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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxybenzone
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Accession:CHEBI:34283 term browser browse the term
Definition:A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.
Synonyms:exact_synonym: (2-hydroxy-4-methoxyphenyl)(phenyl)methanone
 related_synonym: 2-Benzoyl-5-methoxyphenol;   2-Hydroxy-4-methoxybenzophenone;   4-Methoxy-2-hydroxybenzophenone;   Benzophenone-3;   Formula=C14H12O3;   InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3;   InChIKey=DXGLGDHPHMLXJC-UHFFFAOYSA-N;   SMILES=COc1ccc(C(=O)c2ccccc2)c(O)c1;   oxibenzona;   oxybenzonum
 alt_id: CHEBI:569732
 xref: Beilstein:1913145;   CAS:131-57-7;   DrugBank:DB01428;   Drug_Central:3412;   HMDB:HMDB0015497;   KEGG:C14285;   KEGG:D05309;   LINCS:LSM-3309
 xref_mesh: MESH:C005290
 xref: PMID:11169173;   PMID:22721600;   PMID:26118430;   PMID:26167727;   PMID:26295590;   PMID:26487337;   PMID:26589946;   PMID:26686077;   PMID:26736174;   PMID:27085067;   PMID:27544106;   PMID:27796700;   PMID:28192168;   Patent:US2773903;   Patent:US2861104;   Patent:US2861105;   Patent:US3073866;   Reaxys:1913145;   Wikipedia:Oxybenzone


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oxybenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad10 acyl-CoA dehydrogenase family, member 10 increases expression EXP oxybenzone results in increased expression of ACAD10 mRNA CTD PMID:30316929 NCBI chr12:34,901,211...34,943,973 JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 increases expression EXP oxybenzone results in increased expression of ACAD9 mRNA CTD PMID:30316929 NCBI chr 2:118,943,170...118,966,150 JBrowse link
G Acbd3 acyl-CoA binding domain containing 3 decreases expression EXP oxybenzone results in decreased expression of ACBD3 mRNA CTD PMID:30316929 NCBI chr13:92,455,813...92,484,556 JBrowse link
G Aco2 aconitase 2 affects expression EXP oxybenzone affects the expression of ACO2 mRNA CTD PMID:30316929 NCBI chr 7:113,385,677...113,428,794 JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP oxybenzone results in increased expression of ACOT2 mRNA CTD PMID:30316929 NCBI chr 6:103,611,744...103,619,404 JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression EXP oxybenzone results in increased expression of ACOX1 mRNA CTD PMID:30316929 NCBI chr10:101,406,197...101,431,242 JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression EXP oxybenzone results in decreased expression of ACSL5 mRNA CTD PMID:30316929 NCBI chr 1:254,289,513...254,336,608 JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression EXP oxybenzone results in increased expression of ACSS2 mRNA CTD PMID:30316929 NCBI chr 3:144,003,808...144,047,452 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein] CTD PMID:32407875 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 affects expression EXP oxybenzone affects the expression of ADPRHL1 mRNA CTD PMID:30316929 NCBI chr16:76,283,199...76,298,614 JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression
increases expression
EXP oxybenzone results in decreased expression of AHR mRNA
oxybenzone results in increased expression of AHR protein
CTD PMID:15458797 PMID:30099065 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression EXP oxybenzone results in increased expression of AIF1 mRNA; oxybenzone results in increased expression of AIF1 protein CTD PMID:31368502 NCBI chr20:3,646,784...3,652,670 JBrowse link
G Apoc3 apolipoprotein C3 increases expression EXP oxybenzone results in increased expression of APOC3 mRNA CTD PMID:30316929 NCBI chr 8:46,531,478...46,533,658 JBrowse link
G Apol2 apolipoprotein L, 2 increases expression EXP oxybenzone results in increased expression of APOL2 mRNA CTD PMID:30316929 NCBI chr 7:109,331,367...109,338,632 JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP oxybenzone results in decreased expression of AQP1 mRNA CTD PMID:30316929 NCBI chr 4:84,482,512...84,494,690 JBrowse link
G Ar androgen receptor multiple interactions
