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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-hydroxyethyl methacrylate
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Accession:CHEBI:34288 term browser browse the term
Definition:An enoate ester that is the monomethacryloyl derivative of ethylene glycol.
Synonyms:related_synonym: 1,2-Ethanediol mono(2-methyl)-2-propenoate;   2-(Methacryloyloxy)ethanol;   2-Hydroxyethyl 2-methylacrylate;   2-Hydroxyethylmethacrylate;   Ethylene glycol methacrylate;   Ethylene glycol monomethacrylate;   Formula=C6H10O3;   Glycol methacrylate;   Glycol monomethacrylate;   HEMA;   Hydroxyethyl methacrylate;   InChI=1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3;   InChIKey=WOBHKFSMXKNTIM-UHFFFAOYSA-N;   SMILES=CC(=C)C(=O)OCCO;   beta-Hydroxyethyl methacrylate
 alt_id: CHEBI:53441
 xref: Beilstein:1071583;   CAS:868-77-9;   Gmelin:936557;   KEGG:C14530
 xref_mesh: MESH:C005044
 xref: PMID:10444249;   PMID:11714252;   PMID:15186380;   PMID:22886489;   PMID:22889382;   PMID:23137186;   PMID:23157270;   PMID:23182953;   PMID:23275084;   PMID:23305206;   PMID:23360228;   PMID:23370864;   PMID:23399173;   PMID:23466546;   PMID:23516576;   PMID:23587005;   PMID:23611114;   PMID:23670604;   PMID:23673616;   Reaxys:1071583;   Wikipedia:(Hydroxyethyl)methacrylate



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2-hydroxyethyl methacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO hydroxyethyl methacrylate results in increased expression of ADM mRNA CTD PMID:30497689 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C2 mRNA CTD PMID:30497689 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA CTD PMID:30497689 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO hydroxyethyl methacrylate results in increased expression of ALDH3A2 mRNA CTD PMID:30497689 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of ATG5 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]
CTD PMID:28184909 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of BECN1 mRNA; hydroxyethyl methacrylate results in increased expression of BECN1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]
CTD PMID:28184909 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO hydroxyethyl methacrylate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased activity of CASP3 protein]
CTD PMID:33248029 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA] CTD PMID:28184909 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased degradation of CAT mRNA]; hydroxyethyl methacrylate results in increased expression of and results in increased degradation of CAT mRNA CTD PMID:33248029 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO hydroxyethyl methacrylate results in decreased expression of COL1A1 mRNA; hydroxyethyl methacrylate results in decreased expression of COL1A1 protein CTD PMID:20668299 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO hydroxyethyl methacrylate results in decreased expression of CXCL12 protein CTD PMID:30517439 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO hydroxyethyl methacrylate results in increased expression of DNAJB4 mRNA CTD PMID:30497689 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO hydroxyethyl methacrylate results in increased expression of FBXO30 mRNA CTD PMID:30497689 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion
ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein] CTD PMID:19176594 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of FTH1 mRNA CTD PMID:30497689 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLC mRNA; hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLM mRNA; hydroxyethyl methacrylate results in increased expression of GCLM protein CTD PMID:30497689 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of HMOX1 mRNA; hydroxyethyl methacrylate results in increased expression of HMOX1 protein CTD PMID:30497689 PMID:33248029 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1A mRNA CTD PMID:30497689
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1B mRNA CTD PMID:30497689 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; hydroxyethyl methacrylate promotes the reaction [triethylene glycol dimethacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; triethylene glycol dimethacrylate promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:23182953 PMID:28188892 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydroxyethyl methacrylate results in decreased secretion of IL6 protein CTD PMID:19176594 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA; hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein]
CTD PMID:28184909 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO hydroxyethyl methacrylate results in increased expression of MAP3K14 mRNA CTD PMID:30497689 NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 increases expression ISO hydroxyethyl methacrylate results in increased expression of MRPL19 mRNA CTD PMID:30497689 NCBI chr 4:114,521,824...114,526,053
Ensembl chr 4:114,521,824...114,526,053
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO hydroxyethyl methacrylate results in increased expression of NFE2L2 protein CTD PMID:30497689 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha increases response to substance
multiple interactions
ISO NFKBIA protein results in increased susceptibility to hydroxyethyl methacrylate
NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]
CTD PMID:19176594 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of NQO1 mRNA; hydroxyethyl methacrylate results in increased expression of NQO1 protein CTD PMID:30497689 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of OSGIN1 mRNA CTD PMID:30497689 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein] CTD PMID:28184909 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein; hydroxyethyl methacrylate affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein; hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:19176594 PMID:28184909 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SPSB1 mRNA CTD PMID:30497689 NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SQSTM1 mRNA; hydroxyethyl methacrylate results in increased expression of SQSTM1 protein CTD PMID:30497689 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SRXN1 mRNA CTD PMID:30497689 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]
hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; hydroxyethyl methacrylate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
CTD PMID:19176594 PMID:23182953 PMID:28188892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of TXNRD1 mRNA CTD PMID:30497689 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO hydroxyethyl methacrylate results in increased expression of UGDH mRNA CTD PMID:30497689 NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases secretion
ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein] CTD PMID:19176594 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        polymerisation monomer 74
          2-hydroxyethyl methacrylate 38
Path 2
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          alpha,beta-unsaturated monocarboxylic acid 12218
                                            acrylic acid 5905
                                              methacrylic acid 82
                                                2-hydroxyethyl methacrylate 38
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