CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: oxybenzone
Accession: CHEBI:34283
browse the term
Definition: A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.
Synonyms: exact_synonym: (2-hydroxy-4-methoxyphenyl)(phenyl)methanone
related_synonym: 2-Benzoyl-5-methoxyphenol; 2-Hydroxy-4-methoxybenzophenone; 4-Methoxy-2-hydroxybenzophenone; Benzophenone-3; Formula=C14H12O3; InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3; InChIKey=DXGLGDHPHMLXJC-UHFFFAOYSA-N; SMILES=COc1ccc(C(=O)c2ccccc2)c(O)c1; oxibenzona; oxybenzonum
alt_id: CHEBI:569732
xref: CAS:131-57-7; DrugBank:DB01428; Drug_Central:3412; HMDB:HMDB0015497; KEGG:C14285; KEGG:D05309; LINCS:LSM-3309
xref_mesh: MESH:C005290
xref: PMID:11169173; PMID:22721600; PMID:26118430; PMID:26167727; PMID:26295590; PMID:26487337; PMID:26589946; PMID:26686077; PMID:26736174; PMID:27085067; PMID:27544106; PMID:27796700; PMID:28192168; Patent:US2773903; Patent:US2861104; Patent:US2861105; Patent:US3073866; Reaxys:1913145; Wikipedia:Oxybenzone
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Acad10
acyl-CoA dehydrogenase family, member 10
increases expression
EXP
oxybenzone results in increased expression of ACAD10 mRNA
CTD
PMID:30316929
NCBI chr12:34,901,211...34,943,973
Ensembl chr12:34,901,219...34,982,521
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Acad9
acyl-CoA dehydrogenase family, member 9
increases expression
EXP
oxybenzone results in increased expression of ACAD9 mRNA
CTD
PMID:30316929
NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
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Acbd3
acyl-CoA binding domain containing 3
decreases expression
EXP
oxybenzone results in decreased expression of ACBD3 mRNA
CTD
PMID:30316929
NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
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Aco2
aconitase 2
affects expression
EXP
oxybenzone affects the expression of ACO2 mRNA
CTD
PMID:30316929
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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Acot2
acyl-CoA thioesterase 2
increases expression
EXP
oxybenzone results in increased expression of ACOT2 mRNA
CTD
PMID:30316929
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acox1
acyl-CoA oxidase 1
increases expression
EXP
oxybenzone results in increased expression of ACOX1 mRNA
CTD
PMID:30316929
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Acsl5
acyl-CoA synthetase long-chain family member 5
decreases expression
EXP
oxybenzone results in decreased expression of ACSL5 mRNA
CTD
PMID:30316929
NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
EXP
oxybenzone results in increased expression of ACSS2 mRNA
CTD
PMID:30316929
NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
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Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]
CTD
PMID:32407875 PMID:34864131
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adprhl1
ADP-ribosylhydrolase like 1
affects expression
EXP
oxybenzone affects the expression of ADPRHL1 mRNA
CTD
PMID:30316929
NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440
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Ahr
aryl hydrocarbon receptor
decreases expression increases expression
EXP
oxybenzone results in decreased expression of AHR mRNA oxybenzone results in increased expression of AHR protein
CTD
PMID:15458797 PMID:30099065
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aif1
allograft inflammatory factor 1
increases expression
EXP
oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein
CTD
PMID:31368502
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Akt3
AKT serine/threonine kinase 3
increases expression
ISO
oxybenzone results in increased expression of AKT3 mRNA
CTD
PMID:36581016
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Angpt1
angiopoietin 1
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT1 mRNA
CTD
PMID:38387520
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Angpt2
angiopoietin 2
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPT2 mRNA
CTD
PMID:38387520
NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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Angpt4
angiopoietin 4
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of ANGPT4 mRNA
CTD
PMID:38387520
NCBI chr 3:140,420,389...140,454,213
Ensembl chr 3:140,420,389...140,453,583
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Angptl4
angiopoietin-like 4
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of ANGPTL4 mRNA
CTD
PMID:38387520
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Apc
APC regulator of WNT signaling pathway
increases expression
ISO
oxybenzone results in increased expression of APC mRNA
CTD
PMID:36581016
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Apoc3
apolipoprotein C3
increases expression
EXP
oxybenzone results in increased expression of APOC3 mRNA
CTD
PMID:30316929
NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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Apol2
apolipoprotein L2
increases expression
EXP
oxybenzone results in increased expression of APOL2 mRNA
CTD
PMID:30316929
NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558
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Aqp1
aquaporin 1
decreases expression
EXP
oxybenzone results in decreased expression of AQP1 mRNA
CTD
PMID:30316929
NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
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Ar
androgen receptor
multiple interactions affects localization
ISO EXP
oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] oxybenzone affects the localization of AR protein
CTD
PMID:12730620 PMID:15537743 PMID:15950433 PMID:30099065 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Areg
amphiregulin
increases expression decreases expression
ISO
oxybenzone results in increased expression of AREG mRNA oxybenzone results in decreased expression of AREG mRNA
CTD
PMID:31939680 PMID:38382712
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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Atf2
activating transcription factor 2
increases expression
ISO
oxybenzone results in increased expression of ATF2 mRNA
CTD
PMID:36581016
NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
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Atg2b
autophagy related 2B
increases expression
ISO
oxybenzone results in increased expression of ATG2B mRNA
CTD
PMID:36581016
NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
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Atm
ATM serine/threonine kinase
increases expression
ISO
oxybenzone results in increased expression of ATM mRNA
CTD
PMID:36581016
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atp5f1a
ATP synthase F1 subunit alpha
increases expression
EXP
oxybenzone results in increased expression of ATP5F1A mRNA
CTD
PMID:30316929