affects localization
ISO
EXP
oxybenzone binds to and results in decreased activity of AR protein; oxybenzone inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; oxybenzone inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
oxybenzone affects the localization of AR protein
CTD PMID:12730620 PMID:15537743 PMID:15950433 PMID:30099065 PMID:33049310 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Areg amphiregulin increases expression ISO oxybenzone results in increased expression of AREG mRNA CTD PMID:31939680 NCBI chr14:16,972,185...16,981,443 JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP oxybenzone results in increased expression of ATP5A1 mRNA CTD PMID:30316929 NCBI chr18:71,292,406...71,300,342 JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression EXP oxybenzone results in increased expression of ATP5B mRNA CTD PMID:30316929 NCBI chr 7:515,454...521,858 JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma increases expression EXP oxybenzone results in increased expression of ATP5C1 mRNA CTD PMID:30316929 NCBI chr17:68,423,927...68,446,169 JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 decreases expression EXP oxybenzone results in decreased expression of ATP5G2 mRNA CTD PMID:30316929 NCBI chr 7:133,791,341...133,799,713 JBrowse link
G Bad BCL2-associated agonist of cell death increases expression EXP oxybenzone results in increased expression of BAD mRNA CTD PMID:30316929 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression EXP oxybenzone results in increased expression of BAK1 mRNA; oxybenzone results in increased expression of BAK1 protein CTD PMID:30099065 PMID:30316929 NCBI chr20:5,100,480...5,109,669 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP oxybenzone results in increased expression of BAX mRNA; oxybenzone results in increased expression of BAX protein CTD PMID:30099065 PMID:30316929 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP oxybenzone results in decreased expression of BCL2L1 mRNA CTD PMID:30316929 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone increases expression EXP oxybenzone results in increased expression of BCS1L mRNA CTD PMID:30316929 NCBI chr 9:76,164,925...76,168,940 JBrowse link
G Casp1 caspase 1 decreases expression EXP oxybenzone results in decreased expression of CASP1 mRNA CTD PMID:30316929 NCBI chr 8:2,587,812...2,597,403 JBrowse link
G Casp2 caspase 2 increases expression EXP oxybenzone results in increased expression of CASP2 mRNA CTD PMID:30316929 NCBI chr 4:71,149,632...71,167,388 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
EXP oxybenzone results in increased activity of CASP3 protein
oxybenzone results in increased expression of and results in increased activity of CASP3 protein
CTD PMID:30099065 PMID:31368502 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp4 caspase 4 decreases expression EXP oxybenzone results in decreased expression of CASP4 mRNA CTD PMID:30316929 NCBI chr 8:2,599,017...2,635,097 JBrowse link
G Casp9 caspase 9 increases activity
increases expression
EXP oxybenzone results in increased activity of CASP9 protein
oxybenzone results in increased expression of CASP9 mRNA
CTD PMID:30099065 PMID:30316929 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression EXP oxybenzone results in decreased expression of CCL21 mRNA CTD PMID:30316929 NCBI chr 5:56,980,557...56,981,661 JBrowse link
G Cited4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 increases expression EXP oxybenzone results in increased expression of CITED4 mRNA CTD PMID:30316929 NCBI chr 5:134,246,936...134,247,827 JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression EXP oxybenzone results in increased expression of COX15 mRNA CTD PMID:30316929 NCBI chr 1:242,605,588...242,622,279 JBrowse link
