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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,6-di-tert-butyl-4-methylphenol
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Accession:CHEBI:34247 term browser browse the term
Definition:A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.
Synonyms:related_synonym: 2,6-Bis(1,1-dimethylethyl)-4-methylphenol;   2,6-Di-t-butyl-4-methylphenol;   2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene;   2,6-Di-tert-butyl-4-cresol;   2,6-Di-tert-butyl-p-cresol;   BHT;   Butylated hydroxytoluene;   Butylhydroxytoluene;   Formula=C15H24O;   InChI=1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3;   InChIKey=NLZUEZXRPGMBCV-UHFFFAOYSA-N;   SMILES=Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
 xref: Beilstein:1911640;   CAS:128-37-0;   KEGG:C14693;   KEGG:D02413;   LINCS:LSM-19020
 xref_mesh: MESH:D002084
 xref: PMID:11837686;   PMID:24612426;   PMID:24617543;   Reaxys:1911640;   Wikipedia:Butylated_hydroxytoluene


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2,6-di-tert-butyl-4-methylphenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO [Butylated Hydroxytoluene co-treated with iron(II)-ascorbic acid complex] results in increased expression of ABCA1 protein; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of ABCA1 protein]
Butylated Hydroxytoluene results in increased expression of ABCA1 mRNA
CTD PMID:17070507 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of ACTG1 mRNA CTD PMID:12082028 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Agt angiotensinogen multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein] CTD PMID:17532611 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of AIFM2 protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of AIFM2 protein] CTD PMID:14987999 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 increases expression
increases activity
EXP Butylated Hydroxytoluene results in increased expression of AKR7A3 protein
Butylated Hydroxytoluene results in increased activity of AKR7A3 protein
CTD PMID:8198522 PMID:9328168 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation EXP Butylated Hydroxytoluene results in increased phosphorylation of AKT1 protein CTD PMID:17604070 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects localization
multiple interactions
ISO Butylated Hydroxytoluene affects the localization of ALOX5 protein
celecoxib inhibits the reaction [Butylated Hydroxytoluene affects the localization of ALOX5 protein]
CTD PMID:12376474 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA1 protein] CTD PMID:12576517 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoa2 apolipoprotein A2 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]; Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein] CTD PMID:12576517 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Apoa4 apolipoprotein A4 increases expression EXP Butylated Hydroxytoluene results in increased expression of APOA4 mRNA CTD PMID:12082028 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Ar androgen receptor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein] CTD PMID:10696776 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of ARG1 mRNA CTD PMID:19925653 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; Butylated Hydroxytoluene inhibits the reaction [Free Radicals results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:181,026,606...181,044,859 JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of ATP6V1A protein]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]
CTD PMID:12470298 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G C5 complement C5 increases expression EXP Butylated Hydroxytoluene results in increased expression of HC mRNA CTD PMID:12082028 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G Capn2 calpain 2 affects expression ISO Butylated Hydroxytoluene affects the expression of CAPN2 protein CTD PMID:7716780 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Caprin1 cell cycle associated protein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of CAPRIN1 mRNA CTD PMID:19925653 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Butylated Hydroxytoluene results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 multiple interactions
decreases activity
ISO
EXP
[Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased activity of CASP3 protein
Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased cleavage of and results in increased activity of CASP3 protein]; Butylated Hydroxytoluene inhibits the reaction [Lithium Carbonate results in increased activity of CASP3 protein]
[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein; zAsp(Ome)-Arg-His-Asp(Ome)-fluoromethyl ketone inhibits the reaction [[Butylated Hydroxytoluene co-treated with Oxygen] results in increased cleavage of CASP3 protein]
Butylated Hydroxytoluene results in decreased activity of CASP3 protein
CTD PMID:10783138 PMID:14981915 PMID:16272459 PMID:27588890 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol results in decreased activity of CAT protein] CTD PMID:9306888 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc116 coiled-coil domain containing 116 increases expression ISO Butylated Hydroxytoluene results in increased expression of CCDC116 mRNA CTD PMID:19925653 NCBI chr11:83,842,707...83,850,607
Ensembl chr11:83,845,557...83,850,607
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Butylated Hydroxytoluene results in increased expression of CCL17 mRNA CTD PMID:19925653 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CCL2 protein]
Butylated Hydroxytoluene results in increased secretion of CCL2 protein
Butylated Hydroxytoluene results in increased expression of CCL2 protein
