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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:34450 term browser browse the term
Definition:An EET obtained by formal epoxidation of the 5,6-double bond of arachidonic acid.
Synonyms:exact_synonym: 4-{3-[(2Z,5Z,8Z)-tetradeca-2,5,8-trien-1-yl]oxiran-2-yl}butanoic acid
 related_synonym: (8Z,11Z,14Z)-5,6-Epoxyeicosa-8,11,14-trienoic acid;   (8Z,11Z,14Z)-5,6-Epoxyicosa-8,11,14-trienoic acid;   5,6-EpETrE;   5,6-Epoxy-8,11,14-eicosatrienoic acid;   5,6-epoxy-8,11,14-icosatrienoic acid;   5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid;   5,6-epoxy-8Z,11Z,14Z-icosatrienoic acid;   Formula=C20H32O3;   InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-;   InChIKey=VBQNSZQZRAGRIX-QNEBEIHSSA-N;   SMILES=CCCCC\\C=C/C\\C=C/C\\C=C/CC1OC1CCCC(O)=O
 alt_id: CHEBI:63973
 xref: CAS:81246-84-6;   HMDB:HMDB0002190;   KEGG:C14768;   LIPID_MAPS_instance:LMFA03080002
 xref_mesh: MESH:C040776
 xref: Reaxys:4498036
 cyclic_relationship: is_conjugate_acid_of CHEBI:131992

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5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        biochemical role 19380
          metabolite 19358
            EET 13
              5,6-EET 2
                5,6-epoxy-(8Z,11Z,14Z)-icosatrienoyl-CoA 0
                N-[(8Z,11Z,14Z)-5,6-epoxyicosatrienoyl]ethanolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19710
                    p-block element atom 19710
                      carbon group element atom 19631
                        carbon atom 19621
                          organic molecular entity 19621
                            organic group 18730
                              organic divalent group 18721
                                organodiyl group 18721
                                  carbonyl group 18670
                                    carbonyl compound 18670
                                      carboxylic acid 18367
                                        monocarboxylic acid 17639
                                          fatty acid 16023
                                            unsaturated fatty acid 953
                                              polyunsaturated fatty acid 688
                                                fatty acid 20:4 332
                                                  icosatetraenoic acid 332
                                                    icosa-5,8,11,14-tetraenoic acid 286
                                                      arachidonic acid 286
                                                        EET 13
                                                          5,6-EET 2
                                                            5,6-epoxy-(8Z,11Z,14Z)-icosatrienoyl-CoA 0
                                                            N-[(8Z,11Z,14Z)-5,6-epoxyicosatrienoyl]ethanolamine 0
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