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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,6-di-tert-butyl-4-methylphenol
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Accession:CHEBI:34247 term browser browse the term
Definition:A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
Synonyms:related_synonym: 2,6-Bis(1,1-dimethylethyl)-4-methylphenol;   2,6-Di-t-butyl-4-methylphenol;   2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene;   2,6-Di-tert-butyl-4-cresol;   2,6-Di-tert-butyl-p-cresol;   BHT;   Butylated hydroxytoluene;   Butylhydroxytoluene;   Formula=C15H24O;   InChI=1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3;   InChIKey=NLZUEZXRPGMBCV-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
 xref: Beilstein:1911640;   CAS:128-37-0;   KEGG:C14693;   KEGG:D02413;   LINCS:LSM-19020
 xref_mesh: MESH:D002084
 xref: PMID:11837686;   PMID:24612426;   PMID:24617543;   Reaxys:1911640;   Wikipedia:Butylated_hydroxytoluene


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2,6-di-tert-butyl-4-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]
Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA
CTD PMID:17070507 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of ACTG1 mRNA CTD PMID:12082028 NCBI chr10:109,518,429...109,521,288
Ensembl chr 3:75,643,054...75,644,954
Ensembl chr10:75,643,054...75,644,954
JBrowse link
G Agt angiotensinogen multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of AIFM2 protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of AIFM2 protein] CTD PMID:14987999 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression
increases activity
EXP Butylated Hydroxytoluene results in increased expression of AKR7A3 protein
Butylated Hydroxytoluene results in increased activity of AKR7A3 protein
CTD PMID:8198522, PMID:9328168 NCBI chr 5:157,801,120...157,813,756
Ensembl chr 5:157,801,163...157,813,756
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Butylated Hydroxytoluene results in increased phosphorylation of AKT1 protein CTD PMID:17604070 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects localization
multiple interactions
ISO Butylated Hydroxytoluene affects the localization of ALOX5 protein
celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein]
CTD PMID:12376474 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein] CTD PMID:12576517 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein] CTD PMID:12576517 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Apoa4 apolipoprotein A4 increases expression EXP Butylated Hydroxytoluene results in increased expression of APOA4 mRNA CTD PMID:12082028 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Ar androgen receptor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:10696776 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arg1 arginase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of ARG1 mRNA CTD PMID:19925653 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]
CTD PMID:12470298 NCBI chr11:61,531,386...61,584,634
Ensembl chr11:61,531,416...61,584,634
JBrowse link
G C5 complement C5 increases expression EXP Butylated Hydroxytoluene results in increased expression of HC mRNA CTD PMID:12082028 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G Capn2 calpain 2 affects expression ISO Butylated Hydroxytoluene affects the expression of CAPN2 protein CTD PMID:7716780 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of CAPRIN1 mRNA CTD PMID:19925653 NCBI chr 3:93,701,830...93,789,580
Ensembl chr 3:93,702,487...93,789,617
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Butylated Hydroxytoluene results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO
EXP
[Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein
Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]
[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein; zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein]
Butylated Hydroxytoluene results in decreased activity of CASP3 protein
CTD PMID:10783138, PMID:14981915, PMID:16272459, PMID:27588890 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein] CTD PMID:9306888 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression ISO Butylated Hydroxytoluene results in increased expression of CCDC116 mRNA CTD PMID:19925653 NCBI chr11:88,092,794...88,100,220
Ensembl chr11:88,095,170...88,098,252
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Butylated Hydroxytoluene results in increased expression of CCL17 mRNA CTD PMID:19925653 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]
Butylated Hydroxytoluene results in increased secretion of CCL2 protein
Butylated Hydroxytoluene results in increased expression of CCL2 protein
CTD PMID:16443645, PMID:16822543 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CCL5 mRNA CTD PMID:19925653 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccna2 cyclin A2 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; Butylated Hydroxytoluene results in increased expression of CCNA2 mRNA CTD PMID:12867420 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA CTD PMID:12867420, PMID:19000923 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CCND1 protein CTD PMID:16272459 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNE1 mRNA CTD PMID:12867420 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccnf cyclin F increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of CCNF mRNA CTD PMID:12867420 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Cd19 CD19 molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD19 mRNA CTD PMID:19925653 NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
