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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,3-benzothiazole-2-thiol
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Accession:CHEBI:34292 term browser browse the term
Definition:1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.
Synonyms:related_synonym: 1,3-Benzothiazol-2-yl hydrosulfide;   2-Benzothiazolethiol;   2-MBT;   2-Mercaptobenzothiazole;   2-sulfanyl-1,3-benzothiazole;   Benzothiazole-2-thiol;   Benzothiazolethiol;   Captax;   Formula=C7H5NS2;   InChI=1S/C7H5NS2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9);   InChIKey=YXIWHUQXZSMYRE-UHFFFAOYSA-N;   MBT;   Mercaptobenzothiazole;   SMILES=Sc1nc2ccccc2s1;   benzothiazolyl mercaptan
 alt_id: CHEBI:282886
 xref: Beilstein:508810;   CAS:149-30-4;   KEGG:C14437;   LINCS:LSM-18993
 xref_mesh: MESH:C005563
 xref: PMID:18568896;   PMID:18844695;   PMID:19158128;   PMID:21616561;   PMID:23063874;   PMID:23178179;   PMID:23340394;   UM-BBD_compID:c1019


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1,3-benzothiazole-2-thiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO captax results in increased expression of AHR mRNA CTD PMID:21590714 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases activity
increases expression
ISO captax results in increased activity of AKR1C2 promoter
captax results in increased expression of AKR1C2 mRNA
CTD PMID:20491607, PMID:20713136, PMID:21195160 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression ISO captax results in increased expression of AMPD3 mRNA CTD PMID:24211530 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO captax results in increased expression of ATF3 mRNA CTD PMID:23999411 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO captax results in decreased expression of CCL2 mRNA CTD PMID:20713136 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO captax results in increased secretion of CCL4 protein CTD PMID:16314067 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO captax results in increased expression of CCR2 mRNA CTD PMID:20713136
G Ccr5 C-C motif chemokine receptor 5 increases expression ISO captax results in increased expression of CCR5 mRNA CTD PMID:20713136 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Cd86 CD86 molecule increases expression ISO captax results in increased expression of CD86 protein CTD PMID:12423654 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression ISO captax results in decreased expression of CREB1 mRNA CTD PMID:20385217 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO captax results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl14 C-X-C motif chemokine ligand 14 decreases expression ISO captax results in decreased expression of CXCL14 mRNA; captax results in decreased expression of CXCL14 protein CTD PMID:31734321 NCBI chr17:9,109,731...9,117,754
Ensembl chr17:9,109,731...9,117,750
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO captax results in increased expression of CXCL2 protein CTD PMID:23178550 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO captax results in increased expression of CXCL1 mRNA CTD PMID:20713136 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO captax results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO captax results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 5:126,894,837...126,911,532
Ensembl chr 5:126,895,286...126,911,520
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO captax results in increased expression of DNAJB4 mRNA CTD PMID:23999411, PMID:27965148 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO captax results in increased expression of ENPP2 protein CTD PMID:22952646 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO captax results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO captax results in increased expression of FTH1 mRNA CTD PMID:24211530 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO captax results in increased expression of FTL mRNA CTD PMID:24211530 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO captax results in increased expression of GCLC mRNA CTD PMID:20491607 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO captax results in increased expression of GCLM mRNA CTD PMID:23999411, PMID:24211530 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO captax results in increased expression of HMOX1 mRNA CTD PMID:20713136, PMID:23445166, PMID:24211530 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ifng interferon gamma increases secretion ISO captax results in increased secretion of IFNG protein CTD PMID:22245253 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il18 interleukin 18 increases expression ISO captax results in increased expression of IL18 protein CTD PMID:23063874 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO captax results in increased expression of IL1A protein CTD PMID:23178550 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il2 interleukin 2 increases secretion ISO captax results in increased secretion of IL2 protein CTD PMID:22245253 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 increases secretion ISO captax results in increased secretion of IL6 protein CTD PMID:22245253 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il7r interleukin 7 receptor increases expression ISO captax results in increased expression of IL7R mRNA CTD PMID:20713136
G Mmp9 matrix metallopeptidase 9 increases expression ISO captax results in increased expression of MMP9 mRNA; captax results in increased expression of MMP9 protein CTD PMID:22952646 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO captax results in increased expression of MYC mRNA CTD PMID:24211530 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 affects expression ISO captax affects the expression of NFKB1 mRNA CTD PMID:20385217 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Notch3 notch receptor 3 decreases expression ISO captax results in decreased expression of NOTCH3 mRNA CTD PMID:20713136 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO captax results in increased expression of NQO1 mRNA CTD PMID:24211530 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO captax results in increased expression of PMAIP1 mRNA CTD PMID:20713136 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Rgs1 regulator of G-protein signaling 1 increases expression ISO captax results in increased expression of RGS1 mRNA CTD PMID:20713136 NCBI chr13:61,066,196...61,070,772
Ensembl chr13:61,066,153...61,070,599
JBrowse link
G Sel1l3 SEL1L family member 3 increases expression ISO captax results in increased expression of SEL1L3 mRNA CTD PMID:24211530 NCBI chr14:60,122,968...60,229,565
Ensembl chr14:60,123,169...60,229,734
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO captax inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr16:20,297,414...20,307,401
Ensembl chr16:20,297,414...20,307,400
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO captax results in increased expression of SLC7A11 mRNA CTD PMID:24211530 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO captax results in increased expression of SQSTM1 mRNA CTD PMID:24211530 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Syne2 spectrin repeat containing nuclear envelope protein 2 decreases expression ISO captax results in decreased expression of SYNE2 mRNA CTD PMID:24211530 NCBI chr 6:98,884,269...99,153,551 JBrowse link
G Tnf tumor necrosis factor decreases expression ISO captax results in decreased expression of TNF mRNA CTD PMID:20385217 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnnt2 troponin T2, cardiac type decreases expression ISO captax results in decreased expression of TNNT2 mRNA CTD PMID:24211530 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tpo thyroid peroxidase multiple interactions
decreases activity
ISO
EXP
captax binds to and results in decreased activity of TPO protein
captax results in decreased activity of TPO protein
CTD PMID:23959146, PMID:26865668, PMID:26884060, PMID:31629072 NCBI chr 6:49,020,918...49,089,855
Ensembl chr 6:49,021,044...49,089,855
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO captax results in increased expression of TXNRD1 mRNA CTD PMID:23445166, PMID:24211530 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO captax results in increased expression of VEGFA protein CTD PMID:25617811 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
dibenzothiazol-2-yl disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma multiple interactions ISO [dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IFNG protein CTD PMID:12062936 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [dibenzothiazyl disulfide co-treated with Sodium Dodecyl Sulfate] results in increased expression of IL4 protein CTD PMID:12062936 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        biochemical role 19282
          metabolite 19263
            1,3-benzothiazole-2-thiol 48
              dibenzothiazol-2-yl disulfide 2
              tyrphostin AG 825 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              chalcogen hydride 2425
                                sulfur hydride 2046
                                  hydrogen sulfide 2046
                                    thiol group 1938
                                      thiol 1938
                                        aryl thiol 329
                                          1,3-benzothiazole-2-thiol 48
                                            dibenzothiazol-2-yl disulfide 2
                                            tyrphostin AG 825 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.