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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2',4,5-tetrachlorobiphenyl
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Accession:CHEBI:34205 term browser browse the term
Definition:A tetrachlorobiphenyl that is biphenyl in which the hydrogens at positions 2, 4, 5, and 2' are replaced by chlorines.
Synonyms:exact_synonym: 2,2',4,5-tetrachloro-1,1'-biphenyl
 related_synonym: 2,2',4,5-tetrachlorodiphenyl;   Formula=C12H6Cl4;   InChI=1S/C12H6Cl4/c13-9-4-2-1-3-7(9)8-5-11(15)12(16)6-10(8)14/h1-6H;   InChIKey=XBTHILIDLBPRPM-UHFFFAOYSA-N;   PCB 48;   SMILES=Clc1ccccc1-c1cc(Cl)c(Cl)cc1Cl
 xref: Beilstein:6401616;   CAS:70362-47-9;   KEGG:C14360
 xref_mesh: MESH:C042128


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2,2',4,5-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity ISO
EXP		 2,4,4',5-tetrachlorobiphenyl results in increased activity of AHR protein CTD PMID:25654323 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,2',4,5'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4',5-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Casp3 caspase 3 affects activity ISO 2,4,4',5-tetrachlorobiphenyl affects the activity of CASP3 protein CTD PMID:19362103 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 affects activity ISO 2,4,4',5-tetrachlorobiphenyl affects the activity of CASP7 protein CTD PMID:19362103 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases activity ISO 2,4,4',5-tetrachlorobiphenyl results in increased activity of CASP9 protein CTD PMID:19362103 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,4,4',5-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA CTD PMID:25654323 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,4,4',5-tetrachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl CTD PMID:27913846 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 affects expression
multiple interactions		 ISO 2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein
[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,4,4',5-tetrachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl] affects the expression of GNRH1 protein; fulvestrant affects the reaction [2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein]		 CTD PMID:19362103 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene CTD PMID:27913846 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein CTD PMID:19751709 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein CTD PMID:19751709 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO 2,4,4',5-tetrachlorobiphenyl results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl CTD PMID:27913846 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 2,4,4',5-tetrachlorobiphenyl affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      chemical role 19539
        environmental contaminant 18812
          persistent organic pollutant 16532
            polychlorobiphenyl 5807
              tetrachlorobiphenyl 2143
                2,2',4,5-tetrachlorobiphenyl 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19744
                        hydrogen molecular entity 19736
                          hydrides 19102
                            organic hydride 18616
                              organic fundamental parent 18616
                                hydrocarbon 18367
                                  halohydrocarbon 15411
                                    haloarene 6210
                                      chloroarene 5809
                                        chlorobiphenyl 5809
                                          polychlorobiphenyl 5807
                                            tetrachlorobiphenyl 2143
                                              2,2',4,5-tetrachlorobiphenyl 16
paths to the root