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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4-chloro-m-cresol
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Accession:CHEBI:34395 term browser browse the term
Definition:A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.
Synonyms:related_synonym: 1-chloro-2-methyl-4-hydroxybenzene;   2-chloro-5-hydroxytoluene;   3-methyl-4-chlorophenol;   4-Chloro-3-methylphenol;   4-chloro-5-methylphenol;   6-chloro-3-hydroxytoluene;   Formula=C7H7ClO;   InChI=1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3;   InChIKey=CFKMVGJGLGKFKI-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1C)Cl)O;   p-chloro-m-cresol;   p-chlorocresol;   para-chloro-meta-cresol
 xref: CAS:59-50-7;   KEGG:C14331;   KEGG:D03468
 xref_mesh: MESH:C006984
 xref: PDBeChem:43M;   PMID:10360873;   PMID:10625004;   PMID:12761215;   PMID:12884985;   PMID:12944669;   PMID:15491450;   PMID:15537710;   PMID:16168959;   PMID:16530265;   PMID:16601083;   PMID:16807860;   PMID:19904006;   PMID:20818538;   PMID:23561324;   PMID:25479114;   PMID:27591377;   PMID:30655298;   PMID:30684528;   PMID:31165076;   PMID:31988840;   Wikipedia:P-Chlorocresol


show annotations for term's descendants           Sort by:
4-chloro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor affects activity EXP chlorocresol affects the activity of AHR protein CTD PMID:18294747 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Ar androgen receptor affects activity
multiple interactions		 EXP
ISO		 chlorocresol affects the activity of AR protein
chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]		 CTD PMID:18294747 PMID:18324785 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding		 ISO chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]
chlorocresol binds to ESRRG protein		 CTD PMID:17964775 NCBI chr 1:187,340,707...187,947,082
Ensembl chr 1:187,340,988...187,947,082 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]] CTD PMID:17707769 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle increases activity
affects response to substance
increases response to substance
multiple interactions		 ISO chlorocresol results in increased activity of RYR1 protein
RYR1 protein alternative form affects the susceptibility to chlorocresol
RYR1 gene mutant form results in increased susceptibility to chlorocresol; RYR1 protein mutant form results in increased susceptibility to chlorocresol; RYR1 protein results in increased susceptibility to chlorocresol
[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; [chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]; RYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]		 CTD PMID:12810058 PMID:15210166 PMID:16372898 PMID:17707769 PMID:18719443 More... NCBI chr 7:28,702,765...28,824,599
Ensembl chr 7:28,702,769...28,824,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        antimicrobial agent 19567
          4-chloro-m-cresol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic molecule 21662
                              organic cyclic compound 21269
                                carbocyclic compound 19701
                                  benzenoid aromatic compound 18846
                                    benzenes 18648
                                      toluenes 7300
                                        hydroxytoluene 1990
                                          4-chloro-m-cresol 5
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