G Cox16 cytochrome c oxidase assembly factor COX16 decreases expression EXP oxybenzone results in decreased expression of COX16 mRNA CTD PMID:30316929 NCBI chr 6:101,162,231...101,181,277 JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 increases expression EXP oxybenzone results in increased expression of COX17 mRNA CTD PMID:30316929 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox18 cytochrome c oxidase assembly factor COX18 increases expression EXP oxybenzone results in increased expression of COX18 mRNA CTD PMID:30316929 NCBI chr14:17,864,581...17,877,483 JBrowse link
G Cox5a cytochrome c oxidase subunit 5A increases expression EXP oxybenzone results in increased expression of COX5A mRNA CTD PMID:30316929 NCBI chr 8:57,922,374...57,933,781 JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 decreases expression EXP oxybenzone results in decreased expression of COX6B2 mRNA CTD PMID:30316929 NCBI chr 1:69,094,009...69,095,312 JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression EXP oxybenzone results in decreased expression of COX7A2 mRNA CTD PMID:30316929 NCBI chr 8:80,716,824...80,720,922 JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression EXP oxybenzone results in increased expression of CPT1B mRNA CTD PMID:30316929 NCBI chr 7:120,491,354...120,500,833 JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression EXP oxybenzone results in increased expression of CPT2 mRNA CTD PMID:30316929 NCBI chr 5:122,664,677...122,682,126 JBrowse link
G Cpxm2 carboxypeptidase X (M14 family), member 2 decreases expression EXP oxybenzone results in decreased expression of CPXM2 mRNA CTD PMID:30316929 NCBI chr 1:186,836,797...186,947,222 JBrowse link
G Cstl1 cystatin-like 1 decreases expression EXP oxybenzone results in decreased expression of CSTL1 mRNA CTD PMID:30316929 NCBI chr 3:136,199,914...136,204,912 JBrowse link
G Cybrd1 cytochrome b reductase 1 increases expression EXP oxybenzone results in increased expression of CYBRD1 mRNA CTD PMID:30316929 NCBI chr 3:55,934,874...55,962,132 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP19A1 mRNA CTD PMID:30599193 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of CYP21A1 mRNA CTD PMID:30316929 NCBI chr20:4,020,217...4,026,923 JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of CYP24A1 mRNA CTD PMID:30316929 NCBI chr 3:159,275,947...159,290,383 JBrowse link
G Cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP26C1 mRNA CTD PMID:30316929 NCBI chr 1:235,458,961...235,468,433 JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP oxybenzone results in increased expression of CYP27B1 mRNA CTD PMID:30316929 NCBI chr 7:62,869,340...62,876,242 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression EXP oxybenzone results in decreased expression of CYP2B3 mRNA CTD PMID:30316929 NCBI chr 1:81,652,762...81,732,153 JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 increases expression EXP oxybenzone results in increased expression of CYP2D3 mRNA CTD PMID:30316929 NCBI chr 7:113,917,711...113,922,068 JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP oxybenzone results in decreased expression of CYP4A3 mRNA CTD PMID:30316929 NCBI chr 5:129,097,571...129,115,488 JBrowse link
G Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 increases expression EXP oxybenzone results in increased expression of CYP4F18 mRNA CTD PMID:30316929 NCBI chr16:17,763,543...17,804,944 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression EXP oxybenzone results in increased expression of CYP7A1 mRNA CTD PMID:30316929 NCBI chr 5:19,376,979...19,386,676 JBrowse link
G Dap death-associated protein decreases expression EXP oxybenzone results in decreased expression of DAP mRNA CTD PMID:30316929 NCBI chr 2:82,199,206...82,251,771 JBrowse link
G Dapk3 death-associated protein kinase 3 increases expression EXP oxybenzone results in increased expression of DAPK3 mRNA CTD PMID:30316929 NCBI chr 7:8,524,182...8,532,552 JBrowse link
G Daxx death-domain associated protein increases expression EXP oxybenzone results in increased expression of DAXX mRNA CTD PMID:30316929 NCBI chr20:4,970,090...4,976,145 JBrowse link
