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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxyethyl methacrylate
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Accession:CHEBI:34288 term browser browse the term
Definition:An enoate ester that is the monomethacryloyl derivative of ethylene glycol.
Synonyms:related_synonym: 1,2-Ethanediol mono(2-methyl)-2-propenoate;   2-(Methacryloyloxy)ethanol;   2-Hydroxyethyl 2-methylacrylate;   2-Hydroxyethylmethacrylate;   Ethylene glycol methacrylate;   Ethylene glycol monomethacrylate;   Formula=C6H10O3;   Glycol methacrylate;   Glycol monomethacrylate;   HEMA;   Hydroxyethyl methacrylate;   InChI=1S/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3;   InChIKey=WOBHKFSMXKNTIM-UHFFFAOYSA-N;   SMILES=CC(=C)C(=O)OCCO;   beta-Hydroxyethyl methacrylate
 alt_id: CHEBI:53441
 xref: CAS:868-77-9;   Gmelin:936557;   KEGG:C14530
 xref_mesh: MESH:C005044
 xref: PMID:10444249;   PMID:11714252;   PMID:15186380;   PMID:22886489;   PMID:22889382;   PMID:23137186;   PMID:23157270;   PMID:23182953;   PMID:23275084;   PMID:23305206;   PMID:23360228;   PMID:23370864;   PMID:23399173;   PMID:23466546;   PMID:23516576;   PMID:23587005;   PMID:23611114;   PMID:23670604;   PMID:23673616;   Reaxys:1071583;   Wikipedia:(Hydroxyethyl)methacrylate


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2-hydroxyethyl methacrylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO hydroxyethyl methacrylate results in increased expression of ADM mRNA CTD PMID:30497689 NCBI chr 1:174,164,178...174,182,372 JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C2 mRNA CTD PMID:30497689 NCBI chr17:70,669,684...70,717,935 JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases expression ISO hydroxyethyl methacrylate results in increased expression of AKR1C3 mRNA CTD PMID:30497689 NCBI chr17:71,020,884...71,037,779 JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression ISO hydroxyethyl methacrylate results in increased expression of ALDH3A2 mRNA CTD PMID:30497689 NCBI chr10:46,427,789...46,448,449 JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 ISO hydroxyethyl methacrylate results in increased expression of ATG5 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]		 CTD PMID:28184909 NCBI chr20:49,380,835...49,471,826 JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 ISO hydroxyethyl methacrylate results in increased expression of BECN1 mRNA; hydroxyethyl methacrylate results in increased expression of BECN1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]		 CTD PMID:28184909 NCBI chr10:86,731,649...86,747,002 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO hydroxyethyl methacrylate results in increased activity of CASP3 protein
Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased activity of CASP3 protein]		 CTD PMID:33248029 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp9 caspase 9 multiple interactions
increases expression		 ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA] CTD PMID:28184909
G Cat catalase multiple interactions ISO Ascorbic Acid inhibits the reaction [hydroxyethyl methacrylate results in increased degradation of CAT mRNA]; hydroxyethyl methacrylate results in increased expression of and results in increased degradation of CAT mRNA CTD PMID:33248029 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO hydroxyethyl methacrylate results in decreased expression of COL1A1 mRNA; hydroxyethyl methacrylate results in decreased expression of COL1A1 protein CTD PMID:20668299 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO hydroxyethyl methacrylate results in decreased expression of CXCL12 protein CTD PMID:30517439 NCBI chr 4:152,060,781...152,073,628 JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO hydroxyethyl methacrylate results in increased expression of DNAJB4 mRNA CTD PMID:30497689 NCBI chr 2:243,790,296...243,819,042 JBrowse link
G Fbxo30 F-box protein 30 increases expression ISO hydroxyethyl methacrylate results in increased expression of FBXO30 mRNA CTD PMID:30497689 NCBI chr 1:5,655,341...5,671,558 JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
increases secretion		 ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of FGF2 protein] CTD PMID:19176594 NCBI chr 2:122,164,454...122,218,796 JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of FTH1 mRNA CTD PMID:30497689 NCBI chr 1:216,052,037...216,054,325 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLC mRNA; hydroxyethyl methacrylate results in increased expression of GCLC protein CTD PMID:30497689 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO hydroxyethyl methacrylate results in increased expression of GCLM mRNA; hydroxyethyl methacrylate results in increased expression of GCLM protein CTD PMID:30497689 NCBI chr 2:213,032,135...213,052,192 JBrowse link
