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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-chloro-m-cresol
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Accession:CHEBI:34395 term browser browse the term
Definition:A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.
Synonyms:related_synonym: 1-chloro-2-methyl-4-hydroxybenzene;   2-chloro-5-hydroxytoluene;   3-methyl-4-chlorophenol;   4-Chloro-3-methylphenol;   4-chloro-5-methylphenol;   6-chloro-3-hydroxytoluene;   Formula=C7H7ClO;   InChI=1S/C7H7ClO/c1-5-4-6(9)2-3-7(5)8/h2-4,9H,1H3;   InChIKey=CFKMVGJGLGKFKI-UHFFFAOYSA-N;   SMILES=C1=C(C=CC(=C1C)Cl)O;   p-chloro-m-cresol;   p-chlorocresol;   para-chloro-meta-cresol
 xref: CAS:59-50-7;   KEGG:C14331;   KEGG:D03468
 xref_mesh: MESH:C006984
 xref: PDBeChem:43M;   PMID:10360873;   PMID:10625004;   PMID:12761215;   PMID:12884985;   PMID:12944669;   PMID:15491450;   PMID:15537710;   PMID:16168959;   PMID:16530265;   PMID:16601083;   PMID:16807860;   PMID:19904006;   PMID:20818538;   PMID:23561324;   PMID:25479114;   PMID:27591377;   PMID:30655298;   PMID:30684528;   PMID:31165076;   PMID:31988840;   Wikipedia:P-Chlorocresol



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4-chloro-m-cresol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO chlorocresol affects the activity of AHR protein CTD PMID:18294747 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Ar androgen receptor affects activity
multiple interactions
ISO chlorocresol affects the activity of AR protein
chlorocresol inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD PMID:18294747 PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Esrrg estrogen-related receptor gamma multiple interactions
affects binding
ISO chlorocresol inhibits the reaction [afimoxifene binds to ESRRG protein]
chlorocresol binds to ESRRG protein
CTD PMID:17964775 NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]] CTD PMID:17707769 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Ryr1 ryanodine receptor 1 increases activity
multiple interactions
affects response to substance
increases response to substance
ISO chlorocresol results in increased activity of RYR1 protein
[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; [chlorocresol results in increased activity of RYR1 protein] which affects the localization of Calcium; [chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]]; Dantrolene inhibits the reaction [[chlorocresol results in increased activity of RYR1 protein] which results in increased transport of Calcium]; RYR1 protein polymorphism affects the reaction [chlorocresol results in increased secretion of Calcium]
RYR1 protein alternative form affects the susceptibility to chlorocresol
RYR1 gene mutant form results in increased susceptibility to chlorocresol; RYR1 protein mutant form results in increased susceptibility to chlorocresol; RYR1 protein results in increased susceptibility to chlorocresol
CTD PMID:12810058 PMID:15210166 PMID:16372898 PMID:17707769 PMID:18719443 More... NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        antimicrobial agent 17793
          4-chloro-m-cresol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                carbocyclic compound 18521
                                  benzenoid aromatic compound 17760
                                    benzenes 17560
                                      toluenes 6305
                                        hydroxytoluene 129
                                          4-chloro-m-cresol 5
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