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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:34450 term browser browse the term
Definition:An EET obtained by formal epoxidation of the 5,6-double bond of arachidonic acid.
Synonyms:exact_synonym: 4-{3-[(2Z,5Z,8Z)-tetradeca-2,5,8-trien-1-yl]oxiran-2-yl}butanoic acid
 related_synonym: (8Z,11Z,14Z)-5,6-Epoxyeicosa-8,11,14-trienoic acid;   (8Z,11Z,14Z)-5,6-Epoxyicosa-8,11,14-trienoic acid;   5,6-EpETrE;   5,6-Epoxy-8,11,14-eicosatrienoic acid;   5,6-epoxy-8,11,14-icosatrienoic acid;   5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid;   5,6-epoxy-8Z,11Z,14Z-icosatrienoic acid;   Formula=C20H32O3;   InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-;   InChIKey=VBQNSZQZRAGRIX-QNEBEIHSSA-N;   SMILES=CCCCC\\C=C/C\\C=C/C\\C=C/CC1OC1CCCC(O)=O
 alt_id: CHEBI:63973
 xref: CAS:81246-84-6;   HMDB:HMDB0002190;   KEGG:C14768;   LIPID_MAPS_instance:LMFA03080002
 xref_mesh: MESH:C040776
 xref: Reaxys:4498036
 cyclic_relationship: is_conjugate_acid_of CHEBI:131992

show annotations for term's descendants           Sort by:
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid] CTD PMID:12675279 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19860
    role 19832
      biological role 19830
        biochemical role 19538
          metabolite 19525
            EET 13
              5,6-EET 2
                5,6-epoxy-(8Z,11Z,14Z)-icosatrienoyl-CoA 0
                N-[(8Z,11Z,14Z)-5,6-epoxyicosatrienoyl]ethanolamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19860
    subatomic particle 19858
      composite particle 19858
        hadron 19858
          baryon 19858
            nucleon 19858
              atomic nucleus 19858
                atom 19858
                  main group element atom 19804
                    p-block element atom 19804
                      carbon group element atom 19745
                        carbon atom 19741
                          organic molecular entity 19741
                            heteroorganic entity 19494
                              organochalcogen compound 19257
                                organooxygen compound 19173
                                  carbon oxoacid 18641
                                    carboxylic acid 18638
                                      monocarboxylic acid 18012
                                        fatty acid 16843
                                          unsaturated fatty acid 1673
                                            polyunsaturated fatty acid 839
                                              fatty acid 20:4 361
                                                icosatetraenoic acid 361
                                                  icosa-5,8,11,14-tetraenoic acid 318
                                                    arachidonic acid 318
                                                      EET 13
                                                        5,6-EET 2
                                                          5,6-epoxy-(8Z,11Z,14Z)-icosatrienoyl-CoA 0
                                                          N-[(8Z,11Z,14Z)-5,6-epoxyicosatrienoyl]ethanolamine 0
paths to the root