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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:5-Nitro-2-(3-phenylpropylamino)benzoic acid
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Accession:CHEBI:34457 term browser browse the term
Definition:A nitrobenzoic acid that has formula C16H16N2O4.
Synonyms:related_synonym: Formula=C16H16N2O4;   InChI=1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20);   InChIKey=WBSMIPAMAXNXFS-UHFFFAOYSA-N;   NPPB;   SMILES=OC(=O)c1cc(ccc1NCCCc1ccccc1)N(=O)=O
 xref: CAS:107254-86-4;   KEGG:C13705;   LINCS:LSM-24963
 xref_mesh: MESH:C058176


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5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Fluorouracil]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Ano6 anoctamin 6 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of ANO6 protein CTD PMID:24478309 NCBI chr 7:137,142,063...137,335,208
Ensembl chr 7:137,142,170...137,335,208
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Best1 bestrophin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of BEST1 protein CTD PMID:19828819 NCBI chr 1:226,033,146...226,049,893
Ensembl chr 1:226,030,875...226,049,929
JBrowse link
G Casp3 caspase 3 decreases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased expression of CASP3 protein CTD PMID:21538933 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CCND1 mRNA CTD PMID:21538933 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity
ISO
EXP
5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid analog binds to and results in increased activity of CFTR protein mutant form; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein; 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of CFTR protein mutant form
5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein
CTD PMID:15131065 PMID:15277574 PMID:15389550 PMID:15634668 PMID:15802612 PMID:15857825 NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
JBrowse link
G Clcn3 chloride voltage-gated channel 3 decreases activity
increases expression
multiple interactions
ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CLCN3 protein
5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA
[5-nitro-2-(3-phenylpropylamino)benzoic acid results in increased expression of CLCN3 mRNA] which results in decreased susceptibility to Cisplatin
CTD PMID:17699636 PMID:21538933 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Gpr35 G protein-coupled receptor 35 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid binds to and results in increased activity of GPR35 protein CTD PMID:20826425 NCBI chr 9:100,129,428...100,141,269
Ensembl chr 9:100,137,881...100,138,801
JBrowse link
G Ifng interferon gamma multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased metabolism of Nitric Oxide] CTD PMID:9918806 PMID:19446535 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] CTD PMID:9918806 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]] CTD PMID:9918806 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA] CTD PMID:19446535 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Panx1 Pannexin 1 decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Sct secretin decreases activity ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of SCT protein CTD PMID:10880878 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC16A1 protein results in increased uptake of Butyrates] CTD PMID:19023563 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitrites]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein promotes the reaction [MAPK1 protein results in increased phosphorylation of ATF2 protein]]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein]; 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [TNF protein results in increased transport of Chlorides] CTD PMID:9918806 PMID:10783394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid promotes the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,169,307...42,177,582
Ensembl chr 1:42,169,501...42,177,582
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      group 19787
        inorganic group 19219
          nitro group 7290
            nitro compound 7290
              C-nitro compound 6890
                nitrobenzoic acid 30
                  5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic group 18569
                              organic divalent group 18560
                                organodiyl group 18560
                                  carbonyl group 18468
                                    carbonyl compound 18468
                                      carboxylic acid 18142
                                        aromatic carboxylic acid 10919
                                          benzoic acids 10888
                                            nitrobenzoic acid 30
                                              5-Nitro-2-(3-phenylpropylamino)benzoic acid 20
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