CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: carmustine
Accession: CHEBI:3423
browse the term
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Synonyms: exact_synonym: 1,3-bis(2-chloroethyl)-1-nitrosourea
related_synonym: BCNU; Bicnu (TN); Bischloroethyl nitrosourea; Formula=C5H9Cl2N3O2; Gliadel; InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11); InChIKey=DLGOEMSEDOSKAD-UHFFFAOYSA-N; N,N'-Bis(2-chloroethyl)-N-nitrosourea; SMILES=ClCCNC(=O)N(CCCl)N=O; carmustina; carmustinum
xref: CAS:154-93-8; DrugBank:DB00262; Drug_Central:512; KEGG:D00254
xref_mesh: MESH:D002330
xref: Wikipedia:Carmustine
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression multiple interactions
ISO
Carmustine results in increased expression of ABCB1 protein [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine
CTD
PMID:11792417 PMID:15239124
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc2
ATP binding cassette subfamily C member 2
affects response to substance
ISO
ABCC2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcg5
ATP binding cassette subfamily G member 5
affects response to substance
ISO
ABCG5 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Acer2
alkaline ceramidase 2
increases expression
EXP
Carmustine results in increased expression of ACER2 mRNA
CTD
PMID:16005536
NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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Acp3
acid phosphatase 3
decreases expression
EXP
Carmustine results in decreased expression of ACP3 mRNA
CTD
PMID:16005536
NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236
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Actc1
actin, alpha, cardiac muscle 1
decreases expression
ISO
Carmustine results in decreased expression of ACTC1 mRNA
CTD
PMID:15980968
NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
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Actg2
actin gamma 2, smooth muscle
decreases expression
ISO
Carmustine results in decreased expression of ACTG2 mRNA
CTD
PMID:15980968
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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Actn1
actinin, alpha 1
decreases expression
ISO
Carmustine results in decreased expression of ACTN1 mRNA
CTD
PMID:15980968
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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Adam15
ADAM metallopeptidase domain 15
decreases expression
ISO
Carmustine results in decreased expression of ADAM15 mRNA
CTD
PMID:15980968
NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113
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Adamts4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
decreases expression
ISO
Carmustine results in decreased expression of ADAMTS4 mRNA
CTD
PMID:15980968
NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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Adcyap1
adenylate cyclase activating polypeptide 1
decreases expression
ISO
Carmustine results in decreased expression of ADCYAP1 mRNA
CTD
PMID:15980968
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
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Adra1b
adrenoceptor alpha 1B
decreases expression
ISO
Carmustine results in decreased expression of ADRA1B mRNA
CTD
PMID:15980968
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Agr3
anterior gradient 3, protein disulphide isomerase family member
affects response to substance
ISO
AGR3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:52,643,391...52,666,638
Ensembl chr 6:52,643,391...52,666,638
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Agt
angiotensinogen
decreases response to substance
ISO
AGT protein mutant form results in decreased susceptibility to Carmustine; AGT protein results in decreased susceptibility to Carmustine
CTD
PMID:11034089
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Akr1b1
aldo-keto reductase family 1 member B1
affects response to substance
ISO
AKR1B1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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Akr1c1
aldo-keto reductase family 1, member C1
affects response to substance
ISO
AKR1C1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation affects response to substance multiple interactions
EXP ISO
Carmustine results in decreased phosphorylation of AKT1 protein AKT1 protein affects the susceptibility to Carmustine LCN2 protein promotes the reaction [Carmustine results in decreased phosphorylation of AKT1 protein]
CTD
PMID:18430789 PMID:19860839
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
decreases expression
ISO
Carmustine results in decreased expression of AKT2 mRNA
CTD
PMID:15980968
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Alad
aminolevulinate dehydratase
decreases expression multiple interactions
ISO
Carmustine results in decreased expression of ALAD mRNA [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein
CTD
PMID:15980968 PMID:19162187
NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
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Alas2
5'-aminolevulinate synthase 2
decreases expression
EXP
Carmustine results in decreased expression of ALAS2 mRNA
CTD
PMID:16005536
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
affects response to substance
ISO
ALDH1A3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Alox12
arachidonate 12-lipoxygenase, 12S type
affects response to substance decreases expression
ISO EXP
ALOX12 protein affects the susceptibility to Carmustine Carmustine results in decreased expression of ALOX12 mRNA
CTD
PMID:16005536 PMID:19373248
NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
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Alox15b
arachidonate 15-lipoxygenase, type B
decreases expression
ISO
Carmustine results in decreased expression of ALOX15B mRNA
CTD
PMID:15980968
NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
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Amh
anti-Mullerian hormone
decreases expression
ISO
Carmustine results in decreased expression of AMH mRNA
CTD
PMID:15980968
NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
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Ank2
ankyrin 2
affects response to substance
ISO
ANK2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
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Ankrd1
ankyrin repeat domain 1
affects response to substance
ISO
ANKRD1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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Ap1s2
adaptor related protein complex 1 subunit sigma 2
affects response to substance
ISO
AP1S2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr X:30,572,746...30,598,961
Ensembl chr X:30,572,751...30,597,262
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Apc
APC regulator of WNT signaling pathway
affects response to substance
ISO
APC mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Apc2
APC regulator of WNT signaling pathway 2
decreases expression
ISO
Carmustine results in decreased expression of APC2 mRNA
CTD
PMID:15980968
NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases response to substance decreases response to substance
ISO
APEX1 protein mutant form results in increased susceptibility to Carmustine APEX1 protein results in decreased susceptibility to Carmustine
CTD
PMID:12231548 PMID:16243814 PMID:17259346 PMID:19470598
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Aplnr
apelin receptor
decreases expression
ISO
Carmustine results in decreased expression of APLNR mRNA
CTD
PMID:15980968
NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
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Aqp8
aquaporin 8
decreases expression
ISO
Carmustine results in decreased expression of AQP8 mRNA
CTD
PMID:15980968
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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Arf1
ADP-ribosylation factor 1
affects response to substance
ISO
ARF1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
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Arpc2
actin related protein 2/3 complex, subunit 2
decreases expression
ISO
Carmustine results in decreased expression of ARPC2 mRNA
CTD
PMID:15980968
NCBI chr 9:75,820,782...75,851,471
Ensembl chr 9:75,820,770...75,851,471
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Arrdc2
arrestin domain containing 2
affects response to substance
ISO
ARRDC2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029
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Artn
artemin
decreases expression
ISO
Carmustine results in decreased expression of ARTN mRNA
CTD
PMID:15980968
NCBI chr 5:131,458,596...131,470,193
Ensembl chr 5:131,464,756...131,468,025
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Asmtl
acetylserotonin O-methyltransferase-like
decreases expression
ISO
Carmustine results in decreased expression of ASMTL mRNA
CTD
PMID:15980968
NCBI chr12:16,315,335...16,318,083
Ensembl chr12:16,315,414...16,318,080
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
decreases expression
ISO
Carmustine results in decreased expression of ATP1A3 mRNA
CTD
PMID:15980968
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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Atp4b
ATPase H+/K+ transporting subunit beta
decreases expression
ISO
Carmustine results in decreased expression of ATP4B mRNA
CTD
PMID:15980968
NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063
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Atp5f1d
ATP synthase F1 subunit delta
decreases expression
ISO
Carmustine results in decreased expression of ATP5F1D mRNA
CTD
PMID:15980968
NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929
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Atp6v0c
ATPase H+ transporting V0 subunit C
decreases expression
ISO
Carmustine results in decreased expression of ATP6V0C mRNA
CTD
PMID:15980968
NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500
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Atr
ATR serine/threonine kinase
multiple interactions
ISO
ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]
CTD
PMID:19261750
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Atxn2l
ataxin 2-like
decreases expression
ISO
Carmustine results in decreased expression of ATXN2L mRNA
CTD
PMID:15980968
NCBI chr 1:181,078,293...181,090,079
Ensembl chr 1:181,078,288...181,089,686
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Avpr1a
arginine vasopressin receptor 1A
increases expression
ISO
Carmustine results in increased expression of AVPR1A mRNA
CTD
PMID:15980968
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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B4galt5
beta-1,4-galactosyltransferase 5
decreases expression
ISO
Carmustine results in decreased expression of B4GALT5 mRNA
CTD
PMID:15980968
NCBI chr 3:156,018,056...156,033,983
Ensembl chr 3:156,018,053...156,070,074
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Baiap2
BAR/IMD domain containing adaptor protein 2
decreases expression
ISO
Carmustine results in decreased expression of BAIAP2 mRNA
CTD
PMID:15980968
NCBI chr10:105,223,065...105,290,130
Ensembl chr10:105,223,090...105,290,134
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Baiap3
BAI1-associated protein 3
decreases expression
ISO
Carmustine results in decreased expression of BAIAP3 mRNA
CTD
PMID:15980968
NCBI chr10:14,260,269...14,273,019
Ensembl chr10:14,260,269...14,273,019
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Carmustine results in increased expression of BAX protein
CTD
PMID:20920327
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl10
BCL10, immune signaling adaptor
increases expression
ISO
Carmustine results in increased expression of BCL10 mRNA
CTD
PMID:15980968
NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression affects response to substance
ISO
[Fenretinide co-treated with Carmustine] results in decreased expression of BCL2 protein Carmustine results in decreased expression of BCL2 protein BCL2 protein affects the susceptibility to Carmustine
CTD
PMID:15332326 PMID:16187019 PMID:18430789 PMID:20920327
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
affects response to substance decreases expression multiple interactions
ISO EXP
BCL2L1 protein affects the susceptibility to Carmustine Carmustine results in decreased expression of BCL2L1 mRNA; Carmustine results in decreased expression of BCL2L1 protein [Fenretinide co-treated with Carmustine] results in decreased expression of BCL2L1 protein
CTD
PMID:15332326 PMID:16187019 PMID:19860839
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Becn1
beclin 1
decreases expression
ISO
Carmustine results in decreased expression of BECN1 mRNA
CTD
PMID:15980968
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bicd1
BICD cargo adaptor 1
decreases expression
ISO
Carmustine results in decreased expression of BICD1 mRNA
CTD
PMID:15980968
NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434
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Blk
BLK proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
Carmustine results in decreased expression of BLK mRNA
CTD
PMID:15980968
NCBI chr15:37,626,746...37,665,053
Ensembl chr15:37,627,039...37,665,031
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Bmal1
basic helix-loop-helix ARNT like 1
decreases expression
EXP
Carmustine results in decreased expression of BMAL1 mRNA
CTD
PMID:16005536
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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Bmp5
bone morphogenetic protein 5
affects response to substance
ISO
BMP5 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925
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Bmp7
bone morphogenetic protein 7
decreases expression
ISO
Carmustine results in decreased expression of BMP7 mRNA
CTD
PMID:15980968
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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Brf1
BRF1, RNA polymerase III transcription initiation factor subunit
decreases expression
ISO
Carmustine results in decreased expression of BRF1 mRNA
CTD
PMID:15980968
NCBI chr 6:132,034,378...132,081,313
Ensembl chr 6:132,037,272...132,081,278
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Cadm1
cell adhesion molecule 1
affects response to substance
ISO
CADM1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Calb2
