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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acephate
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Accession:CHEBI:34520 term browser browse the term
Definition:A phosphoramide that is methamidophos in which one of the hydrogens is replaced by an acetyl group.
Synonyms:exact_synonym: O,S-dimethyl acetylphosphoroamidothioate
 related_synonym: Acetamidophos;   Acetylphosphoramidothioic acid O,S-dimethyl ester;   Formula=C4H10NO3PS;   InChI=1S/C4H10NO3PS/c1-4(6)5-9(7,8-2)10-3/h1-3H3,(H,5,6,7);   InChIKey=YASYVMFAVPKPKE-UHFFFAOYSA-N;   N-(Methoxy(methylthio)phosphinoyl)acetamide;   O,S-Dimethylacetylphosphoroamidothioate;   O,S-dimethyl acetylamidothiophosphate;   SMILES=COP(=O)(NC(C)=O)SC
 xref: Beilstein:1936365;   CAS:30560-19-1;   KEGG:C14426
 xref_mesh: MESH:C001969
 xref: PMID:16526463;   PMID:24001830;   PMID:24138465;   PPDB:9;   Patent:CN102989760;   Patent:CN102993230;   Reaxys:1936365;   Wikipedia:Acephate


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acephate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein] CTD PMID:9074804 PMID:11048668 PMID:12039681 PMID:22778074 PMID:23000449 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO acephate results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Bche butyrylcholinesterase decreases expression EXP acephate results in decreased expression of BCHE protein CTD PMID:31326399 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
acephate results in decreased activity of CAT protein
CTD PMID:10874619 PMID:22034174 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Crh corticotropin releasing hormone increases expression
multiple interactions
increases secretion
EXP acephate results in increased expression of CRH mRNA
acephate promotes the reaction [FOS protein binds to CRH promoter]; Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]; Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]
CTD PMID:12039681 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP1A1 protein; [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B2 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP acephate promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC protein] CTD PMID:22778074 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein] CTD PMID:19118596 PMID:22778074 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link

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  CHEBI ontology 19810
    role 19758
      application 19420
        agrochemical 14503
          acephate 15
Path 2
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  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      chalcogen 19391
                        oxygen atom 19353
                          oxygen molecular entity 19353
                            hydroxides 19103
                              oxoacid 18235
                                pnictogen oxoacid 10181
                                  phosphorus oxoacid 9072
                                    phosphoric acids 7831
                                      phosphoric acid 7831
                                        phosphoric acid derivative 7511
                                          phosphate 7511
                                            organic phosphate 7510
                                              organic thiophosphate 2874
                                                methamidophos 38
                                                  acephate 15
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