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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:monobenzone
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Accession:CHEBI:34380 term browser browse the term
Definition:The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.
Synonyms:related_synonym: 4-(Benzyloxyl)phenol;   4-(Phenylmethoxy)phenol;   4-Benzyloxy-phenol;   4-Benzyloxyphenol;   Formula=C13H12O2;   Hydroquinone benzyl ether;   Hydroquinone monobenzyl ether;   InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2;   InChIKey=VYQNWZOUAUKGHI-UHFFFAOYSA-N;   MONOBENZYL ETHER OF HYDROQUINONE;   Monobenzyl hydroquinone;   SMILES=OC1=CC=C(OCC2=CC=CC=C2)C=C1;   monobenzona;   monobenzonum;   p-(Benzyloxy)phenol;   p-Hydroxyphenyl benzyl ether
 alt_id: CHEBI:428158
 xref: CAS:103-16-2;   DrugBank:DB00600;   Drug_Central:1834;   KEGG:C14244;   KEGG:D05072;   LINCS:LSM-5642
 xref_mesh: MESH:C006429
 xref: PMID:14843106;   PMID:20498710;   PMID:21326294;   PMID:21566576;   PMID:21689385;   PMID:32785935;   Patent:EP0175701;   Patent:WO8504101;   Reaxys:1958305;   Wikipedia:Monobenzone



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monobenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP monobenzone binds to AFP protein CTD PMID:23013281 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Ar androgen receptor affects binding EXP monobenzone binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO monobenzone results in increased activity of NR1I2 protein
[monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO monobenzone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      chemical role 19589
        antioxidant 15678
          hydroquinone 968
            monobenzone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic molecule 19856
                              organic cyclic compound 19612
                                organic aromatic compound 19451
                                  phenols 18642
                                    benzenediols 8998
                                      benzenediol 1137
                                        hydroquinone 968
                                          monobenzone 5
paths to the root