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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Atp5f1b
ATP synthase F1 subunit beta
increases expression
EXP
oxybenzone results in increased expression of ATP5F1B mRNA
CTD
PMID:30316929
NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
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Atp5f1c
ATP synthase F1 subunit gamma
increases expression
EXP
oxybenzone results in increased expression of ATP5F1C mRNA
CTD
PMID:30316929
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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Atp5mc2
ATP synthase membrane subunit c locus 2
decreases expression
EXP
oxybenzone results in decreased expression of ATP5MC2 mRNA
CTD
PMID:30316929
NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
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Atr
ATR serine/threonine kinase
increases expression
ISO
oxybenzone results in increased expression of ATR mRNA
CTD
PMID:36581016
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Bad
BCL2-associated agonist of cell death
increases expression
EXP
oxybenzone results in increased expression of BAD mRNA
CTD
PMID:30316929
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bak1
BCL2-antagonist/killer 1
increases expression
EXP
oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein
CTD
PMID:30099065 PMID:30316929
NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
increases expression
EXP
oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein
CTD
PMID:30099065 PMID:30316929
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
decreases expression
EXP
oxybenzone results in decreased expression of BCL2L1 mRNA
CTD
PMID:30316929
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bcs1l
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
increases expression
EXP
oxybenzone results in increased expression of BCS1L mRNA
CTD
PMID:30316929
NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938
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Blm
BLM RecQ like helicase
increases expression
ISO
oxybenzone results in increased expression of BLM mRNA
CTD
PMID:36581016
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Brca1
BRCA1, DNA repair associated
increases expression
ISO
oxybenzone results in increased expression of BRCA1 mRNA
CTD
PMID:36581016
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
increases expression
ISO
oxybenzone results in increased expression of CACNA2D1 mRNA
CTD
PMID:36581016
NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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Casp1
caspase 1
decreases expression
EXP
oxybenzone results in decreased expression of CASP1 mRNA
CTD
PMID:30316929
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp2
caspase 2
increases expression
EXP
oxybenzone results in increased expression of CASP2 mRNA
CTD
PMID:30316929
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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Casp3
caspase 3
increases activity multiple interactions
EXP
oxybenzone results in increased activity of CASP3 protein oxybenzone results in increased expression of and results in increased activity of CASP3 protein
CTD
PMID:30099065 PMID:31368502
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4
caspase 4
decreases expression
EXP
oxybenzone results in decreased expression of CASP4 mRNA
CTD
PMID:30316929
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp9
caspase 9
increases activity increases expression
EXP
oxybenzone results in increased activity of CASP9 protein oxybenzone results in increased expression of CASP9 mRNA
CTD
PMID:30099065 PMID:30316929
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl21
C-C motif chemokine ligand 21
decreases expression
EXP
oxybenzone results in decreased expression of CCL21 mRNA
CTD
PMID:30316929
NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
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Ccne2
cyclin E2
increases expression
ISO
oxybenzone results in increased expression of CCNE2 mRNA
CTD
PMID:36581016
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
increases expression
ISO
oxybenzone results in increased expression of CHUK mRNA
CTD
PMID:36581016
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Cited4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
increases expression
EXP
oxybenzone results in increased expression of CITED4 mRNA
CTD
PMID:30316929
NCBI chr 5:134,246,936...134,247,827
Ensembl chr 5:134,246,682...134,248,135
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Cox15
cytochrome c oxidase assembly homolog COX15
increases expression
EXP
oxybenzone results in increased expression of COX15 mRNA
CTD
PMID:30316929
NCBI chr 1:242,605,588...242,622,279
Ensembl chr 1:242,605,588...242,622,261
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Cox16
cytochrome c oxidase assembly factor COX16
decreases expression
EXP
oxybenzone results in decreased expression of COX16 mRNA
CTD
PMID:30316929
NCBI chr 6:101,162,231...101,181,277
Ensembl chr 6:101,019,680...101,181,246
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Cox17
cytochrome c oxidase copper chaperone COX17
increases expression
EXP
oxybenzone results in increased expression of COX17 mRNA
CTD
PMID:30316929
NCBI chr11:62,400,733...62,406,507
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Cox18
cytochrome c oxidase assembly factor COX18
increases expression
EXP
oxybenzone results in increased expression of COX18 mRNA
CTD
PMID:30316929
NCBI chr14:17,864,581...17,877,483
Ensembl chr14:17,865,857...17,877,480
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Cox5a
cytochrome c oxidase subunit 5A
increases expression
EXP
oxybenzone results in increased expression of COX5A mRNA
CTD
PMID:30316929
NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
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Cox6b2
cytochrome c oxidase subunit 6B2
decreases expression
EXP
oxybenzone results in decreased expression of COX6B2 mRNA
CTD
PMID:30316929
NCBI chr 1:69,094,009...69,095,312
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Cox7a2
cytochrome c oxidase subunit 7A2
decreases expression
EXP
oxybenzone results in decreased expression of COX7A2 mRNA
CTD
PMID:30316929
NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633 Ensembl chr 8:51,301,168...51,301,633
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Cpt1b
carnitine palmitoyltransferase 1B
increases expression
EXP
oxybenzone results in increased expression of CPT1B mRNA
CTD
PMID:30316929
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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Cpt2
carnitine palmitoyltransferase 2
increases expression
EXP
oxybenzone results in increased expression of CPT2 mRNA
CTD
PMID:30316929
NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
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Cpxm2
carboxypeptidase X (M14 family), member 2
