|
G |
Adora2b |
adenosine A2B receptor |
increases expression |
ISO |
butylphen results in increased expression of ADORA2B mRNA |
CTD |
PMID:10571726 |
|
NCBI chr10:46,940,394...46,956,772
|
|
G |
Ar |
androgen receptor |
affects binding multiple interactions |
EXP ISO |
butylphen binds to AR protein butylphen inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] |
CTD |
PMID:14565775 PMID:33049310 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Esr1 |
estrogen receptor 1 |
increases activity multiple interactions affects binding |
ISO EXP |
butylphen results in increased activity of ESR1 protein butylphen binds to and results in increased activity of ESR1 protein butylphen binds to ESR1 protein |
CTD |
PMID:12598185 PMID:18028983 PMID:19913605 PMID:33049310 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Esr2 |
estrogen receptor 2 |
multiple interactions affects binding |
ISO |
butylphen binds to and results in increased activity of ESR2 protein butylphen binds to ESR2 protein |
CTD |
PMID:31836225 PMID:33049310 |
|
NCBI chr 6:100,589,553...100,645,240
|
|
G |
Esrrg |
estrogen-related receptor gamma |
increases activity |
ISO |
butylphen results in increased activity of ESRRG protein |
CTD |
PMID:31127318 |
|
NCBI chr13:101,699,043...102,316,877
|
|
G |
Fas |
Fas cell surface death receptor |
decreases expression |
ISO |
butylphen results in decreased expression of FAS protein |
CTD |
PMID:15816839 |
|
NCBI chr 1:241,212,155...241,245,774
|
|
G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [butylphen results in increased expression of IL1A protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein] |
CTD |
PMID:28836394 |
|
NCBI chr 3:136,979,804...136,990,236
|
|
G |
Lrp1 |
LDL receptor related protein 1 |
increases expression |
ISO |
butylphen results in increased expression of LRP1 protein |
CTD |
PMID:15816839 |
|
NCBI chr 7:65,265,639...65,346,196
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
butylphen binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:33049310 |
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions increases activity |
ISO |
butylphen binds to and results in decreased activity of NR1I3 protein alternative form butylphen results in increased activity of NR1I3 protein |
CTD |
PMID:20869355 PMID:28927721 |
|
NCBI chr13:86,165,327...86,170,362
|
|
G |
Pgr |
progesterone receptor |
increases expression |
ISO |
butylphen results in increased expression of PGR protein |
CTD |
PMID:11879974 |
|
NCBI chr 8:14,354,398...14,413,271
|
|
G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
multiple interactions |
ISO |
Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased abundance of Reactive Oxygen Species]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of IL1A protein]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein] |
CTD |
PMID:28836394 |
|
NCBI chr 2:34,612,946...34,697,660
|
|
G |
Rpl24 |
ribosomal protein L24 |
increases expression |
ISO |
butylphen results in increased expression of RPL24 mRNA |
CTD |
PMID:10571726 |
|
NCBI chr11:58,122,997...58,128,405
|
|
G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
butylphen results in increased expression of TFF1 protein |
CTD |
PMID:11879974 |
|
NCBI chr20:9,235,736...9,239,597
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO |
Acetylcysteine inhibits the reaction [butylphen results in increased expression of TNF protein]; Acetylcysteine promotes the reaction [PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein]]; PIK3R1 protein modified form inhibits the reaction [butylphen results in increased expression of TNF protein] |
CTD |
PMID:28836394 |
|
NCBI chr20:3,626,685...3,629,303
|
|
G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression |
ISO |
butylphen results in increased expression of TNFRSF10A protein |
CTD |
PMID:15816839 |
|
NCBI chr15:51,249,883...51,278,091
|
|
G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
increases expression |
ISO |
butylphen results in increased expression of TNFRSF1A protein |
CTD |
PMID:15816839 |
|
NCBI chr 4:159,837,119...159,849,817
|
|
G |
Tnfrsf1b |
TNF receptor superfamily member 1B |
increases expression |
ISO |
butylphen results in increased expression of TNFRSF1B protein |
CTD |
PMID:15816839 |
|
NCBI chr 5:157,070,642...157,104,216
|
|
G |
Tyrp1 |
tyrosinase-related protein 1 |
increases expression |
ISO |
butylphen results in increased expression of TYRP1 protein |
CTD |
PMID:15816839 |
|
NCBI chr 5:100,327,111...100,345,657
|
|
G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
affects metabolic processing increases metabolic processing |
EXP |
UGT1A6 gene polymorphism affects the metabolism of butylphen UGT1A6 protein results in increased metabolism of butylphen |
CTD |
PMID:9429234 |
|
NCBI chr 9:96,195,018...96,256,264
|
|
G |
Ugt2b1 |
UDP glucuronosyltransferase 2 family, polypeptide B1 |
increases glucuronidation |
EXP |
UGT2B1 protein results in increased glucuronidation of butylphen |
CTD |
PMID:8302279 |
|
NCBI chr14:21,378,882...21,390,631
|
|
|
G |
Akr7a3 |
aldo-keto reductase family 7 member A3 |
multiple interactions |
EXP |
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA |
CTD |
PMID:22467020 |
|
NCBI chr 5:151,590,968...151,601,394
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Dihydrotestosterone inhibits the reaction [ethofenprox results in increased activity of AR protein] |
CTD |
PMID:15064155 |
|
NCBI chr X:63,104,771...63,273,934
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity |
EXP |
ethofenprox results in increased activity of CYP1A1 protein |
CTD |
PMID:20009351 |
|
NCBI chr 8:66,991,940...66,998,014
|
|
G |
Cyp2b2 |
cytochrome P450, family 2, subfamily b, polypeptide 2 |
multiple interactions |
EXP |
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of CYP2B2 mRNA |
CTD |
PMID:22467020 |
|
NCBI chr 1:90,722,243...90,736,272
|
|
G |
Esr1 |
estrogen receptor 1 |
decreases activity |
EXP |
ethofenprox results in decreased activity of ESR1 protein |
CTD |
PMID:20410157 |
|
NCBI chr 1:43,511,685...43,904,454
|
|
G |
Gsta5 |
glutathione S-transferase alpha 5 |
multiple interactions |
EXP |
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA |
CTD |
PMID:22467020 |
|
NCBI chr 8:79,105,561...79,117,472
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA |
CTD |
PMID:22467020 |
|
NCBI chr19:52,205,374...52,220,267
|
|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions |
ISO |
ethofenprox binds to and results in increased activity of NR1I2 protein |
CTD |
PMID:21115097 |
|
NCBI chr11:75,965,717...76,006,733
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions increases activity |
EXP ISO |
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of NR1I3 mRNA; ethofenprox affects the localization of and results in increased activity of NR1I3 protein ethofenprox results in increased activity of NR1I3 protein |
CTD |
PMID:22467020 PMID:28927721 |
|
NCBI chr13:86,165,327...86,170,362
|
|
G |
Sult2a1 |
sulfotransferase family 2A member 1 |
multiple interactions |
EXP |
[ethofenprox co-treated with Diethylnitrosamine] results in decreased expression of SULT2A1 mRNA |
CTD |
PMID:22467020 |
|
NCBI chr 1:84,582,011...84,639,001
|
|
G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
multiple interactions |
EXP |
[ethofenprox co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA |
CTD |
PMID:22467020 |
|
NCBI chr 9:96,195,018...96,256,264
|
|