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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-aminopyridine
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Accession:CHEBI:34385 term browser browse the term
Definition:An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Synonyms:exact_synonym: pyridin-4-amine
 related_synonym: 4-AP;   4-Pyridinamine;   4-Pyridylamine;   Ampyra;   Avitrol;   Dalfampridine;   Fampridine;   Formula=C5H6N2;   InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7);   InChIKey=NUKYPUAOHBNCPY-UHFFFAOYSA-N;   N07XX07;   SMILES=Nc1ccncc1;   fampridina;   fampridinum;   gamma-Aminopyridine;   p-Aminopyridine
 xref: CAS:504-24-5;   Drug_Central:4163;   KEGG:C13728;   KEGG:D04127
 xref_mesh: MESH:D015761
 xref: PDBeChem:4AP;   PMID:11049865;   PMID:12509600;   PMID:12525889;   PMID:12853442;   PMID:12860480;   PMID:14585815;   PMID:14970964;   PMID:15052305;   PMID:15202573;   PMID:15678081;   PMID:16088375;   PMID:16417531;   PMID:16567254;   PMID:16806301;   PMID:17014896;   PMID:17071731;   PMID:17629412;   PMID:18394011;   PMID:19302905;   PMID:19443164;   PMID:19542906;   PMID:19818752;   PMID:19915712;   PMID:19966074;   PMID:20044444;   PMID:20112006;   PMID:20473651;   PMID:20967295;   PMID:21573085;   PMID:21694807;   PMID:22000073;   PMID:22073939;   PMID:22135060;   PMID:22497693;   PMID:22703551;   PMID:22936332;   PMID:23077091;   PMID:23146002;   PMID:7507992;   PMID:8208758;   PMID:8569870;   PMID:8599505;   PMID:8813586;   PMID:9178370;   PPDB:1348;   Reaxys:105782;   Wikipedia:Dalfampridine


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4-aminopyridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 9430015G10Rik RIKEN cDNA 9430015G10 gene increases expression ISO 4-Aminopyridine results in increased expression of C1ORF159 mRNA CTD PMID:24378259 NCBI chr 4:156,109,998...156,127,265
Ensembl chr 4:156,109,982...156,127,265
JBrowse link
G Adra1b adrenergic receptor, alpha 1b multiple interactions ISO 4-Aminopyridine inhibits the reaction [ADRA1B protein results in increased susceptibility to Phenylephrine] CTD PMID:18480251 NCBI chr11:43,774,605...43,901,250
Ensembl chr11:43,774,606...43,901,210
JBrowse link
G Bax BCL2-associated X protein increases expression ISO 4-Aminopyridine results in increased expression of BAX mRNA CTD PMID:24378259 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO 4-Aminopyridine results in decreased expression of BIRC2 mRNA CTD PMID:24378259 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 4-Aminopyridine results in decreased expression of BIRC3 mRNA CTD PMID:24378259 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Bmf BCL2 modifying factor increases expression ISO 4-Aminopyridine results in increased expression of BMF mRNA CTD PMID:24378259 NCBI chr 2:118,528,757...118,549,686
Ensembl chr 2:118,528,757...118,549,687
JBrowse link
G Casp3 caspase 3 increases activity ISO 4-Aminopyridine results in increased activity of CASP3 protein CTD PMID:24378259 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 increases activity ISO 4-Aminopyridine results in increased activity of CASP7 protein CTD PMID:24378259 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp9 caspase 9 increases activity ISO 4-Aminopyridine results in increased activity of CASP9 protein CTD PMID:24378259 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cd40 CD40 antigen increases expression ISO 4-Aminopyridine results in increased expression of CD40 mRNA CTD PMID:24378259 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd40lg CD40 ligand increases expression ISO 4-Aminopyridine results in increased expression of CD40LG mRNA CTD PMID:24378259 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Ctsb cathepsin B increases expression ISO 4-Aminopyridine results in increased expression of CTSB mRNA CTD PMID:24378259 NCBI chr14:63,122,462...63,145,923
Ensembl chr14:63,122,462...63,145,923
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO 4-Aminopyridine results in increased expression of DPYSL4 mRNA CTD PMID:24378259 NCBI chr 7:139,085,981...139,101,795
Ensembl chr 7:139,086,001...139,102,704
JBrowse link
G Gad2 glutamic acid decarboxylase 2 increases expression
multiple interactions
ISO 4-Aminopyridine results in increased expression of GAD2 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]
