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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-nonylphenol
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Accession:CHEBI:34440 term browser browse the term
Definition:A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Synonyms:related_synonym: 4-n-Nonylphenol;   Formula=C15H24O;   InChI=1S/C15H24O/c1-2-3-4-5-6-7-8-9-14-10-12-15(16)13-11-14/h10-13,16H,2-9H2,1H3;   InChIKey=IGFHQQFPSIBGKE-UHFFFAOYSA-N;   SMILES=CCCCCCCCCc1ccc(O)cc1;   p-Nonylphenol;   p-n-Nonylphenol;   para Nonyl phenol
 xref: CAS:104-40-5;   HMDB:HMDB0038982;   KEGG:C14550;   LINCS:LSM-19987
 xref_mesh: MESH:C041594
 xref: PMID:18506497;   PMID:21823570;   PMID:22133150;   PMID:24805085;   PPDB:1543;   Reaxys:2047450


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4-nonylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression
multiple interactions		 ISO 4-nonylphenol results in decreased expression of ABCG2 protein
fulvestrant affects the reaction [4-nonylphenol results in decreased expression of ABCG2 protein]		 CTD PMID:27036933 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 multiple interactions ISO ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]] CTD PMID:28703301 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 affects response to substance
multiple interactions		 ISO ADAM17 protein affects the susceptibility to 4-nonylphenol
[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]		 CTD PMID:28703301 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression EXP 4-nonylphenol results in increased expression of ADIPOQ protein CTD PMID:24388992 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Afap1l2 actin filament associated protein 1-like 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of AFAP1L2 mRNA CTD PMID:23626723 NCBI chr 1:255,964,238...256,060,828
Ensembl chr 1:255,964,238...256,060,820 		JBrowse link
G Afp alpha-fetoprotein affects binding EXP 4-nonylphenol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor affects activity
affects binding
increases activity		 ISO
EXP		 4-nonylphenol affects the activity of AHR protein
4-nonylphenol binds to AHR protein
4-nonylphenol results in increased activity of AHR protein		 CTD PMID:18294747 PMID:20436506 PMID:28728110 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
decreases expression		 EXP 4-nonylphenol results in decreased phosphorylation of AKT1 protein
[bisphenol A co-treated with 4-nonylphenol] results in increased expression of AKT1 mRNA; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased expression of AKT1 mRNA]		 CTD PMID:26804764 PMID:30228064 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP 4-nonylphenol results in increased expression of AKT2 mRNA CTD PMID:30228064 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Amh anti-Mullerian hormone decreases expression ISO 4-nonylphenol analog results in decreased expression of AMH mRNA CTD PMID:27086933 NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 affects expression
increases expression		 EXP 4-nonylphenol affects the expression of APAF1 mRNA
4-nonylphenol results in increased expression of APAF1 protein		 CTD PMID:26804764 PMID:27109770 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor affects activity
multiple interactions
decreases expression		 ISO 4-nonylphenol affects the activity of AR protein
4-nonylphenol inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
4-nonylphenol analog results in decreased expression of AR mRNA		 CTD PMID:16169144 PMID:18294747 PMID:27086933 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Atg12 autophagy related 12 increases expression EXP 4-nonylphenol results in increased expression of ATG12 mRNA CTD PMID:28041982 PMID:30228064 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418 		JBrowse link
G Atg3 autophagy related 3 increases expression EXP 4-nonylphenol results in increased expression of ATG3 mRNA CTD PMID:28041982 NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224 		JBrowse link
G Atg5 autophagy related 5 increases expression EXP 4-nonylphenol results in increased expression of ATG5 mRNA CTD PMID:28041982 PMID:30228064 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 increases expression EXP 4-nonylphenol results in increased expression of ATG7 mRNA CTD PMID:28041982 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G B3gnt3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of B3GNT3 mRNA CTD PMID:23626723 NCBI chr16:18,401,405...18,410,821
Ensembl chr16:18,401,405...18,410,766 		JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression ISO 4-nonylphenol results in increased expression of B4GALT1 mRNA CTD PMID:14605097 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP 4-nonylphenol results in increased expression of BAD mRNA; 4-nonylphenol results in increased expression of BAD protein CTD PMID:26804764 PMID:27087316 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