decreases expression
EXP
oxybenzone results in decreased expression of CPXM2 mRNA
CTD
PMID:30316929
NCBI chr 1:186,836,797...186,947,222
Ensembl chr 1:186,836,797...186,947,220
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Creb1
cAMP responsive element binding protein 1
increases expression
ISO
oxybenzone results in increased expression of CREB1 mRNA
CTD
PMID:36581016
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Csn2
casein beta
increases expression decreases methylation
ISO
oxybenzone results in increased expression of CSN2 mRNA; oxybenzone results in increased expression of CSN2 protein oxybenzone results in decreased methylation of CSN2 promoter
CTD
PMID:32946892
NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817
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Cstl1
cystatin-like 1
decreases expression
EXP
oxybenzone results in decreased expression of CSTL1 mRNA
CTD
PMID:30316929
NCBI chr 3:136,199,914...136,204,912
Ensembl chr 3:136,199,914...136,204,912
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Cybrd1
cytochrome b reductase 1
increases expression
EXP
oxybenzone results in increased expression of CYBRD1 mRNA
CTD
PMID:30316929
NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
increases expression
EXP
oxybenzone results in increased expression of CYP19A1 mRNA
CTD
PMID:30599193
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp24a1
cytochrome P450, family 24, subfamily a, polypeptide 1
decreases expression
EXP
oxybenzone results in decreased expression of CYP24A1 mRNA
CTD
PMID:30316929
NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383
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Cyp26c1
cytochrome P450, family 26, subfamily C, polypeptide 1
increases expression
EXP
oxybenzone results in increased expression of CYP26C1 mRNA
CTD
PMID:30316929
NCBI chr 1:235,458,961...235,468,433
Ensembl chr 1:235,459,356...235,466,842
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Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
increases expression
EXP
oxybenzone results in increased expression of CYP27B1 mRNA
CTD
PMID:30316929
NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases expression
EXP
oxybenzone results in decreased expression of CYP2B3 mRNA
CTD
PMID:30316929
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2d3
cytochrome P450, family 2, subfamily d, polypeptide 3
increases expression
EXP
oxybenzone results in increased expression of CYP2D3 mRNA
CTD
PMID:30316929
NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
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Cyp4a3
cytochrome P450, family 4, subfamily a, polypeptide 3
decreases expression
EXP
oxybenzone results in decreased expression of CYP4A3 mRNA
CTD
PMID:30316929
NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463
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Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
increases expression
EXP
oxybenzone results in increased expression of CYP4F18 mRNA
CTD
PMID:30316929
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression
EXP
oxybenzone results in increased expression of CYP7A1 mRNA
CTD
PMID:30316929
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Dap
death-associated protein
decreases expression
EXP
oxybenzone results in decreased expression of DAP mRNA
CTD
PMID:30316929
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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Dapk3
death-associated protein kinase 3
increases expression
EXP
oxybenzone results in increased expression of DAPK3 mRNA
CTD
PMID:30316929
NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558
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Daxx
death-domain associated protein
increases expression increases methylation
EXP ISO
oxybenzone results in increased expression of DAXX mRNA oxybenzone results in increased methylation of DAXX gene
CTD
PMID:30316929 PMID:34523531
NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
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Dedd
death effector domain-containing
increases expression
EXP
oxybenzone results in increased expression of DEDD mRNA
CTD
PMID:30316929
NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
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Dffa
DNA fragmentation factor subunit alpha
increases expression
EXP
oxybenzone results in increased expression of DFFA mRNA
CTD
PMID:30316929
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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Dhodh
dihydroorotate dehydrogenase
increases expression
EXP
oxybenzone results in increased expression of DHODH mRNA
CTD
PMID:30316929
NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
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Dld
dihydrolipoamide dehydrogenase
increases expression
ISO
oxybenzone results in increased expression of DLD mRNA
CTD
PMID:36581016
NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
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Dlst
dihydrolipoamide S-succinyltransferase
increases expression
EXP
oxybenzone results in increased expression of DLST mRNA
CTD
PMID:30316929
NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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Dlx3
distal-less homeobox 3
affects expression
EXP
oxybenzone affects the expression of DLX3 mRNA
CTD
PMID:30316929
NCBI chr10:80,064,489...80,069,891
Ensembl chr10:80,064,489...80,069,872
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Dmtf1
cyclin D binding myb-like transcription factor 1
increases expression
ISO
oxybenzone results in increased expression of DMTF1 mRNA
CTD
PMID:36581016
NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967
G
Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
decreases expression
EXP
oxybenzone results in decreased expression of DNAJC15 mRNA
CTD
PMID:30316929
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
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Echs1
enoyl-CoA hydratase, short chain 1
increases expression
EXP
oxybenzone results in increased expression of ECHS1 mRNA
CTD
PMID:30316929
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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Eif4e
eukaryotic translation initiation factor 4E
increases expression
ISO
oxybenzone results in increased expression of EIF4E mRNA
CTD
PMID:36581016
NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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Esr1
estrogen receptor 1
decreases expression multiple interactions increases expression
EXP ISO
oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein oxybenzone binds to and results in increased activity of ESR1 protein; oxybenzone promotes the reaction [ESR1 protein binds to ESR1 protein] oxybenzone results in increased expression of ESR1 mRNA
CTD
PMID:15458797 PMID:16079615 PMID:30099065 PMID:32946892 PMID:33049310 PMID:37696476 More...
