CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 8,9-EET
Accession: CHEBI:34490
browse the term
Definition: An EET obtained by formal epoxidation of the 8,9-double bond of arachidonic acid.
Synonyms: exact_synonym: (5Z)-7-{3-[(2Z,5Z)-undeca-2,5-dien-1-yl]oxiran-2-yl}hept-5-enoic acid
related_synonym: (+/-)8,9-EpETrE; (5Z,11Z,14Z)-8,9-Epoxyeicosa-5,11,14-trienoic acid; (5Z,11Z,14Z)-8,9-Epoxyicosa-5,11,14-trienoic acid; 8,9-Epoxyeicosatrienoic acid; 8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid; 8,9-epoxy-5Z,11Z,14Z-icosatrienoic acid; 8,9-epoxyicosatrienoic acid; Formula=C20H32O3; InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,12-9-,13-10-; InChIKey=DBWQSCSXHFNTMO-TYAUOURKSA-N; SMILES=CCCCC\\C=C/C\\C=C/CC1OC1C\\C=C/CCCC(O)=O
alt_id: CHEBI:63972
xref: HMDB:HMDB0002232; KEGG:C14769; LIPID_MAPS_instance:LMFA03080003
xref_mesh: MESH:C050715
xref: Reaxys:4697201
cyclic_relationship: is_conjugate_acid_of CHEBI:84025
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases chemical synthesis
ISO
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD
PMID:12675279
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Ephx1
epoxide hydrolase 1
affects hydrolysis
ISO
EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid
CTD
PMID:28975360
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Ephx2
epoxide hydrolase 2
increases abundance
ISO
EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid
CTD
PMID:19896470
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19831
role
19807
biological role
19805
biochemical role
19515
metabolite
19502
EET
13
8,9-EET
3
(8R,9S)-EET
0
(8S,9R)-EET
0
8(9)-EET methyl ester
0
8,9-epoxy-(5Z,11Z,14Z)-icosatrienoyl-CoA
0
N-[(5Z,11Z,14Z)-8,9-epoxyicosatrienoyl]ethanolamine
0
Path 2
CHEBI ontology
19831
subatomic particle
19829
composite particle
19829
hadron
19829
baryon
19829
nucleon
19829
atomic nucleus
19829
atom
19829
main group element atom
19779
p-block element atom
19779
carbon group element atom
19728
carbon atom
19724
organic molecular entity
19724
heteroorganic entity
19477
organochalcogen compound
19240
organooxygen compound
19155
carbon oxoacid
18613
carboxylic acid
18610
monocarboxylic acid
17966
fatty acid
16685
unsaturated fatty acid
1096
polyunsaturated fatty acid
838
fatty acid 20:4
359
icosatetraenoic acid
359
icosa-5,8,11,14-tetraenoic acid
315
arachidonic acid
315
EET
13
8,9-EET
3
(8R,9S)-EET
0
(8S,9R)-EET
0
8(9)-EET methyl ester
0
8,9-epoxy-(5Z,11Z,14Z)-icosatrienoyl-CoA
0
N-[(5Z,11Z,14Z)-8,9-epoxyicosatrienoyl]ethanolamine
0