G Dedd death effector domain-containing increases expression EXP oxybenzone results in increased expression of DEDD mRNA CTD PMID:30316929 NCBI chr13:83,755,874...83,769,982 JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases expression EXP oxybenzone results in increased expression of DFFA mRNA CTD PMID:30316929 NCBI chr 5:159,540,718...159,553,639 JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) increases expression EXP oxybenzone results in increased expression of DHODH mRNA CTD PMID:30316929 NCBI chr19:37,551,858...37,573,327 JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase increases expression EXP oxybenzone results in increased expression of DLST mRNA CTD PMID:30316929 NCBI chr 6:104,758,511...104,783,296 JBrowse link
G Dlx3 distal-less homeobox 3 affects expression EXP oxybenzone affects the expression of DLX3 mRNA CTD PMID:30316929 NCBI chr10:80,064,489...80,069,891 JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression EXP oxybenzone results in decreased expression of DNAJC15 mRNA CTD PMID:30316929 NCBI chr15:53,182,060...53,249,675 JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 increases expression EXP oxybenzone results in increased expression of ECHS1 mRNA CTD PMID:30316929 NCBI chr 1:194,895,036...194,903,863 JBrowse link
G Esr1 estrogen receptor 1 decreases expression
increases expression
multiple interactions
EXP
ISO
oxybenzone results in decreased expression of ESR1 mRNA; oxybenzone results in decreased expression of ESR1 protein
oxybenzone results in increased expression of ESR1 mRNA
oxybenzone binds to and results in increased activity of ESR1 protein
CTD PMID:15458797 PMID:16079615 PMID:30099065 PMID:33049310 NCBI chr 1:41,106,335...41,499,104 JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects expression
decreases expression
ISO
EXP
oxybenzone binds to and results in increased activity of ESR2 protein
oxybenzone affects the expression of ESR2 protein
oxybenzone results in decreased expression of ESR2 mRNA
CTD PMID:16079615 PMID:30099065 PMID:33049310 NCBI chr 6:94,858,438...94,909,630 JBrowse link
G Esrra estrogen related receptor, alpha decreases expression EXP oxybenzone results in decreased expression of ESRRA mRNA CTD PMID:15458797 NCBI chr 1:204,104,100...204,114,182 JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA] CTD PMID:32407875 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G Fam180a family with sequence similarity 180, member A decreases expression EXP oxybenzone results in decreased expression of FAM180A mRNA CTD PMID:30316929 NCBI chr 4:63,992,867...64,008,047 JBrowse link
G Fam71b family with sequence similarity 71, member B decreases expression EXP oxybenzone results in decreased expression of FAM71B mRNA CTD PMID:30316929 NCBI chr10:30,829,877...30,833,115 JBrowse link
G Fam71f2 family with sequence similarity 71, member F2 decreases expression EXP oxybenzone results in decreased expression of FAM71F2 mRNA CTD PMID:30316929 NCBI chr 4:57,880,019...57,890,824 JBrowse link
G Flg filaggrin affects response to substance
multiple interactions
ISO FLG gene mutant form affects the susceptibility to oxybenzone
[FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Estradiol; [FLG gene mutant form affects the susceptibility to oxybenzone] which results in increased secretion of Testosterone
CTD PMID:30245359 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Foxl2 forkhead box L2 increases expression
multiple interactions
EXP oxybenzone results in increased expression of FOXL2 mRNA
4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of FOXL2 mRNA]
CTD PMID:30599193 NCBI chr 8:99,512,971...99,514,500 JBrowse link
G Frzb frizzled-related protein decreases expression EXP oxybenzone results in decreased expression of FRZB mRNA CTD PMID:30316929 NCBI chr 3:65,332,274...65,365,208 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO [FLG gene mutant form affects the susceptibility to oxybenzone] which results in decreased secretion of FSHB protein CTD PMID:30245359 NCBI chr 3:93,548,560...93,552,370 JBrowse link