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions decreases expression affects expression
ISO EXP
oxybenzone binds to and results in increased activity of ESR2 protein oxybenzone results in decreased expression of ESR2 mRNA oxybenzone affects the expression of ESR2 protein
CTD
PMID:16079615 PMID:30099065 PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Esrra
estrogen related receptor, alpha
decreases expression
EXP
oxybenzone results in decreased expression of ESRRA mRNA
CTD
PMID:15458797
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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Fabp4
fatty acid binding protein 4
multiple interactions
ISO
oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]
CTD
PMID:32407875 PMID:34864131
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Fam180a
family with sequence similarity 180, member A
decreases expression
EXP
oxybenzone results in decreased expression of FAM180A mRNA
CTD
PMID:30316929
NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047
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Fgf2
fibroblast growth factor 2
increases expression
ISO
oxybenzone results in increased expression of FGF2 mRNA
CTD
PMID:36581016
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Flg
filaggrin
affects response to substance multiple interactions
ISO
FLG gene mutant form affects the susceptibility to oxybenzone [FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone
CTD
PMID:30245359
NCBI chr 2:178,884,793...178,912,986
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Fn1
fibronectin 1
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of FN1 mRNA
CTD
PMID:38387520
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Foxl2
forkhead box L2
increases expression multiple interactions
EXP
oxybenzone results in increased expression of FOXL2 mRNA 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA]
CTD
PMID:30599193
NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427
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Frzb
frizzled-related protein
decreases expression
EXP
oxybenzone results in decreased expression of FRZB mRNA
CTD
PMID:30316929
NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
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Fshb
follicle stimulating hormone subunit beta
multiple interactions
ISO
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein
CTD
PMID:30245359
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Fst
follistatin
increases expression
EXP
oxybenzone results in increased expression of FST mRNA
CTD
PMID:30599193
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
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Garin1a
golgi associated RAB2 interactor 1A
decreases expression
EXP
oxybenzone results in decreased expression of GARIN1A mRNA
CTD
PMID:30316929
NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820
G
Garin3
golgi associated RAB2 interactor family member 3
decreases expression
EXP
oxybenzone results in decreased expression of GARIN3 mRNA
CTD
PMID:30316929
NCBI chr10:30,829,877...30,833,115
Ensembl chr10:30,829,877...30,833,111
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Gper1
G protein-coupled estrogen receptor 1
affects expression
EXP
oxybenzone affects the expression of GPER1 protein
CTD
PMID:30099065
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
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Greb1
growth regulating estrogen receptor binding 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of GREB1 mRNA]
CTD
PMID:33405908
NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
affects expression
EXP
oxybenzone affects the expression of GRIN1 protein
CTD
PMID:31368502
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
affects expression
EXP
oxybenzone affects the expression of GRIN2A protein
CTD
PMID:31368502
NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
G
Gsta2
glutathione S-transferase alpha 2
decreases expression
EXP
oxybenzone results in decreased expression of GSTA2 mRNA
CTD
PMID:30316929
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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Gsta5
glutathione S-transferase alpha 5
decreases expression
EXP
oxybenzone results in decreased expression of GSTA5 mRNA
CTD
PMID:30316929
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
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Gstm1
glutathione S-transferase mu 1
increases expression
EXP
oxybenzone results in increased expression of GSTM1 mRNA
CTD
PMID:30316929
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
increases expression
EXP
oxybenzone results in increased expression of GSTP1 mRNA
CTD
PMID:30316929
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gstt2
glutathione S-transferase theta 2
increases expression
EXP
oxybenzone results in increased expression of GSTT2 mRNA
CTD
PMID:30316929
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
G
Gstt4
glutathione S-transferase, theta 4
decreases expression
EXP
oxybenzone results in decreased expression of GSTT4 mRNA
CTD
PMID:30316929
NCBI chr20:12,835,178...12,842,306
Ensembl chr20:12,835,178...12,842,292
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Gzmb
granzyme B
decreases expression
ISO
oxybenzone results in decreased expression of GZMB mRNA
CTD
PMID:38431166
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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H2ax
H2A.X variant histone
increases expression multiple interactions
ISO
oxybenzone results in increased expression of H2AX protein modified form Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]
CTD
PMID:31939680
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
decreases expression
EXP
oxybenzone results in decreased expression of HADHA mRNA
CTD
PMID:30316929
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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Hdac1
histone deacetylase 1
increases expression
EXP
oxybenzone results in increased expression of HDAC1 protein
CTD
PMID:31368502
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
G
Hdac2
histone deacetylase 2
increases expression
EXP
oxybenzone results in increased expression of HDAC2 protein
CTD
PMID:31368502
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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Hdac9
histone deacetylase 9
increases expression
ISO
oxybenzone results in increased expression of HDAC9 mRNA
CTD
PMID:36581016
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
G
Hif1a
hypoxia inducible factor 1 subunit alpha
increases expression multiple interactions
ISO
oxybenzone results in increased expression of HIF1A mRNA [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of HIF1A mRNA
CTD
PMID:36581016 PMID:38387520
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hltf
helicase-like transcription factor
increases expression
ISO
oxybenzone results in increased expression of HLTF mRNA
CTD
PMID:36581016
NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
increases expression
ISO
