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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Bisphenol B
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Accession:CHEBI:34581 term browser browse the term
Definition:A bisphenol that has formula C16H18O2.
Synonyms:related_synonym: 2,2-Bis(4-hydroxyphenyl)butane;   4,4'-(1-Methylpropylidene)bisphenol;   4,4'-Dihydroxy-2,2-diphenylbutane;   Formula=C16H18O2;   InChI=1S/C16H18O2/c1-3-16(2,12-4-8-14(17)9-5-12)13-6-10-15(18)11-7-13/h4-11,17-18H,3H2,1-2H3;   InChIKey=HTVITOHKHWFJKO-UHFFFAOYSA-N;   SMILES=CCC(C)(c1ccc(O)cc1)c1ccc(O)cc1
 xref: CAS:77-40-7;   KEGG:C14225
 xref_mesh: MESH:C492482


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Bisphenol B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP bisphenol B results in increased expression of ABCB1 mRNA CTD PMID:22214767 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G AGR3 anterior gradient 3, protein disulphide isomerase family member increases expression EXP bisphenol B results in increased expression of AGR3 mRNA CTD PMID:28591870 NCBI chr 7:16,854,711...16,881,983
Ensembl chr 7:16,859,412...16,881,987
JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases acetylation ISO bisphenol B results in increased acetylation of AKT1 protein CTD PMID:31332466 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 decreases expression EXP bisphenol B results in decreased expression of ALDH1A3 mRNA CTD PMID:28591870 NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626
JBrowse link
G AR androgen receptor decreases activity
increases activity
multiple interactions
EXP bisphenol B results in decreased activity of AR protein
bisphenol B results in increased activity of AR protein
bisphenol B inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; bisphenol B inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bisphenol B inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]
CTD PMID:24563381, PMID:27561732, PMID:29392883, PMID:30582956, PMID:30951782 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CAT catalase decreases activity ISO bisphenol B results in decreased activity of CAT protein CTD PMID:29940534, PMID:31424294 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases acetylation ISO bisphenol B results in increased acetylation of CREB1 protein CTD PMID:31332466 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP bisphenol B results in increased expression of CYP3A4 mRNA CTD PMID:22214767 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DIO1 iodothyronine deiodinase 1 increases expression ISO bisphenol B results in increased expression of DIO1 mRNA CTD PMID:28167136 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression ISO bisphenol B results in decreased expression of DIO2 mRNA CTD PMID:28167136 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757
JBrowse link
G EPAS1 endothelial PAS domain protein 1 decreases expression EXP bisphenol B results in decreased expression of EPAS1 mRNA CTD PMID:28591870 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G ESR1 estrogen receptor 1 decreases expression
affects binding
increases activity
affects activity
multiple interactions
EXP
ISO
bisphenol B results in decreased expression of ESR1 protein
bisphenol B binds to ESR1 protein
bisphenol B results in increased activity of ESR1 protein
bisphenol B affects the activity of ESR1 protein
bisphenol B binds to and results in decreased activity of ESR1 protein; bisphenol B binds to and results in increased activity of ESR1 protein; bisphenol B inhibits the reaction [Estradiol binds to ESR1 protein]; bisphenol B results in increased activity of and affects the localization of ESR1 protein; Fulvestrant inhibits the reaction [bisphenol B results in increased activity of ESR1 protein]
CTD PMID:11750080, PMID:12504345, PMID:21256200, PMID:23611293, PMID:24856822, PMID:25012808, PMID:28591870, PMID:29392883, PMID:30143207, PMID:30582956, PMID:30951782, PMID:31195007, PMID:31388671 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 increases activity
multiple interactions
EXP bisphenol B results in increased activity of ESR2 protein
bisphenol B inhibits the reaction [Estradiol binds to ESR2 protein]
CTD PMID:30582956, PMID:30951782, PMID:31195007 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G ESRRG estrogen related receptor gamma multiple interactions EXP bisphenol B binds to and results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr 1:216,503,246...217,137,702
Ensembl chr 1:216,503,246...217,137,755
JBrowse link
G FSHB follicle stimulating hormone subunit beta decreases expression ISO bisphenol B results in decreased expression of FSHB protein CTD PMID:31424294 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,016...30,235,261
JBrowse link
G GABBR2 gamma-aminobutyric acid type B receptor subunit 2 decreases expression EXP bisphenol B results in decreased expression of GABBR2 mRNA CTD PMID:28591870 NCBI chr 9:98,288,104...98,708,935
Ensembl chr 9:98,288,109...98,708,935
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 affects binding EXP bisphenol B binds to GPER1 protein CTD PMID:28858478 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G GREB1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
EXP bisphenol B promotes the reaction [Estradiol results in increased expression of GREB1 mRNA]
bisphenol B results in increased expression of GREB1 mRNA