JBrowse link
G Cd37 CD37 molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD37 mRNA CTD PMID:19925653 NCBI chr 1:101,230,470...101,236,061
Ensembl chr 1:101,230,533...101,236,065
JBrowse link
G Cd3d CD3d molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD3D mRNA CTD PMID:19925653 NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form CTD PMID:15390079 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd81 Cd81 molecule increases expression EXP Butylated Hydroxytoluene results in increased expression of CD81 mRNA CTD PMID:12082028 NCBI chr 1:216,237,663...216,253,460
Ensembl chr 1:216,237,697...216,253,311
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein CTD PMID:16272459 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CDK2AP2 mRNA CTD PMID:12082028 NCBI chr 1:219,345,638...219,347,709
Ensembl chr 1:219,345,918...219,347,728
JBrowse link
G Cfi complement factor I increases expression ISO Butylated Hydroxytoluene results in increased expression of CFI mRNA CTD PMID:19925653 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cldn2 claudin 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of CLDN2 mRNA CTD PMID:19925653 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression ISO Butylated Hydroxytoluene results in increased expression of COL18A1 mRNA CTD PMID:19925653 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 increases expression ISO Butylated Hydroxytoluene results in increased expression of COX6B2 mRNA CTD PMID:19925653 NCBI chr 1:72,661,099...72,662,436
Ensembl chr 1:72,661,211...72,662,434
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] affects the localization of CTNNB1 protein; [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CTNNB1 protein CTD PMID:16272459 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol affects the localization of CYCS protein] CTD PMID:19121293 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Butylated Hydroxytoluene results in increased expression of CYP1A1 mRNA
Butylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:19925653, PMID:21094198 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2B1 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B1 protein CTD PMID:15110098 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2B2 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B2 protein CTD PMID:12082028, PMID:15110098, PMID:18539377 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2C6V1 mRNA CTD PMID:18539377 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2J2 mRNA CTD PMID:24021950 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP3A9 mRNA CTD PMID:18539377 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dcx doublecortin multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein] CTD PMID:17067360 NCBI chr  X:115,098,675...115,175,515
Ensembl chr  X:115,098,675...115,175,299
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of DIABLO protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of DIABLO protein] CTD PMID:14987999 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Butylated Hydroxytoluene results in increased expression of DNAJC3 mRNA CTD PMID:19925653 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Dock2 dedicator of cytokinesis 2 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of DOCK2 mRNA CTD PMID:19925653 NCBI chr10:19,181,512...19,603,171 JBrowse link
G Elavl1 ELAV like RNA binding protein 1 affects localization ISO Butylated Hydroxytoluene affects the localization of ELAVL1 protein CTD PMID:10900464 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Eln elastin multiple interactions ISO [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNA CTD PMID:10761639 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863
JBrowse link
G Epor erythropoietin receptor increases expression ISO Butylated Hydroxytoluene results in increased expression of EPOR mRNA CTD PMID:19925653 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G Ereg epiregulin increases expression ISO Butylated Hydroxytoluene results in increased expression of EREG mRNA CTD PMID:19925653 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Evpl envoplakin increases expression ISO Butylated Hydroxytoluene results in increased expression of EVPL mRNA CTD PMID:19925653 NCBI chr10:105,100,538...105,116,802
Ensembl chr10:105,100,336...105,116,916
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of FOSL1 mRNA CTD PMID:19000923, PMID:19925653 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Foxf1 forkhead box F1 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of FOXF1 mRNA CTD PMID:11238010 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086
JBrowse link
G Foxm1 forkhead box M1 affects localization
affects response to substance
increases expression
ISO Butylated Hydroxytoluene affects the localization of FOXM1 mRNA
FOXM1 protein affects the susceptibility to Butylated Hydroxytoluene
[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 protein
CTD PMID:11238010, PMID:12867420, PMID:18345025, PMID:19672312 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of GFPT2 mRNA CTD PMID:19925653 NCBI chr10:35,279,237...35,325,506
Ensembl chr10:35,279,236...35,325,508
JBrowse link
G Ggta1 glycoprotein, alpha-galactosyltransferase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of GGTA1 mRNA CTD PMID:19925653 NCBI chr 3:14,614,099...14,701,185
Ensembl chr 3:14,614,122...14,644,951
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases phosphorylation ISO
EXP