oxybenzone results in increased expression of HMGCR mRNA
CTD
PMID:32407875
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
oxybenzone results in increased expression of HMGCS1 mRNA
CTD
PMID:32407875
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
decreases expression
EXP
oxybenzone results in decreased expression of HMGCS2 mRNA
CTD
PMID:30316929
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hsd17b10
hydroxysteroid (17-beta) dehydrogenase 10
decreases expression
EXP
oxybenzone results in decreased expression of HSD17B10 mRNA
CTD
PMID:30316929
NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
decreases activity
EXP
oxybenzone results in decreased activity of HSD3B2 protein
CTD
PMID:37217011
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Hsdl2
hydroxysteroid dehydrogenase like 2
decreases expression
EXP
oxybenzone results in decreased expression of HSDL2 mRNA
CTD
PMID:30316929
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
G
Hsp90aa1
heat shock protein 90 alpha family class A member 1
increases expression
ISO
oxybenzone results in increased expression of HSP90AA1 mRNA
CTD
PMID:36581016
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
G
Hykk
hydroxylysine kinase
increases expression
EXP
oxybenzone results in increased expression of HYKK mRNA
CTD
PMID:30316929
NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
G
Icam1
intercellular adhesion molecule 1
multiple interactions decreases expression
ISO
bisphenol A inhibits the reaction [oxybenzone results in decreased expression of ICAM1 mRNA]
CTD
PMID:38431166
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
decreases expression
EXP
oxybenzone results in decreased expression of IDH2 mRNA
CTD
PMID:30316929
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
G
Idh3g
isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma
increases expression
EXP
oxybenzone results in increased expression of IDH3G mRNA
CTD
PMID:30316929
NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171
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Il19
interleukin 19
increases expression
EXP
oxybenzone results in increased expression of IL19 mRNA
CTD
PMID:30316929
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
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Ins1
insulin 1
multiple interactions
ISO
oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]
CTD
PMID:32407875
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Ins2
insulin 2
multiple interactions
ISO
oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]
CTD
PMID:34864131
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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Iqcf6
IQ motif containing F6
decreases expression
EXP
oxybenzone results in decreased expression of IQCF6 mRNA
CTD
PMID:30316929
NCBI chr 8:107,263,673...107,264,726
Ensembl chr 8:107,263,654...107,264,724
G
Itga4
integrin subunit alpha 4
increases expression
ISO
oxybenzone results in increased expression of ITGA4 mRNA
CTD
PMID:36581016
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
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Kras
KRAS proto-oncogene, GTPase
increases expression
ISO
oxybenzone results in increased expression of KRAS mRNA
CTD
PMID:36581016
NCBI chr 4:178,185,418...178,218,484
G
Krt18
keratin 18
decreases expression
EXP
oxybenzone results in decreased expression of KRT18 mRNA
CTD
PMID:30316929
NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166 Ensembl chr10:133,157,475...133,161,166
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Lck
LCK proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
oxybenzone results in decreased expression of LCK mRNA
CTD
PMID:36581016
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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Ldhd
lactate dehydrogenase D
increases methylation
ISO
oxybenzone results in increased methylation of LDHD gene
CTD
PMID:34523531
NCBI chr19:39,583,529...39,588,397
Ensembl chr19:39,573,621...39,595,575
G
Lef1
lymphoid enhancer binding factor 1
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of LEF1 mRNA
CTD
PMID:38387520
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
G
Lifr
LIF receptor subunit alpha
increases expression
ISO
oxybenzone results in increased expression of LIFR mRNA
CTD
PMID:36581016
NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
G
Lsmem1
leucine-rich single-pass membrane protein 1
increases expression
EXP
oxybenzone results in increased expression of LSMEM1 mRNA
CTD
PMID:30316929
NCBI chr 6:57,251,720...57,261,590
Ensembl chr 6:57,252,056...57,261,653
G
Magel2
MAGE family member L2
increases expression
EXP
oxybenzone results in increased expression of MAGEL2 mRNA
CTD
PMID:30316929
NCBI chr 1:115,880,142...115,884,684
Ensembl chr 1:115,880,474...115,884,250
G
Mapk6
mitogen-activated protein kinase 6
increases expression
ISO
oxybenzone results in increased expression of MAPK6 mRNA
CTD
PMID:36581016
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
G
Mcc
MCC regulator of WNT signaling pathway
decreases expression
EXP
oxybenzone results in decreased expression of MCC mRNA
CTD
PMID:30316929
NCBI chr18:36,794,206...37,266,237
Ensembl chr18:36,798,372...37,266,819
G
Med13
mediator complex subunit 13
increases expression
ISO
oxybenzone results in increased expression of MED13 mRNA
CTD
PMID:36581016
NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242
G
Medag
mesenteric estrogen-dependent adipogenesis
decreases expression
EXP
oxybenzone results in decreased expression of MEDAG mRNA
CTD
PMID:30316929
NCBI chr12:5,613,191...5,634,583
Ensembl chr12:5,613,208...5,634,767
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Mre11
MRE11 homolog, double strand break repair nuclease
increases expression
ISO
oxybenzone results in increased expression of MRE11 mRNA
CTD
PMID:36581016
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
G
Msh2
mutS homolog 2
increases expression
ISO
oxybenzone results in increased expression of MSH2 mRNA
CTD
PMID:36581016
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
G
Mybl1
MYB proto-oncogene like 1
increases expression multiple interactions
ISO
oxybenzone results in increased expression of MYBL1 mRNA Fulvestrant inhibits the reaction [oxybenzone results in increased expression of MYBL1 mRNA]
CTD
PMID:33405908
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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Nbn
nibrin
increases expression
ISO
oxybenzone results in increased expression of NBN mRNA
CTD
PMID:36581016
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions increases expression
ISO
oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] oxybenzone results in increased expression of NCOA2 mRNA
CTD
PMID:32407875 PMID:36581016
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
G
Ndufa11
NADH:ubiquinone oxidoreductase subunit A11
decreases expression
EXP
oxybenzone results in decreased expression of NDUFA11 mRNA
CTD
PMID:30316929
NCBI chr 9:1,550,487...1,554,546
Ensembl chr 9:1,550,468...1,555,601
G
Ndufa3