increases expression		 EXP
ISO		 3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BAX protein]
4-nonylphenol results in decreased expression of BAX mRNA; 4-nonylphenol results in decreased expression of BAX protein
4-nonylphenol results in increased expression of BAX mRNA; 4-nonylphenol results in increased expression of BAX protein		 CTD PMID:15461258 PMID:26804032 PMID:26804764 PMID:27087316 PMID:27109770 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
multiple interactions		 ISO
EXP		 4-nonylphenol results in increased expression of BCL2 mRNA
4-nonylphenol results in decreased expression of BCL2 mRNA; 4-nonylphenol results in decreased expression of BCL2 protein
[bisphenol A co-treated with 4-nonylphenol] results in decreased expression of BCL2 mRNA		 CTD PMID:15461258 PMID:26804764 PMID:27087316 PMID:27109770 PMID:30228064 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP 4-nonylphenol results in decreased expression of BCL2L1 mRNA; 4-nonylphenol results in decreased expression of BCL2L1 protein CTD PMID:27087316 PMID:27109770 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression EXP 4-nonylphenol results in increased expression of BCL2L11 protein CTD PMID:26804764 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 EXP 3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein]
4-nonylphenol results in increased expression of BECN1 mRNA; 4-nonylphenol results in increased expression of BECN1 protein		 CTD PMID:26804764 PMID:28041982 PMID:30228064 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO 4-nonylphenol results in increased cleavage of and results in increased activity of BID protein CTD PMID:22056370 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Btc betacellulin multiple interactions ISO [ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; [RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein; ADAM10 protein affects the reaction [[ADAM17 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein] CTD PMID:28703301 NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049 		JBrowse link
G Casp1 caspase 1 increases expression
decreases expression		 EXP 4-nonylphenol results in increased expression of CASP1 mRNA
4-nonylphenol results in decreased expression of CASP1 mRNA		 CTD PMID:27087316 PMID:27109770 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp2 caspase 2 increases expression EXP 4-nonylphenol results in increased expression of CASP2 mRNA CTD PMID:27087316 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
affects expression
increases expression		 ISO
EXP		 4-nonylphenol results in increased cleavage of CASP3 protein
3-methyladenine promotes the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; 4-nonylphenol results in decreased expression of and results in increased phosphorylation of CASP3 protein; [bisphenol A co-treated with 4-nonylphenol] results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased expression of CASP3 protein modified form]
4-nonylphenol affects the expression of CASP3 mRNA
4-nonylphenol results in increased expression of and results in increased activity of CASP3 protein; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of and results in increased activity of CASP3 protein		 CTD PMID:22056370 PMID:26804764 PMID:27109770 PMID:29029336 PMID:30228064 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases expression EXP 4-nonylphenol results in increased expression of CASP4 mRNA CTD PMID:27087316 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp6 caspase 6 decreases expression EXP 4-nonylphenol results in decreased expression of CASP6 mRNA CTD PMID:27109770 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Casp7 caspase 7 decreases expression EXP 4-nonylphenol results in decreased expression of CASP7 mRNA CTD PMID:27109770 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression
increases expression
multiple interactions		 ISO
EXP		 4-nonylphenol results in increased cleavage of CASP8 protein
4-nonylphenol results in decreased expression of CASP8 mRNA
4-nonylphenol results in increased expression of CASP8 mRNA
4-nonylphenol affects the reaction [bisphenol A results in increased expression of CASP8 mRNA]; bisphenol A affects the reaction [4-nonylphenol results in increased expression of CASP8 mRNA]		 CTD PMID:22056370 PMID:27087316 PMID:30228064 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases expression
decreases expression		 ISO
EXP		 4-nonylphenol results in increased cleavage of CASP9 protein
4-nonylphenol results in increased expression of CASP9 mRNA
