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ONTOLOGY REPORT - ANNOTATIONS


Term:4-aminopyridine
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Accession:CHEBI:34385 term browser browse the term
Definition:An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.
Synonyms:exact_synonym: pyridin-4-amine
 related_synonym: 4-AP;   4-Pyridinamine;   4-Pyridylamine;   Ampyra;   Avitrol;   Dalfampridine;   Fampridine;   Formula=C5H6N2;   InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7);   InChIKey=NUKYPUAOHBNCPY-UHFFFAOYSA-N;   N07XX07;   SMILES=Nc1ccncc1;   fampridina;   fampridinum;   gamma-Aminopyridine;   p-Aminopyridine
 xref: CAS:504-24-5;   Drug_Central:4163;   KEGG:C13728;   KEGG:D04127
 xref_mesh: MESH:D015761
 xref: PDBeChem:4AP;   PMID:11049865;   PMID:12509600;   PMID:12525889;   PMID:12853442;   PMID:12860480;   PMID:14585815;   PMID:14970964;   PMID:15052305;   PMID:15202573;   PMID:15678081;   PMID:16088375;   PMID:16417531;   PMID:16567254;   PMID:16806301;   PMID:17014896;   PMID:17071731;   PMID:17629412;   PMID:18394011;   PMID:19302905;   PMID:19443164;   PMID:19542906;   PMID:19818752;   PMID:19915712;   PMID:19966074;   PMID:20044444;   PMID:20112006;   PMID:20473651;   PMID:20967295;   PMID:21573085;   PMID:21694807;   PMID:22000073;   PMID:22073939;   PMID:22135060;   PMID:22497693;   PMID:22703551;   PMID:22936332;   PMID:23077091;   PMID:23146002;   PMID:7507992;   PMID:8208758;   PMID:8569870;   PMID:8599505;   PMID:8813586;   PMID:9178370;   PPDB:1348;   Reaxys:105782;   Wikipedia:Dalfampridine


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4-aminopyridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:6480464
G Birc3 baculoviral IAP repeat-containing 3 JBrowse link 8 6,048,590 6,076,828 RGD:6480464
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Dpysl4 dihydropyrimidinase-like 4 JBrowse link 1 211,423,022 211,438,533 RGD:6480464
G Gad2 glutamate decarboxylase 2 JBrowse link 17 89,171,576 89,234,770 RGD:6480464
G Galnt5 polypeptide N-acetylgalactosaminyltransferase 5 JBrowse link 3 44,025,964 44,072,073 RGD:6480464
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D JBrowse link 1 101,819,068 101,859,146 RGD:6480464
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:6480464
G Jph3 junctophilin 3 JBrowse link 19 54,553,419 54,613,477 RGD:6480464
G Kcna10 potassium voltage-gated channel subfamily A member 10 JBrowse link 2 209,920,590 209,932,665 RGD:6480464
G Kcnd3 potassium voltage-gated channel subfamily D member 3 JBrowse link 2 207,923,775 208,140,727 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnip1 potassium voltage-gated channel interacting protein 1 JBrowse link 10 18,558,128 18,942,677 RGD:6480464
G Mag myelin-associated glycoprotein JBrowse link 1 89,345,325 89,360,905 RGD:6480464
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha JBrowse link 3 150,801,289 150,802,935 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:6480464
G Olr1583 olfactory receptor 1583 JBrowse link 13 91,725,324 91,726,265 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G RGD1311517 similar to RIKEN cDNA 9430015G10 JBrowse link 5 173,542,058 173,559,761 RGD:6480464
G S100a7a S100 calcium binding protein A7A JBrowse link 2 190,058,093 190,063,132 RGD:6480464
G Syn1 synapsin I JBrowse link X 1,321,315 1,379,202 RGD:6480464
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:6480464
torasemide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:6480464
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:6480464
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 JBrowse link 1 147,236,480 147,307,988 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 JBrowse link 19 34,408,275 34,761,003 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19779
    role 19727
      application 19373
        pesticide 16246
          avicide 4076
            4-aminopyridine 41
              4-aminonicotinic acid 0
              4-aminopyridine-3-methanol 0
              torasemide + 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19779
    subatomic particle 19777
      composite particle 19777
        hadron 19777
          baryon 19777
            nucleon 19777
              atomic nucleus 19777
                atom 19777
                  main group element atom 19664
                    main group molecular entity 19664
                      s-block molecular entity 19406
                        hydrogen molecular entity 19397
                          hydrides 18386
                            inorganic hydride 17221
                              pnictogen hydride 17184
                                nitrogen hydride 17020
                                  azane 16716
                                    ammonia 16715
                                      organic amino compound 16714
                                        aromatic amine 13627
                                          aminopyridine 360
                                            4-aminopyridine 41
                                              4-aminonicotinic acid 0
                                              4-aminopyridine-3-methanol 0
                                              torasemide + 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.