calbindin 2
decreases expression
ISO
Carmustine results in decreased expression of CALB2 mRNA
CTD
PMID:15980968
NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438
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Car6
carbonic anhydrase 6
decreases expression
ISO
Carmustine results in decreased expression of CA6 mRNA
CTD
PMID:15980968
NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
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Casp3
caspase 3
increases activity increases expression multiple interactions increases cleavage
EXP ISO
Carmustine results in increased activity of CASP3 protein Carmustine results in increased expression of CASP3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; [LCN2 protein co-treated with Carmustine] results in increased cleavage of and results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Carmustine results in increased activity of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [Carmustine results in increased activity of and results in increased cleavage of CASP3 protein]; Zinc Sulfate inhibits the reaction [Carmustine results in increased activity of CASP3 protein] Carmustine results in increased cleavage of CASP3 protein [Carmustine co-treated with 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid] results in increased activity of CASP3 protein; Disulfiram promotes the reaction [Carmustine results in increased cleavage of CASP3 protein]
CTD
PMID:18590702 PMID:19860839 PMID:20046642 PMID:20920327 PMID:21600974 PMID:24193513 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
decreases activity multiple interactions
EXP
Carmustine results in decreased activity of CAT protein Acetylcysteine inhibits the reaction [Carmustine results in decreased activity of CAT protein]
CTD
PMID:20332008
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
affects activity decreases expression increases expression affects response to substance
ISO
Carmustine affects the activity of CCL2 protein Carmustine results in decreased expression of CCL2 protein Carmustine results in increased expression of CCL2 mRNA CCL2 mRNA affects the susceptibility to Carmustine
CTD
PMID:15980968 PMID:16365179 PMID:17522861
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccn4
cellular communication network factor 4
affects response to substance
ISO
CCN4 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:98,645,238...98,677,253
Ensembl chr 7:98,645,182...98,677,248
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Ccnd1
cyclin D1
affects response to substance
ISO
CCND1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccne1
cyclin E1
increases expression
EXP
Carmustine results in increased expression of CCNE1 mRNA
CTD
PMID:16005536
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Cd151
CD151 molecule (Raph blood group)
decreases expression
ISO
Carmustine results in decreased expression of CD151 mRNA
CTD
PMID:15980968
NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753
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Cd44
CD44 molecule
affects response to substance
ISO
CD44 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd68
Cd68 molecule
decreases expression
ISO
Carmustine results in decreased expression of CD68 mRNA
CTD
PMID:15980968
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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Cd79a
CD79a molecule
decreases expression
ISO
Carmustine results in decreased expression of CD79A mRNA
CTD
PMID:15980968
NCBI chr 1:80,493,581...80,497,936
Ensembl chr 1:80,493,581...80,497,935
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Cd80
Cd80 molecule
increases expression
ISO
Carmustine results in increased expression of CD80 mRNA
CTD
PMID:15980968
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Cdc25b
cell division cycle 25B
decreases expression
EXP
Carmustine results in decreased expression of CDC25B mRNA
CTD
PMID:16005536
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
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Cdh13
cadherin 13
affects response to substance
ISO
CDH13 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
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Cdk8
cyclin-dependent kinase 8
decreases expression
ISO
Carmustine results in decreased expression of CDK8 mRNA
CTD
PMID:15980968
NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
[Carmustine co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein; MDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]
CTD
PMID:15735757 PMID:16193384 PMID:18632648 PMID:20472715
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1c
cyclin-dependent kinase inhibitor 1C
affects response to substance
ISO
CDKN1C mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases response to substance
ISO
CDKN2A protein results in increased susceptibility to Carmustine
CTD
PMID:16786135
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Cdkn3
cyclin-dependent kinase inhibitor 3
decreases expression
EXP
Carmustine results in decreased expression of CDKN3 mRNA
CTD
PMID:16005536
NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
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Cdx4
caudal type homeo box 4
decreases expression
ISO
Carmustine results in decreased expression of CDX4 mRNA
CTD
PMID:15980968
NCBI chr X:68,326,874...68,335,461
Ensembl chr X:68,326,874...68,335,461
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Cebpb
CCAAT/enhancer binding protein beta
decreases expression
ISO
Carmustine results in decreased expression of CEBPB mRNA
CTD
PMID:15980968
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Cgref1
cell growth regulator with EF hand domain 1
increases expression
EXP
Carmustine results in increased expression of CGREF1 mRNA
CTD
PMID:16005536
NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852
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Chd2
chromodomain helicase DNA binding protein 2
affects response to substance
ISO
CHD2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502
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Chek1
checkpoint kinase 1
multiple interactions
ISO
ATR protein affects the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Caffeine inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein; O(6)-benzylguanine promotes the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]
CTD
PMID:19261750
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chrm4
cholinergic receptor, muscarinic 4
decreases expression
ISO
Carmustine results in decreased expression of CHRM4 mRNA
CTD
PMID:15980968
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Chrnb3
cholinergic receptor nicotinic beta 3 subunit
decreases expression
ISO
Carmustine results in decreased expression of CHRNB3 mRNA
CTD
PMID:15980968
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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Chrng
cholinergic receptor nicotinic gamma subunit
decreases expression
ISO
Carmustine results in decreased expression of CHRNG mRNA
CTD
PMID:15980968
NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482
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Ckm
creatine kinase, M-type
decreases expression
ISO
Carmustine results in decreased expression of CKM mRNA
CTD
PMID:15980968
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Clic1
chloride intracellular channel 1
multiple interactions decreases response to substance
ISO
[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of CLIC1 protein] which results in increased susceptibility to Carmustine CLIC1 protein results in decreased susceptibility to Carmustine
CTD
PMID:18590702
NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
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Cntnap1
contactin associated protein 1
increases expression
ISO
Carmustine results in increased expression of CNTNAP1 mRNA
CTD
PMID:15980968
NCBI chr10:86,109,850...86,125,612
Ensembl chr10:86,111,643...86,125,611
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Col1a1
collagen type I alpha 1 chain
affects response to substance
ISO
COL1A1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col5a3
collagen type V alpha 3 chain
decreases expression
EXP
Carmustine results in decreased expression of COL5A3 mRNA
CTD
PMID:16005536
NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853
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Col9a1
collagen type IX alpha 1 chain
decreases expression
ISO
Carmustine results in decreased expression of COL9A1 mRNA
CTD
PMID:15980968
NCBI chr 9:26,585,034...26,668,222
Ensembl chr 9:26,585,034...26,668,213
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Cox6a2
cytochrome c oxidase subunit 6A2
decreases expression
ISO
Carmustine results in decreased expression of COX6A2 mRNA
CTD
PMID:15980968
NCBI chr 1:182,788,528...182,790,746
Ensembl chr 1:182,788,528...182,789,274
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Crabp1
cellular retinoic acid binding protein 1
decreases expression
ISO
Carmustine results in decreased expression of CRABP1 mRNA
CTD
PMID:15980968
NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360
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Crat
carnitine O-acetyltransferase
decreases expression
ISO
Carmustine results in decreased expression of CRAT mRNA
CTD
PMID:15980968
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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Crybb1
crystallin, beta B1
decreases expression
ISO
Carmustine results in decreased expression of CRYBB1 mRNA
CTD
PMID:15980968
NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344
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Csf2
colony stimulating factor 2
affects response to substance
ISO
CSF2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csgalnact1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
affects response to substance
ISO
CSGALNACT1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319
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Csrp3
cysteine and glycine rich protein 3
affects response to substance
ISO
CSRP3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
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Cst5
cystatin D
decreases expression
ISO
Carmustine results in decreased expression of CST5 mRNA
CTD
PMID:15980968
NCBI chr 3:137,573,194...137,577,754
Ensembl chr 3:137,573,194...137,577,754
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Ctf1
cardiotrophin 1
decreases expression
ISO
Carmustine results in decreased expression of CTF1 mRNA
CTD
PMID:15980968
NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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Ctnnal1
catenin alpha-like 1
increases expression
ISO
Carmustine results in increased expression of CTNNAL1 mRNA
CTD
PMID:15980968
NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431
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Ctsl
cathepsin L
increases expression
EXP
Carmustine results in increased expression of CTSL mRNA
CTD
PMID:16005536
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cux2
cut-like homeobox 2
affects expression
EXP
Carmustine affects the expression of CUX2 mRNA
CTD
PMID:19174181
NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806
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Cxcl1
C-X-C motif chemokine ligand 1
affects response to substance
ISO
CXCL1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl2
C-X-C motif chemokine ligand 2
affects response to substance
ISO
CXCL2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl3
C-X-C motif chemokine ligand 3
affects response to substance
ISO
CXCL1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases expression
ISO
Carmustine results in decreased expression of CYP19A1 mRNA
CTD
PMID:15980968
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]
CTD
PMID:16087946
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
CYP3A5 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin]
CTD
PMID:16087946
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyth1
cytohesin 1
increases expression
ISO
Carmustine results in increased expression of CYTH1 mRNA
CTD
PMID:15980968
NCBI chr10:103,402,727...103,485,826
Ensembl chr10:103,366,145...103,485,760
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Def6
DEF6 guanine nucleotide exchange factor
affects response to substance
ISO
DEF6 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr20:6,268,579...6,290,030
Ensembl chr20:6,268,601...6,289,961
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Dhrs3
dehydrogenase/reductase 3
affects response to substance
ISO
DHRS3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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Dhx16
DEAH-box helicase 16
decreases expression
ISO
Carmustine results in decreased expression of DHX16 mRNA
CTD
PMID:15980968
NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948
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Dhx37
DEAH-box helicase 37
affects response to substance
ISO
DHX37 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802
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Dkk1
dickkopf WNT signaling pathway inhibitor 1
increases response to substance
ISO
DKK1 protein results in increased susceptibility to Carmustine
CTD
PMID:20920327
NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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Dmrtc2
DMRT-like family C2
affects response to substance
ISO
DMRTC2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:80,466,259...80,473,883
Ensembl chr 1:80,466,132...80,473,531
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Dnase1l2
deoxyribonuclease 1 like 2
decreases expression
ISO
Carmustine results in decreased expression of DNASE1L2 mRNA
CTD
PMID:15980968
NCBI chr10:13,471,850...13,473,447
Ensembl chr10:13,471,479...13,473,763
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Dvl1
dishevelled segment polarity protein 1
decreases expression
ISO
Carmustine results in decreased expression of DVL1 mRNA
CTD
PMID:15980968
NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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Dyrk1b
dual specificity tyrosine phosphorylation regulated kinase 1B
affects response to substance
ISO
DYRK1B mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:83,479,168...83,497,011
Ensembl chr 1:83,479,147...83,487,169