CTD PMID:16443645 PMID:16822543 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CCL5 mRNA CTD PMID:19925653 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccna2 cyclin A2 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; Butylated Hydroxytoluene results in increased expression of CCNA2 mRNA CTD PMID:12867420 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA CTD PMID:12867420 PMID:19000923 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CCND1 protein CTD PMID:16272459 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; Butylated Hydroxytoluene results in increased expression of CCNE1 mRNA CTD PMID:12867420 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccnf cyclin F increases expression ISO [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of CCNF mRNA CTD PMID:12867420 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Cd19 CD19 molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD19 mRNA CTD PMID:19925653 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Cd37 CD37 molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD37 mRNA CTD PMID:19925653 NCBI chr 1:95,719,171...95,724,662
Ensembl chr 1:95,719,190...95,724,648
JBrowse link
G Cd3d CD3d molecule decreases expression ISO Butylated Hydroxytoluene results in decreased expression of CD3D mRNA CTD PMID:19925653 NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of CD44 mRNA alternative form CTD PMID:15390079 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd81 Cd81 molecule increases expression EXP Butylated Hydroxytoluene results in increased expression of CD81 mRNA CTD PMID:12082028 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in decreased expression of CDH1 protein CTD PMID:16272459 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CDK2AP2 mRNA CTD PMID:12082028 NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
JBrowse link
G Cfi complement factor I increases expression ISO Butylated Hydroxytoluene results in increased expression of CFI mRNA CTD PMID:19925653 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of CHEK1 mRNA CTD PMID:19000923 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Cldn2 claudin 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of CLDN2 mRNA CTD PMID:19925653 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression ISO Butylated Hydroxytoluene results in increased expression of COL18A1 mRNA CTD PMID:19925653 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Cox6b2 cytochrome c oxidase subunit 6B2 increases expression ISO Butylated Hydroxytoluene results in increased expression of COX6B2 mRNA CTD PMID:19925653 NCBI chr 1:69,094,009...69,095,312 JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of CSF2 protein] CTD PMID:16822543 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] affects the localization of CTNNB1 protein; [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of CTNNB1 protein CTD PMID:16272459 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [cholestane-3,5,6-triol affects the localization of CYCS protein] CTD PMID:19121293 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Butylated Hydroxytoluene results in increased expression of CYP1A1 mRNA
Butylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
CTD PMID:19925653 PMID:21094198 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2B1 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B1 protein CTD PMID:15110098 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2B2 mRNA; Butylated Hydroxytoluene results in increased expression of CYP2B2 protein CTD PMID:12082028 PMID:15110098 PMID:18539377 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2B6 mRNA CTD PMID:18570159 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP2C6V1 mRNA CTD PMID:18539377 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP2J2 mRNA CTD PMID:24021950 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of CYP3A4 mRNA CTD PMID:18570159 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP Butylated Hydroxytoluene results in increased expression of CYP3A9 mRNA CTD PMID:18539377 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dcx doublecortin multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Ethanol results in decreased expression of DCX protein] CTD PMID:17067360 NCBI chr  X:107,430,767...107,573,612
Ensembl chr  X:107,430,767...107,507,476
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [ganglioside, GD3 results in increased secretion of DIABLO protein]; Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased secretion of DIABLO protein] CTD PMID:14987999 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 increases expression ISO Butylated Hydroxytoluene results in increased expression of DNAJC3 mRNA CTD PMID:19925653 NCBI chr15:96,025,729...96,065,114
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dock2 dedicator of cytokinesis 2 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of DOCK2 mRNA CTD PMID:19925653 NCBI chr10:18,827,237...19,244,823 JBrowse link
G Elavl1 ELAV like RNA binding protein 1 affects localization ISO Butylated Hydroxytoluene affects the localization of ELAVL1 protein CTD PMID:10900464 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
JBrowse link
G Eln elastin multiple interactions ISO [Oxygen co-treated with Butylated Hydroxytoluene] results in increased expression of ELN mRNA CTD PMID:10761639 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Epor erythropoietin receptor increases expression ISO Butylated Hydroxytoluene results in increased expression of EPOR mRNA CTD PMID:19925653 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Ereg epiregulin increases expression ISO Butylated Hydroxytoluene results in increased expression of EREG mRNA CTD PMID:19925653 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Evpl envoplakin increases expression ISO Butylated Hydroxytoluene results in increased expression of EVPL mRNA CTD PMID:19925653 NCBI chr10:101,458,421...101,474,687