G Fst follistatin increases expression EXP oxybenzone results in increased expression of FST mRNA CTD PMID:30599193 NCBI chr 2:46,123,260...46,130,584 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 affects expression EXP oxybenzone affects the expression of GPER1 protein CTD PMID:30099065 NCBI chr12:15,217,217...15,222,679 JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [oxybenzone results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP oxybenzone affects the expression of GRIN1 protein CTD PMID:31368502 NCBI chr 3:8,103,680...8,130,603 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP oxybenzone affects the expression of GRIN2A protein CTD PMID:31368502 NCBI chr10:5,630,684...6,043,341 JBrowse link
G Gsta2 glutathione S-transferase alpha 2 decreases expression EXP oxybenzone results in decreased expression of GSTA2 mRNA CTD PMID:30316929 NCBI chr 8:79,184,535...79,196,827 JBrowse link
G Gsta5 glutathione S-transferase alpha 5 decreases expression EXP oxybenzone results in decreased expression of GSTA5 mRNA CTD PMID:30316929 NCBI chr 8:79,105,561...79,117,472 JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression EXP oxybenzone results in increased expression of GSTM1 mRNA CTD PMID:30316929 NCBI chr 2:195,649,845...195,655,402 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP oxybenzone results in increased expression of GSTP1 mRNA CTD PMID:30316929 NCBI chr 1:201,337,762...201,340,230 JBrowse link
G Gstt2 glutathione S-transferase, theta 2 increases expression EXP oxybenzone results in increased expression of GSTT2 mRNA CTD PMID:30316929 NCBI chr20:12,819,617...12,823,288 JBrowse link
G Gstt4 glutathione S-transferase, theta 4 decreases expression EXP oxybenzone results in decreased expression of GSTT4 mRNA CTD PMID:30316929 NCBI chr20:12,835,178...12,842,306 JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
ISO oxybenzone results in increased expression of H2AX protein modified form
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form]
CTD PMID:31939680 NCBI chr 8:44,671,927...44,673,257 JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP oxybenzone results in decreased expression of HADHA mRNA CTD PMID:30316929 NCBI chr 6:26,187,969...26,227,605 JBrowse link
G Hdac1 histone deacetylase 1 increases expression EXP oxybenzone results in increased expression of HDAC1 protein CTD PMID:31368502 NCBI chr 5:141,853,992...141,881,057 JBrowse link
G Hdac2 histone deacetylase 2 increases expression EXP oxybenzone results in increased expression of HDAC2 protein CTD PMID:31368502 NCBI chr20:40,548,250...40,571,609 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO oxybenzone results in increased expression of HMGCR mRNA CTD PMID:32407875 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO oxybenzone results in increased expression of HMGCS1 mRNA CTD PMID:32407875 NCBI chr 2:51,649,368...51,667,100 JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression EXP oxybenzone results in decreased expression of HMGCS2 mRNA CTD PMID:30316929 NCBI chr 2:185,875,609...185,903,505 JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression EXP oxybenzone results in decreased expression of HSD17B10 mRNA CTD PMID:30316929 NCBI chr  X:21,089,152...21,091,597 JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression EXP oxybenzone results in decreased expression of HSDL2 mRNA CTD PMID:30316929 NCBI chr 5:74,443,933...74,479,104 JBrowse link
G Hykk hydroxylysine kinase increases expression EXP oxybenzone results in increased expression of HYKK mRNA CTD PMID:30316929 NCBI chr 8:55,315,919...55,339,720 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases expression EXP oxybenzone results in decreased expression of IDH2 mRNA CTD PMID:30316929 NCBI chr 1:134,038,644...134,057,969 JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma increases expression EXP oxybenzone results in increased expression of IDH3G mRNA CTD PMID:30316929 NCBI chr  X:151,515,244...151,524,175 JBrowse link
G Il19 interleukin 19 increases expression EXP oxybenzone results in increased expression of IL19 mRNA CTD PMID:30316929 NCBI chr13:42,397,715...42,411,637 JBrowse link
