Lhb luteinizing hormone beta decreases expression ISO bisphenol B results in decreased expression of LHB protein CTD PMID:31424294 NCBI chr 7:45,417,608...45,421,855
Ensembl chr 7:45,420,820...45,421,897
Ensembl chr 7:45,420,820...45,421,897
JBrowse link
G Mgp matrix Gla protein increases expression ISO bisphenol B results in increased expression of MGP mRNA CTD PMID:28591870 NCBI chr 6:136,872,435...136,875,823
Ensembl chr 6:136,872,435...136,875,823
JBrowse link
G Myb myeloblastosis oncogene increases expression ISO bisphenol B results in increased expression of MYB mRNA CTD PMID:28591870 NCBI chr10:21,124,930...21,160,984
Ensembl chr10:21,124,935...21,160,984
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO 4-cumylphenol promotes the reaction [bisphenol B results in increased activity of NR1I2 protein]; bisphenol B inhibits the reaction [TO-901317 binds to NR1I2 protein]; bisphenol B promotes the reaction [4-cumylphenol results in increased activity of NR1I2 protein] CTD PMID:22214767, PMID:30582956, PMID:30951782, PMID:31195007 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions
decreases activity
ISO bisphenol B results in increased activity of NR1I3 protein
bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]
bisphenol B results in decreased activity of NR1I3 protein
CTD PMID:28927721, PMID:30582956, PMID:31195007 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO bisphenol B inhibits the reaction [Dexamethasone binds to NR3C1 protein]; bisphenol B inhibits the reaction [Hydrocortisone binds to NR3C1 protein]; bisphenol B inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:28078411, PMID:30582956, PMID:31195007 NCBI chr18:39,410,545...39,519,421
Ensembl chr18:39,410,545...39,519,421
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO bisphenol B inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:30951782 NCBI chr 8:76,898,083...77,245,012
Ensembl chr 8:76,899,442...77,245,012
JBrowse link
G Oga O-GlcNAcase increases expression
multiple interactions
ISO bisphenol B results in increased expression of OGA mRNA
bisphenol B results in increased expression of and results in decreased activity of OGA protein
CTD PMID:31332466 NCBI chr19:45,750,255...45,783,644
Ensembl chr19:45,750,259...45,783,837
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO bisphenol B results in increased expression of PGR mRNA
bisphenol B inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:28591870, PMID:31195007, PMID:31388671 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Psca prostate stem cell antigen decreases expression ISO bisphenol B results in decreased expression of PSCA mRNA CTD PMID:28591870 NCBI chr15:74,714,839...74,717,065
Ensembl chr15:74,714,839...74,717,069
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO bisphenol B binds to SHBG protein CTD PMID:25349334 NCBI chr11:69,610,282...69,618,026
Ensembl chr11:69,614,804...69,617,905
JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO bisphenol B results in decreased expression of THRA mRNA CTD PMID:28167136 NCBI chr11:98,740,776...98,769,006
Ensembl chr11:98,740,638...98,769,006
JBrowse link
G Thrb thyroid hormone receptor beta decreases expression ISO bisphenol B results in decreased expression of THRB mRNA CTD PMID:28167136 NCBI chr14:17,659,225...18,040,097
Ensembl chr14:17,660,261...18,038,090
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 increases expression ISO bisphenol B results in increased expression of UGT1A1 mRNA CTD PMID:22214767 NCBI chr 1:88,211,959...88,220,002
Ensembl chr 1:88,211,959...88,218,997
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21416
    chemical entity 21414
      molecular entity 21408
        polyatomic entity 21273
          heteroatomic molecular entity 21181
            hydroxides 20047
              organic hydroxy compound 19069
                phenols 18342
                  bisphenol 17287
                    Bisphenol B 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 21416
    subatomic particle 21412
      composite particle 21412
        hadron 21412
          baryon 21412
            nucleon 21412
              atomic nucleus 21412
                atom 21412
                  main group element atom 21307
                    p-block element atom 21307
                      carbon group element atom 21082
                        carbon atom 20979
                          organic molecular entity 20979
                            organic molecule 20853
                              organic cyclic compound 20372
                                organic aromatic compound 19984
                                  phenols 18342
                                    bisphenol 17287
                                      Bisphenol B 33
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.