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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-Hydroxybenzophenone
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Accession:CHEBI:34421 term browser browse the term
Definition:A benzophenone that has formula C13H10O2.
Synonyms:related_synonym: (4-Hydroxyphenyl)phenylmethanone;   Formula=C13H10O2;   InChI=1S/C13H10O2/c14-12-8-6-11(7-9-12)13(15)10-4-2-1-3-5-10/h1-9,14H;   InChIKey=NPFYZDNDJHZQKY-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C(=O)c1ccccc1
 xref: CAS:1137-42-4;   KEGG:C14230
 xref_mesh: MESH:C024292


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4-Hydroxybenzophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding EXP 4-hydroxybenzophenone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Esr1 estrogen receptor 1 increases activity
multiple interactions
affects binding
EXP
ISO
4-hydroxybenzophenone results in increased activity of ESR1 protein
4-hydroxybenzophenone binds to and results in increased activity of ESR1 protein; 4-hydroxybenzophenone inhibits the reaction [Estradiol binds to ESR1 protein]
4-hydroxybenzophenone binds to ESR1 protein
CTD PMID:11354909 PMID:12504345 PMID:12765246 PMID:16079615 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO 4-hydroxybenzophenone binds to and results in increased activity of ESR2 protein CTD PMID:16079615 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Flg filaggrin multiple interactions
affects response to substance
ISO [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in increased secretion of Estradiol CTD PMID:30245359 NCBI chr 2:193,565,401...193,574,297 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FLG gene mutant form affects the susceptibility to 4-hydroxybenzophenone] which results in decreased secretion of FSHB protein CTD PMID:30245359 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    chemical entity 19781
      group 19699
        inorganic group 19180
          oxo group 18526
            organic oxo compound 18526
              carbonyl compound 18526
                ketone 16828
                  aromatic ketone 12095
                    benzophenones 1190
                      4-Hydroxybenzophenone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      ketone 16828
                                        aromatic ketone 12095
                                          benzophenones 1190
                                            4-Hydroxybenzophenone 5
paths to the root