G Ins2 insulin 2 multiple interactions ISO oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ protein]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA] CTD PMID:32407875 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Iqcf6 IQ motif containing F6 decreases expression EXP oxybenzone results in decreased expression of IQCF6 mRNA CTD PMID:30316929 NCBI chr 8:107,263,654...107,264,665 JBrowse link
G Krt18 keratin 18 decreases expression EXP oxybenzone results in decreased expression of KRT18 mRNA CTD PMID:30316929 NCBI chr 7:133,157,486...133,161,162 JBrowse link
G Lsmem1 leucine-rich single-pass membrane protein 1 increases expression EXP oxybenzone results in increased expression of LSMEM1 mRNA CTD PMID:30316929 NCBI chr 6:57,250,221...57,262,240 JBrowse link
G Magel2 MAGE family member L2 increases expression EXP oxybenzone results in increased expression of MAGEL2 mRNA CTD PMID:30316929 NCBI chr 1:115,880,137...115,884,680 JBrowse link
G Mcc MCC regulator of WNT signaling pathway decreases expression EXP oxybenzone results in decreased expression of MCC mRNA CTD PMID:30316929 NCBI chr18:36,794,206...37,266,237 JBrowse link
G Medag mesenteric estrogen-dependent adipogenesis decreases expression EXP oxybenzone results in decreased expression of MEDAG mRNA CTD PMID:30316929 NCBI chr12:5,613,191...5,634,701 JBrowse link
G Mybl1 MYB proto-oncogene like 1 increases expression
multiple interactions
ISO oxybenzone results in increased expression of MYBL1 mRNA
Fulvestrant inhibits the reaction [oxybenzone results in increased expression of MYBL1 mRNA]
CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179 JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein] CTD PMID:32407875 NCBI chr 5:5,835,642...6,069,693 JBrowse link
G Ndufa11 NADH:ubiquinone oxidoreductase subunit A11 decreases expression EXP oxybenzone results in decreased expression of NDUFA11 mRNA CTD PMID:30316929 NCBI chr 9:1,550,487...1,554,546 JBrowse link
G Ndufa3 NADH:ubiquinone oxidoreductase subunit A3 decreases expression EXP oxybenzone results in decreased expression of NDUFA3 mRNA CTD PMID:30316929 NCBI chr 1:65,597,562...65,600,242 JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 increases expression EXP oxybenzone results in increased expression of NDUFA9 mRNA CTD PMID:30316929 NCBI chr 4:159,659,242...159,688,034 JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 increases expression EXP oxybenzone results in increased expression of NDUFAB1 mRNA CTD PMID:30316929 NCBI chr 1:176,644,696...176,658,131 JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 increases expression EXP oxybenzone results in increased expression of NDUFB10 mRNA CTD PMID:30316929 NCBI chr10:13,749,273...13,751,434 JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 increases expression EXP oxybenzone results in increased expression of NDUFB7 mRNA CTD PMID:30316929 NCBI chr19:24,568,241...24,572,579 JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 decreases expression EXP oxybenzone results in decreased expression of NDUFS2 mRNA CTD PMID:30316929 NCBI chr13:83,654,402...83,671,474 JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 affects expression EXP oxybenzone affects the expression of NDUFV3 mRNA CTD PMID:30316929 NCBI chr20:9,612,462...9,621,622 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO oxybenzone binds to and results in increased activity of NR1I2 protein CTD PMID:33049310 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO oxybenzone results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193 JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP oxybenzone results in increased expression of NRF1 mRNA CTD PMID:30316929 NCBI chr 4:58,664,932...58,772,328 JBrowse link
G Ntn5 netrin 5 increases expression EXP oxybenzone results in increased expression of NTN5 mRNA CTD PMID:30316929 NCBI chr 1:96,156,985...96,165,997 JBrowse link
G Ogdh oxoglutarate dehydrogenase increases expression
decreases expression
EXP oxybenzone results in increased expression of OGDH mRNA