Butylated Hydroxytoluene results in decreased phosphorylation of GJA1 protein CTD PMID:7586169 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gnmt glycine N-methyltransferase increases expression EXP Butylated Hydroxytoluene results in increased expression of GNMT mRNA CTD PMID:12082028 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression EXP Butylated Hydroxytoluene results in increased expression of GPLD1 mRNA CTD PMID:12082028 NCBI chr17:42,085,027...42,131,344
Ensembl chr17:42,085,028...42,127,678
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases activity
EXP Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene results in increased expression of and results in increased activity of GSTA5 protein
Butylated Hydroxytoluene results in increased activity of GSTA5 protein
CTD PMID:8198522, PMID:9328168 NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of GSTM2 mRNA CTD PMID:12082028, PMID:18539377 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
EXP
ISO
Butylated Hydroxytoluene results in increased expression of GSTP1 mRNA
Butylated Hydroxytoluene results in increased alkylation of and results in decreased activity of GSTP1 protein
CTD PMID:15110098, PMID:21536018 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr20:13,799,102...13,816,527
Ensembl chr20:13,799,102...13,816,526
JBrowse link
G Gzma granzyme A decreases expression ISO Butylated Hydroxytoluene results in decreased expression of GZMA mRNA CTD PMID:19925653 NCBI chr 2:44,968,846...44,981,436
Ensembl chr 2:44,968,765...44,981,458
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression EXP Butylated Hydroxytoluene affects the expression of HCK mRNA CTD PMID:18539377 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Butylated Hydroxytoluene results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:257,901,856...257,953,889
Ensembl chr 1:257,766,691...257,949,183
Ensembl chr 1:257,766,691...257,949,183
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [Butylated Hydroxytoluene results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:27,983,925...28,003,260
Ensembl chr 2:27,984,117...28,003,186
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity EXP Butylated Hydroxytoluene results in increased activity of HMGCR protein CTD PMID:9199277 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
increases expression
ISO
EXP
Butylated Hydroxytoluene affects the expression of HMOX1 mRNA
Butylated Hydroxytoluene results in increased expression of HMOX1 mRNA
CTD PMID:8743975, PMID:12420312 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA CTD PMID:16272459 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 affects localization
increases expression
multiple interactions
ISO Butylated Hydroxytoluene affects the localization of HNRNPA1 protein
Butylated Hydroxytoluene results in increased expression of HNRNPA1 protein
[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein
CTD PMID:15390079 NCBI chr 7:144,865,302...144,871,592
Ensembl chr 7:144,865,608...144,871,585
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions ISO [Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein CTD PMID:17477362 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects localization ISO Butylated Hydroxytoluene affects the localization of HNRNPD protein CTD PMID:10900464 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases methylation
increases response to substance
EXP
ISO
Butylated Hydroxytoluene results in decreased methylation of HRAS gene
HRAS protein results in increased susceptibility to Butylated Hydroxytoluene
CTD PMID:9780227, PMID:11599794 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Butylated Hydroxytoluene results in increased expression of HSPA9 mRNA CTD PMID:19925653 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein] CTD PMID:16822543 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il15 interleukin 15 affects expression EXP Butylated Hydroxytoluene affects the expression of IL15 mRNA CTD PMID:18539377 NCBI chr19:23,542,606...23,624,366
Ensembl chr19:23,542,889...23,554,594
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:47,133,483...47,184,316
Ensembl chr 9:47,134,034...47,182,170
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein] CTD PMID:16822543 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Ilk integrin-linked kinase multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein CTD PMID:16272459 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kng2 kininogen 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of KNG1 mRNA CTD PMID:19925653 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO Butylated Hydroxytoluene results in increased mutagenesis of KRAS gene CTD PMID:20101149 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA CTD PMID:16272459 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
JBrowse link
G Lep leptin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Butylated Hydroxytoluene results in increased expression of MAPK14 mRNA CTD PMID:19925653 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mbp myelin basic protein increases expression ISO Butylated Hydroxytoluene results in increased expression of MBP mRNA CTD PMID:19925653 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]
Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]
CTD PMID:12470298 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Myl3 myosin light chain 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of MYL3 mRNA CTD PMID:19925653 NCBI chr 8:119,030,852...119,036,996
Ensembl chr 8:119,030,875...119,036,996
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to Butylated Hydroxytoluene CTD PMID:10535991 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15713255 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]
Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased phosphorylation of NFKBIA protein]
CTD PMID:16478757, PMID:17532611 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] CTD PMID:9748608 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
EXP Butylated Hydroxytoluene results in increased activity of NQO1 protein
Butylated Hydroxytoluene results in increased expression of NQO1 mRNA
CTD PMID:16045903, PMID:20308224 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] CTD PMID:17070507 NCBI chr 1:100,554,577...100,559,896
Ensembl chr 1:100,554,544...100,559,942
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA] CTD PMID:17070507 NCBI chr 3:80,004,130...80,014,197
Ensembl chr 3:80,004,130...80,012,750
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Butylated Hydroxytoluene binds to and results in decreased activity of NR1I3 protein alternative form; Butylated Hydroxytoluene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nras NRAS proto-oncogene, GTPase increases activity EXP Butylated Hydroxytoluene results in increased activity of NRAS CTD PMID:3040652 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of NRBF2 mRNA CTD PMID:12082028 NCBI chr20:22,728,145...22,746,477
Ensembl chr20:22,728,208...22,746,474
JBrowse link
G Nup54 nucleoporin 54 increases expression ISO Butylated Hydroxytoluene results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr14:17,123,434...17,141,832
Ensembl chr14:17,123,360...17,141,767
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of OGG1 mRNA] CTD PMID:20676402 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Parn poly(A)-specific ribonuclease decreases expression ISO Butylated Hydroxytoluene results in decreased expression of PARN mRNA CTD PMID:19925653 NCBI chr10:1,309,724...1,461,123
Ensembl chr10:1,308,414...1,461,269
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein]; Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] CTD PMID:2126186 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Butylated Hydroxytoluene results in increased expression of PCNA protein CTD PMID:11238010 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of PER2 mRNA CTD PMID:19925653 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] CTD PMID:18603805 NCBI chr  X:77,263,399...77,279,373
Ensembl chr  X:77,263,359...77,279,367
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Butylated Hydroxytoluene results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:40,460,047...40,717,982
Ensembl chr  X:40,460,047...40,717,982
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Butylated Hydroxytoluene results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of PKNOX2 mRNA CTD PMID:19925653 NCBI chr 8:39,361,698...39,551,700
Ensembl chr 8:39,361,218...39,551,700
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression ISO Butylated Hydroxytoluene results in increased expression of PLA2G4A protein CTD PMID:16443645 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] CTD PMID:10856522 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pomp proteasome maturation protein increases expression EXP Butylated Hydroxytoluene results in increased expression of POMP mRNA CTD PMID:12082028 NCBI chr12:8,746,948...8,759,433
Ensembl chr12:8,746,855...8,759,599
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein] CTD PMID:17916643 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link
G Pou2f1 POU class 2 homeobox 1 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of POU2F1 mRNA CTD PMID:19925653 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPAR mRNA] CTD PMID:17070507 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Butylated Hydroxytoluene results in increased expression of PPARG mRNA
Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPARG mRNA]
CTD PMID:17070507, PMID:19925653 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Butylated Hydroxytoluene results in decreased expression of PRKCA protein CTD PMID:7716780 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]
CTD PMID:12470298, PMID:17532611 NCBI chr15:19,667,453...19,688,916
Ensembl chr15:19,667,453...19,688,914
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of PTGS1 protein CTD PMID:11696405 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Butylated Hydroxytoluene results in increased expression of PTGS2 protein
Butylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]
CTD PMID:11696405, PMID:17067360 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO Butylated Hydroxytoluene results in increased expression of PTHLH mRNA CTD PMID:19925653 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases expression ISO Butylated Hydroxytoluene results in decreased expression of RAB31 mRNA CTD PMID:19925653 NCBI chr 9:113,370,072...113,504,606
Ensembl chr 9:113,370,033...113,504,605
JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO Butylated Hydroxytoluene results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,469,803...159,482,869
Ensembl chr 4:159,469,804...159,482,869
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15713255, PMID:16478757 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:37,599,540...37,648,818
Ensembl chr 3:37,599,728...37,647,631
JBrowse link
G Rnf112 ring finger protein 112 affects expression EXP Butylated Hydroxytoluene affects the expression of RNF112 mRNA CTD PMID:18539377 NCBI chr10:47,719,034...47,726,050
Ensembl chr10:47,719,014...47,725,172
JBrowse link
