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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-chloro-m-cresol
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Accession:CHEBI:34395 term browser browse the term
Definition:A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.
Synonyms:related_synonym: 1-chloro-2-methyl-4-hydroxybenzene;   2-chloro-5-hydroxytoluene;   3-methyl-4-chlorophenol;   4-Chloro-3-methylphenol;   4-chloro-5-methylphenol;   6-chloro-3-hydroxytoluene;   Formula=C7H7ClO;   InChI=1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3;   InChIKey=CFKMVGJGLGKFKI-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1C)Cl)O;   p-chloro-m-cresol;   p-chlorocresol;   para-chloro-meta-cresol
 xref: CAS:59-50-7;   KEGG:C14331;   KEGG:D03468
 xref_mesh: MESH:C006984
 xref: PDBeChem:43M;   PMID:10360873;   PMID:10625004;   PMID:12761215;   PMID:12884985;   PMID:12944669;   PMID:15491450;   PMID:15537710;   PMID:16168959;   PMID:16530265;   PMID:16601083;   PMID:16807860;   PMID:19904006;   PMID:20818538;   PMID:23561324;   PMID:25479114;   PMID:27591377;   PMID:30655298;   PMID:30684528;   PMID:31165076;   PMID:31988840;   Wikipedia:P-Chlorocresol


show annotations for term's descendants           Sort by:
4-chloro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO chlorocresol affects the activity of AHR protein CTD PMID:18294747 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor affects activity
multiple interactions		 ISO chlorocresol affects the activity of AR protein
chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]		 CTD PMID:18294747 PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding		 ISO chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]
chlorocresol binds to ESRRG protein		 CTD PMID:17964775 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]] CTD PMID:17707769 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
multiple interactions
affects response to substance
increases response to substance		 ISO chlorocresol results in increased activity of RYR1 protein
[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; [chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]; RYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]
RYR1 protein alternative form affects the susceptibility to chlorocresol
RYR1 gene mutant form results in increased susceptibility to chlorocresol; RYR1 protein mutant form results in increased susceptibility to chlorocresol; RYR1 protein results in increased susceptibility to chlorocresol		 CTD PMID:12810058 PMID:15210166 PMID:16372898 PMID:17707769 PMID:18719443 More... NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        antimicrobial agent 18104
          4-chloro-m-cresol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                carbocyclic compound 18563
                                  benzenoid aromatic compound 17970
                                    benzenes 17830
                                      toluenes 7233
                                        hydroxytoluene 1906
                                          4-chloro-m-cresol 5
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