oxybenzone results in decreased expression of OGDH mRNA
CTD PMID:30316929 NCBI chr14:81,150,021...81,217,479 JBrowse link
G Olr97 olfactory receptor 97 increases expression EXP oxybenzone results in increased expression of OLR97 mRNA CTD PMID:30316929 NCBI chr 1:157,778,486...157,782,381 JBrowse link
G Pdcd11 programmed cell death 11 increases expression EXP oxybenzone results in increased expression of PDCD11 mRNA CTD PMID:30316929 NCBI chr 1:245,980,840...246,021,999 JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein decreases expression EXP oxybenzone results in decreased expression of PDCD6IP mRNA CTD PMID:30316929 NCBI chr 8:113,590,998...113,646,795 JBrowse link
G Pdcd7 programmed cell death 7 increases expression EXP oxybenzone results in increased expression of PDCD7 mRNA CTD PMID:30316929 NCBI chr 8:65,862,604...65,877,333 JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO oxybenzone binds to and results in decreased activity of PGR protein
oxybenzone results in increased expression of PGR mRNA
CTD PMID:15537743 PMID:31939680 NCBI chr 8:6,073,216...6,131,552 JBrowse link
G Phf24 PHD finger protein 24 increases expression EXP oxybenzone results in increased expression of PHF24 mRNA CTD PMID:30316929 NCBI chr 5:57,143,428...57,171,054 JBrowse link
G Polm DNA polymerase mu decreases expression EXP oxybenzone results in decreased expression of POLM mRNA CTD PMID:30316929 NCBI chr14:80,707,075...80,716,677 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO oxybenzone results in increased expression of PPARA mRNA CTD PMID:32407875 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding
multiple interactions
increases expression
ISO oxybenzone binds to PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein
oxybenzone binds to and results in increased activity of PPARG protein; oxybenzone promotes the reaction [[Glucose co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; oxybenzone promotes the reaction [NCOA2 protein binds to PPARG protein]
oxybenzone results in increased expression of PPARG mRNA
CTD PMID:32407875 PMID:33049310 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Prss37 serine protease 37 decreases expression EXP oxybenzone results in decreased expression of PRSS37 mRNA CTD PMID:30316929 NCBI chr 4:69,322,977...69,334,555 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP oxybenzone results in increased expression of RELA protein CTD PMID:31368502 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Retn resistin decreases expression EXP oxybenzone results in decreased expression of RETN mRNA CTD PMID:30316929 NCBI chr12:1,710,881...1,712,621 JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression EXP oxybenzone results in increased expression of SDHA mRNA CTD PMID:30316929 NCBI chr 1:28,935,965...28,960,936 JBrowse link
G Serpinc1 serpin family C member 1 increases expression EXP oxybenzone results in increased expression of SERPINC1 mRNA CTD PMID:30316929 NCBI chr13:73,257,208...73,271,476 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression
ISO Fulvestrant inhibits the reaction [oxybenzone results in increased expression of SGK1 mRNA] CTD PMID:33405908 NCBI chr 1:22,980,257...23,098,122 JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 increases expression EXP oxybenzone results in increased expression of SH3GLB1 mRNA CTD PMID:30316929 NCBI chr 2:233,750,838...233,784,817 JBrowse link
G Shank1 SH3 and multiple ankyrin repeat domains 1 increases expression EXP oxybenzone results in increased expression of SHANK1 mRNA CTD PMID:30316929 NCBI chr 1:94,807,879...94,857,356 JBrowse link
G Slc1a2 solute carrier family 1 member 2 affects expression EXP oxybenzone affects the expression of SLC1A2 protein CTD PMID:31368502 NCBI chr 3:89,005,129...89,126,498 JBrowse link
G Slc7a11 solute carrier family 7 member 11 affects expression EXP oxybenzone affects the expression of SLC7A11 protein CTD PMID:31368502 NCBI chr 2:134,382,002...134,517,622 JBrowse link
G Sox9 SRY-box transcription factor 9 multiple interactions
