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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2',4,5-tetrachlorobiphenyl
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Accession:CHEBI:34205 term browser browse the term
Definition:A tetrachlorobiphenyl that is biphenyl in which the hydrogens at positions 2, 4, 5, and 2' are replaced by chlorines.
Synonyms:exact_synonym: 2,2',4,5-tetrachloro-1,1'-biphenyl
 related_synonym: 2,2',4,5-tetrachlorodiphenyl;   Formula=C12H6Cl4;   InChI=1S/C12H6Cl4/c13-9-4-2-1-3-7(9)8-5-11(15)12(16)6-10(8)14/h1-6H;   InChIKey=XBTHILIDLBPRPM-UHFFFAOYSA-N;   PCB 48;   SMILES=Clc1ccccc1-c1cc(Cl)c(Cl)cc1Cl
 xref: Beilstein:6401616;   CAS:70362-47-9;   KEGG:C14360
 xref_mesh: MESH:C042128

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2,2',4,5-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity ISO
EXP		 2,4,4',5-tetrachlorobiphenyl results in increased activity of AHR protein CTD PMID:25654323 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,2',4,5'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4',5-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Casp3 caspase 3 affects activity ISO 2,4,4',5-tetrachlorobiphenyl affects the activity of CASP3 protein CTD PMID:19362103 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 affects activity ISO 2,4,4',5-tetrachlorobiphenyl affects the activity of CASP7 protein CTD PMID:19362103 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 increases activity ISO 2,4,4',5-tetrachlorobiphenyl results in increased activity of CASP9 protein CTD PMID:19362103 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,4,4',5-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA CTD PMID:25654323 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,4,4',5-tetrachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl CTD PMID:27913846 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 affects expression
multiple interactions		 ISO 2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein
[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,4,4',5-tetrachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl] affects the expression of GNRH1 protein; fulvestrant affects the reaction [2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein]		 CTD PMID:19362103 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene CTD PMID:27913846 NCBI chr  X:158,196,640...158,228,815
Ensembl chr  X:158,197,149...158,228,749 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein CTD PMID:19751709 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein CTD PMID:19751709 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO 2,4,4',5-tetrachlorobiphenyl results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:110,226,565...110,232,202
Ensembl chr  X:110,226,572...110,232,179 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl CTD PMID:27913846 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 2,4,4',5-tetrachlorobiphenyl affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      chemical role 19309
        environmental contaminant 18641
          persistent organic pollutant 15817
            polychlorobiphenyl 5771
              tetrachlorobiphenyl 2144
                2,2',4,5-tetrachlorobiphenyl 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    main group molecular entity 19732
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18745
                            organic hydride 18291
                              organic fundamental parent 18291
                                hydrocarbon 18015
                                  halohydrocarbon 14039
                                    haloarene 6176
                                      chloroarene 5773
                                        chlorobiphenyl 5773
                                          polychlorobiphenyl 5771
                                            tetrachlorobiphenyl 2144
                                              2,2',4,5-tetrachlorobiphenyl 16
paths to the root