Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-tert-butylphenol
go back to main search page
Accession:CHEBI:34444 term browser browse the term
Definition:A member of the class of phenols that is phenol substituted with a tert-butyl group at position 4.
Synonyms:related_synonym: 4-(1,1-Dimethylethyl)phenol;   4-tert-Butyl-phenol;   Butylphen;   Formula=C10H14O;   InChI=1S/C10H14O/c1-10(2,3)8-4-6-9(11)7-5-8/h4-7,11H,1-3H3;   InChIKey=QHPQWRBYOIRBIT-UHFFFAOYSA-N;   PTBP;   SMILES=CC(C)(C)c1ccc(O)cc1;   p-t-Butyl phenol;   p-tert-Butylphenol;   para-tertiary-butylphenol
 alt_id: CHEBI:117047
 xref: CAS:98-54-4;   HMDB:HMDB0032063;   KEGG:C14200
 xref_mesh: MESH:C006862
 xref: PMID:24801287;   PMID:26302341;   PMID:26819047;   PMID:8462290;   Reaxys:1817334



show annotations for term's descendants           Sort by:
4-tert-butylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor increases expression ISO butylphen results in increased expression of ADORA2B mRNA CTD PMID:10571726 NCBI chr10:46,940,394...46,956,772 JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
butylphen binds to AR protein
butylphen inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD PMID:14565775 PMID:33049310 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
affects binding
ISO
EXP
butylphen results in increased activity of ESR1 protein
butylphen binds to and results in increased activity of ESR1 protein
butylphen binds to ESR1 protein
CTD PMID:12598185 PMID:18028983 PMID:19913605 PMID:33049310 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
ISO butylphen binds to and results in increased activity of ESR2 protein
butylphen binds to ESR2 protein
CTD PMID:31836225 PMID:33049310 NCBI chr 6:100,589,553...100,645,240 JBrowse link
G Esrrg estrogen-related receptor gamma increases activity ISO butylphen results in increased activity of ESRRG protein CTD PMID:31127318 NCBI chr13:101,699,043...102,316,877 JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO butylphen results in decreased expression of FAS protein CTD PMID:15816839 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein] CTD PMID:28836394 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Lrp1 LDL receptor related protein 1 increases expression ISO butylphen results in increased expression of LRP1 protein CTD PMID:15816839 NCBI chr 7:65,265,639...65,346,196 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO butylphen binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity
ISO butylphen binds to and results in decreased activity of NR1I3 protein alternative form
butylphen results in increased activity of NR1I3 protein
CTD PMID:20869355 PMID:28927721 NCBI chr13:86,165,327...86,170,362 JBrowse link
G Pgr progesterone receptor increases expression ISO butylphen results in increased expression of PGR protein CTD PMID:11879974 NCBI chr 8:14,354,398...14,413,271 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions ISO Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein] CTD PMID:28836394 NCBI chr 2:34,612,946...34,697,660 JBrowse link
G Rpl24 ribosomal protein L24 increases expression ISO butylphen results in increased expression of RPL24 mRNA CTD PMID:10571726 NCBI chr11:58,122,997...58,128,405 JBrowse link
G Tff1 trefoil factor 1 increases expression ISO butylphen results in increased expression of TFF1 protein CTD PMID:11879974 NCBI chr20:9,235,736...9,239,597 JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [butylphen results in increased expression of TNF protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein] CTD PMID:28836394 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO butylphen results in increased expression of TNFRSF10A protein CTD PMID:15816839 NCBI chr15:51,249,883...51,278,091 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO butylphen results in increased expression of TNFRSF1A protein CTD PMID:15816839 NCBI chr 4:159,837,119...159,849,817 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO butylphen results in increased expression of TNFRSF1B protein CTD PMID:15816839 NCBI chr 5:157,070,642...157,104,216 JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO butylphen results in increased expression of TYRP1 protein CTD PMID:15816839 NCBI chr 5:100,327,111...100,345,657 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 affects metabolic processing
increases metabolic processing
EXP UGT1A6 gene polymorphism affects the metabolism of butylphen
UGT1A6 protein results in increased metabolism of butylphen
CTD PMID:9429234 NCBI chr 9:96,195,018...96,256,264 JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of butylphen CTD PMID:8302279 NCBI chr14:21,378,882...21,390,631 JBrowse link
etofenprox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a3 aldo-keto reductase family 7 member A3 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA CTD PMID:22467020 NCBI chr 5:151,590,968...151,601,394 JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP ethofenprox results in increased activity of CYP1A1 protein CTD PMID:20009351 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA CTD PMID:22467020 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Esr1 estrogen receptor 1 decreases activity EXP ethofenprox results in decreased activity of ESR1 protein CTD PMID:20410157 NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA CTD PMID:22467020 NCBI chr 8:79,105,561...79,117,472 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA CTD PMID:22467020 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO ethofenprox binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
increases activity
EXP
ISO
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein
ethofenprox results in increased activity of NR1I3 protein
CTD PMID:22467020 PMID:28927721 NCBI chr13:86,165,327...86,170,362 JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA CTD PMID:22467020 NCBI chr 1:84,582,011...84,639,001 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions EXP [ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA CTD PMID:22467020 NCBI chr 9:96,195,018...96,256,264 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19869
      biological role 19867
        aetiopathogenetic role 19243
          allergen 17702
            4-tert-butylphenol 27
              2-(4-ethoxyphenyl)-2-methylpropan-1-ol + 11
              halfenprox 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic aromatic compound 19382
                                  phenols 18681
                                    4-tert-butylphenol 27
                                      2-(4-ethoxyphenyl)-2-methylpropan-1-ol + 11
                                      halfenprox 0
paths to the root