4-nonylphenol results in decreased expression of CASP9 mRNA		 CTD PMID:22056370 PMID:27087316 PMID:27109770 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression EXP 4-nonylphenol results in decreased expression of CAT mRNA CTD PMID:27087316 PMID:27109770 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccbe1 collagen and calcium binding EGF domains 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CCBE1 mRNA CTD PMID:23626723 NCBI chr18:59,579,851...59,823,977
Ensembl chr18:59,580,768...59,824,400 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions		 ISO 4-nonylphenol results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]		 CTD PMID:23384675 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636 		JBrowse link
G Ccna2 cyclin A2 decreases expression EXP 4-nonylphenol results in decreased expression of CCNA2 protein CTD PMID:26804764 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 increases expression EXP 4-nonylphenol results in increased expression of CCNB1 protein CTD PMID:26804764 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
increases expression		 EXP
ISO		 4-nonylphenol results in decreased expression of CCND1 protein
4-nonylphenol results in increased expression of CCND1 mRNA; 4-nonylphenol results in increased expression of CCND1 protein		 CTD PMID:26804032 PMID:26804764 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 4-nonylphenol results in decreased expression of CCNE1 mRNA CTD PMID:26804032 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression		 EXP
ISO		 4-nonylphenol results in increased expression of CDKN1A protein
4-nonylphenol results in decreased expression of CDKN1A protein		 CTD PMID:26804032 PMID:26804764 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
decreases expression		 EXP
ISO		 4-nonylphenol results in increased expression of CDKN1B protein
4-nonylphenol results in decreased expression of CDKN1B mRNA		 CTD PMID:26804032 PMID:26804764 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C increases expression ISO 4-nonylphenol results in increased expression of CDKN1C protein CTD PMID:26027920 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation ISO 4-nonylphenol results in increased phosphorylation of CHEK1 protein CTD PMID:32466334 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO 4-nonylphenol results in increased phosphorylation of CHEK2 protein CTD PMID:32466334 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] CTD PMID:11711029 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:11711029 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions ISO 4-nonylphenol inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]; 4-nonylphenol promotes the reaction [Tamoxifen inhibits the reaction [Acetylcholine affects the activity of [CHRNA3 protein binds to CHRNB4 protein]]] CTD PMID:11711029 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Col14a1 collagen type XIV alpha 1 chain multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of COL14A1 mRNA CTD PMID:23626723 NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein] CTD PMID:23626723 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of CSF1R mRNA CTD PMID:23626723 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Csf2 colony stimulating factor 2 increases secretion ISO 4-nonylphenol results in increased secretion of CSF2 protein CTD PMID:20194071 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctsd cathepsin D increases expression ISO 4-nonylphenol results in increased expression of CTSD protein CTD PMID:26804032 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP11A1 mRNA CTD PMID:29029336 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of CYP17A1 mRNA
4-nonylphenol results in decreased expression of CYP17A1 mRNA		 CTD PMID:29029336 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 mRNA; [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of CYP19A1 protein
4-nonylphenol results in decreased expression of CYP19A1 mRNA; 4-nonylphenol results in decreased expression of CYP19A1 protein		 CTD PMID:29029336 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression EXP 4-nonylphenol results in decreased expression of CYP1B1 mRNA CTD PMID:27087316 PMID:27109770 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]
4-nonylphenol results in increased expression of CYP2B6 mRNA
4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]; [4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; NR1I3 protein promotes the reaction [4-nonylphenol results in increased expression of CYP2B10 mRNA]		 CTD PMID:17483497 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP 4-nonylphenol promotes the reaction [NR1I2 protein results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:17483497 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DIO2 mRNA CTD PMID:23626723 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein] CTD PMID:23626723 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein] CTD PMID:23626723 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L mRNA; [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein; wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein] CTD PMID:23626723 NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516 		JBrowse link