NADH:ubiquinone oxidoreductase subunit A3
decreases expression
EXP
oxybenzone results in decreased expression of NDUFA3 mRNA
CTD
PMID:30316929
NCBI chr 1:65,597,567...65,600,197
Ensembl chr 1:65,597,578...65,600,235
G
Ndufa9
NADH:ubiquinone oxidoreductase subunit A9
increases expression
EXP
oxybenzone results in increased expression of NDUFA9 mRNA
CTD
PMID:30316929
NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018
G
Ndufab1
NADH:ubiquinone oxidoreductase subunit AB1
increases expression
EXP
oxybenzone results in increased expression of NDUFAB1 mRNA
CTD
PMID:30316929
NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
G
Ndufb10
NADH:ubiquinone oxidoreductase subunit B10
increases expression
EXP
oxybenzone results in increased expression of NDUFB10 mRNA
CTD
PMID:30316929
NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442
G
Ndufb7
NADH:ubiquinone oxidoreductase subunit B7
increases expression
EXP
oxybenzone results in increased expression of NDUFB7 mRNA
CTD
PMID:30316929
NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579
G
Ndufs2
NADH:ubiquinone oxidoreductase core subunit S2
decreases expression
EXP
oxybenzone results in decreased expression of NDUFS2 mRNA
CTD
PMID:30316929
NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
G
Ndufv3
NADH:ubiquinone oxidoreductase subunit V3
affects expression
EXP
oxybenzone affects the expression of NDUFV3 mRNA
CTD
PMID:30316929
NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 Ensembl chr13:9,612,431...9,623,074
G
Nf1
neurofibromin 1
increases expression
ISO
oxybenzone results in increased expression of NF1 mRNA
CTD
PMID:36581016
NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
G
Nfat5
nuclear factor of activated T-cells 5
increases expression
ISO
oxybenzone results in increased expression of NFAT5 mRNA
CTD
PMID:36581016
NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
oxybenzone binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
oxybenzone results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
increases expression
ISO
oxybenzone results in increased expression of NR3C1 mRNA
CTD
PMID:36581016
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrf1
nuclear respiratory factor 1
increases expression
EXP
oxybenzone results in increased expression of NRF1 mRNA
CTD
PMID:30316929
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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Nrip1
nuclear receptor interacting protein 1
increases expression
ISO
oxybenzone results in increased expression of NRIP1 mRNA
CTD
PMID:36581016
NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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Ntn5
netrin 5
increases expression
EXP
oxybenzone results in increased expression of NTN5 mRNA
CTD
PMID:30316929
NCBI chr 1:96,156,948...96,165,997
Ensembl chr 1:96,156,985...96,165,630
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Ogdh
oxoglutarate dehydrogenase
increases expression decreases expression
EXP
oxybenzone results in increased expression of OGDH mRNA oxybenzone results in decreased expression of OGDH mRNA
CTD
PMID:30316929
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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Pdcd11
programmed cell death 11
increases expression
EXP
oxybenzone results in increased expression of PDCD11 mRNA
CTD
PMID:30316929
NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999
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Pdcd6ip
programmed cell death 6 interacting protein
decreases expression
EXP
oxybenzone results in decreased expression of PDCD6IP mRNA
CTD
PMID:30316929
NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773
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Pdcd7
programmed cell death 7
increases expression
EXP
oxybenzone results in increased expression of PDCD7 mRNA
CTD
PMID:30316929
NCBI chr 8:65,862,606...65,877,333
Ensembl chr 8:65,862,387...65,877,333
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Pgr
progesterone receptor
multiple interactions increases expression decreases expression
ISO
oxybenzone binds to and results in decreased activity of PGR protein oxybenzone results in increased expression of PGR mRNA oxybenzone results in decreased expression of PGR mRNA
CTD
PMID:15537743 PMID:31939680 PMID:32946892 PMID:38382712 PMID:38431166
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phf24
PHD finger protein 24
increases expression
EXP
oxybenzone results in increased expression of PHF24 mRNA
CTD
PMID:30316929
NCBI chr 5:57,143,428...57,171,054
Ensembl chr 5:57,142,632...57,168,497
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Pias1
protein inhibitor of activated STAT, 1
increases expression
ISO
oxybenzone results in increased expression of PIAS1 mRNA
CTD
PMID:36581016
NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
increases expression
ISO
oxybenzone results in increased expression of PIK3R1 mRNA
CTD
PMID:36581016
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Polm
DNA polymerase mu
decreases expression
EXP
oxybenzone results in decreased expression of POLM mRNA
CTD
PMID:30316929
NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086
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Ppara
peroxisome proliferator activated receptor alpha
increases expression
ISO
oxybenzone results in increased expression of PPARA mRNA
CTD
PMID:32407875
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Pparg
peroxisome proliferator-activated receptor gamma
affects binding increases expression multiple interactions
ISO
oxybenzone binds to PPARG protein oxybenzone results in increased expression of PPARG mRNA oxybenzone binds to and results in increased activity of PPARG protein; oxybenzone promotes the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
CTD
PMID:32407875 PMID:33049310 PMID:34864131
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppp1cb
protein phosphatase 1 catalytic subunit beta
increases expression
ISO
oxybenzone results in increased expression of PPP1CB mRNA
CTD
PMID:36581016
NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
increases expression
ISO
oxybenzone results in increased expression of PRKACB mRNA
CTD
PMID:36581016
NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198
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Prkci
protein kinase C, iota
increases expression
ISO
oxybenzone results in increased expression of PRKCI mRNA
CTD
PMID:36581016
NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
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Prss37
serine protease 37
decreases expression
EXP
oxybenzone results in decreased expression of PRSS37 mRNA
CTD
PMID:30316929
NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555
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Pten
phosphatase and tensin homolog
increases expression
ISO
oxybenzone results in increased expression of PTEN mRNA
CTD
PMID:36581016
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
oxybenzone results in increased expression of PTGS2 mRNA
CTD
PMID:36581016
