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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carvedilol
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Accession:CHEBI:3441 term browser browse the term
Definition:A member of the class of carbazoles that is an adrenergic antagonist with non-selective beta- and alpha-1 receptor blocking properties which helps in the management of congestive heart failure.
Synonyms:exact_synonym: 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
 related_synonym: (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol;   Formula=C24H26N2O4;   InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3;   InChIKey=OGHNVEJMJSYVRP-UHFFFAOYSA-N;   SKF 105517;   SMILES=COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12;   carvedilolum
 xref: Beilstein:1514452;   CAS:72956-09-3;   DrugBank:DB01136;   Drug_Central:522;   HMDB:HMDB0015267;   KEGG:C06875;   KEGG:D00255;   LINCS:LSM-1310
 xref_mesh: MESH:C043211
 xref: PMID:11389884;   PMID:15184840;   PMID:17383596;   PMID:18992766;   Patent:DE2815926;   Patent:US4503067;   Reaxys:1514452;   Wikipedia:Carvedilol


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carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH5 cadherin 5 decreases expression
increases expression		 EXP Carvedilol results in decreased expression of CDH5 mRNA
Carvedilol results in increased expression of CDH5 protein		 CTD PMID:16824628 NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177 		JBrowse link
G CTNNB1 catenin beta 1 decreases expression
increases expression		 EXP Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein		 CTD PMID:16824628 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions		 EXP Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]		 CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G JUP junction plakoglobin increases expression
decreases expression		 EXP Carvedilol results in increased expression of JUP protein
Carvedilol results in decreased expression of JUP mRNA		 CTD PMID:16824628 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5162
    role 5116
      application 909
        pharmaceutical 744
          drug 744
            cardiovascular drug 96
              carvedilol 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 5162
    subatomic particle 5153
      composite particle 5153
        hadron 5140
          baryon 5140
            nucleon 5153
              atomic nucleus 5140
                atom 5153
                  main group element atom 5125
                    p-block element atom 5122
                      carbon group element atom 5028
                        carbon atom 5039
                          organic molecular entity 5039
                            organic molecule 4988
                              organic cyclic compound 4929
                                organic heterocyclic compound 4705
                                  organic heteropolycyclic compound 4511
                                    organic heterotricyclic compound 65
                                      dibenzopyrrole 5
                                        carbazoles 5
                                          carvedilol 4
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