G Ebf2 EBF transcription factor 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of EBF2 mRNA CTD PMID:23626723 NCBI chr15:41,435,509...41,634,403
Ensembl chr15:41,435,509...41,634,403 		JBrowse link
G Eeig1 estrogen-induced osteoclastogenesis regulator 1 increases expression ISO 4-nonylphenol results in increased expression of EEIG1 mRNA CTD PMID:14605097 NCBI chr 3:15,822,441...15,854,651
Ensembl chr 3:15,823,144...15,854,643 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 EXP 4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]		 CTD PMID:26804764 PMID:28041982 PMID:30228064 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO 4-nonylphenol results in decreased expression of ERBB2 mRNA CTD PMID:16393665 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
decreases expression
increases activity
affects localization
affects binding		 ISO
EXP		 4-nonylphenol binds to and results in increased activity of ESR1 protein; 4-nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; ESR1 protein inhibits the reaction [4-nonylphenol results in increased expression of CCN5 mRNA]
4-nonylphenol results in decreased expression of ESR1 mRNA
4-nonylphenol results in increased activity of ESR1 protein; 4-nonylphenol results in increased activity of ESR1 protein mutant form
4-nonylphenol affects the localization of ESR1 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR1 mRNA]
4-nonylphenol binds to ESR1 protein
4-nonylphenol results in decreased expression of ESR1 mRNA; 4-nonylphenol results in decreased expression of ESR1 protein
4-nonylphenol analog results in decreased expression of ESR1 mRNA; 4-nonylphenol analog results in decreased expression of ESR1 protein		 CTD PMID:11518614 PMID:11530281 PMID:12127041 PMID:12598185 PMID:16393665 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects localization
multiple interactions
affects binding
decreases expression		 ISO 4-nonylphenol affects the localization of ESR2 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]
4-nonylphenol binds to and results in increased activity of ESR2 protein; [4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA
4-nonylphenol binds to ESR2 protein
4-nonylphenol analog results in decreased expression of ESR2 mRNA; 4-nonylphenol analog results in decreased expression of ESR2 protein		 CTD PMID:11518614 PMID:12224631 PMID:19913605 PMID:20950447 PMID:21783566 More... NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Fas Fas cell surface death receptor increases expression EXP 4-nonylphenol results in increased expression of FAS mRNA; 4-nonylphenol results in increased expression of FAS protein CTD PMID:27087316 PMID:27109770 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand increases expression EXP 4-nonylphenol results in increased expression of FASLG mRNA; 4-nonylphenol results in increased expression of FASLG protein CTD PMID:27087316 PMID:27109770 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fasn fatty acid synthase increases expression EXP 4-nonylphenol results in increased expression of FASN mRNA CTD PMID:24388992 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fcgr3a Fc gamma receptor 3A multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of FCGR3A mRNA CTD PMID:23626723 NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 4-nonylphenol results in increased expression of FOS mRNA; 4-nonylphenol results in increased expression of FOS protein CTD PMID:24308608 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression
multiple interactions		 EXP 4-nonylphenol results in decreased expression of FSHB protein
[4-nonylphenol results in increased susceptibility to bisphenol A] which results in increased secretion of FSHB protein		 CTD PMID:27087316 PMID:27109770 PMID:30228064 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gcnt4 glucosaminyl (N-acetyl) transferase 4 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of GCNT4 mRNA CTD PMID:23626723 NCBI chr 2:28,253,325...28,283,082
Ensembl chr 2:28,252,860...28,283,082 		JBrowse link
G Gh1 growth hormone 1 increases secretion
increases expression
multiple interactions		 EXP 4-nonylphenol results in increased secretion of GH1 protein
4-nonylphenol results in increased expression of GH1 mRNA; 4-nonylphenol results in increased expression of GH1 protein
fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of GH1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of GH1 protein]		 CTD PMID:19145065 PMID:19463694 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 increases expression ISO 4-nonylphenol results in increased expression of GPER1 mRNA CTD PMID:29783106 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP 4-nonylphenol results in decreased expression of GPX1 mRNA CTD PMID:27109770 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO 4-nonylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of HAS2 mRNA CTD PMID:23626723 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases secretion
multiple interactions		 ISO 4-nonylphenol results in increased secretion of HBEGF protein
3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of HBEGF protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of HBEGF protein]		 CTD PMID:28703301 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO 4-nonylphenol inhibits the reaction [Vitamin A results in increased expression of HOXA1 mRNA] CTD PMID:23696197 NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases activity ISO 4-nonylphenol results in decreased activity of HSD11B1 protein CTD PMID:16184081 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO 4-nonylphenol results in decreased activity of HSD11B2 protein CTD PMID:16184081 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO 4-nonylphenol results in decreased expression of HSD3B1 mRNA CTD PMID:29029336 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Ifng interferon gamma affects secretion
decreases expression		 ISO
EXP		 4-nonylphenol affects the secretion of IFNG protein
4-nonylphenol results in decreased expression of IFNG mRNA		 CTD PMID:20194071 PMID:27109770 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases secretion ISO 4-nonylphenol results in increased secretion of IL10 protein CTD PMID:20194071 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta affects secretion
affects expression		 ISO
EXP		 4-nonylphenol affects the secretion of IL1B protein
4-nonylphenol affects the expression of IL1B mRNA		 CTD PMID:20194071 PMID:27109770 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 affects secretion ISO 4-nonylphenol affects the secretion of IL4 protein CTD PMID:20194071 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO 4-nonylphenol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319 		JBrowse link
G Kcnb2 potassium voltage-gated channel subfamily B member 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of KCNB2 mRNA CTD PMID:23626723 NCBI chr 5:3,567,012...4,028,564
Ensembl chr 5:3,569,685...4,028,599 		JBrowse link
G Kcnv1 potassium voltage-gated channel modifier subfamily V member 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KCNV1 mRNA CTD PMID:23626723 NCBI chr 7:76,260,695...76,269,170
Ensembl chr 7:76,260,695...76,269,170 		JBrowse link
G Klk6 kallikrein related-peptidase 6 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of KLK6 mRNA CTD PMID:23626723 NCBI chr 1:94,278,863...94,286,136
Ensembl chr 1:94,280,340...94,286,121 		JBrowse link
G Lamp3 lysosomal-associated membrane protein 3 decreases expression ISO 4-nonylphenol results in decreased expression of LAMP3 mRNA CTD PMID:20678512 NCBI chr11:81,153,491...81,224,643
Ensembl chr11:81,193,649...81,221,784 		JBrowse link
G Lep leptin increases expression EXP 4-nonylphenol results in increased expression of LEP protein CTD PMID:24388992 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
affects expression
decreases expression
increases secretion		 EXP 4-nonylphenol inhibits the reaction [bisphenol A results in increased secretion of LHB protein]; 4-nonylphenol results in decreased expression of and results in decreased secretion of LHB protein; bisphenol A inhibits the reaction [4-nonylphenol results in increased secretion of LHB protein]
4-nonylphenol affects the expression of LHB protein
4-nonylphenol results in decreased expression of LHB protein		 CTD PMID:15888928 PMID:17033158 PMID:27087316 PMID:27109770 PMID:30228064 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 increases expression EXP 4-nonylphenol results in increased expression of LPAR3 mRNA CTD PMID:24460192 NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357 		JBrowse link
G Lpl lipoprotein lipase increases expression EXP 4-nonylphenol results in increased expression of LPL mRNA CTD PMID:24388992 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Ltf lactotransferrin multiple interactions ISO [4-nonylphenol co-treated with ESR1 protein] results in increased expression of LTF mRNA; [4-nonylphenol co-treated with ESR2 protein] results in increased expression of LTF mRNA CTD PMID:21783566 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression EXP 4-nonylphenol results in increased expression of MAP1LC3A mRNA CTD PMID:30228064 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP
ISO		 4-nonylphenol results in increased phosphorylation of MAPK1 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK1 protein]
