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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-Nitro-2-(3-phenylpropylamino)benzoic acid
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Accession:CHEBI:34457 term browser browse the term
Definition:A nitrobenzoic acid that has formula C16H16N2O4.
Synonyms:related_synonym: Formula=C16H16N2O4;   InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20);   InChIKey=WBSMIPAMAXNXFS-UHFFFAOYSA-N;   NPPB;   SMILES=OC(=O)c1cc(ccc1NCCCc1ccccc1)N(=O)=O
 xref: CAS:107254-86-4;   KEGG:C13705;   LINCS:LSM-24963
 xref_mesh: MESH:C058176


show annotations for term's descendants           Sort by:
5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Ano6 anoctamin 6 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein CTD PMID:24478309 NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Best1 bestrophin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063 		JBrowse link
G Casp3 caspase 3 decreases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased expression of CASP3 protein CTD PMID:21538933 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CCND1 mRNA CTD PMID:21538933 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity		 ISO
EXP		 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein mutant form; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein mutant form
5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein		 CTD PMID:15131065 PMID:15277574 PMID:15389550 PMID:15634668 PMID:15802612 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 decreases activity
multiple interactions
increases expression		 ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CLCN3 protein
[5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA] which results in decreased susceptibility to Cisplatin		 CTD PMID:17699636 PMID:21538933 NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299 		JBrowse link
G Ifng interferon gamma multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide] CTD PMID:9918806 PMID:19446535 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:9918806 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:19446535 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Panx1 Pannexin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Sct secretin decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of SCT protein CTD PMID:10880878 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] CTD PMID:19023563 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:9918806 PMID:10783394 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      group 19768
        inorganic group 19361
          nitro group 11131
            nitro compound 11131
              C-nitro compound 10843
                nitrobenzoic acid 30
                  5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      aromatic carboxylic acid 12571
                                        benzoic acids 12570
                                          nitrobenzoic acid 30
                                            5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
paths to the root