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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:34380 term browser browse the term
Definition:The monobenzyl ether of hydroquinone. It is used as a topical drug for medical depigmentation.
Synonyms:related_synonym: 4-(Benzyloxyl)phenol;   4-(Phenylmethoxy)phenol;   4-Benzyloxy-phenol;   4-Benzyloxyphenol;   Formula=C13H12O2;   Hydroquinone benzyl ether;   Hydroquinone monobenzyl ether;   InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2;   InChIKey=VYQNWZOUAUKGHI-UHFFFAOYSA-N;   MONOBENZYL ETHER OF HYDROQUINONE;   Monobenzyl hydroquinone;   SMILES=OC1=CC=C(OCC2=CC=CC=C2)C=C1;   monobenzona;   monobenzonum;   p-(Benzyloxy)phenol;   p-Hydroxyphenyl benzyl ether
 alt_id: CHEBI:428158
 xref: CAS:103-16-2;   DrugBank:DB00600;   Drug_Central:1834;   KEGG:C14244;   KEGG:D05072;   LINCS:LSM-5642
 xref_mesh: MESH:C006429
 xref: PMID:14843106;   PMID:20498710;   PMID:21326294;   PMID:21566576;   PMID:21689385;   PMID:32785935;   Patent:EP0175701;   Patent:WO8504101;   Reaxys:1958305;   Wikipedia:Monobenzone

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monobenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP monobenzone binds to AFP protein CTD PMID:23013281 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor affects binding EXP monobenzone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO [monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO monobenzone results in increased activity of NR1I2 protein
[monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO monobenzone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19817
    role 19767
      chemical role 19289
        antioxidant 14242
          hydroquinone 876
            monobenzone 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19817
    subatomic particle 19815
      composite particle 19815
        hadron 19815
          baryon 19815
            nucleon 19815
              atomic nucleus 19815
                atom 19815
                  main group element atom 19705
                    p-block element atom 19705
                      carbon group element atom 19614
                        carbon atom 19603
                          organic molecular entity 19603
                            organic molecule 19532
                              organic cyclic compound 19348
                                organic aromatic compound 19180
                                  phenols 18160
                                    benzenediols 6088
                                      benzenediol 1044
                                        hydroquinone 876
                                          monobenzone 5
paths to the root