4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK1 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK1 protein]		 CTD PMID:17174995 PMID:19463694 PMID:20870566 PMID:20950447 PMID:28849599 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP
ISO		 4-nonylphenol results in increased phosphorylation of MAPK3 protein
4-nonylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]; fulvestrant inhibits the reaction [4-nonylphenol results in increased phosphorylation of MAPK3 protein]
4-nonylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-nonylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]		 CTD PMID:19463694 PMID:20870566 PMID:20950447 PMID:28849599 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 4-nonylphenol analog results in increased phosphorylation of MAPK8 protein CTD PMID:27086933 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation ISO 4-nonylphenol analog results in increased phosphorylation of MAPK9 protein CTD PMID:27086933 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP 4-nonylphenol results in decreased expression of MCL1 protein CTD PMID:26804764 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions
increases phosphorylation		 EXP 4-nonylphenol results in decreased phosphorylation of MTOR protein
4-nonylphenol inhibits the reaction [bisphenol A results in decreased expression of MTOR mRNA]; 4-nonylphenol inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; AICA ribonucleotide promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; bisphenol A inhibits the reaction [4-nonylphenol results in increased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]		 CTD PMID:26804764 PMID:28041982 PMID:30228064 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Naalad2 N-acetylated alpha-linked acidic dipeptidase 2 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NAALAD2 mRNA CTD PMID:23626723 NCBI chr 8:15,406,119...15,479,714
Ensembl chr 8:15,407,043...15,479,714 		JBrowse link
G Nid1 nidogen 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of NID1 mRNA CTD PMID:23626723 NCBI chr17:86,085,133...86,158,272
Ensembl chr17:86,085,077...86,158,267 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects binding
multiple interactions
increases activity		 ISO
EXP		 4-nonylphenol binds to NR1I2 protein
4-nonylphenol binds to and results in increased activity of NR1I2 protein
4-nonylphenol results in increased activity of NR1I2 protein
4-nonylphenol promotes the reaction [NR1I2 protein results in increased expression of CYP3A23-3A1 mRNA]		 CTD PMID:15792627 PMID:17483497 PMID:20869355 PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
multiple interactions
affects localization
increases response to substance		 ISO 4-nonylphenol results in increased activity of NR1I3 protein; 4-nonylphenol results in increased activity of NR1I3 protein alternative form
1,5-benzothiazepine analog inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; 4-nonylphenol binds to and results in increased activity of NR1I3 protein; 4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form; 4-nonylphenol inhibits the reaction [PK 11195 results in decreased activity of NR1I3 protein]; 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B10 mRNA]; 7-acetoxy-6,7-dihydro-6-(4-methoxyphenyl)pyrrolo(2,1-d)(1,5)benzothiazepine inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; Clotrimazole inhibits the reaction [4-nonylphenol results in increased activity of NR1I3 protein]; PK 11195 results in decreased susceptibility to [4-nonylphenol binds to and results in increased activity of NR1I3 protein alternative form]
4-nonylphenol affects the localization of NR1I3 protein
4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]; 4-nonylphenol promotes the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]; [4-nonylphenol inhibits the reaction [androstan-3-ol binds to and results in decreased activity of NR1I3 protein]] which results in increased expression of CYP2B6 mRNA; NR1I3 protein promotes the reaction [4-nonylphenol results in increased expression of CYP2B10 mRNA]
NR1I3 protein results in increased susceptibility to 4-nonylphenol		 CTD PMID:17483497 PMID:20869355 PMID:21227907 PMID:21315811 PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Or10h1d olfactory receptor family 10 subfamily H member 1D multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of OR10H1 mRNA CTD PMID:23626723 NCBI chr 7:12,839,664...12,840,620
Ensembl chr 7:12,839,050...12,849,389 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta multiple interactions
decreases activity		 EXP 4-nonylphenol inhibits the reaction [Triiodothyronine, Reverse binds to P4HB protein]
4-nonylphenol results in decreased activity of P4HB protein		 CTD PMID:16617682 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
affects expression
decreases expression		 ISO
EXP		 4-nonylphenol results in increased expression of PCNA mRNA
4-nonylphenol results in increased expression of PCNA protein