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptpn4
protein tyrosine phosphatase, non-receptor type 4
increases expression
ISO
oxybenzone results in increased expression of PTPN4 mRNA
CTD
PMID:36581016
NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170
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Rad17
RAD17 checkpoint clamp loader component
increases expression
ISO
oxybenzone results in increased expression of RAD17 mRNA
CTD
PMID:36581016
NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
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Rad50
RAD50 double strand break repair protein
increases expression
ISO
oxybenzone results in increased expression of RAD50 mRNA
CTD
PMID:36581016
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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Rap2a
RAP2A, member of RAS oncogene family
increases expression
ISO
oxybenzone results in increased expression of RAP2A mRNA
CTD
PMID:36581016
NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138
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Rb1
RB transcriptional corepressor 1
increases expression
ISO
oxybenzone results in increased expression of RB1 mRNA
CTD
PMID:36581016
NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
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Rb1cc1
RB1-inducible coiled-coil 1
increases expression
ISO
oxybenzone results in increased expression of RB1CC1 mRNA
CTD
PMID:36581016
NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
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Rbbp8
RB binding protein 8, endonuclease
increases expression
ISO
oxybenzone results in increased expression of RBBP8 mRNA
CTD
PMID:36581016
NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
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Rbl1
RB transcriptional corepressor like 1
increases expression
ISO
oxybenzone results in increased expression of RBL1 mRNA
CTD
PMID:36581016
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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Rel
REL proto-oncogene, NF-kB subunit
increases expression
ISO
oxybenzone results in increased expression of REL mRNA
CTD
PMID:36581016
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
EXP
oxybenzone results in increased expression of RELA protein
CTD
PMID:31368502
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Retn
resistin
decreases expression
EXP
oxybenzone results in decreased expression of RETN mRNA
CTD
PMID:30316929
NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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Rfc1
replication factor C subunit 1
increases expression
ISO
oxybenzone results in increased expression of RFC1 mRNA
CTD
PMID:36581016
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
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Rictor
RPTOR independent companion of MTOR, complex 2
increases expression
ISO
oxybenzone results in increased expression of RICTOR mRNA
CTD
PMID:36581016
NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
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Rock1
Rho-associated coiled-coil containing protein kinase 1
increases expression
ISO
oxybenzone results in increased expression of ROCK1 mRNA
CTD
PMID:36581016
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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Rock2
Rho-associated coiled-coil containing protein kinase 2
increases expression
ISO
oxybenzone results in increased expression of ROCK2 mRNA
CTD
PMID:36581016
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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Rps6kb1
ribosomal protein S6 kinase B1
increases expression
ISO
oxybenzone results in increased expression of RPS6KB1 mRNA
CTD
PMID:36581016
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
oxybenzone results in increased expression of RRM2B mRNA
CTD
PMID:36581016
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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Sdha
succinate dehydrogenase complex flavoprotein subunit A
increases expression
EXP
oxybenzone results in increased expression of SDHA mRNA
CTD
PMID:30316929
NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
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Serpinc1
serpin family C member 1
increases expression
EXP
oxybenzone results in increased expression of SERPINC1 mRNA
CTD
PMID:30316929
NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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Sgk1
serum/glucocorticoid regulated kinase 1
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of SGK1 mRNA]
CTD
PMID:33405908
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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Sh3glb1
SH3 domain -containing GRB2-like endophilin B1
increases expression
EXP
oxybenzone results in increased expression of SH3GLB1 mRNA
CTD
PMID:30316929
NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784
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Shank1
SH3 and multiple ankyrin repeat domains 1
increases expression
EXP
oxybenzone results in increased expression of SHANK1 mRNA
CTD
PMID:30316929
NCBI chr 1:94,807,879...94,857,356
Ensembl chr 1:94,808,276...94,855,824
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Slc1a2
solute carrier family 1 member 2
affects expression
EXP
oxybenzone affects the expression of SLC1A2 protein
CTD
PMID:31368502
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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Slc7a11
solute carrier family 7 member 11
affects expression
EXP
oxybenzone affects the expression of SLC7A11 protein
CTD
PMID:31368502
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Smc3
structural maintenance of chromosomes 3
increases expression
ISO
oxybenzone results in increased expression of SMC3 mRNA
CTD
PMID:36581016
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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Sox9
SRY-box transcription factor 9
multiple interactions increases expression
EXP
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA]
CTD
PMID:30599193
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Sstr3
somatostatin receptor 3
increases expression
EXP
oxybenzone results in increased expression of SSTR3 mRNA
CTD
PMID:30316929
NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769
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Stag1
STAG1 cohesin complex component
increases expression
ISO
oxybenzone results in increased expression of STAG1 mRNA
CTD
PMID:36581016
NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
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Stat5a
signal transducer and activator of transcription 5A
increases expression affects localization
ISO
oxybenzone results in increased expression of STAT5A mRNA oxybenzone affects the localization of STAT5A protein
CTD
PMID:32946892
NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
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Sult1a1
sulfotransferase family 1A member 1
