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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,4-dibromophenol
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Accession:CHEBI:34238 term browser browse the term
Definition:A bromophenol that is phenol in which the hydrogens at positions 2 and 4 have been replaced by bromines.
Synonyms:related_synonym: 2,4-DBP;   Formula=C6H4Br2O;   InChI=1S/C6H4Br2O/c7-4-1-2-6(9)5(8)3-4/h1-3,9H;   InChIKey=FAXWFCTVSHEODL-UHFFFAOYSA-N;   SMILES=C1=CC(=CC(=C1O)Br)Br
 xref: AGR:IND44086700;   CAS:615-58-7;   FooDB:FDB008794;   HMDB:HMDB0032079;   KEGG:C14521;   KNApSAcK:C00033541
 xref_mesh: MESH:C013930
 xref: PMID:16911838;   PMID:19664797;   PMID:20065618;   PMID:21459404;   PMID:22697042;   PMID:23786809;   PMID:25229997;   PMID:25817024;   PMID:26295539;   PMID:26602791;   PMID:27085014;   PMID:28893619;   PMID:29191314;   Reaxys:1861291;   Wikipedia:2\,4-Dibromophenol



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2,4-dibromophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression
multiple interactions
ISO 2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form
Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]
CTD PMID:33961949 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; pifithrin inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein]; TRP53 promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein] CTD PMID:33961949 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression ISO 2,4-dibromophenol results in increased expression of CYP11A1 mRNA CTD PMID:17447562 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases expression ISO 2,4-dibromophenol results in increased expression of CYP11B2 mRNA CTD PMID:17447562 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO 2,4-dibromophenol results in increased expression of CYP17A1 mRNA CTD PMID:17447562 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression ISO 2,4-dibromophenol results in increased expression of CYP19A1 mRNA CTD PMID:17447562 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; pifithrin promotes the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form] CTD PMID:33961949 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO 2,4-dibromophenol results in increased expression of HMGCR mRNA CTD PMID:17447562 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 increases expression ISO 2,4-dibromophenol results in increased expression of HSD17B1 mRNA CTD PMID:17447562 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO 2,4-dibromophenol results in increased expression of HSD17B4 mRNA CTD PMID:17447562 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 increases expression ISO 2,4-dibromophenol results in increased expression of HSD3B2 mRNA CTD PMID:17447562 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Star steroidogenic acute regulatory protein increases expression ISO 2,4-dibromophenol results in increased expression of STAR mRNA CTD PMID:17447562 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO 2,4-dibromophenol metabolite results in increased expression of and affects the localization of TRP53 protein; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of TRP53 protein modified form]; Acetylcysteine inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of TRP53 protein]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of CASP3 protein modified form]; TRP53 inhibits the reaction [2,4-dibromophenol metabolite results in increased expression of H2AX protein modified form]; TRP53 promotes the reaction [2,4-dibromophenol metabolite results in increased expression of CDKN1A protein] CTD PMID:33961949 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ttr transthyretin affects binding ISO 2,4-dibromophenol binds to TTR protein CTD PMID:10869457 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19757
    role 19730
      application 19563
        flame retardant 5056
          brominated flame retardant 3672
            2,4-dibromophenol 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    p-block element atom 19703
                      carbon group element atom 19649
                        carbon atom 19645
                          organic molecular entity 19645
                            organic molecule 19604
                              organic cyclic compound 19407
                                carbocyclic compound 18514
                                  benzenoid aromatic compound 17839
                                    benzenes 17679
                                      bromobenzenes 4034
                                        bromophenol 1161
                                          2,4-dibromophenol 14
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