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E2f1
E2F transcription factor 1
increases expression
ISO
Carmustine results in increased expression of E2F1 protein
CTD
PMID:18632648
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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Ecm2
extracellular matrix protein 2
increases expression
ISO
Carmustine results in increased expression of ECM2 mRNA
CTD
PMID:15980968
NCBI chr17:15,120,194...15,152,536
Ensembl chr17:15,120,196...15,152,516
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Ednra
endothelin receptor type A
affects response to substance
ISO
EDNRA mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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Eef1g
eukaryotic translation elongation factor 1 gamma
increases expression
ISO
Carmustine results in increased expression of EEF1G mRNA
CTD
PMID:15980968
NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
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Eif2b1
eukaryotic translation initiation factor 2B subunit alpha
increases expression
ISO
Carmustine results in increased expression of EIF2B1 mRNA
CTD
PMID:15980968
NCBI chr12:32,025,593...32,033,848
Ensembl chr12:32,025,557...32,046,601
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Eif4a2
eukaryotic translation initiation factor 4A2
affects response to substance
ISO
EIF4A2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
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Eif6
eukaryotic translation initiation factor 6
decreases expression
ISO
Carmustine results in decreased expression of EIF6 mRNA
CTD
PMID:15980968
NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
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Elmo1
engulfment and cell motility 1
affects response to substance
ISO
ELMO1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:44,286,495...44,822,668
Ensembl chr17:44,286,485...44,822,788
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Enc1
ectodermal-neural cortex 1
increases expression
EXP
Carmustine results in increased expression of ENC1 mRNA
CTD
PMID:16005536
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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Ephx1
epoxide hydrolase 1
decreases expression
ISO
Carmustine results in decreased expression of EPHX1 mRNA
CTD
PMID:15980968
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
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Espn
espin
increases expression
EXP
Carmustine results in increased expression of ESPN mRNA
CTD
PMID:16005536
NCBI chr 5:162,626,560...162,660,439
Ensembl chr 5:162,626,560...162,660,256
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Esrra
estrogen related receptor, alpha
increases expression
ISO
Carmustine results in increased expression of ESRRA mRNA
CTD
PMID:15980968
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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Etv1
ETS variant transcription factor 1
affects response to substance affects expression
ISO EXP
ETV1 mRNA affects the susceptibility to Carmustine Carmustine affects the expression of ETV1 mRNA
CTD
PMID:16365179 PMID:19174181
NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775
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Extl1
exostosin-like glycosyltransferase 1
affects response to substance
ISO
EXTL1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:146,573,911...146,589,115
Ensembl chr 5:146,573,912...146,589,115
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Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
decreases expression
ISO
Carmustine results in decreased expression of EZH2 mRNA
CTD
PMID:15980968
NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362
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F3
coagulation factor III, tissue factor
increases expression
EXP
Carmustine results in increased expression of F3 mRNA
CTD
PMID:16005536
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Fancc
FA complementation group C
affects response to substance
ISO
FANCC mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
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Fancd2
FA complementation group D2
increases ubiquitination affects localization
ISO
Carmustine results in increased ubiquitination of FANCD2 protein Carmustine affects the localization of FANCD2 protein
CTD
PMID:17221219
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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Fbln5
fibulin 5
decreases expression
EXP
Carmustine results in decreased expression of FBLN5 mRNA
CTD
PMID:16005536
NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755
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Fbn1
fibrillin 1
decreases expression
ISO
Carmustine results in decreased expression of FBN1 mRNA
CTD
PMID:15980968
NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
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Fbxo32
F-box protein 32
affects response to substance
ISO
FBXO32 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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Fech
ferrochelatase
multiple interactions
ISO
[MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]
CTD
PMID:12950064
NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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Fgf2
fibroblast growth factor 2
decreases response to substance
ISO
FGF2 protein results in decreased susceptibility to Carmustine
CTD
PMID:20221717
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fhl2
four and a half LIM domains 2
affects response to substance
ISO
FHL2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192
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Fkbp1a
FKBP prolyl isomerase 1A
decreases expression
ISO
Carmustine results in decreased expression of FKBP1A mRNA
CTD
PMID:15980968
NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
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Fkbp5
FKBP prolyl isomerase 5
increases expression
EXP
Carmustine results in increased expression of FKBP5 mRNA
CTD
PMID:16005536
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fnta
farnesyltransferase, CAAX box, subunit alpha
decreases expression increases expression
ISO
Carmustine results in decreased expression of FNTA mRNA Carmustine results in increased expression of FNTA mRNA
CTD
PMID:15980968
NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
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Foxf2
forkhead box F2
affects response to substance
ISO
FOXF2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:32,835,730...32,842,547
Ensembl chr17:32,836,777...32,842,176
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Foxj1
forkhead box J1
decreases expression
ISO
Carmustine results in decreased expression of FOXJ1 mRNA
CTD
PMID:15980968
NCBI chr10:101,566,299...101,570,370
Ensembl chr10:101,566,304...101,570,237
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Fth1
ferritin heavy chain 1
multiple interactions decreases expression decreases response to substance
ISO
Carmustine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA] Carmustine results in decreased expression of FTH1 mRNA FTH1 results in decreased susceptibility to Carmustine
CTD
PMID:15980968 PMID:16631525 PMID:21385903
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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Ftl1
ferritin light chain 1
decreases expression
ISO
Carmustine results in decreased expression of FTL mRNA
CTD
PMID:15980968
NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
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Fut8
fucosyltransferase 8
affects response to substance
ISO
FUT8 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:95,949,246...96,176,677
Ensembl chr 6:95,949,991...96,176,677
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Fyn
FYN proto-oncogene, Src family tyrosine kinase
decreases expression
ISO
Carmustine results in decreased expression of FYN mRNA
CTD
PMID:15980968
NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
decreases expression affects response to substance
ISO
Carmustine results in decreased expression of GABRA2 mRNA GABRA2 mRNA affects the susceptibility to Carmustine
CTD
PMID:15980968 PMID:16365179
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
decreases expression
ISO
Carmustine results in decreased expression of GABRA6 mRNA
CTD
PMID:15980968
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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Galnt15
polypeptide N-acetylgalactosaminyltransferase 15
affects response to substance
ISO
GALNT15 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:7,227,232...7,267,002
Ensembl chr16:7,227,271...7,267,014
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Gamt
guanidinoacetate N-methyltransferase
decreases expression
ISO
Carmustine results in decreased expression of GAMT mRNA
CTD
PMID:15980968
NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778
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Garnl3
GTPase activating Rap/RanGAP domain-like 3
affects response to substance
ISO
GARNL3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:16,288,718...16,432,308
Ensembl chr 3:16,288,719...16,430,837
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Gast
gastrin
decreases expression
ISO
Carmustine results in decreased expression of GAST mRNA
CTD
PMID:15980968
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
EXP
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein
CTD
PMID:12967637 PMID:16288907
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gcm1
glial cells missing transcription factor 1
increases expression
ISO
Carmustine results in increased expression of GCM1 mRNA
CTD
PMID:15980968
NCBI chr 8:78,925,687...78,938,924
Ensembl chr 8:78,925,687...78,938,924
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Gdi1
GDP dissociation inhibitor 1
increases expression
ISO
Carmustine results in increased expression of GDI1 mRNA
CTD
PMID:15980968
NCBI chr X:152,087,611...152,094,274
Ensembl chr X:152,087,444...152,094,272
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Gdi2
GDP dissociation inhibitor 2
increases expression
ISO
Carmustine results in increased expression of GDI2 mRNA
CTD
PMID:15980968
NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366
G
Gdnf
glial cell derived neurotrophic factor
decreases response to substance
ISO
GDNF protein results in decreased susceptibility to Carmustine
CTD
PMID:19138852
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
G
Gfap
glial fibrillary acidic protein
decreases expression multiple interactions
ISO EXP
Carmustine results in decreased expression of GFAP mRNA Carmustine results in decreased expression of GFAP protein Melatonin inhibits the reaction [Carmustine results in decreased expression of GFAP protein]
CTD
PMID:15980968 PMID:17572393
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Ghsr
growth hormone secretagogue receptor
decreases expression
ISO
Carmustine results in decreased expression of GHSR mRNA
CTD
PMID:15980968
NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
G
Glrb
glycine receptor, beta
affects response to substance
ISO
GLRB mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489
G
Gnrhr
gonadotropin releasing hormone receptor
increases expression
ISO
Carmustine results in increased expression of GNRHR mRNA
CTD
PMID:15980968
NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
G
Golga2
golgin A2
decreases expression
ISO
Carmustine results in decreased expression of GOLGA2 mRNA
CTD
PMID:15980968
NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
G
Golga4
golgin A4
increases expression
ISO
Carmustine results in increased expression of GOLGA4 mRNA
CTD
PMID:15980968
NCBI chr 8:118,208,200...118,285,003
G
Gp1bb
glycoprotein Ib platelet subunit beta
decreases expression
ISO
Carmustine results in decreased expression of GP1BB mRNA
CTD
PMID:15980968
NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392
G
Gpr25
G protein-coupled receptor 25
decreases expression
ISO
Carmustine results in decreased expression of GPR25 mRNA
CTD
PMID:15980968
NCBI chr13:47,712,815...47,714,721
Ensembl chr13:47,713,592...47,714,671
G
Gpr32
G protein-coupled receptor 32
decreases expression
ISO
Carmustine results in decreased expression of GPR32 mRNA
CTD
PMID:15980968
NCBI chr 1:94,756,863...94,757,895
G
Gpr37
G protein-coupled receptor 37
decreases expression
ISO
Carmustine results in decreased expression of GPR37 mRNA
CTD
PMID:15980968
NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
G
Gpr65
G-protein coupled receptor 65
increases expression
ISO
Carmustine results in increased expression of GPR65 mRNA
CTD
PMID:15980968
NCBI chr 6:117,515,786...117,536,514
Ensembl chr 6:117,515,648...117,536,512
G
Grb7
growth factor receptor bound protein 7
decreases expression
ISO
Carmustine results in decreased expression of GRB7 mRNA
CTD
PMID:15980968
NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
G
Grn
granulin precursor
decreases expression
ISO
Carmustine results in decreased expression of GRN mRNA
CTD
PMID:15980968
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
G
Gsr
glutathione-disulfide reductase
multiple interactions decreases activity
ISO EXP
[Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Doxorubicin; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to zinc chloride; Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]; NADP affects the reaction [Carmustine results in decreased activity of GSR protein] [[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide; [Carmustine results in decreased activity of GSR protein] which results in decreased susceptibility to chromium hexavalent ion; [Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein [Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Streptozocin; [Carmustine results in decreased activity of GSR protein] which results in increased uptake of Calcium; MT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; Zinc Sulfate inhibits the reaction [Carmustine results in decreased activity of GSR protein]
CTD
PMID:2116959 PMID:12114195 PMID:12433058 PMID:12477282 PMID:12632252 PMID:12967637 PMID:15104113 PMID:15321730 PMID:15720826 PMID:15857610 PMID:16160061 PMID:16288907 PMID:17382203 PMID:17498860 PMID:18155673 PMID:18528683 PMID:19401447 PMID:19668867 PMID:19856331 PMID:20046642 PMID:21600974 More...