increases expression
EXP 4-(2-phenyl-5,7-bis(trifluoromethyl)pyrazolo(1,5-a)pyrimidin-3-yl)phenol inhibits the reaction [oxybenzone results in increased expression of SOX9 mRNA] CTD PMID:30599193 NCBI chr10:97,806,485...97,811,994 JBrowse link
G Sstr3 somatostatin receptor 3 increases expression EXP oxybenzone results in increased expression of SSTR3 mRNA CTD PMID:30316929 NCBI chr 7:110,092,563...110,109,043 JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP oxybenzone results in decreased expression of SULT1A1 mRNA CTD PMID:30316929 NCBI chr 1:181,272,022...181,276,750 JBrowse link
G Tex46 testis expressed 46 decreases expression EXP oxybenzone results in decreased expression of TEX46 mRNA CTD PMID:30316929 NCBI chr 5:148,849,293...148,853,685 JBrowse link
G Tfam transcription factor A, mitochondrial increases expression EXP oxybenzone results in increased expression of TFAM mRNA CTD PMID:30316929 NCBI chr20:17,356,243...17,368,293 JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO [oxybenzone co-treated with 2,4-dihydroxybenzophenone co-treated with octylmethoxycinnamate co-treated with enzacamene] results in increased expression of TFF1 mRNA; [oxybenzone co-treated with 2,4-dihydroxybenzophenone] results in increased expression of TFF1 mRNA
oxybenzone results in increased expression of TFF1 mRNA
CTD PMID:16183391 NCBI chr20:9,235,736...9,239,597 JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression EXP oxybenzone results in increased expression of TMPRSS4 mRNA CTD PMID:30316929 NCBI chr 8:45,475,819...45,508,409 JBrowse link
G Tp53 tumor protein p53 decreases expression EXP oxybenzone results in decreased expression of TP53 mRNA CTD PMID:30316929 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO oxybenzone results in increased expression of TP53BP1 protein CTD PMID:31939680 NCBI chr 3:108,166,574...108,270,229 JBrowse link
G Tspo translocator protein decreases expression EXP oxybenzone results in decreased expression of TSPO mRNA CTD PMID:30316929 NCBI chr 7:114,720,188...114,730,450 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP oxybenzone results in decreased expression of UGT1A6 mRNA CTD PMID:30316929 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt2a3 UDP glucuronosyltransferase family 2 member A3 decreases expression EXP oxybenzone results in decreased expression of UGT2A3 mRNA CTD PMID:30316929 NCBI chr14:20,572,825...20,590,295 JBrowse link
G Upk1b uroplakin 1B decreases expression EXP oxybenzone results in decreased expression of UPK1B mRNA CTD PMID:30316929 NCBI chr11:61,953,687...61,991,029 JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression EXP oxybenzone affects the expression of UQCR11 mRNA CTD PMID:30316929 NCBI chr 7:9,305,042...9,309,753 JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP oxybenzone results in increased expression of UQCRC1 mRNA CTD PMID:30316929 NCBI chr 8:109,589,735...109,601,481 JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 decreases expression EXP oxybenzone results in decreased expression of UQCRFS1 mRNA CTD PMID:30316929 NCBI chr17:33,977,908...33,982,478 JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII increases expression EXP oxybenzone results in increased expression of UQCRQ mRNA CTD PMID:30316929 NCBI chr10:37,585,864...37,589,328 JBrowse link
G V1ra14 vomeronasal 1 receptor A14 increases expression EXP oxybenzone results in increased expression of V1RA14 mRNA CTD PMID:30316929
G Vdac1 voltage-dependent anion channel 1 decreases expression EXP oxybenzone results in decreased expression of VDAC1 mRNA CTD PMID:30316929 NCBI chr10:36,532,306...36,559,642 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          oxybenzone 160
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      ketone 16858
                                        aromatic ketone 12304
                                          benzophenones 1189
                                            hydroxybenzophenone 160
                                              oxybenzone 160
paths to the root