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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-tert-butylphenol
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Accession:CHEBI:34444 term browser browse the term
Definition:A member of the class of phenols that is phenol substituted with a tert-butyl group at position 4.
Synonyms:related_synonym: 4-(1,1-Dimethylethyl)phenol;   4-tert-Butyl-phenol;   Butylphen;   Formula=C10H14O;   InChI=1S/C10H14O/c1-10(2,3)8-4-6-9(11)7-5-8/h4-7,11H,1-3H3;   InChIKey=QHPQWRBYOIRBIT-UHFFFAOYSA-N;   PTBP;   SMILES=CC(C)(C)c1ccc(O)cc1;   p-t-Butyl phenol;   p-tert-Butylphenol;   para-tertiary-butylphenol
 alt_id: CHEBI:117047
 xref: Beilstein:1817334;   CAS:98-54-4;   HMDB:HMDB0032063;   KEGG:C14200
 xref_mesh: MESH:C006862
 xref: PMID:24801287;   PMID:26302341;   PMID:26819047;   PMID:8462290;   Reaxys:1817334

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4-tert-butylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor increases expression ISO butylphen results in increased expression of ADORA2B mRNA CTD PMID:10571726 NCBI chr10:48,569,563...48,586,366
Ensembl chr10:48,569,555...48,586,365 		JBrowse link
G Ar androgen receptor affects binding EXP butylphen binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Esr1 estrogen receptor 1 increases activity
affects binding		 ISO
EXP		 butylphen results in increased activity of ESR1 protein
butylphen binds to ESR1 protein		 CTD PMID:12598185, PMID:18028983, PMID:19913605 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO butylphen results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr13:106,063,799...106,683,353
Ensembl chr13:106,463,368...106,683,436 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO butylphen results in decreased expression of FAS protein CTD PMID:15816839 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein] CTD PMID:28836394 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086 		JBrowse link
G Lrp1 LDL receptor related protein 1 increases expression ISO butylphen results in increased expression of LRP1 protein CTD PMID:15816839 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 ISO butylphen binds to and results in decreased activity of NR1I3 protein alternative form
butylphen results in increased activity of NR1I3 protein		 CTD PMID:20869355, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Pgr progesterone receptor increases expression ISO butylphen results in increased expression of PGR protein CTD PMID:11879974 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein] CTD PMID:28836394 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867 		JBrowse link
G Rpl24 ribosomal protein L24 increases expression ISO butylphen results in increased expression of RPL24 mRNA CTD PMID:10571726 NCBI chr11:47,116,885...47,122,093
Ensembl chr11:47,116,886...47,122,095 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO butylphen results in increased expression of TFF1 protein CTD PMID:11879974 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [butylphen results in increased expression of TNF protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein] CTD PMID:28836394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO butylphen results in increased expression of TNFRSF10A protein CTD PMID:15816839 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO butylphen results in increased expression of TNFRSF1A protein CTD PMID:15816839 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO butylphen results in increased expression of TNFRSF1B protein CTD PMID:15816839 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO butylphen results in increased expression of TYRP1 protein CTD PMID:15816839 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing		 EXP UGT1A6 gene polymorphism affects the metabolism of butylphen
UGT1A6 protein results in increased metabolism of butylphen		 CTD PMID:9429234 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of butylphen CTD PMID:8302279 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444 		JBrowse link
etofenprox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA CTD PMID:22467020 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP ethofenprox results in increased activity of CYP1A1 protein CTD PMID:20009351 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:22467020 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity EXP ethofenprox results in decreased activity of ESR1 protein CTD PMID:20410157 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:22467020 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:22467020 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethofenprox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity		 EXP
ISO		 [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein
ethofenprox results in increased activity of NR1I3 protein		 CTD PMID:22467020, PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA CTD PMID:22467020 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA CTD PMID:22467020 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        aetiopathogenetic role 18951
          allergen 16937
            4-tert-butylphenol 26
              2-(4-ethoxyphenyl)-2-methylpropan-1-ol + 11
              halfenprox 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic aromatic compound 19146
                                  phenols 18144
                                    4-tert-butylphenol 26
                                      2-(4-ethoxyphenyl)-2-methylpropan-1-ol + 11
                                      halfenprox 0
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