CTD PMID:24856822, PMID:28591870, PMID:31388671 NCBI chr 2:11,481,675...11,642,788
Ensembl chr 2:11,482,341...11,642,788
JBrowse link
G INSL3 insulin like 3 increases expression EXP bisphenol B results in increased expression of INSL3 protein CTD PMID:28482050 NCBI chr19:17,816,512...17,821,519
Ensembl chr19:17,816,512...17,821,574
JBrowse link
G LHB luteinizing hormone subunit beta decreases expression ISO bisphenol B results in decreased expression of LHB protein CTD PMID:31424294 NCBI chr19:49,015,980...49,017,091
Ensembl chr19:49,015,980...49,017,090
Ensembl chr19:49,015,980...49,017,090
JBrowse link
G MGP matrix Gla protein increases expression EXP bisphenol B results in increased expression of MGP mRNA CTD PMID:28591870 NCBI chr12:14,880,864...14,885,854
Ensembl chr12:14,880,864...14,885,857
JBrowse link
G MYB MYB proto-oncogene, transcription factor increases expression EXP bisphenol B results in increased expression of MYB mRNA CTD PMID:28591870 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity
EXP 4-cumylphenol promotes the reaction [bisphenol B results in increased activity of NR1I2 protein]; bisphenol B inhibits the reaction [TO-901317 binds to NR1I2 protein]; bisphenol B promotes the reaction [4-cumylphenol results in increased activity of NR1I2 protein] CTD PMID:22214767, PMID:30582956, PMID:30951782, PMID:31195007 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,485
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity
multiple interactions
decreases activity
EXP bisphenol B results in increased activity of NR1I3 protein
bisphenol B inhibits the reaction [Clotrimazole binds to NR1I3 protein]
bisphenol B results in decreased activity of NR1I3 protein
CTD PMID:28927721, PMID:30582956, PMID:31195007 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 multiple interactions EXP bisphenol B inhibits the reaction [Dexamethasone binds to NR3C1 protein]; bisphenol B inhibits the reaction [Hydrocortisone binds to NR3C1 protein]; bisphenol B inhibits the reaction [Hydrocortisone results in increased activity of NR3C1 protein] CTD PMID:28078411, PMID:30582956, PMID:31195007 NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
JBrowse link
G NR3C2 nuclear receptor subfamily 3 group C member 2 multiple interactions EXP bisphenol B inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:30951782 NCBI chr 4:148,078,764...148,444,698
Ensembl chr 4:148,078,762...148,444,698
JBrowse link
G OGA O-GlcNAcase increases expression
multiple interactions
ISO bisphenol B results in increased expression of OGA mRNA
bisphenol B results in increased expression of and results in decreased activity of OGA protein
CTD PMID:31332466 NCBI chr10:101,784,445...101,818,709
Ensembl chr10:101,784,443...101,818,465
JBrowse link
G PGR progesterone receptor increases expression
multiple interactions
EXP bisphenol B results in increased expression of PGR mRNA
bisphenol B inhibits the reaction [Progesterone binds to PGR protein]
CTD PMID:28591870, PMID:31195007, PMID:31388671 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PRICKLE2-AS3 PRICKLE2 antisense RNA 3 decreases expression EXP bisphenol B results in decreased expression of PRICKLE2-AS3 mRNA CTD PMID:28591870 NCBI chr 3:64,187,544...64,201,561
Ensembl chr 3:64,187,544...64,200,965
JBrowse link
G PSCA prostate stem cell antigen decreases expression EXP bisphenol B results in decreased expression of PSCA mRNA CTD PMID:28591870 NCBI chr 8:142,670,297...142,682,725
Ensembl chr 8:142,670,308...142,682,725
JBrowse link
G SHBG sex hormone binding globulin affects binding EXP bisphenol B binds to SHBG protein CTD PMID:25349334 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
G THRA thyroid hormone receptor alpha decreases expression ISO bisphenol B results in decreased expression of THRA mRNA CTD PMID:28167136 NCBI chr17:40,062,193...40,093,867
Ensembl chr17:40,058,290...40,093,867
JBrowse link
G THRB thyroid hormone receptor beta decreases expression ISO bisphenol B results in decreased expression of THRB mRNA CTD PMID:28167136 NCBI chr 3:24,117,153...24,495,708
Ensembl chr 3:24,117,153...24,495,756
JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP bisphenol B results in increased expression of UGT1A1 mRNA CTD PMID:22214767 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24191
    chemical entity 24157
      molecular entity 24108
        polyatomic entity 24021
          heteroatomic molecular entity 23534
            hydroxides 22297
              organic hydroxy compound 20677
                phenols 19340
                  bisphenol 17622
                    Bisphenol B 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 24191
    subatomic particle 24144
      composite particle 24144
        hadron 24144
          baryon 24144
            nucleon 24144
              atomic nucleus 24144
                atom 24144
                  main group element atom 23976
                    p-block element atom 23976
                      carbon group element atom 23703
                        carbon atom 23660
                          organic molecular entity 23660
                            organic molecule 23528
                              organic cyclic compound 22619
                                organic aromatic compound 22216
                                  phenols 19340
                                    bisphenol 17622
                                      Bisphenol B 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.