CTD PMID:25917026 NCBI chr 2:22,621,015...22,693,877
Ensembl chr 2:22,622,205...22,693,874
JBrowse link
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 decreases expression ISO 4-Aminopyridine results in decreased expression of GALNT5 mRNA CTD PMID:24378259 NCBI chr 2:57,997,850...58,041,027
Ensembl chr 2:57,997,884...58,045,860
JBrowse link
G Grin2d glutamate receptor, ionotropic, NMDA2D (epsilon 4) multiple interactions EXP [Bicuculline co-treated with 4-Aminopyridine] results in decreased expression of GRIN2D protein CTD PMID:19911010 NCBI chr 7:45,831,883...45,871,194
Ensembl chr 7:45,831,883...45,878,378
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] affects the localization of HDAC5 protein CTD PMID:15773917 NCBI chr11:102,195,747...102,230,172
Ensembl chr11:102,194,432...102,230,166
JBrowse link
G Jph3 junctophilin 3 increases expression ISO 4-Aminopyridine results in increased expression of JPH3 mRNA CTD PMID:24378259 NCBI chr 8:121,730,559...121,791,083
Ensembl chr 8:121,729,623...121,794,276
JBrowse link
G Kcna10 potassium voltage-gated channel, shaker-related subfamily, member 10 multiple interactions ISO 4-Aminopyridine inhibits the reaction [KCNA10 protein results in increased transport of Potassium] CTD PMID:10836990 NCBI chr 3:107,183,143...107,195,721
Ensembl chr 3:107,183,056...107,195,721
JBrowse link
G Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 increases expression
multiple interactions
ISO 4-Aminopyridine results in increased expression of KCND3 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]
CTD PMID:25917026 NCBI chr 3:105,451,890...105,674,002
Ensembl chr 3:105,452,330...105,674,002
JBrowse link
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 decreases activity ISO 4-Aminopyridine results in decreased activity of KCNH2 protein CTD PMID:19915712 NCBI chr 5:24,319,589...24,351,684
Ensembl chr 5:24,319,589...24,351,604
JBrowse link
G Kcnip1 Kv channel-interacting protein 1 decreases expression
increases expression
multiple interactions
ISO 4-Aminopyridine results in decreased expression of KCNIP1 mRNA
4-Aminopyridine results in increased expression of KCNIP1 mRNA
KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased abundance of gamma-Aminobutyric Acid]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of GAD2 mRNA]; KCNIP1 mRNA promotes the reaction [4-Aminopyridine results in increased expression of KCND3 mRNA]
CTD PMID:24378259 PMID:25917026 NCBI chr11:33,629,339...33,993,348
Ensembl chr11:33,629,339...33,993,152
JBrowse link
G Mag myelin-associated glycoprotein decreases expression ISO 4-Aminopyridine results in decreased expression of MAG mRNA CTD PMID:24378259 NCBI chr 7:30,899,175...30,914,922
Ensembl chr 7:30,899,176...30,914,873
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO 4-Aminopyridine results in increased expression of MAP1LC3A mRNA CTD PMID:24378259 NCBI chr 2:155,276,364...155,278,073
Ensembl chr 2:155,276,297...155,278,073
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK1 protein]
4-Aminopyridine results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; [4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK1 protein]
CTD PMID:19911010 PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] results in increased activity of and results in increased phosphorylation of MAPK3 protein]
4-Aminopyridine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; [4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of MAPK3 protein]
CTD PMID:19911010 PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; [Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] affects the localization of NCOR2 protein] CTD PMID:15773917 NCBI chr 5:125,017,153...125,179,238
Ensembl chr 5:125,017,153...125,179,219
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [alitretinoin results in increased activity of RARA protein]] CTD PMID:15773917 NCBI chr11:98,927,800...98,974,942
Ensembl chr11:98,927,818...98,974,942
JBrowse link
G S100a7a S100 calcium binding protein A7A decreases expression ISO 4-Aminopyridine results in decreased expression of S100A7A mRNA CTD PMID:24378259 NCBI chr 3:90,651,925...90,658,130
Ensembl chr 3:90,654,017...90,658,669
JBrowse link
G Syn1 synapsin I affects response to substance
increases response to substance
increases expression
multiple interactions
EXP
ISO