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstm1
glutathione S-transferase mu 1
affects response to substance multiple interactions decreases response to substance
ISO
GSTM1 gene affects the susceptibility to Carmustine GSTM1 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] GSTM1 protein results in decreased susceptibility to Carmustine
CTD
PMID:16087946 PMID:20067466
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
decreases nitrosation
ISO
GSTM2 protein results in decreased nitrosation of Carmustine
CTD
PMID:11841793
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Gstm5
glutathione S-transferase, mu 5
multiple interactions decreases nitrosation affects metabolic processing
ISO
GSTM3 protein results in decreased nitrosation of and results in decreased activity of Carmustine GSTM3 protein results in decreased nitrosation of Carmustine GSTM3 protein affects the metabolism of Carmustine
CTD
PMID:8395980 PMID:11841793 PMID:15247628
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
G
Gstp1
glutathione S-transferase pi 1
multiple interactions decreases response to substance
ISO
GSTP1 gene SNP results in increased susceptibility to [Carmustine co-treated with Doxorubicin co-treated with Cyclophosphamide co-treated with Melphalan] GSTP1 protein results in decreased susceptibility to Carmustine
CTD
PMID:12791655 PMID:16899598
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gstt1
glutathione S-transferase theta 1
affects response to substance decreases nitrosation affects metabolic processing
ISO
GSTT1 protein affects the susceptibility to Carmustine GSTT1 protein results in decreased nitrosation of Carmustine GSTT1 protein affects the metabolism of Carmustine
CTD
PMID:11841793 PMID:16874663 PMID:17827337
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Gtf2f1
general transcription factor IIF subunit 1
decreases expression
ISO
Carmustine results in decreased expression of GTF2F1 mRNA
CTD
PMID:15980968
NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
G
Gucy1b2
guanylate cyclase 1 soluble subunit beta 2
decreases expression
EXP
Carmustine results in decreased expression of GUCY1B2 mRNA
CTD
PMID:16005536
NCBI chr15:36,589,501...36,669,441
Ensembl chr15:36,598,883...36,669,441
G
H2ax
H2A.X variant histone
decreases expression affects localization multiple interactions increases phosphorylation
ISO
Carmustine results in decreased expression of H2AX mRNA Carmustine affects the localization of H2AX protein MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein]; MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein]
CTD
PMID:15980968 PMID:20472715
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hacl1
2-hydroxyacyl-CoA lyase 1
decreases expression
EXP
Carmustine results in decreased expression of HACL1 mRNA
CTD
PMID:16005536
NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
G
Hadh
hydroxyacyl-CoA dehydrogenase
decreases expression
ISO
Carmustine results in decreased expression of HADH mRNA
CTD
PMID:15980968
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
G
Hagh
hydroxyacyl glutathione hydrolase
decreases expression
ISO
Carmustine results in decreased expression of HAGH mRNA
CTD
PMID:15980968
NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504
G
Hcfc1
host cell factor C1
decreases expression
ISO
Carmustine results in decreased expression of HCFC1 mRNA
CTD
PMID:15980968
NCBI chr X:151,687,779...151,712,688
Ensembl chr X:151,687,779...151,712,638
G
Hhat
hedgehog acyltransferase
affects response to substance
ISO
HHAT mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr13:104,024,507...104,283,580
Ensembl chr13:104,010,916...104,282,893
G
Hif1a
hypoxia inducible factor 1 subunit alpha
decreases response to substance multiple interactions
EXP
HIF1A protein results in decreased susceptibility to Carmustine [cobaltous chloride results in increased activity of HIF1A protein] which results in decreased susceptibility to Carmustine; [Deferoxamine results in increased activity of HIF1A protein] which results in decreased susceptibility to Carmustine
CTD
PMID:14980978 PMID:15965067
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Hmgn2
high mobility group nucleosomal binding domain 2
decreases expression
ISO
Carmustine results in decreased expression of HMGN2 mRNA
CTD
PMID:15980968
NCBI chr 5:146,192,126...146,195,580
Ensembl chr 5:146,192,126...146,195,521 Ensembl chr16:146,192,126...146,195,521
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
Carmustine inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]
CTD
PMID:16631525
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnf1a
HNF1 homeobox A
decreases expression
ISO
Carmustine results in decreased expression of HNF1A mRNA
CTD
PMID:15980968
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
G
Hoxa4
homeo box A4
decreases expression
ISO
Carmustine results in decreased expression of HOXA4 mRNA
CTD
PMID:15980968
NCBI chr 4:81,289,677...81,291,685
Ensembl chr 4:81,289,682...81,291,685
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
increases mutagenesis
ISO
Carmustine results in increased mutagenesis of HPRT1 gene
CTD
PMID:17116724
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
G
Icam5
intercellular adhesion molecule 5
decreases expression
ISO
Carmustine results in decreased expression of ICAM5 mRNA
CTD
PMID:15980968
NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588
G
Ids
iduronate 2-sulfatase
decreases expression
ISO
Carmustine results in decreased expression of IDS mRNA
CTD
PMID:15980968
NCBI chr X:149,025,976...149,046,641
Ensembl chr X:149,025,976...149,046,663
G
Ier3
immediate early response 3
decreases expression
ISO
Carmustine results in decreased expression of IER3 mRNA
CTD
PMID:15980968
NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
G
Igf1
insulin-like growth factor 1
decreases expression increases expression
ISO
Carmustine results in decreased expression of IGF1 protein Carmustine results in increased expression of IGF1 protein
CTD
PMID:15286697 PMID:18443378
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igf2
insulin-like growth factor 2
affects response to substance
ISO
IGF2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
G
Igfbp3
insulin-like growth factor binding protein 3
decreases expression
EXP
Carmustine results in decreased expression of IGFBP3 mRNA
CTD
PMID:16005536
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
G
Ikbkg
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
decreases expression
ISO
Carmustine results in decreased expression of IKBKG mRNA
CTD
PMID:15980968
NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499
G
Il12b
interleukin 12B
multiple interactions
ISO
Carmustine promotes the reaction [Lipopolysaccharides results in increased expression of IL12B protein]
CTD
PMID:12688424
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Carmustine promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
CTD
PMID:11970852 PMID:12433058
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1r1
interleukin 1 receptor type 1
affects response to substance
ISO
IL1R1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
G
Il6
interleukin 6
affects response to substance multiple interactions
ISO EXP
IL6 mRNA affects the susceptibility to Carmustine Carmustine promotes the reaction [Oligodeoxyribonucleotides analog results in increased secretion of IL6 protein] Carmustine promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD
PMID:11970852 PMID:12433058 PMID:12477282 PMID:16365179
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inhba
inhibin subunit beta A
affects response to substance
ISO
INHBA mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
G
Inppl1
inositol polyphosphate phosphatase-like 1
decreases expression
ISO
Carmustine results in decreased expression of INPPL1 mRNA
CTD
PMID:15980968
NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
G
Insig1
insulin induced gene 1
decreases expression
ISO
Carmustine results in decreased expression of INSIG1 mRNA
CTD
PMID:15980968
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
G
Insl3
insulin-like 3
decreases expression
ISO
Carmustine results in decreased expression of INSL3 mRNA
CTD
PMID:15980968
NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560
G
Ipo4
importin 4
affects response to substance
ISO
IPO4 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr15:29,117,365...29,127,382
Ensembl chr15:29,117,365...29,127,285
G
Irag2
inositol 1,4,5-triphosphate receptor associated 2
decreases expression
ISO
Carmustine results in decreased expression of IRAG2 mRNA
CTD
PMID:15980968
NCBI chr 4:178,088,902...178,143,569
Ensembl chr 4:178,088,507...178,143,557
G
Irs1
insulin receptor substrate 1
decreases expression
ISO
Carmustine results in decreased expression of IRS1 mRNA
CTD
PMID:15980968
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
G
Islr
immunoglobulin superfamily containing leucine-rich repeat
decreases expression
ISO EXP
Carmustine results in decreased expression of ISLR mRNA
CTD
PMID:15980968 PMID:16005536
NCBI chr 8:58,571,155...58,574,128
Ensembl chr 8:58,570,777...58,574,130
G
Itga3
integrin subunit alpha 3
decreases expression
ISO
Carmustine results in decreased expression of ITGA3 mRNA
CTD
PMID:15980968
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
G
Itgb1
integrin subunit beta 1
decreases expression
ISO
Carmustine results in decreased expression of ITGB1 protein
CTD
PMID:18443378
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Itgb3
integrin subunit beta 3
increases response to substance multiple interactions
ISO EXP
ITGB3 protein results in increased susceptibility to Carmustine 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [ITGB3 protein results in increased susceptibility to Carmustine]
CTD
PMID:21332719
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
G
Itih1
inter-alpha trypsin inhibitor, heavy chain 1
decreases expression
ISO
Carmustine results in decreased expression of ITIH1 mRNA
CTD
PMID:15980968
NCBI chr16:6,122,246...6,136,363
Ensembl chr16:6,122,248...6,136,363
G
Kcna4
potassium voltage-gated channel subfamily A member 4
multiple interactions
EXP
[Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCNA4 protein
CTD
PMID:16288907
NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162
G
Kcnab2
potassium voltage-gated channel subfamily A regulatory beta subunit 2
affects response to substance
ISO
KCNAB2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243
G
Kcnd2
potassium voltage-gated channel subfamily D member 2
multiple interactions
EXP
[Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 mRNA; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 protein
CTD
PMID:16288907
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases expression
ISO
Carmustine results in decreased expression of KCNH2 mRNA
CTD
PMID:15980968
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kif2c
kinesin family member 2C
decreases expression
EXP
Carmustine results in decreased expression of KIF2C mRNA
CTD
PMID:16005536
NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
G
Kif5a
kinesin family member 5A
decreases expression
ISO
Carmustine results in decreased expression of KIF5A mRNA
CTD
PMID:15980968
NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858
G
Krt17
keratin 17
decreases expression
ISO
Carmustine results in decreased expression of KRT17 mRNA
CTD
PMID:15980968
NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
G
Krt31
keratin 31
decreases expression
ISO
Carmustine results in decreased expression of KRT31 mRNA
CTD
PMID:15980968
NCBI chr10:84,979,393...84,982,898
Ensembl chr10:84,979,352...84,982,832
G
Krt8
keratin 8
affects response to substance
ISO
KRT8 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
G
Lad1
ladinin 1
decreases expression
ISO
Carmustine results in decreased expression of LAD1 mRNA
CTD
PMID:15980968
NCBI chr13:47,249,605...47,263,967
Ensembl chr13:47,249,605...47,263,967
G
Lair1
leukocyte-associated immunoglobulin-like receptor 1
increases expression
ISO
Carmustine results in increased expression of LAIR1 mRNA
CTD
PMID:15980968
NCBI chr 1:70,068,571...70,187,851
Ensembl chr 1:70,157,681...70,185,807
G
Lamb3
laminin subunit beta 3
decreases expression
ISO
Carmustine results in decreased expression of LAMB3 mRNA
CTD
PMID:15980968
NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
G
Lbp
lipopolysaccharide binding protein
affects response to substance
ISO
LBP mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
G
Lcn2
lipocalin 2
increases response to substance multiple interactions
ISO EXP
LCN2 protein results in increased susceptibility to Carmustine [LCN2 protein co-treated with Carmustine] results in increased cleavage of and results in increased activity of CASP3 protein; LCN2 protein promotes the reaction [Carmustine results in decreased phosphorylation of AKT1 protein]
CTD
PMID:19860839
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Ldlr
low density lipoprotein receptor
affects uptake
ISO
LDLR protein affects the uptake of Carmustine analog
CTD
PMID:12107554
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
G
Lif
LIF, interleukin 6 family cytokine
increases response to substance
ISO
LIF mRNA results in increased susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
G
Lig1
DNA ligase 1
decreases expression
EXP
Carmustine results in decreased expression of LIG1 mRNA
CTD
PMID:16005536
NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
G
Lins1
lines homolog 1
affects response to substance
ISO
LINS1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:120,267,586...120,295,013
Ensembl chr 1:120,267,693...120,293,607
G
Lman1l
lectin, mannose-binding, 1 like
affects response to substance
ISO
LMAN1L mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 8:58,010,839...58,029,599
Ensembl chr 8:58,010,839...58,023,681
G
Lmtk2
lemur tyrosine kinase 2
affects response to substance
ISO
LMTK2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr12:10,426,772...10,508,750
Ensembl chr12:10,426,777...10,508,750
G
Lmx1b
LIM homeobox transcription factor 1 beta
decreases expression
ISO
Carmustine results in decreased expression of LMX1B mRNA
CTD
PMID:15980968
NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899
G
Loxl1
lysyl oxidase-like 1
decreases expression