G Sell selectin L decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SELL mRNA CTD PMID:19925653 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] CTD PMID:10856522 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpinh1 serpin family H member 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SERPINH1 mRNA CTD PMID:19925653 NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
JBrowse link
G Shisa2 shisa family member 2 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SHISA2 mRNA CTD PMID:19925653 NCBI chr15:39,945,095...39,949,393
Ensembl chr15:39,945,095...39,949,393
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA CTD PMID:19925653 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression ISO Butylated Hydroxytoluene results in increased expression of SLC39A11 mRNA CTD PMID:19925653 NCBI chr10:101,754,842...102,169,100
Ensembl chr10:101,754,830...102,084,035
JBrowse link
G Slfn4 schlafen family member 4 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SLFN4 mRNA CTD PMID:19925653 NCBI chr10:70,411,686...70,435,162
Ensembl chr10:70,411,738...70,435,156
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA CTD PMID:14981915 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spib Spi-B transcription factor decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SPIB mRNA CTD PMID:19925653 NCBI chr 1:100,531,538...100,537,397
Ensembl chr 1:100,531,457...100,537,377
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SPP1 mRNA CTD PMID:19925653 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 multiple interactions
increases expression
affects localization
ISO [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein
Butylated Hydroxytoluene results in increased expression of SRSF1 protein
Butylated Hydroxytoluene affects the localization of SRSF1 protein
CTD PMID:15390079 NCBI chr10:75,334,200...75,341,197
Ensembl chr10:75,335,146...75,341,197
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stom stomatin increases expression ISO Butylated Hydroxytoluene results in increased expression of STOM mRNA CTD PMID:19925653 NCBI chr 3:14,515,576...14,538,199
Ensembl chr 3:14,514,868...14,538,241
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] CTD PMID:9748608 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression
increases expression
EXP
ISO
Butylated Hydroxytoluene affects the expression of TDO2 mRNA
Butylated Hydroxytoluene results in increased expression of TDO2 mRNA
CTD PMID:18539377, PMID:19925653 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM protein] CTD PMID:20676402 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M protein] CTD PMID:20676402 NCBI chr 1:44,433,116...44,474,674
Ensembl chr 1:44,433,116...44,474,674
JBrowse link
G Tfb2m transcription factor B2, mitochondrial multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M protein] CTD PMID:20676402 NCBI chr13:97,820,493...97,838,275
Ensembl chr13:97,820,493...97,838,228
JBrowse link
G Tfrc transferrin receptor increases expression ISO Butylated Hydroxytoluene results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfa transforming growth factor alpha decreases response to substance EXP Butylated Hydroxytoluene results in decreased susceptibility to TGFA protein CTD PMID:7593635 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thpo thrombopoietin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 NCBI chr11:82,845,676...82,853,439
Ensembl chr11:83,868,655...83,873,910
Ensembl chr11:83,868,655...83,873,910
JBrowse link
G Tmem45b transmembrane protein 45b decreases expression ISO Butylated Hydroxytoluene results in decreased expression of TMEM45B mRNA CTD PMID:19925653 NCBI chr 8:32,563,872...32,609,212
Ensembl chr 8:32,563,874...32,609,212
JBrowse link
G Tnc tenascin C increases expression ISO Butylated Hydroxytoluene results in increased expression of TNC mRNA CTD PMID:19925653 NCBI chr 5:79,789,686...79,874,555
Ensembl chr 5:79,789,671...79,874,671
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
decreases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene results in increased susceptibility to TNF protein
Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased uptake of Excitatory Amino Acid Agents]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein]
Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]]; Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Quartz results in increased secretion of TNF protein]]; Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Butylated Hydroxytoluene results in decreased expression of TNF protein
CTD PMID:9721806, PMID:12470298, PMID:15713255, PMID:16822543, PMID:16910777, PMID:19298665 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Butylated Hydroxytoluene results in increased expression of TP53 mRNA CTD PMID:9780227 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ttr transthyretin increases expression EXP Butylated Hydroxytoluene results in increased expression of TTR mRNA CTD PMID:12082028 NCBI chr18:15,532,963...15,542,180
Ensembl chr18:15,532,963...15,540,177
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of UBE2G2 mRNA CTD PMID:19925653 NCBI chr20:11,700,089...11,721,823
Ensembl chr20:11,700,089...11,721,838
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
Butylated Hydroxytoluene results in increased expression of VEGFA mRNA
CTD PMID:16822543, PMID:19000923 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      chemical role 19250
        antioxidant 14211
          2,6-di-tert-butyl-4-methylphenol 173
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic aromatic compound 19119
                                  phenols 18112
                                    phenol 1326
                                      2,6-di-tert-butyl-4-methylphenol 173
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.