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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Carnosol
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Accession:CHEBI:3429 term browser browse the term
Definition:A diterpenoid that has formula C20H26O4.
Synonyms:related_synonym: Formula=C20H26O4;   InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1;   InChIKey=XUSYGBPHQBWGAD-PJSUUKDQSA-N;   SMILES=CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
 xref: CAS:5957-80-2;   HMDB:HMDB0002121;   KEGG:C09069;   KNApSAcK:C00003410;   LINCS:LSM-37166
 xref_mesh: MESH:C068623



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Carnosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases expression ISO carnosol results in decreased expression of AHR protein CTD PMID:22374940 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Casp3 caspase 3 multiple interactions ISO carnosol inhibits the reaction [Rotenone results in increased activity of CASP3 protein] CTD PMID:17047462 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] CTD PMID:22374940 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; carnosol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein] CTD PMID:22374940 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO carnosol results in increased expression of GCLC mRNA CTD PMID:20116392 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO carnosol results in increased expression of GCLM mRNA CTD PMID:20116392 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
ISO carnosol results in increased expression of HMOX1 protein
carnosol results in increased expression of HMOX1 mRNA; carnosol results in increased expression of HMOX1 protein
Acetylcysteine inhibits the reaction [carnosol results in increased expression of HMOX1 protein]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]
[HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]
CTD PMID:20116392 PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [HMOX1 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; [NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:20116392 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO carnosol inhibits the reaction [IFNG protein results in increased abundance of Dinoprostone]; carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]; HMOX1 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; tin protoporphyrin IX inhibits the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]] CTD PMID:23942037 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO carnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein] CTD PMID:20116392 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP carnosol inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA] CTD PMID:15252869 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO carnosol results in increased phosphorylation of MAPK1 protein CTD PMID:17047462 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO carnosol results in increased phosphorylation of MAPK3 protein CTD PMID:17047462 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases localization
multiple interactions
ISO carnosol results in increased localization of NFE2L2 protein
NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]]; NFE2L2 protein promotes the reaction [carnosol inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]]
[NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]] which results in increased expression of ICAM1 protein; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]
CTD PMID:20116392 PMID:23942037 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO carnosol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:20116392 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO carnosol results in increased expression of NR4A2 protein CTD PMID:17047462 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases glutathionylation
ISO [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol results in increased glutathionylation of RELA protein] CTD PMID:20116392 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases expression
ISO 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [carnosol results in increased expression of TH protein]; carnosol inhibits the reaction [Rotenone results in decreased expression of TH protein]; U 0126 inhibits the reaction [carnosol results in increased expression of TH protein] CTD PMID:17047462 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; carnosol inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; carnosol inhibits the reaction [TNF protein results in increased phosphorylation of IKBKB protein]; diethyl maleate inhibits the reaction [[carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]] which results in increased glutathionylation of RELA protein]; diethyl maleate inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; HMOX1 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; NFE2L2 mutant form inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
carnosol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:20116392 PMID:23942037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tyr tyrosinase decreases expression ISO carnosol results in decreased expression of TYR mRNA; carnosol results in decreased expression of TYR protein CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      atom 19799
        nonmetal atom 19686
          carbon atom 19609
            organic molecular entity 19609
              isoprenoid 12725
                terpenoid 12295
                  diterpenoid 11518
                    Carnosol 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  terpene 12725
                                    diterpene 11518
                                      diterpenoid 11518
                                        Carnosol 20
paths to the root