ISO
Carmustine results in decreased expression of LOXL1 mRNA
CTD
PMID:15980968
NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356
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Lrch4
leucine rich repeats and calponin homology domain containing 4
decreases expression
ISO
Carmustine results in decreased expression of LRCH4 mRNA
CTD
PMID:15980968
NCBI chr12:19,057,582...19,072,573
Ensembl chr12:19,057,587...19,068,577
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Lsp1
lymphocyte-specific protein 1
decreases expression
EXP
Carmustine results in decreased expression of LSP1 mRNA
CTD
PMID:16005536
NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416
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Mad1l1
mitotic arrest deficient 1 like 1
decreases expression
ISO
Carmustine results in decreased expression of MAD1L1 mRNA
CTD
PMID:15980968
NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
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Map4k2
mitogen activated protein kinase kinase kinase kinase 2
decreases expression
ISO
Carmustine results in decreased expression of MAP4K2 mRNA
CTD
PMID:15980968
NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331
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Mapk10
mitogen activated protein kinase 10
decreases expression
ISO
Carmustine results in decreased expression of MAPK10 mRNA
CTD
PMID:15980968
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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Masp1
MBL associated serine protease 1
affects response to substance
ISO
MASP1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974
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Mat1a
methionine adenosyltransferase 1A
decreases expression
ISO
Carmustine results in decreased expression of MAT1A mRNA
CTD
PMID:15980968
NCBI chr16:16,983,084...17,001,284
Ensembl chr16:16,983,022...17,001,274
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Mdk
midkine
decreases expression
ISO
Carmustine results in decreased expression of MDK mRNA
CTD
PMID:15980968
NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130
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Mdm4
MDM4 regulator of p53
multiple interactions decreases response to substance
ISO
[Carmustine co-treated with MDM4 protein] results in increased expression of POLH protein; MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein]; MDM4 protein promotes the reaction [Carmustine results in increased expression of CDKN1A protein]; MDM4 protein promotes the reaction [Carmustine results in increased expression of TP53 protein]; MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein] MDM4 protein results in decreased susceptibility to Carmustine
CTD
PMID:20472715
NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226
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Mecom
MDS1 and EVI1 complex locus
affects response to substance
ISO
MECOM mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590
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Med1
mediator complex subunit 1
decreases expression
ISO
Carmustine results in decreased expression of MED1 mRNA
CTD
PMID:15980968
NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
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Meg3
maternally expressed 3
affects response to substance
ISO
MEG3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:128,491,808...128,524,010
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Mgat3
beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
decreases expression
ISO
Carmustine results in decreased expression of MGAT3 mRNA
CTD
PMID:15980968
NCBI chr 7:111,708,353...111,761,825
Ensembl chr 7:111,675,730...111,762,026
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Mgmt
O-6-methylguanine-DNA methyltransferase
increases alkylation affects response to substance decreases response to substance decreases activity multiple interactions decreases expression increases response to substance
ISO EXP
Carmustine results in increased alkylation of MGMT protein MGMT gene modified form affects the susceptibility to Carmustine; MGMT promoter modified form affects the susceptibility to Carmustine; MGMT protein affects the susceptibility to Carmustine MGMT mRNA results in decreased susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine analog; MGMT results in decreased susceptibility to Carmustine Carmustine results in decreased activity of MGMT protein [O(6)-benzylguanine results in decreased activity of MGMT protein] which affects the susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine] Carmustine results in decreased expression of MGMT protein [MGMT protein co-treated with ABCB1 protein] results in decreased susceptibility to Carmustine; [MGMT protein mutant form co-treated with FECH protein] results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; [O(6)-benzyl-2'-deoxyguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [O(6)-benzyl-N-acetylguanosine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [O(6)-benzylguanine co-treated with Carmustine] results in decreased activity of MGMT protein; [O(6)-benzylguanine results in decreased activity of MGMT protein] which results in increased susceptibility to Carmustine; [Tamoxifen results in increased degradation of MGMT protein] which results in increased susceptibility to Carmustine; MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein mutant form results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; MGMT protein results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]; MGMT protein results in decreased susceptibility to [O(6)-benzylguanine co-treated with Carmustine]; O(6)-benzylguanine inhibits the reaction [MGMT protein mutant form results in decreased susceptibility to Carmustine] MGMT mutant form results in increased susceptibility to Carmustine
CTD
PMID:8823159 PMID:9918549 PMID:11792417 PMID:11945064 PMID:12036916 PMID:12394182 PMID:12479369 PMID:12684420 PMID:12950064 PMID:14506174 PMID:14617757 PMID:14670122 PMID:14707273 PMID:14742745 PMID:15104113 PMID:15284838 PMID:15319033 PMID:15814657 PMID:15833865 PMID:16033832 PMID:16039682 PMID:16126841 PMID:16278409 PMID:16365179 PMID:16405512 PMID:16432170 PMID:16899598 PMID:16927363 PMID:17597106 PMID:18430789 PMID:18492797 PMID:19415780 PMID:19637364 PMID:19844954 PMID:20450874 PMID:20556481 PMID:20654586 PMID:26208482 More...
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Mgst2
microsomal glutathione S-transferase 2
affects response to substance
ISO
MGST2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
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Mlh1
mutL homolog 1
affects response to substance
ISO
MLH1 protein affects the susceptibility to Carmustine
CTD
PMID:18430789
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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Mlph
melanophilin
affects response to substance
ISO
MLPH mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983
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Mpg
N-methylpurine-DNA glycosylase
decreases response to substance
ISO
MPG protein results in decreased susceptibility to Carmustine
CTD
PMID:16288039
NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
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Mpst
mercaptopyruvate sulfurtransferase
affects response to substance
ISO
MPST mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
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Msh2
mutS homolog 2
affects response to substance
ISO
MSH2 protein affects the susceptibility to Carmustine
CTD
PMID:18430789
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Msr1
macrophage scavenger receptor 1
decreases expression
ISO
Carmustine results in decreased expression of MSR1 mRNA
CTD
PMID:15980968
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
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Mt2A
metallothionein 2A
affects response to substance multiple interactions
ISO EXP
MT2A mRNA affects the susceptibility to Carmustine MT2 protein affects the susceptibility to Carmustine MT2 protein inhibits the reaction [Carmustine results in decreased activity of GSR protein]; MT2 protein inhibits the reaction [Carmustine results in increased expression of TNF protein]
CTD
PMID:16365179 PMID:18528683
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mturn
maturin, neural progenitor differentiation regulator homolog
affects response to substance
ISO
MTURN mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 4:83,807,528...83,828,494
Ensembl chr 4:83,807,579...83,824,950
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Muc2
mucin 2, oligomeric mucus/gel-forming
decreases expression
ISO
Carmustine results in decreased expression of MUC2 mRNA
CTD
PMID:15980968
NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756
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Mug2
murinoglobulin 2
decreases expression
ISO
Carmustine results in decreased expression of PZP mRNA
CTD
PMID:15980968
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
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Mvd
mevalonate diphosphate decarboxylase
decreases expression
ISO
Carmustine results in decreased expression of MVD mRNA
CTD
PMID:15980968
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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Mybl2
MYB proto-oncogene like 2
increases expression
EXP
Carmustine results in increased expression of MYBL2 mRNA
CTD
PMID:16005536
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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Mybph
myosin binding protein H
decreases expression
ISO
Carmustine results in decreased expression of MYBPH mRNA
CTD
PMID:15980968
NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
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Myd88
MYD88, innate immune signal transduction adaptor
decreases expression
ISO
Carmustine results in decreased expression of MYD88 mRNA
CTD
PMID:15980968
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Myod1
myogenic differentiation 1
decreases expression
ISO
Carmustine results in decreased expression of MYOD1 mRNA
CTD
PMID:15980968
NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
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Myog
myogenin
decreases expression
ISO
Carmustine results in decreased expression of MYOG mRNA
CTD
PMID:15980968
NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
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Nbl1
NBL1, DAN family BMP antagonist
affects response to substance
ISO
NBL1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719
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Ndufc1
NADH:ubiquinone oxidoreductase subunit C1
decreases expression
ISO
Carmustine results in decreased expression of NDUFC1 mRNA
CTD
PMID:15980968
NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874
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Nek6
NIMA-related kinase 6
increases expression
EXP
Carmustine results in increased expression of NEK6 mRNA
CTD
PMID:16005536
NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990
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Nes
nestin
increases expression multiple interactions
EXP
Carmustine results in increased expression of NES protein Melatonin inhibits the reaction [Carmustine results in increased expression of NES protein]
CTD
PMID:17572393
NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
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Nfat5
nuclear factor of activated T-cells 5
affects response to substance
ISO
NFAT5 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675
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Nfe2l2
NFE2 like bZIP transcription factor 2
affects response to substance
ISO
[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Carmustine
CTD
PMID:19303893
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfib
nuclear factor I/B
affects response to substance
ISO
NFIB mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
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Nfix
nuclear factor I X
affects response to substance
ISO
NFIX mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO EXP
Carmustine results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]] [Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to NFKB1 protein]; [Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]] Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Carmustine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD
PMID:11970852 PMID:12433058 PMID:12477282 PMID:12675310
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions increases response to substance
ISO EXP
NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]] NFKBIA gene mutant form results in increased susceptibility to Carmustine; NFKBIA mRNA results in increased susceptibility to Carmustine Carmustine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Carmustine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
CTD
PMID:11970852 PMID:12433058 PMID:12675310 PMID:16365179
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Ngef
neuronal guanine nucleotide exchange factor
decreases expression
EXP
Carmustine results in decreased expression of NGEF mRNA
CTD
PMID:16005536
NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914
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Ngf
nerve growth factor
affects activity
EXP
Carmustine affects the activity of NGF protein
CTD
PMID:15935206
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nid2
nidogen 2
decreases expression
EXP
Carmustine results in decreased expression of NID2 mRNA
CTD
PMID:16005536
NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
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Nin
ninein
affects response to substance
ISO
NIN mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
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Nkd2
NKD inhibitor of WNT signaling pathway 2
affects response to substance
ISO
NKD2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821
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Nkx2-2
NK2 homeobox 2
decreases expression
ISO
Carmustine results in decreased expression of NKX2-2 mRNA
CTD
