CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4-tert-butylphenol
Accession: CHEBI:34444
browse the term
Definition: A member of the class of phenols that is phenol substituted with a tert-butyl group at position 4.
Synonyms: related_synonym: 4-(1,1-Dimethylethyl)phenol; 4-tert-Butyl-phenol; Butylphen; Formula=C10H14O; InChI=1S/C10H14O/c1-10(2,3)8-4-6-9(11)7-5-8/h4-7,11H,1-3H3; InChIKey=QHPQWRBYOIRBIT-UHFFFAOYSA-N; PTBP; SMILES=CC(C)(C)c1ccc(O)cc1; p-t-Butyl phenol; p-tert-Butylphenol; para-tertiary-butylphenol
alt_id: CHEBI:117047
xref: Beilstein:1817334; CAS:98-54-4; HMDB:HMDB0032063; KEGG:C14200
xref_mesh: MESH:C006862
xref: PMID:24801287; PMID:26302341; PMID:26819047; PMID:8462290; Reaxys:1817334
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Adora2b
adenosine A2B receptor
increases expression
ISO
butylphen results in increased expression of ADORA2B mRNA
CTD
PMID:10571726
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
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Ar
androgen receptor
affects binding multiple interactions
EXP ISO
butylphen binds to AR protein butylphen inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:14565775 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Esr1
estrogen receptor 1
increases activity multiple interactions affects binding
ISO EXP
butylphen results in increased activity of ESR1 protein butylphen binds to and results in increased activity of ESR1 protein butylphen binds to ESR1 protein
CTD
PMID:12598185 PMID:18028983 PMID:19913605 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions affects binding
ISO
butylphen binds to and results in increased activity of ESR2 protein butylphen binds to ESR2 protein
CTD
PMID:31836225 PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Esrrg
estrogen-related receptor gamma
increases activity
ISO
butylphen results in increased activity of ESRRG protein
CTD
PMID:31127318
NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
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Fas
Fas cell surface death receptor
decreases expression
ISO
butylphen results in decreased expression of FAS protein
CTD
PMID:15816839
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Il1a
interleukin 1 alpha
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]
CTD
PMID:28836394
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Lrp1
LDL receptor related protein 1
increases expression
ISO
butylphen results in increased expression of LRP1 protein
CTD
PMID:15816839
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
butylphen binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions increases activity
ISO
butylphen binds to and results in decreased activity of NR1I3 protein alternative form butylphen results in increased activity of NR1I3 protein
CTD
PMID:20869355 PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Pgr
progesterone receptor
increases expression
ISO
butylphen results in increased expression of PGR protein
CTD
PMID:11879974
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
multiple interactions
ISO
Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]
CTD
PMID:28836394
NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
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Rpl24
ribosomal protein L24
increases expression
ISO
butylphen results in increased expression of RPL24 mRNA
CTD
PMID:10571726
NCBI chr11:44,653,937...44,659,346
Ensembl chr11:44,653,937...44,659,370
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Tff1
trefoil factor 1
increases expression
ISO
butylphen results in increased expression of TFF1 protein
CTD
PMID:11879974
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [butylphen results in increased expression of TNF protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]
CTD
PMID:28836394
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf10b
TNF receptor superfamily member 10b
increases expression
ISO
butylphen results in increased expression of TNFRSF10A protein
CTD
PMID:15816839
NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
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Tnfrsf1a
TNF receptor superfamily member 1A
increases expression
ISO
butylphen results in increased expression of TNFRSF1A protein
CTD
PMID:15816839
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Tnfrsf1b
TNF receptor superfamily member 1B
increases expression
ISO
butylphen results in increased expression of TNFRSF1B protein
CTD
PMID:15816839
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Tyrp1
tyrosinase-related protein 1
increases expression
ISO
butylphen results in increased expression of TYRP1 protein
CTD
PMID:15816839
NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
affects metabolic processing increases metabolic processing
EXP
UGT1A6 gene polymorphism affects the metabolism of butylphen UGT1A6 protein results in increased metabolism of butylphen
CTD
PMID:9429234
NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b17
UDP glucuronosyltransferase family 2 member B17
increases glucuronidation
EXP
UGT2B1 protein results in increased glucuronidation of butylphen
CTD
PMID:8302279
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Akr7a3
aldo-keto reductase family 7 member A3
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA
CTD
PMID:22467020
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
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Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity
EXP
ethofenprox results in increased activity of CYP1A1 protein
CTD
PMID:20009351
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA
CTD
PMID:22467020
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
G
Esr1
estrogen receptor 1
decreases activity
EXP
ethofenprox results in decreased activity of ESR1 protein
CTD
PMID:20410157
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Gsta5
glutathione S-transferase alpha 5
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
CTD
PMID:22467020
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA
CTD
PMID:22467020
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
ethofenprox binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
multiple interactions increases activity
EXP ISO
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein ethofenprox results in increased activity of NR1I3 protein
CTD
PMID:22467020 PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Sult2a1
sulfotransferase family 2A member 1
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA
CTD
PMID:22467020
NCBI chr 1:75,451,178...75,508,142
Ensembl chr 1:74,911,100...75,508,134
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
multiple interactions
EXP
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
CTD
PMID:22467020
NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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