4-nonylphenol affects the expression of PCNA mRNA
4-nonylphenol results in decreased expression of PCNA mRNA; 4-nonylphenol results in decreased expression of PCNA protein		 CTD PMID:15461258 PMID:18839522 PMID:27087316 PMID:27109770 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdzk1 PDZ domain containing 1 increases expression ISO 4-nonylphenol results in increased expression of PDZK1 mRNA CTD PMID:14605097 PMID:16393665 NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514 		JBrowse link
G Pgr progesterone receptor increases expression
decreases expression		 ISO
EXP		 4-nonylphenol results in increased expression of PGR mRNA
4-nonylphenol analog results in decreased expression of PGR mRNA		 CTD PMID:16393665 PMID:17033158 PMID:27086933 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma increases expression
multiple interactions		 EXP 4-nonylphenol results in increased expression of PIK3CG mRNA
4-nonylphenol promotes the reaction [bisphenol A results in increased expression of PIK3CG mRNA]; bisphenol A promotes the reaction [4-nonylphenol results in increased expression of PIK3CG mRNA]		 CTD PMID:30228064 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO 4-nonylphenol results in increased expression of POU5F1 mRNA CTD PMID:20615461 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression EXP 4-nonylphenol results in increased expression of PPARG mRNA CTD PMID:24388992 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppfia4 PTPRF interacting protein alpha 4 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of PPFIA4 mRNA CTD PMID:23626723 NCBI chr13:45,753,827...45,802,305
Ensembl chr13:45,753,827...45,802,261 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of EIF4EBP1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in increased expression of BECN1 protein] CTD PMID:28041982 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [4-nonylphenol results in increased susceptibility to bisphenol A] which results in decreased expression of PRKAA2 mRNA; [bisphenol A co-treated with 4-nonylphenol] results in decreased expression of PRKAA2 mRNA CTD PMID:30228064 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prl prolactin increases expression
multiple interactions
increases secretion		 EXP
ISO		 4-nonylphenol results in increased expression of PRL mRNA
fulvestrant inhibits the reaction [4-nonylphenol results in increased expression of PRL mRNA]; fulvestrant inhibits the reaction [4-nonylphenol results in increased secretion of PRL protein]
4-nonylphenol affects the reaction [Estriol results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estradiol results in increased secretion of PRL protein]; 4-nonylphenol inhibits the reaction [Estrone results in increased secretion of PRL protein]		 CTD PMID:17174995 PMID:19463694 PMID:20950447 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Pten phosphatase and tensin homolog decreases phosphorylation
increases expression
multiple interactions		 EXP 4-nonylphenol results in decreased phosphorylation of PTEN protein
4-nonylphenol results in increased expression of PTEN mRNA
4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased phosphorylation of PTEN protein]		 CTD PMID:30228064 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rhbdf2 rhomboid 5 homolog 2 multiple interactions
affects response to substance		 ISO [RHBDF2 protein affects the susceptibility to 4-nonylphenol] which affects the secretion of BTC protein CTD PMID:28703301 NCBI chr10:101,833,157...101,860,283
Ensembl chr10:101,833,157...101,860,283 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 EXP Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein]; PRKAA1 protein promotes the reaction [4-nonylphenol results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:26804764 PMID:28041982 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO 4-nonylphenol results in decreased expression of RXRA mRNA CTD PMID:16013040 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G S100g S100 calcium binding protein G increases expression EXP 4-nonylphenol results in increased expression of S100G mRNA; 4-nonylphenol results in increased expression of S100G protein CTD PMID:17365578 NCBI chr  X:31,705,853...31,708,422
Ensembl chr  X:31,705,866...31,708,433 		JBrowse link
G Sbspon somatomedin B and thrombospondin, type 1 domain containing multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SBSPON mRNA CTD PMID:23626723 NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420 		JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of SDR16C5 mRNA CTD PMID:23626723 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970 		JBrowse link
G Serf1 small EDRK-rich factor 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of SERF1A mRNA CTD PMID:23626723 NCBI chr 2:31,475,902...31,482,030