decreases expression
EXP
oxybenzone results in decreased expression of SULT1A1 mRNA
CTD
PMID:30316929
NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
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Taf9b
TATA-box binding protein associated factor 9b
increases expression
ISO
oxybenzone results in increased expression of TAF9B mRNA
CTD
PMID:36581016
NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604
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Tbk1
TANK-binding kinase 1
increases expression
ISO
oxybenzone results in increased expression of TBK1 mRNA
CTD
PMID:36581016
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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Tex46
testis expressed 46
decreases expression
EXP
oxybenzone results in decreased expression of TEX46 mRNA
CTD
PMID:30316929
NCBI chr 5:148,849,307...148,853,742
Ensembl chr 5:148,849,307...148,853,742
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Tfam
transcription factor A, mitochondrial
increases expression
EXP ISO
oxybenzone results in increased expression of TFAM mRNA
CTD
PMID:30316929 PMID:36581016
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Tff1
trefoil factor 1
multiple interactions increases expression
ISO
[oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA oxybenzone results in increased expression of TFF1 mRNA
CTD
PMID:16183391
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TGFB1 mRNA; [oxybenzone co-treated with Dietary Fats] results in decreased expression of TGFB1 mRNA
CTD
PMID:38387520
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tgfbr1
transforming growth factor, beta receptor 1
increases expression
ISO
oxybenzone results in increased expression of TGFBR1 mRNA
CTD
PMID:36581016
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
G
Timp1
TIMP metallopeptidase inhibitor 1
multiple interactions decreases expression
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 mRNA; [oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TIMP1 protein oxybenzone results in decreased expression of TIMP1 mRNA
CTD
PMID:38387520
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tmprss4
transmembrane serine protease 4
increases expression
EXP
oxybenzone results in increased expression of TMPRSS4 mRNA
CTD
PMID:30316929
NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
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Tnfsf11
TNF superfamily member 11
decreases expression
ISO
oxybenzone results in decreased expression of TNFSF11 mRNA
CTD
PMID:38382712
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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Topbp1
DNA topoisomerase II binding protein 1
increases expression
ISO
oxybenzone results in increased expression of TOPBP1 mRNA
CTD
PMID:36581016
NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
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Tp53
tumor protein p53
decreases expression
EXP
oxybenzone results in decreased expression of TP53 mRNA
CTD
PMID:30316929
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53bp1
tumor protein p53 binding protein 1
increases expression
ISO
oxybenzone results in increased expression of TP53BP1 protein
CTD
PMID:31939680
NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822
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Tpr
translocated promoter region, nuclear basket protein
increases expression
ISO
oxybenzone results in increased expression of TPR mRNA
CTD
PMID:36581016
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Tspo
translocator protein
decreases expression
EXP
oxybenzone results in decreased expression of TSPO mRNA
CTD
PMID:30316929
NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
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Twist1
twist family bHLH transcription factor 1
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of TWIST1 mRNA; [oxybenzone co-treated with Dietary Fats analog] results in decreased expression of TWIST1 mRNA
CTD
PMID:38387520
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
decreases expression
EXP
oxybenzone results in decreased expression of UGT1A6 mRNA
CTD
PMID:30316929
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2a3
UDP glucuronosyltransferase family 2 member A3
decreases expression
EXP
oxybenzone results in decreased expression of UGT2A3 mRNA
CTD
PMID:30316929
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
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Upk1b
uroplakin 1B
decreases expression
EXP
oxybenzone results in decreased expression of UPK1B mRNA
CTD
PMID:30316929
NCBI chr11:61,953,687...61,991,029
Ensembl chr11:61,953,648...61,991,029
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Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
affects expression
EXP
oxybenzone affects the expression of UQCR11 mRNA
CTD
PMID:30316929
NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
G
Uqcrc1
ubiquinol-cytochrome c reductase core protein 1
increases expression
EXP
oxybenzone results in increased expression of UQCRC1 mRNA
CTD
PMID:30316929
NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
G
Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
decreases expression
EXP
oxybenzone results in decreased expression of UQCRFS1 mRNA
CTD
PMID:30316929
NCBI chr17:33,977,908...33,982,478
Ensembl chr17:33,977,921...33,982,479
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Uqcrq
ubiquinol-cytochrome c reductase, complex III subunit VII
increases expression
EXP
oxybenzone results in increased expression of UQCRQ mRNA
CTD
PMID:30316929
NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169
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Vdac1
voltage-dependent anion channel 1
decreases expression
EXP
oxybenzone results in decreased expression of VDAC1 mRNA
CTD
PMID:30316929
NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
[oxybenzone co-treated with Dietary Fats analog co-treated with Dietary Fats] results in decreased expression of VEGFA mRNA
CTD
PMID:38387520
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Wnt4
Wnt family member 4
decreases expression
ISO
oxybenzone results in decreased expression of WNT4 mRNA
CTD
PMID:38382712
NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
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Wrn
WRN RecQ like helicase
increases expression
ISO
oxybenzone results in increased expression of WRN mRNA
CTD
PMID:36581016
NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450
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Zeb1
zinc finger E-box binding homeobox 1
increases expression
ISO
oxybenzone results in increased expression of ZEB1 mRNA
CTD
PMID:36581016
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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Zfp420
zinc finger protein 420
increases expression
ISO
oxybenzone results in increased expression of ZNF420 mRNA
CTD
PMID:36581016
NCBI chr 1:85,092,810...85,143,682
Ensembl chr 1:85,132,520...85,143,679
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