Ensembl chr10:101,458,216...101,474,763
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Copper results in increased activity of F3 protein] CTD PMID:7600656 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of FOSL1 mRNA CTD PMID:19000923 PMID:19925653 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Foxf1 forkhead box F1 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of FOXF1 mRNA CTD PMID:11238010 NCBI chr19:49,153,729...49,157,741
Ensembl chr19:49,153,699...49,157,738
JBrowse link
G Foxm1 forkhead box M1 affects localization
affects response to substance
increases expression
ISO Butylated Hydroxytoluene affects the localization of FOXM1 mRNA
FOXM1 protein affects the susceptibility to Butylated Hydroxytoluene
[Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNA2 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNB1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNE1 mRNA; [Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA] which results in increased expression of CCNF mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 mRNA; Butylated Hydroxytoluene results in increased expression of FOXM1 protein
CTD PMID:11238010 PMID:12867420 PMID:18345025 PMID:19672312 NCBI chr 4:161,639,561...161,652,012
Ensembl chr 4:161,638,816...161,650,684
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of GCLC protein CTD PMID:21536018 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gfpt2 glutamine-fructose-6-phosphate transaminase 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of GFPT2 mRNA CTD PMID:19925653 NCBI chr10:34,115,005...34,161,329
Ensembl chr10:34,115,052...34,161,329
JBrowse link
G Ggta1 glycoprotein alpha-galactosyltransferase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of GGTA1 mRNA CTD PMID:19925653 NCBI chr 3:18,732,985...18,824,916
Ensembl chr 3:18,732,991...18,809,908
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases phosphorylation ISO
EXP
Butylated Hydroxytoluene results in decreased phosphorylation of GJA1 protein CTD PMID:7586169 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gnmt glycine N-methyltransferase increases expression EXP Butylated Hydroxytoluene results in increased expression of GNMT mRNA CTD PMID:12082028 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 increases expression EXP Butylated Hydroxytoluene results in increased expression of GPLD1 mRNA CTD PMID:12082028 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
increases activity
EXP Butylated Hydroxytoluene promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Butylated Hydroxytoluene results in increased expression of and results in increased activity of GSTA5 protein
Butylated Hydroxytoluene results in increased activity of GSTA5 protein
CTD PMID:8198522 PMID:9328168 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of GSTM2 mRNA CTD PMID:12082028 PMID:18539377 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
EXP
ISO
Butylated Hydroxytoluene results in increased expression of GSTP1 mRNA
Butylated Hydroxytoluene results in increased alkylation of and results in decreased activity of GSTP1 protein
CTD PMID:15110098 PMID:21536018 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Butylated Hydroxytoluene results in increased expression of GSTT1 mRNA CTD PMID:15110098 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gzma granzyme A decreases expression ISO Butylated Hydroxytoluene results in decreased expression of GZMA mRNA CTD PMID:19925653 NCBI chr 2:44,740,638...44,752,471
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression EXP Butylated Hydroxytoluene affects the expression of HCK mRNA CTD PMID:18539377 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hells helicase, lymphoid specific increases expression ISO Butylated Hydroxytoluene results in increased expression of HELLS mRNA CTD PMID:19000923 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844
JBrowse link
G Hexb hexosaminidase subunit beta multiple interactions EXP zinc chloride inhibits the reaction [Butylated Hydroxytoluene results in increased secretion of HEXB protein] CTD PMID:15272608 NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity EXP Butylated Hydroxytoluene results in increased activity of HMGCR protein CTD PMID:9199277 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 affects expression
increases expression
ISO
EXP
Butylated Hydroxytoluene affects the expression of HMOX1 mRNA
Butylated Hydroxytoluene results in increased expression of HMOX1 mRNA
CTD PMID:8743975 PMID:12420312 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf1a HNF1 homeobox A multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of HNF1A mRNA CTD PMID:16272459 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 affects localization
increases expression
multiple interactions
ISO Butylated Hydroxytoluene affects the localization of HNRNPA1 protein
Butylated Hydroxytoluene results in increased expression of HNRNPA1 protein
[Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of HNRNPA1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of HNRNPA1 protein
CTD PMID:15390079 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 multiple interactions ISO [Methylcholanthrene co-treated with Butylated Hydroxytoluene] affects the expression of HNRNPA2B1 protein CTD PMID:17477362 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D affects localization ISO Butylated Hydroxytoluene affects the localization of HNRNPD protein CTD PMID:10900464 NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
JBrowse link
G Hras HRas proto-oncogene, GTPase decreases methylation
increases response to substance
EXP