Ensembl chr 2:31,475,703...31,482,032 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO 4-nonylphenol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Skil SKI-like proto-oncogene increases expression ISO 4-nonylphenol results in increased expression of SKIL protein CTD PMID:24308608 NCBI chr 2:112,247,047...112,275,176
Ensembl chr 2:112,247,051...112,275,080 		JBrowse link
G Slc7a7 solute carrier family 7 member 7 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of SLC7A7 mRNA CTD PMID:23626723 NCBI chr15:27,822,088...27,873,121
Ensembl chr15:27,822,091...27,865,648 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases phosphorylation		 ISO fulvestrant inhibits the reaction [4-nonylphenol results in decreased phosphorylation of SMAD3 protein] CTD PMID:24308608 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression EXP 4-nonylphenol results in decreased expression of SOD1 mRNA CTD PMID:27087316 PMID:27109770 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in decreased expression of SP1 mRNA CTD PMID:29029336 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP 4-nonylphenol results in increased expression of SREBF1 mRNA CTD PMID:24388992 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with 4-nonylphenol co-treated with 4-tert-octylphenol] results in increased expression of STAR mRNA CTD PMID:29029336 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases metabolic processing ISO SULT1A1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases metabolic processing ISO SULT1B1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO 4-nonylphenol inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] CTD PMID:22414680 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 increases metabolic processing ISO SULT2A1 protein results in increased metabolism of 4-nonylphenol CTD PMID:10623578 NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134 		JBrowse link
G Tf transferrin increases expression ISO 4-nonylphenol analog results in increased expression of TRF mRNA CTD PMID:27086933 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 4-nonylphenol results in increased expression of TFF1 mRNA CTD PMID:16393665 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions
increases secretion		 ISO ADAM10 protein affects the reaction [ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]]; ADAM17 protein affects the reaction [4-nonylphenol results in increased secretion of TGFA protein]; GW280264X inhibits the reaction [4-nonylphenol results in increased secretion of TGFA protein] CTD PMID:28703301 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 4-nonylphenol inhibits the reaction [Triiodothyronine results in increased activity of THRB protein] CTD PMID:31077750 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tnf tumor necrosis factor affects secretion
increases expression
decreases expression		 ISO
EXP		 4-nonylphenol affects the secretion of TNF protein
4-nonylphenol results in increased expression of TNF mRNA; 4-nonylphenol results in increased expression of TNF protein
4-nonylphenol results in decreased expression of TNF protein		 CTD PMID:20194071 PMID:27109770 PMID:28490175 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation		 EXP
ISO		 4-nonylphenol results in increased expression of TP53 mRNA; 4-nonylphenol results in increased expression of TP53 protein
4-nonylphenol results in increased phosphorylation of TP53 protein		 CTD PMID:27087316 PMID:27109770 PMID:32466334 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trmt9b tRNA methyltransferase 9B (putative) multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in increased expression of TRMT9B mRNA CTD PMID:23626723 NCBI chr16:55,740,551...55,792,198
Ensembl chr16:55,743,018...55,792,144 		JBrowse link
G Tsc2 TSC complex subunit 2 decreases phosphorylation
multiple interactions		 EXP 4-nonylphenol results in decreased phosphorylation of TSC2 protein
dorsomorphin inhibits the reaction [4-nonylphenol results in decreased phosphorylation of TSC2 protein]		 CTD PMID:26804764 PMID:28041982 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Ttr transthyretin multiple interactions ISO 4-nonylphenol inhibits the reaction [Thyroxine binds to TTR protein] CTD PMID:31077750 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008 		JBrowse link
G Vipr1 vasoactive intestinal peptide receptor 1 multiple interactions ISO [4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of VIPR1 mRNA CTD PMID:23626723 NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      chemical role 19529
        environmental contaminant 18891
          4-nonylphenol 155
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic aromatic compound 19414
                                  phenols 18680
                                    4-nonylphenol 155
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