PMID:15980968
NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411
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Nos2
nitric oxide synthase 2
multiple interactions decreases response to substance
ISO EXP
[NOS2 protein results in increased chemical synthesis of S-Nitrosoglutathione] which results in decreased susceptibility to Carmustine NOS2 protein results in decreased susceptibility to Carmustine [Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]
CTD
PMID:7532384 PMID:15110396 PMID:15965067
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Npas1
neuronal PAS domain protein 1
decreases expression
ISO
Carmustine results in decreased expression of NPAS1 mRNA
CTD
PMID:15980968
NCBI chr 1:77,167,375...77,187,887
Ensembl chr 1:77,167,381...77,186,762
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Npas2
neuronal PAS domain protein 2
affects response to substance
ISO
NPAS2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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Npl
N-acetylneuraminate pyruvate lyase
affects response to substance
ISO
NPL mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr13:65,655,099...65,697,464
Ensembl chr13:65,655,118...65,697,372
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Npr1
natriuretic peptide receptor 1
decreases expression
EXP
Carmustine results in decreased expression of NPR1 mRNA
CTD
PMID:16005536
NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
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Nr2f1
nuclear receptor subfamily 2, group F, member 1
affects response to substance
ISO
NR2F1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
affects expression
EXP
Carmustine affects the expression of NR4A2 mRNA
CTD
PMID:19174181
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Nrtn
neurturin
decreases expression
ISO
Carmustine results in decreased expression of NRTN mRNA
CTD
PMID:15980968
NCBI chr 9:1,581,860...1,587,835
Ensembl chr 9:1,581,975...1,583,102
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Ogg1
8-oxoguanine DNA glycosylase
decreases response to substance
ISO
OGG1 protein results in decreased susceptibility to Carmustine
CTD
PMID:11181913 PMID:11741815
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Omp
olfactory marker protein
decreases expression
ISO
Carmustine results in decreased expression of OMP mRNA
CTD
PMID:15980968
NCBI chr 1:152,440,278...152,440,828
Ensembl chr 1:152,433,652...152,441,922
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Orm1
orosomucoid 1
increases expression
EXP
Carmustine results in increased expression of ORM1 mRNA
CTD
PMID:16005536
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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P3h3
prolyl 3-hydroxylase 3
affects response to substance
ISO
P3H3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 4:157,646,242...157,662,035
Ensembl chr 4:157,646,243...157,662,035
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Paep
progestagen associated endometrial protein
decreases expression
ISO
Carmustine results in decreased expression of PAEP mRNA
CTD
PMID:15980968
NCBI chr 3:8,531,136...8,534,430
Ensembl chr 3:8,531,138...8,534,430
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage
ISO
Disulfiram promotes the reaction [Carmustine results in increased cleavage of PARP1 protein]
CTD
PMID:24193513
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pax8
paired box 8
decreases expression
ISO
Carmustine results in decreased expression of PAX8 mRNA
CTD
PMID:15980968
NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
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Pbx2
PBX homeobox 2
decreases expression
ISO
Carmustine results in decreased expression of PBX2 mRNA
CTD
PMID:15980968
NCBI chr20:4,151,500...4,156,425
Ensembl chr20:4,151,500...4,156,425
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Pcbd1
pterin-4 alpha-carbinolamine dehydratase 1
decreases expression
ISO
Carmustine results in decreased expression of PCBD1 mRNA
CTD
PMID:15980968
NCBI chr20:29,037,545...29,044,322
Ensembl chr20:28,953,864...29,044,292 Ensembl chr20:28,953,864...29,044,292
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Pcdhb2
protocadherin beta 2
affects response to substance
ISO
PCDHB2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr18:29,005,996...29,008,782
Ensembl chr18:29,005,996...29,008,782
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Pcdhgc3
protocadherin gamma subfamily C, 3
decreases expression
ISO
Carmustine results in decreased expression of PCDHGC3 mRNA
CTD
PMID:15980968
NCBI chr18:29,633,016...29,667,865
Ensembl chr18:29,493,954...29,667,868
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Pcolce
procollagen C-endopeptidase enhancer
decreases expression
ISO
Carmustine results in decreased expression of PCOLCE mRNA
CTD
PMID:15980968
NCBI chr12:19,084,191...19,090,508
Ensembl chr12:19,084,210...19,090,508
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Pcyt1a
phosphate cytidylyltransferase 1A, choline
decreases expression
ISO
Carmustine results in decreased expression of PCYT1A mRNA
CTD
PMID:15980968
NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357
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Pde5a
phosphodiesterase 5A
affects response to substance
ISO
PDE5A mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
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Pdgfb
platelet derived growth factor subunit B
increases expression
ISO
Carmustine results in increased expression of PDGFB protein
CTD
PMID:15286697
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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Pfkfb2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
decreases expression
ISO
Carmustine results in decreased expression of PFKFB2 mRNA
CTD
PMID:15980968
NCBI chr13:42,147,473...42,174,699
Ensembl chr13:42,147,478...42,174,699
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Pfkm
phosphofructokinase, muscle
decreases expression
ISO
Carmustine results in decreased expression of PFKM mRNA
CTD
PMID:15980968
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
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Pfn1
profilin 1
decreases expression
ISO
Carmustine results in decreased expression of PFN1 mRNA
CTD
PMID:15980968
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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Pgm2
phosphoglucomutase 2
affects response to substance
ISO
PGM2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr14:44,166,314...44,199,828
Ensembl chr14:44,164,425...44,199,967
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Phc2
polyhomeotic homolog 2
affects response to substance
ISO
PHC2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:141,000,604...141,099,268
Ensembl chr 5:141,050,842...141,099,268
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Phlda1
pleckstrin homology-like domain, family A, member 1
affects response to substance
ISO
PHLDA1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861
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Pik3c3
phosphatidylinositol 3-kinase, catalytic subunit type 3
affects response to substance
ISO
PIK3C3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
affects response to substance
ISO
PIK3CD mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
increases expression
ISO
Carmustine results in increased expression of PIK3R3 mRNA
CTD
PMID:15980968
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
affects response to substance
ISO
PITPNC1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:92,163,558...92,428,971
Ensembl chr10:92,167,196...92,429,297
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Pknox2
PBX/knotted 1 homeobox 2
decreases expression
EXP
Carmustine results in decreased expression of PKNOX2 mRNA
CTD
PMID:16005536
NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940
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Pkp2
plakophilin 2
increases expression
EXP
Carmustine results in increased expression of PKP2 mRNA
CTD
PMID:16005536
NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730
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Pkp3
plakophilin 3
affects response to substance
ISO
PKP3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:196,187,914...196,198,843
Ensembl chr 1:196,187,835...196,198,844
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Plekhg5
pleckstrin homology and RhoGEF domain containing G5
affects response to substance
ISO
PLEKHG5 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:162,577,999...162,621,518
Ensembl chr 5:162,578,071...162,621,513
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Pnpla2
patatin-like phospholipase domain containing 2
increases expression
EXP
Carmustine results in increased expression of PNPLA2 mRNA
CTD
PMID:16005536
NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
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Polg2
DNA polymerase gamma 2, accessory subunit
affects response to substance
ISO
POLG2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008
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Polh
DNA polymerase eta
multiple interactions
ISO
[Carmustine co-treated with MDM4 protein] results in increased expression of POLH protein
CTD
PMID:20472715
NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
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Polr2e
RNA polymerase II, I and III subunit E
decreases expression
ISO
Carmustine results in decreased expression of POLR2E mRNA
CTD
PMID:15980968
NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643
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Popdc3
popeye domain containing 3
affects response to substance
ISO
POPDC3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr20:48,772,397...48,800,677
Ensembl chr20:48,772,462...48,800,593
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Ppm1g
protein phosphatase, Mg2+/Mn2+ dependent, 1G
decreases expression
ISO
Carmustine results in decreased expression of PPM1G mRNA
CTD
PMID:15980968
NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761
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Prc1
protein regulator of cytokinesis 1
decreases expression
ISO
Carmustine results in decreased expression of PRC1 mRNA
CTD
PMID:17374387
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
affects response to substance
ISO
PREX1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:155,306,950...155,456,688
Ensembl chr 3:155,306,950...155,456,688
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
affects response to substance
ISO
PRKAA2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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Prl
prolactin
decreases expression
ISO
Carmustine results in decreased expression of PRL mRNA
CTD
PMID:15980968
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prm2
protamine 2
decreases expression
ISO
Carmustine results in decreased expression of PRM2 mRNA
CTD
PMID:15980968
NCBI chr10:4,876,285...4,877,026
Ensembl chr10:4,873,372...4,877,026
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Prph
peripherin
decreases expression
EXP
Carmustine results in decreased expression of PRPH mRNA
CTD
PMID:16005536
NCBI chr 7:130,218,149...130,222,136
Ensembl chr 7:130,218,357...130,222,136
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Prrx2
paired related homeobox 2
affects response to substance
ISO
PRRX2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535
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Prss12
serine protease 12
affects response to substance
ISO
PRSS12 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:211,624,134...211,684,126
Ensembl chr 2:211,624,134...211,684,126
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Pth2r
parathyroid hormone 2 receptor
decreases expression
EXP
Carmustine results in decreased expression of PTH2R mRNA
CTD
PMID:16005536
NCBI chr 9:66,706,050...66,810,601
Ensembl chr 9:66,706,050...66,810,036
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Ptpn3
protein tyrosine phosphatase, non-receptor type 3
decreases expression
ISO
Carmustine results in decreased expression of PTPN3 mRNA
CTD
PMID:15980968
NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
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Qpct
glutaminyl-peptide cyclotransferase
affects response to substance
ISO
QPCT mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:15,964,656...15,996,730
Ensembl chr 6:15,964,657...15,996,711
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Rab27b
RAB27B, member RAS oncogene family
affects response to substance
ISO
RAB27B mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180
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Rad23a
RAD23 homolog A, nucleotide excision repair protein
decreases expression
ISO
Carmustine results in decreased expression of RAD23A mRNA
CTD
PMID:15980968
NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695
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Rad51
RAD51 recombinase
decreases expression
ISO
Carmustine results in decreased expression of RAD51 mRNA
CTD
PMID:15980968
NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
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Rad9a
RAD9 checkpoint clamp component A
decreases expression
ISO
Carmustine results in decreased expression of RAD9A mRNA
CTD
PMID:15980968
NCBI chr 1:201,488,511...201,553,582
Ensembl chr 1:201,487,136...201,553,608
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Rbm19
RNA binding motif protein 19
affects response to substance
ISO
RBM19 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr12:36,365,775...36,451,033
Ensembl chr12:36,365,772...36,450,993
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Rcn1
reticulocalbin 1
decreases expression
ISO
Carmustine results in decreased expression of RCN1 mRNA
CTD
PMID:15980968
NCBI chr 3:91,841,052...91,855,295
Ensembl chr 3:91,841,052...91,855,295
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Rel
REL proto-oncogene, NF-kB subunit
multiple interactions
EXP
Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein]
CTD
PMID:11970852 PMID:12433058
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO EXP
Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carmustine results in increased activity of [NFKB1 protein binds to RELA protein]] [Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]; diphenyleneiodonium inhibits the reaction [[Carmustine co-treated with Oligodeoxyribonucleotides analog] results in increased activity of [NFKB1 protein binds to RELA protein]] Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Carmustine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
CTD
PMID:11970852 PMID:12433058 PMID:12477282 PMID:12675310
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Relb
RELB proto-oncogene, NF-kB subunit
multiple interactions
EXP
Carmustine inhibits the reaction [Lipopolysaccharides affects the localization of RELB protein]
CTD
PMID:11970852 PMID:12433058
NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
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Rfc3
replication factor C subunit 3
decreases expression
EXP
Carmustine results in decreased expression of RFC3 mRNA
CTD
PMID:16005536
NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
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Rgcc
regulator of cell cycle
affects response to substance
ISO
RGCC mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141
G
Rgp1
RGP1 homolog, RAB6A GEF complex partner 1
affects response to substance
ISO
RGP1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:57,834,467...57,843,087
Ensembl chr 5:57,834,629...57,843,086
G
Rgr
retinal G protein coupled receptor
decreases expression
ISO
Carmustine results in decreased expression of RGR mRNA
CTD
PMID:15980968
NCBI chr16:12,801,594...12,816,402
Ensembl chr16:12,801,594...12,816,223
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Rhobtb3
Rho-related BTB domain containing 3
affects response to substance
ISO
RHOBTB3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041
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Rit2
Ras-like without CAAX 2
decreases expression
ISO
Carmustine results in decreased expression of RIT2 mRNA
CTD
PMID:15980968
NCBI chr18:22,565,403...22,921,648
Ensembl chr18:22,565,404...22,921,648
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Rnase4
ribonuclease A family member 4
increases expression
ISO
Carmustine results in increased expression of RNASE4 mRNA
CTD
PMID:15980968
NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
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Rorb
RAR-related orphan receptor B
affects expression
EXP
Carmustine affects the expression of RORB mRNA
CTD
PMID:19174181
NCBI chr 1:216,363,629...216,544,390
Ensembl chr 1:216,363,629...216,544,390
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S1pr3
sphingosine-1-phosphate receptor 3
affects response to substance
ISO
S1PR3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
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Sat1
spermidine/spermine N1-acetyl transferase 1
affects response to substance
ISO
SAT1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Scamp5
secretory carrier membrane protein 5
affects response to substance
ISO
SCAMP5 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 8:57,845,831...57,884,516
Ensembl chr 8:57,846,659...57,872,027
G
Scn1b
sodium voltage-gated channel beta subunit 1
increases expression
EXP
Carmustine results in increased expression of SCN1B mRNA
CTD
PMID:16005536
NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739
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Scn8a
sodium voltage-gated channel alpha subunit 8
affects response to substance
ISO
SCN8A mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
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Sdc1
syndecan 1
affects response to substance
ISO
SDC1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
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Sema3a
semaphorin 3A
affects response to substance
ISO
SEMA3A mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
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Septin4
septin 4
decreases expression
EXP
Carmustine results in decreased expression of SEPTIN4 mRNA
CTD
PMID:16005536
NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768
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Septin5
septin 5
decreases expression
ISO
Carmustine results in decreased expression of SEPTIN5 mRNA
CTD
PMID:15980968
NCBI chr11:82,373,601...82,379,393
Ensembl chr11:82,369,754...82,379,393
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Serpinb1a
serpin family B member 1A
affects response to substance
ISO
SERPINB1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102
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Sf1
splicing factor 1
affects response to substance
ISO
SF1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330
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Sfpq
splicing factor proline and glutamine rich
decreases expression
ISO
Carmustine results in decreased expression of SFPQ mRNA
CTD
PMID:15980968
NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472
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Sgca
sarcoglycan, alpha
decreases expression
ISO
Carmustine results in decreased expression of SGCA mRNA
CTD
PMID:15980968
NCBI chr10:79,904,698...79,922,808
Ensembl chr10:79,908,738...79,922,813
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Shmt2
serine hydroxymethyltransferase 2
decreases expression
ISO
Carmustine results in decreased expression of SHMT2 mRNA
CTD
PMID:15980968
NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
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Shox1
SHOX homeobox 1
decreases expression
ISO
Carmustine results in decreased expression of SHOX mRNA
CTD
PMID:15980968
NCBI chr X:116,688,163...116,695,111
Ensembl chr X:116,688,163...116,695,058
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Slc10a1
solute carrier family 10 member 1
increases expression
ISO
Carmustine results in increased expression of SLC10A1 mRNA
CTD
PMID:15980968
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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Slc12a1
solute carrier family 12 member 1
decreases expression
EXP
Carmustine results in decreased expression of SLC12A1 mRNA
CTD
PMID:17727784
NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
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Slc12a2
solute carrier family 12 member 2
increases expression
EXP
Carmustine results in increased expression of SLC12A2 mRNA
CTD
PMID:17727784
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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Slc14a1
solute carrier family 14 member 1 (Kidd blood group)
affects response to substance
ISO
SLC14A1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
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Slc15a2
solute carrier family 15 member 2
affects response to substance
ISO
SLC15A2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
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Slc16a2
solute carrier family 16 member 2
increases expression
ISO
Carmustine results in increased expression of SLC16A2 mRNA
CTD
PMID:15980968
NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771
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Slc19a2
solute carrier family 19 member 2
decreases expression
EXP
Carmustine results in decreased expression of SLC19A2 mRNA
CTD
PMID:16005536
NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
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Slc22a5
solute carrier family 22 member 5
affects response to substance
ISO
SLC22A5 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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Slc30a3
solute carrier family 30 member 3
decreases expression
ISO
Carmustine results in decreased expression of SLC30A3 mRNA
CTD
PMID:15980968
NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720
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Slc3a2
solute carrier family 3 member 2
increases expression
EXP
Carmustine results in increased expression of SLC3A2 mRNA
CTD
PMID:16005536
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc6a2
solute carrier family 6 member 2
increases expression
ISO
Carmustine results in increased expression of SLC6A2 mRNA
CTD
PMID:15980968
NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
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Slco1a4
solute carrier organic anion transporter family, member 1a4
decreases expression
ISO
Carmustine results in decreased expression of SLCO1A2 mRNA
CTD
PMID:15980968
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slpi
secretory leukocyte peptidase inhibitor
affects response to substance
ISO
SLPI mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Smarcd1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
increases expression
ISO
Carmustine results in increased expression of SMARCD1 mRNA
CTD
PMID:15980968
NCBI chr 7:130,829,783...130,840,323
Ensembl chr 7:130,829,768...130,840,323
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Smpd2
sphingomyelin phosphodiesterase 2
increases expression
ISO
Carmustine results in increased expression of SMPD2 mRNA
CTD
PMID:15980968
NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
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Snapc1
small nuclear RNA activating complex, polypeptide 1
increases expression
ISO
Carmustine results in increased expression of SNAPC1 mRNA
CTD
PMID:15980968
NCBI chr 6:92,684,785...92,710,772
Ensembl chr 6:92,684,752...92,707,746
G
Snapc3
small nuclear RNA activating complex, polypeptide 3
increases expression
ISO
Carmustine results in increased expression of SNAPC3 mRNA
CTD
PMID:15980968
NCBI chr 5:97,817,827...97,868,494
Ensembl chr 5:97,817,947...97,844,650
G
Sncg
synuclein, gamma
increases expression
ISO
Carmustine results in increased expression of SNCG mRNA
CTD
PMID:15980968
NCBI chr16:9,700,513...9,705,751
Ensembl chr16:9,700,514...9,705,368
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Snrpb2
small nuclear ribonucleoprotein polypeptide B2
increases expression
ISO
Carmustine results in increased expression of SNRPB2 mRNA
CTD
PMID:15980968
NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812
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Socs1
suppressor of cytokine signaling 1
decreases expression
ISO
Carmustine results in decreased expression of SOCS1 mRNA
CTD
PMID:17374387
NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
G
Sod1
superoxide dismutase 1
decreases activity
ISO
Carmustine results in decreased activity of SOD1 protein
CTD
PMID:19856331
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sod2
superoxide dismutase 2
affects response to substance decreases activity multiple interactions increases response to substance
ISO
SOD2 mRNA affects the susceptibility to Carmustine Carmustine results in decreased activity of SOD2 protein Pyruvates inhibits the reaction [SOD2 protein results in increased susceptibility to Carmustine]
CTD
PMID:8877099 PMID:16365179 PMID:19856331
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
G
Sorbs2
sorbin and SH3 domain containing 2
decreases expression
ISO
Carmustine results in decreased expression of SORBS2 mRNA
CTD
PMID:15980968
NCBI chr16:46,435,220...46,748,743
Ensembl chr16:46,435,237...46,626,514
G
Sox9
SRY-box transcription factor 9
affects response to substance
ISO
SOX9 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
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Sparc
secreted protein acidic and cysteine rich
affects response to substance
ISO
SPARC mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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Speg
striated muscle enriched protein kinase
decreases expression
ISO
Carmustine results in decreased expression of SPEG mRNA
CTD
PMID:15980968
NCBI chr 9:76,865,714...76,923,170
Ensembl chr 9:76,865,754...76,923,144
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Spen
spen family transcriptional repressor
affects response to substance
ISO
SPEN mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811
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Sprr2b
small proline rich protein 2B
decreases expression
ISO
Carmustine results in decreased expression of SPRR2B mRNA
CTD
PMID:15980968
NCBI chr 2:177,852,824...177,853,096
Ensembl chr 2:177,852,824...177,853,096
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Sqle
squalene epoxidase
affects response to substance
ISO
SQLE mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
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Srp14
signal recognition particle 14
decreases expression
ISO
Carmustine results in decreased expression of SRP14 mRNA
CTD
PMID:15980968
NCBI chr 3:105,442,184...105,445,875
Ensembl chr 3:105,442,198...105,445,859
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Sry
sex determining region Y
decreases expression
ISO
Carmustine results in decreased expression of SRY mRNA
CTD
PMID:15980968
NCBI chr Y:441,525...442,037
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St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
affects response to substance
ISO
ST3GAL1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236
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St6gal1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
increases expression
ISO
Carmustine results in increased expression of ST6GAL1 mRNA
CTD
PMID:15980968
NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310
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St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
increases expression
ISO
Carmustine results in increased expression of ST8SIA1 mRNA
CTD
PMID:15980968
NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
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Stam
signal transducing adaptor molecule
decreases expression
ISO
Carmustine results in decreased expression of STAM mRNA
CTD
PMID:15980968
NCBI chr17:77,120,235...77,166,173
Ensembl chr17:77,120,158...77,166,467
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Stc1
stanniocalcin 1
affects response to substance
ISO
STC1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
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Stmn1
stathmin 1
affects response to substance
ISO
