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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:8,9-EET
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Accession:CHEBI:34490 term browser browse the term
Definition:An EET obtained by formal epoxidation of the 8,9-double bond of arachidonic acid.
Synonyms:exact_synonym: (5Z)-7-{3-[(2Z,5Z)-undeca-2,5-dien-1-yl]oxiran-2-yl}hept-5-enoic acid
 related_synonym: (+/-)8,9-EpETrE;   (5Z,11Z,14Z)-8,9-Epoxyeicosa-5,11,14-trienoic acid;   (5Z,11Z,14Z)-8,9-Epoxyicosa-5,11,14-trienoic acid;   8,9-Epoxyeicosatrienoic acid;   8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid;   8,9-epoxy-5Z,11Z,14Z-icosatrienoic acid;   8,9-epoxyicosatrienoic acid;   Formula=C20H32O3;   InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,12-9-,13-10-;   InChIKey=DBWQSCSXHFNTMO-TYAUOURKSA-N;   SMILES=CCCCC\\C=C/C\\C=C/CC1OC1C\\C=C/CCCC(O)=O
 alt_id: CHEBI:63972
 xref: HMDB:HMDB0002232;   KEGG:C14769;   LIPID_MAPS_instance:LMFA03080003
 xref_mesh: MESH:C050715
 xref: Reaxys:4697201
 cyclic_relationship: is_conjugate_acid_of CHEBI:84025



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8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      biological role 19808
        biochemical role 19543
          metabolite 19506
            EET 13
              8,9-EET 3
                (8R,9S)-EET 0
                (8S,9R)-EET 0
                8(9)-EET methyl ester 0
                8,9-epoxy-(5Z,11Z,14Z)-icosatrienoyl-CoA 0
                N-[(5Z,11Z,14Z)-8,9-epoxyicosatrienoyl]ethanolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19722
                        carbon atom 19719
                          organic molecular entity 19719
                            heteroorganic entity 19474
                              organochalcogen compound 19262
                                organooxygen compound 19153
                                  carbon oxoacid 18647
                                    carboxylic acid 18620
                                      monocarboxylic acid 17994
                                        fatty acid 16843
                                          unsaturated fatty acid 1666
                                            polyunsaturated fatty acid 839
                                              fatty acid 20:4 361
                                                icosatetraenoic acid 361
                                                  icosa-5,8,11,14-tetraenoic acid 318
                                                    arachidonic acid 318
                                                      EET 13
                                                        8,9-EET 3
                                                          (8R,9S)-EET 0
                                                          (8S,9R)-EET 0
                                                          8(9)-EET methyl ester 0
                                                          8,9-epoxy-(5Z,11Z,14Z)-icosatrienoyl-CoA 0
                                                          N-[(5Z,11Z,14Z)-8,9-epoxyicosatrienoyl]ethanolamine 0
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