G H2ax H2A.X variant histone increases expression ISO hydroxyethyl methacrylate results in increased expression of H2AX protein CTD PMID:37778984 NCBI chr 8:53,568,718...53,570,072 JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of HMOX1 mRNA; hydroxyethyl methacrylate results in increased expression of HMOX1 protein CTD PMID:30497689 PMID:33248029 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1A mRNA CTD PMID:30497689 NCBI chr20:3,875,411...3,877,866 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO hydroxyethyl methacrylate results in increased expression of HSPA1B mRNA CTD PMID:30497689 NCBI chr20:3,859,756...3,863,800 JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases secretion		 ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in increased secretion of IL1A protein] CTD PMID:37778984 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; hydroxyethyl methacrylate promotes the reaction [triethylene glycol dimethacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; triethylene glycol dimethacrylate promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]] CTD PMID:23182953 PMID:28188892 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydroxyethyl methacrylate results in decreased secretion of IL6 protein CTD PMID:19176594 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Ldha lactate dehydrogenase A increases activity ISO hydroxyethyl methacrylate results in increased activity of LDHA protein CTD PMID:37778984 NCBI chr 1:97,371,823...97,381,247 JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA; hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased expression of MAP1LC3B protein]		 CTD PMID:28184909 NCBI chr19:66,571,631...66,582,270 JBrowse link
G Map3k14 mitogen-activated protein kinase kinase kinase 14 increases expression ISO hydroxyethyl methacrylate results in increased expression of MAP3K14 mRNA CTD PMID:30497689 NCBI chr10:88,665,417...88,715,669 JBrowse link
G Mrpl19 mitochondrial ribosomal protein L19 increases expression ISO hydroxyethyl methacrylate results in increased expression of MRPL19 mRNA CTD PMID:30497689 NCBI chr 4:114,521,824...114,526,053 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO hydroxyethyl methacrylate results in increased expression of NFE2L2 protein CTD PMID:30497689 PMID:37778984 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkbia NFKB inhibitor alpha increases response to substance
multiple interactions		 ISO NFKBIA protein results in increased susceptibility to hydroxyethyl methacrylate
NFKBIA protein affects the reaction [Acetylcysteine results in decreased susceptibility to hydroxyethyl methacrylate]		 CTD PMID:19176594 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of NQO1 mRNA; hydroxyethyl methacrylate results in increased expression of NQO1 protein CTD PMID:30497689 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of OSGIN1 mRNA CTD PMID:30497689 NCBI chr19:47,471,750...47,500,517 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [hydroxyethyl methacrylate results in increased cleavage of PARP1 protein] CTD PMID:28184909 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein]; hydroxyethyl methacrylate affects the localization of and results in decreased activity of RELA protein; hydroxyethyl methacrylate affects the localization of and results in increased phosphorylation of and results in increased activity of RELA protein; hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:19176594 PMID:28184909 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SPSB1 mRNA CTD PMID:30497689 NCBI chr 5:160,358,292...160,418,541 JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SQSTM1 mRNA; hydroxyethyl methacrylate results in increased expression of SQSTM1 protein CTD PMID:30497689 NCBI chr10:35,026,598...35,037,750 JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of SRXN1 mRNA CTD PMID:30497689 NCBI chr 3:161,064,812...161,070,372 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hydroxyethyl methacrylate inhibits the reaction [TNF protein results in increased activity of RELA protein]
hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; hydroxyethyl methacrylate promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD PMID:19176594 PMID:23182953 PMID:28188892 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO hydroxyethyl methacrylate results in increased expression of TXNRD1 mRNA CTD PMID:30497689 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Ugdh UDP-glucose 6-dehydrogenase increases expression ISO hydroxyethyl methacrylate results in increased expression of UGDH mRNA CTD PMID:30497689 NCBI chr14:43,202,480...43,226,002 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases secretion		 ISO Acetylcysteine inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein]; pyrazolanthrone inhibits the reaction [hydroxyethyl methacrylate results in decreased secretion of VEGFA protein] CTD PMID:19176594 NCBI chr 9:22,452,854...22,468,194 JBrowse link
Term paths to the root
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  CHEBI ontology 19898
    role 19869
      chemical role 19500
        polymerisation monomer 72
          2-hydroxyethyl methacrylate 41
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            heteroorganic entity 19535
                              organochalcogen compound 19296
                                organooxygen compound 19213
                                  carbon oxoacid 18682
                                    carboxylic acid 18679
                                      monocarboxylic acid 18028
                                        alpha,beta-unsaturated monocarboxylic acid 13474
                                          acrylic acid 6159
                                            methacrylic acid 359
                                              2-hydroxyethyl methacrylate 41
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