STMN1 mRNA affects the susceptibility to Carmustine
CTD
PMID:17440165
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
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Sts
steroid sulfatase
increases expression
ISO
Carmustine results in increased expression of STS mRNA
CTD
PMID:15980968
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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Stx1b
syntaxin 1B
decreases expression
ISO
Carmustine results in decreased expression of STX1B mRNA
CTD
PMID:15980968
NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280
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Stxbp2
syntaxin binding protein 2
decreases expression
ISO
Carmustine results in decreased expression of STXBP2 mRNA
CTD
PMID:15980968
NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458
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Stxbp6
syntaxin binding protein 6
affects response to substance
ISO
STXBP6 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024
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Synpo2
synaptopodin 2
affects response to substance
ISO
SYNPO2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:211,217,099...211,371,267
Ensembl chr 2:211,216,783...211,371,267
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Syp
synaptophysin
multiple interactions decreases expression
EXP
Melatonin inhibits the reaction [Carmustine results in decreased expression of SYP protein]
CTD
PMID:17572393
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Tac1
tachykinin, precursor 1
decreases expression
ISO
Carmustine results in decreased expression of TAC1 mRNA
CTD
PMID:15980968
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tagln
transgelin
affects response to substance
ISO
TAGLN mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tbx3
T-box transcription factor 3
affects response to substance
ISO
TBX3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
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Tcf21
transcription factor 21
decreases expression
ISO
Carmustine results in decreased expression of TCF21 mRNA
CTD
PMID:15980968
NCBI chr 1:22,701,353...22,704,212
Ensembl chr 1:22,701,353...22,704,202
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Tcim
transcriptional and immune response regulator
increases response to substance
ISO
TCIM mRNA results in increased susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581
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Tdrp
testis development related protein
affects response to substance
ISO
TDRP mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:75,624,047...75,652,635
Ensembl chr16:75,624,907...75,652,420
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Tert
telomerase reverse transcriptase
decreases response to substance
ISO
TERT protein mutant form results in decreased susceptibility to Carmustine
CTD
PMID:12488552
NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561
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Tfap2c
transcription factor AP-2 gamma
affects response to substance
ISO
TFAP2C mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995
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Tfdp1
transcription factor Dp-1
affects response to substance
ISO
TFDP1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:76,162,040...76,200,871
Ensembl chr16:76,162,043...76,200,817
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Tfpi2
tissue factor pathway inhibitor 2
affects response to substance
ISO
TFPI2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
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Tgfb1
transforming growth factor, beta 1
multiple interactions decreases expression
EXP
Melatonin inhibits the reaction [Carmustine results in decreased expression of TGFB1 protein]
CTD
PMID:17572393
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Th
tyrosine hydroxylase
increases activity increases expression
EXP
Carmustine results in increased activity of TH protein Carmustine results in increased expression of TH mRNA; Carmustine results in increased expression of TH protein
CTD
PMID:14670008
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Thbd
thrombomodulin
affects response to substance
ISO
THBD mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
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Tle3
TLE family member 3, transcriptional corepressor
decreases expression
ISO
Carmustine results in decreased expression of TLE3 mRNA
CTD
PMID:15980968
NCBI chr 8:61,857,791...61,903,505
Ensembl chr 8:61,858,200...61,903,493
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Tmem158
transmembrane protein 158
affects response to substance
ISO
TMEM158 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673
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Tmem19
transmembrane protein 19
affects response to substance
ISO
TMEM19 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 7:50,958,884...50,985,601
Ensembl chr 7:50,958,888...50,986,809
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Tmprss15
transmembrane serine protease 15
affects response to substance
ISO
TMPRSS15 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr11:17,677,741...17,802,255
Ensembl chr11:17,677,741...17,802,255
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Tnc
tenascin C
affects response to substance
ISO
TNC mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnf
tumor necrosis factor
multiple interactions increases expression
EXP ISO
[Carmustine co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitrites]; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Carmustine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MT2 protein inhibits the reaction [Carmustine results in increased expression of TNF protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Carmustine]; Zinc Sulfate inhibits the reaction [Carmustine results in increased expression of TNF protein] Carmustine promotes the reaction [Oligodeoxyribonucleotides analog results in increased secretion of TNF protein]
CTD
PMID:7532384 PMID:11970852 PMID:12433058 PMID:12477282 PMID:18528683 PMID:20046642 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip3
TNF alpha induced protein 3
increases response to substance
ISO
TNFAIP3 mRNA results in increased susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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Tnfrsf11b
TNF receptor superfamily member 11B
decreases expression
ISO
Carmustine results in decreased expression of TNFRSF11B mRNA
CTD
PMID:15980968
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
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Tnfrsf19
TNF receptor superfamily member 19
affects response to substance
ISO
TNFRSF19 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795
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Tnfsf10
TNF superfamily member 10
affects response to substance
ISO
TNFSF10 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tp53
tumor protein p53
multiple interactions affects response to substance decreases response to substance increases response to substance increases expression
ISO
[Carmustine co-treated with O(6)-benzylguanine] results in increased expression of TP53 protein; MDM4 protein promotes the reaction [Carmustine results in increased expression of TP53 protein] TP53 protein modified form affects the susceptibility to Carmustine TP53 protein results in decreased susceptibility to Carmustine TP53 results in increased susceptibility to Carmustine
CTD
PMID:10455409 PMID:11861384 PMID:15735757 PMID:16193384 PMID:18632648 PMID:20472715 More...
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpd52l1
TPD52 like 1
affects response to substance
ISO
TPD52L1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
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Traf1
TNF receptor-associated factor 1
decreases expression
ISO
Carmustine results in decreased expression of TRAF1 mRNA
CTD
PMID:15980968
NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
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Trex1
three prime repair exonuclease 1
increases expression
ISO
Carmustine results in increased expression of TREX1 mRNA
CTD
PMID:23578789
NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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Trim50
tripartite motif-containing 50
affects response to substance
ISO
TRIM50 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr12:21,300,784...21,317,668
Ensembl chr12:21,300,785...21,317,668
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Tspan4
tetraspanin 4
decreases expression
ISO
Carmustine results in decreased expression of TSPAN4 mRNA
CTD
PMID:15980968
NCBI chr 1:196,571,307...196,593,842
Ensembl chr 1:196,572,228...196,617,448
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Tubb5
tubulin, beta 5 class I
increases expression
ISO
Carmustine results in increased expression of TUBB mRNA
CTD
PMID:15980968
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
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Tubg1
tubulin, gamma 1
decreases expression
ISO
Carmustine results in decreased expression of TUBG1 mRNA
CTD
PMID:15980968
NCBI chr10:86,052,845...86,059,436
Ensembl chr10:86,052,743...86,059,433
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Tufm
Tu translation elongation factor, mitochondrial
affects response to substance
ISO
TUFM mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
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Tulp3
TUB like protein 3
affects response to substance
ISO
TULP3 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 4:161,590,478...161,632,244
Ensembl chr 4:161,590,479...161,632,149
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Txnrd1
thioredoxin reductase 1
multiple interactions decreases activity
EXP
[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein Carmustine results in decreased activity of TXNRD1 protein
CTD
PMID:16085187 PMID:16288907
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ugt8
UDP glycosyltransferase 8
increases expression
ISO
Carmustine results in increased expression of UGT8 mRNA
CTD
PMID:15980968
NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660
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Upf1
UPF1, RNA helicase and ATPase
decreases expression
ISO
Carmustine results in decreased expression of UPF1 mRNA
CTD
PMID:15980968
NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
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Vamp4
vesicle-associated membrane protein 4
affects response to substance
ISO
VAMP4 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr13:74,919,872...74,942,791
Ensembl chr13:74,919,880...74,933,686
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Vat1l
vesicle amine transport 1-like
affects response to substance
ISO
VAT1L mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr19:42,194,511...42,363,835
Ensembl chr19:42,194,533...42,363,831
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Vgf
VGF nerve growth factor inducible
decreases expression
ISO
Carmustine results in decreased expression of VGF mRNA
CTD
PMID:15980968
NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341
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Vldlr
very low density lipoprotein receptor
affects response to substance
ISO
VLDLR mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
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Wasf2
WASP family member 2
affects response to substance
ISO
WASF2 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 5:145,336,817...145,402,041
Ensembl chr 5:145,336,842...145,399,242
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Wfdc1
WAP four-disulfide core domain 1
affects response to substance
ISO
WFDC1 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108
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Wipf1
WAS/WASL interacting protein family, member 1
decreases expression
ISO
Carmustine results in decreased expression of WIPF1 mRNA
CTD
PMID:15980968
NCBI chr 3:58,314,521...58,416,668
Ensembl chr 3:58,314,542...58,372,742
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Wnt5a
Wnt family member 5A
affects response to substance
ISO
WNT5A mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
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Wt1
WT1 transcription factor
decreases response to substance
ISO
WT1 results in decreased susceptibility to Carmustine
CTD
PMID:20820871
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
decreases expression
ISO
Carmustine results in decreased expression of YWHAH mRNA
CTD
PMID:15980968
NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
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Zbtb17
zinc finger and BTB domain containing 17
decreases expression
ISO
Carmustine results in decreased expression of ZBTB17 mRNA
CTD
PMID:15980968
NCBI chr 5:153,753,508...153,774,613
Ensembl chr 5:153,753,569...153,774,609
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Zc3h13
zinc finger CCCH type containing 13
affects response to substance
ISO
ZC3H13 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr15:50,607,335...50,671,802
Ensembl chr15:50,607,380...50,671,802
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Zfp112
zinc finger protein 112
affects response to substance
ISO
ZNF112 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr 1:79,676,933...79,691,994
Ensembl chr 1:79,676,839...79,691,994
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Zfp189
zinc finger protein 189
increases expression
EXP
Carmustine results in increased expression of ZNF189 mRNA
CTD
PMID:16005536
NCBI chr 5:63,872,596...63,884,348
Ensembl chr 5:63,872,738...63,884,121
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Zfp655
zinc finger protein 655
affects response to substance
ISO
ZNF655 mRNA affects the susceptibility to Carmustine
CTD
PMID:16365179
NCBI chr12:9,349,985...9,375,449
Ensembl chr12:9,357,639...9,374,569
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Zyx
zyxin
decreases expression
ISO
Carmustine results in decreased expression of ZYX mRNA
CTD
PMID:15980968
NCBI chr 4:71,236,767...71,246,553
Ensembl chr 4:71,237,451...71,246,553
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