ISO
Butylated Hydroxytoluene results in decreased methylation of HRAS gene
HRAS protein results in increased susceptibility to Butylated Hydroxytoluene
CTD PMID:9780227 PMID:11599794 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression ISO Butylated Hydroxytoluene results in increased expression of HSPA9 mRNA CTD PMID:19925653 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in decreased expression of IL10 protein] CTD PMID:16822543 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il15 interleukin 15 affects expression EXP Butylated Hydroxytoluene affects the expression of IL15 mRNA CTD PMID:18539377 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1A mRNA] CTD PMID:8435107 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of IL1RL1 mRNA CTD PMID:19000923 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL2 protein] CTD PMID:16822543 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of IL4 protein] CTD PMID:16822543 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Ilk integrin-linked kinase multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of ILK protein CTD PMID:16272459 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Butylated Hydroxytoluene results in increased expression of JUNB mRNA CTD PMID:19000923 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Kng2 kininogen 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of KNG1 mRNA CTD PMID:19925653 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO Butylated Hydroxytoluene results in increased mutagenesis of KRAS gene CTD PMID:20101149 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [Butylated Hydroxytoluene co-treated with Oxygen] results in increased expression of LEF1 mRNA CTD PMID:16272459 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lep leptin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of LEP protein] CTD PMID:16822543 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression ISO Butylated Hydroxytoluene results in increased expression of MAPK14 mRNA CTD PMID:19925653 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mbp myelin basic protein increases expression ISO Butylated Hydroxytoluene results in increased expression of MBP mRNA CTD PMID:19925653 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of MCM3 mRNA CTD PMID:19000923 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]
Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of COX2 protein]
CTD PMID:12470298 Ensembl chr MT:7,006...7,689 JBrowse link
G Myl3 myosin light chain 3 increases expression ISO Butylated Hydroxytoluene results in increased expression of MYL3 mRNA CTD PMID:19925653 NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases response to substance ISO NFE2L2 protein results in decreased susceptibility to Butylated Hydroxytoluene CTD PMID:10535991 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15713255 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [DCD protein results in increased phosphorylation of NFKBIA protein]
Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased phosphorylation of NFKBIA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased phosphorylation of NFKBIA protein]
CTD PMID:16478757 PMID:17532611 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of NGF mRNA] CTD PMID:9748608 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
EXP Butylated Hydroxytoluene results in increased activity of NQO1 protein
Butylated Hydroxytoluene results in increased expression of NQO1 mRNA
CTD PMID:16045903 PMID:20308224 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H2 mRNA] CTD PMID:17070507 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of NR1H3 mRNA] CTD PMID:17070507 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Butylated Hydroxytoluene binds to and results in decreased activity of NR1I3 protein alternative form; Butylated Hydroxytoluene binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nras NRAS proto-oncogene, GTPase increases activity EXP Butylated Hydroxytoluene results in increased activity of NRAS CTD PMID:3040652 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Nrbf2 nuclear receptor binding factor 2 increases expression EXP Butylated Hydroxytoluene results in increased expression of NRBF2 mRNA CTD PMID:12082028 NCBI chr20:21,308,606...21,326,878
Ensembl chr20:21,308,576...21,326,818
JBrowse link
G Nup54 nucleoporin 54 increases expression ISO Butylated Hydroxytoluene results in increased expression of NUP54 mRNA CTD PMID:19000923 NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of OGG1 mRNA] CTD PMID:20676402 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Parn poly(A)-specific ribonuclease decreases expression ISO Butylated Hydroxytoluene results in decreased expression of PARN mRNA CTD PMID:19925653 NCBI chr10:1,410,636...1,548,573
Ensembl chr10:1,410,642...1,548,560
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Benzoyl Peroxide results in increased activity of PARP1 protein]; Butylated Hydroxytoluene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of PARP1 protein] CTD PMID:2126186 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Butylated Hydroxytoluene results in increased expression of PCNA protein CTD PMID:11238010 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Per2 period circadian regulator 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of PER2 mRNA CTD PMID:19925653 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Hydrogen Peroxide results in increased expression of PGK1 protein] CTD PMID:18603805 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Phex phosphate regulating endopeptidase homolog, X-linked increases expression ISO Butylated Hydroxytoluene results in increased expression of PHEX mRNA CTD PMID:19000923 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 increases expression ISO Butylated Hydroxytoluene results in increased expression of PIK3R5 mRNA CTD PMID:19000923 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374
JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of PKNOX2 mRNA CTD PMID:19925653 NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases expression ISO Butylated Hydroxytoluene results in increased expression of PLA2G4A protein CTD PMID:16443645 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein] CTD PMID:10856522 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pomp proteasome maturation protein increases expression EXP Butylated Hydroxytoluene results in increased expression of POMP mRNA CTD PMID:12082028 NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [[Iron co-treated with Ascorbic Acid] results in decreased expression of PON1 protein] CTD PMID:16052486 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pon2 paraoxonase 2 multiple interactions ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of PON2 protein] CTD PMID:17916643 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pou2f1 POU class 2 homeobox 1 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of POU2F1 mRNA CTD PMID:19925653 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPAR mRNA] CTD PMID:17070507 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Butylated Hydroxytoluene results in increased expression of PPARG mRNA
Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in decreased expression of PPARG mRNA]
CTD PMID:17070507 PMID:19925653 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Prkca protein kinase C, alpha decreases expression ISO Butylated Hydroxytoluene results in decreased expression of PRKCA protein CTD PMID:7716780 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [AGT protein results in increased expression of PSMC6 protein]; Butylated Hydroxytoluene inhibits the reaction [Reactive Oxygen Species results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]
CTD PMID:12470298 PMID:17532611 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of PTGS1 protein CTD PMID:11696405 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Butylated Hydroxytoluene results in increased expression of PTGS2 protein
Butylated Hydroxytoluene inhibits the reaction [Ethanol results in increased expression of PTGS2 mRNA]
CTD PMID:11696405 PMID:17067360 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO Butylated Hydroxytoluene results in increased expression of PTHLH mRNA CTD PMID:19925653 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Rab31 RAB31, member RAS oncogene family decreases expression ISO Butylated Hydroxytoluene results in decreased expression of RAB31 mRNA CTD PMID:19925653 NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253
JBrowse link
G Rad21 RAD21 cohesin complex component increases expression ISO Butylated Hydroxytoluene results in increased expression of RAD21 mRNA CTD PMID:19000923 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rad51ap1 RAD51 associated protein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of RAD51AP1 mRNA CTD PMID:19000923 NCBI chr 4:159,759,454...159,772,524
Ensembl chr 4:159,759,459...159,772,524
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Cadmium Chloride results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased activity of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15713255 PMID:16478757 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rif1 replication timing regulatory factor 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of RIF1 mRNA CTD PMID:19000923 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617
JBrowse link
G Rnf112 ring finger protein 112 affects expression EXP Butylated Hydroxytoluene affects the expression of RNF112 mRNA CTD PMID:18539377 NCBI chr10:46,121,146...46,126,691
Ensembl chr10:46,121,148...46,126,699
JBrowse link
G Sell selectin L decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SELL mRNA CTD PMID:19925653 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [LPA protein results in decreased expression of SERPINE1 protein]; Butylated Hydroxytoluene inhibits the reaction [LPA protein results in increased expression of SERPINE1 protein] CTD PMID:10856522 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpinh1 serpin family H member 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SERPINH1 mRNA CTD PMID:19925653 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Shisa2 shisa family member 2 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SHISA2 mRNA CTD PMID:19925653 NCBI chr15:33,806,715...33,811,013
Ensembl chr15:33,805,958...33,811,013
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SLC2A1 mRNA CTD PMID:19000923 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SLC2A3 mRNA CTD PMID:19925653 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc39a11 solute carrier family 39, member 11 increases expression ISO Butylated Hydroxytoluene results in increased expression of SLC39A11 mRNA CTD PMID:19925653 NCBI chr10:98,275,958...98,697,042
Ensembl chr10:98,275,960...98,611,295
JBrowse link
G Slfn4 schlafen family member 4 decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SLFN4 mRNA CTD PMID:19925653 NCBI chr10:67,994,601...68,018,141
Ensembl chr10:68,000,028...68,018,138
Ensembl chr10:68,000,028...68,018,138
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO [Butylated Hydroxyanisole co-treated with Butylated Hydroxytoluene] results in decreased expression of SOD2 mRNA CTD PMID:14981915 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spib Spi-B transcription factor decreases expression ISO Butylated Hydroxytoluene results in decreased expression of SPIB mRNA CTD PMID:19925653 NCBI chr 1:95,018,939...95,024,804
