Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acephate
go back to main search page
Accession:CHEBI:34520 term browser browse the term
Definition:A phosphoramide that is methamidophos in which one of the hydrogens is replaced by an acetyl group.
Synonyms:exact_synonym: O,S-dimethyl acetylphosphoroamidothioate
 related_synonym: Acetamidophos;   Acetylphosphoramidothioic acid O,S-dimethyl ester;   Formula=C4H10NO3PS;   InChI=1S/C4H10NO3PS/c1-4(6)5-9(7,8-2)10-3/h1-3H3,(H,5,6,7);   InChIKey=YASYVMFAVPKPKE-UHFFFAOYSA-N;   N-(Methoxy(methylthio)phosphinoyl)acetamide;   O,S-Dimethylacetylphosphoroamidothioate;   O,S-dimethyl acetylamidothiophosphate;   SMILES=COP(=O)(NC(C)=O)SC
 xref: Beilstein:1936365;   CAS:30560-19-1;   KEGG:C14426
 xref_mesh: MESH:C001969
 xref: PMID:16526463;   PMID:24001830;   PMID:24138465;   PPDB:9;   Patent:CN102989760;   Patent:CN102993230;   Reaxys:1936365;   Wikipedia:Acephate


show annotations for term's descendants           Sort by:
 
acephate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
methamidophos inhibits the reaction [acephate results in decreased activity of ACHE protein] CTD PMID:9074804 PMID:11048668 PMID:12039681 PMID:22778074 PMID:23000449 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alad aminolevulinate dehydratase decreases activity ISO acephate results in decreased activity of ALAD protein CTD PMID:8687997 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO acephate inhibits the reaction [Aldosterone results in increased expression of ALPL mRNA] CTD PMID:29149346 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Bche butyrylcholinesterase decreases expression EXP acephate results in decreased expression of BCHE protein CTD PMID:31326399 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [acephate co-treated with methamidophos co-treated with Nicotine] results in increased activity of CAT protein; [Phorate co-treated with acephate co-treated with Dichlorvos co-treated with Dimethoate] results in decreased activity of CAT protein
acephate results in decreased activity of CAT protein
CTD PMID:10874619 PMID:22034174 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Crh corticotropin releasing hormone increases expression
multiple interactions
increases secretion
EXP acephate results in increased expression of CRH mRNA
acephate promotes the reaction [FOS protein binds to CRH promoter]; Atropine inhibits the reaction [acephate results in increased expression of CRH mRNA]; Atropine inhibits the reaction [acephate results in increased secretion of CRH protein]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased expression of CRH mRNA]; gamma-Aminobutyric Acid inhibits the reaction [acephate results in increased secretion of CRH protein]; Propranolol inhibits the reaction [acephate results in increased expression of CRH mRNA]; Propranolol inhibits the reaction [acephate results in increased secretion of CRH protein]
CTD PMID:12039681 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP1A1 protein; [fenarimol co-treated with acephate] affects the expression of CYP1A1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A1 protein CTD PMID:17686559 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [fenarimol co-treated with acephate] affects the expression of CYP1A2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP1A2 protein CTD PMID:17686559 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B1 protein CTD PMID:17686559 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2B2 protein; [fenarimol co-treated with acephate] affects the expression of CYP2B2 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2B2 protein CTD PMID:17686559 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [acephate co-treated with vinclozolin] affects the expression of CYP2E1 protein; [fenarimol co-treated with acephate] affects the expression of CYP2E1 protein; [fenarimol co-treated with vinclozolin co-treated with acephate] affects the expression of CYP2E1 protein CTD PMID:17686559 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP acephate promotes the reaction [FOS protein binds to CRH promoter] CTD PMID:12039681 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of G6PC1 protein] CTD PMID:22778074 NCBI chr10:86,307,400...86,318,766 JBrowse link
G Gpt glutamic--pyruvic transaminase decreases expression EXP acephate results in decreased expression of GPT protein CTD PMID:33217513 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO acephate inhibits the reaction [Aldosterone affects the localization of NR3C2 protein]; acephate inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] CTD PMID:29149346 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
EXP diphenyldiselenide inhibits the reaction [acephate results in increased activity of TAT protein] CTD PMID:19118596 PMID:22778074 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      application 19481
        agrochemical 15037
          acephate 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      chalcogen 19469
                        oxygen atom 19445
                          oxygen molecular entity 19445
                            hydroxides 19180
                              oxoacid 18498
                                pnictogen oxoacid 10685
                                  phosphorus oxoacid 9666
                                    phosphoric acids 8466
                                      phosphoric acid 8466
                                        phosphoric acid derivative 8172
                                          phosphate 8172
                                            organic phosphate 8171
                                              organic thiophosphate 3715
                                                methamidophos 39
                                                  acephate 16
paths to the root