SYN1 protein affects the susceptibility to 4-Aminopyridine
SYN1 results in increased susceptibility to 4-Aminopyridine
4-Aminopyridine results in increased expression of SYN1 protein modified form
[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein; ciproxifan inhibits the reaction [4-Aminopyridine results in increased expression of SYN1 protein modified form]; typhaneoside inhibits the reaction [[4-Aminopyridine co-treated with Calcium Chloride] results in increased phosphorylation of SYN1 protein]
CTD PMID:22759588 PMID:28132918 PMID:33621091 NCBI chr  X:20,860,511...20,920,918
Ensembl chr  X:20,860,511...20,921,004
JBrowse link
G Traf2 TNF receptor-associated factor 2 increases expression ISO 4-Aminopyridine results in increased expression of TRAF2 mRNA CTD PMID:24378259 NCBI chr 2:25,517,982...25,546,940
Ensembl chr 2:25,517,982...25,546,940
JBrowse link
torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) increases expression ISO Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 affects expression ISO Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr15:74,834,892...74,841,643
Ensembl chr15:74,834,125...74,841,643
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases metabolic processing
multiple interactions
ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]
CTD PMID:15304522 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene affects metabolic processing ISO CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases hydroxylation
increases metabolic processing
ISO CYP2C9 protein results in increased hydroxylation of Torsemide
CYP2C9 protein results in increased metabolism of Torsemide
CTD PMID:9110362 PMID:19082874 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases metabolic processing
increases hydroxylation
ISO CYP2C9 protein results in increased metabolism of Torsemide
CYP2C9 protein results in increased hydroxylation of Torsemide
CTD PMID:9110362 PMID:19082874 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Nppa natriuretic peptide type A decreases expression ISO Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions ISO Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr 8:76,898,083...77,245,012
Ensembl chr 8:76,899,442...77,245,012
JBrowse link
G Ren1 renin 1 structural increases expression ISO Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link
G Slc12a2 solute carrier family 12, member 2 decreases activity
multiple interactions
ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]
CTD PMID:29959396 NCBI chr18:57,878,512...57,946,821
Ensembl chr18:57,878,678...57,946,821
JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects expression
decreases expression
ISO Torsemide affects the expression of TGFB1 protein
Torsemide results in decreased expression of TGFB1 protein
CTD PMID:18001696 PMID:18154949 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21720
    role 21698
      application 21210
        pesticide 16825
          avicide 4119
            4-aminopyridine 42
              4-aminonicotinic acid 0
              4-aminopyridine-3-methanol 0
              torasemide + 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 21720
    subatomic particle 21706
      composite particle 21706
        hadron 21706
          baryon 21706
            nucleon 21706
              atomic nucleus 21706
                atom 21706
                  main group element atom 21621
                    main group molecular entity 21621
                      s-block molecular entity 21158
                        hydrogen molecular entity 21094
                          hydrides 20358
                            inorganic hydride 18054
                              pnictogen hydride 18016
                                nitrogen hydride 17835
                                  azane 17731
                                    ammonia 17730
                                      organic amino compound 17729
                                        aromatic amine 14091
                                          aminopyridine 368
                                            4-aminopyridine 42
                                              4-aminonicotinic acid 0
                                              4-aminopyridine-3-methanol 0
                                              torasemide + 11
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