Ensembl chr 1:95,018,947...95,024,780
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of SPP1 mRNA CTD PMID:19925653 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Srsf1 serine and arginine rich splicing factor 1 multiple interactions
increases expression
affects localization
ISO [Butylated Hydroxytoluene co-treated with Methylcholanthrene] affects the localization of SRSF1 protein; [Butylated Hydroxytoluene co-treated with Methylcholanthrene] results in increased expression of SRSF1 protein
Butylated Hydroxytoluene results in increased expression of SRSF1 protein
Butylated Hydroxytoluene affects the localization of SRSF1 protein
CTD PMID:15390079 NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336
JBrowse link
G Stmn1 stathmin 1 increases expression ISO Butylated Hydroxytoluene results in increased expression of STMN1 mRNA CTD PMID:19000923 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
JBrowse link
G Stom stomatin increases expression ISO Butylated Hydroxytoluene results in increased expression of STOM mRNA CTD PMID:19925653 NCBI chr 3:18,645,058...18,667,343
Ensembl chr 3:18,644,378...18,667,354
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Butylated Hydroxytoluene inhibits the reaction [Streptozocin results in increased expression of TAC1 mRNA] CTD PMID:9748608 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase affects expression
increases expression
EXP
ISO
Butylated Hydroxytoluene affects the expression of TDO2 mRNA
Butylated Hydroxytoluene results in increased expression of TDO2 mRNA
CTD PMID:18539377 PMID:19925653 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFAM protein] CTD PMID:20676402 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
G Tfb1m transcription factor B1, mitochondrial multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB1M protein] CTD PMID:20676402 NCBI chr 1:44,115,240...44,161,737
Ensembl chr 1:44,119,166...44,161,709
JBrowse link
G Tfb2m transcription factor B2, mitochondrial multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M mRNA]; Butylated Hydroxytoluene inhibits the reaction [iron(II)-ascorbic acid complex results in increased expression of TFB2M protein] CTD PMID:20676402 NCBI chr13:91,278,889...91,296,709
Ensembl chr13:91,278,898...91,296,657
JBrowse link
G Tfrc transferrin receptor increases expression ISO Butylated Hydroxytoluene results in increased expression of TFRC mRNA CTD PMID:19000923 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tgfa transforming growth factor alpha decreases response to substance EXP Butylated Hydroxytoluene results in decreased susceptibility to TGFA protein CTD PMID:7593635 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:16757516 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thpo thrombopoietin multiple interactions ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of THPO protein] CTD PMID:16822543 Ensembl chr11:80,182,820...80,188,167 JBrowse link
G Tmem45b transmembrane protein 45b decreases expression ISO Butylated Hydroxytoluene results in decreased expression of TMEM45B mRNA CTD PMID:19925653 NCBI chr 8:29,865,276...29,910,453
Ensembl chr 8:29,865,278...29,910,453
JBrowse link
G Tnc tenascin C increases expression ISO Butylated Hydroxytoluene results in increased expression of TNC mRNA CTD PMID:19925653 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases response to substance
decreases expression
ISO
EXP
Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxytoluene inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of COX2 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]
Butylated Hydroxytoluene results in increased susceptibility to TNF protein
Butylated Hydroxytoluene inhibits the reaction [TNF protein affects the localization of RELA protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in decreased uptake of Excitatory Amino Acid Agents]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Butylated Hydroxytoluene inhibits the reaction [TNF protein results in increased activity of RELA protein]
Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Ascorbic Acid promotes the reaction [Quartz results in increased secretion of TNF protein]]]; Butylated Hydroxytoluene inhibits the reaction [Dextran Sulfate promotes the reaction [Quartz results in increased secretion of TNF protein]]; Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of TNF protein]
Butylated Hydroxytoluene results in decreased expression of TNF protein
CTD PMID:9721806 PMID:12470298 PMID:15713255 PMID:16822543 PMID:16910777 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression EXP Butylated Hydroxytoluene results in increased expression of TP53 mRNA CTD PMID:9780227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ttr transthyretin increases expression EXP Butylated Hydroxytoluene results in increased expression of TTR mRNA CTD PMID:12082028 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Ube2g2 ubiquitin-conjugating enzyme E2G 2 increases expression ISO Butylated Hydroxytoluene results in increased expression of UBE2G2 mRNA CTD PMID:19925653 NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
ISO Butylated Hydroxytoluene inhibits the reaction [Methylnitrosourea results in increased expression of VEGFA protein]
Butylated Hydroxytoluene results in increased expression of VEGFA mRNA
CTD PMID:16822543 PMID:19000923 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        food additive 15111
          2,6-di-tert-butyl-4-methylphenol 174
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic aromatic compound 19176
                                  phenols 18146
                                    phenol 1364
                                      2,6-di-tert-butyl-4-methylphenol 174
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