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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,2',4,5-tetrachlorobiphenyl
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Accession:CHEBI:34205 term browser browse the term
Definition:A tetrachlorobiphenyl that is biphenyl in which the hydrogens at positions 2, 4, 5, and 2' are replaced by chlorines.
Synonyms:exact_synonym: 2,2',4,5-tetrachloro-1,1'-biphenyl
 related_synonym: 2,2',4,5-tetrachlorodiphenyl;   Formula=C12H6Cl4;   InChI=1S/C12H6Cl4/c13-9-4-2-1-3-7(9)8-5-11(15)12(16)6-10(8)14/h1-6H;   InChIKey=XBTHILIDLBPRPM-UHFFFAOYSA-N;   PCB 48;   SMILES=Clc1ccccc1-c1cc(Cl)c(Cl)cc1Cl
 xref: Beilstein:6401616;   CAS:70362-47-9;   KEGG:C14360
 xref_mesh: MESH:C042128


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2,2',4,5-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases activity ISO
EXP 		2,4,4',5-tetrachlorobiphenyl results in increased activity of AHR protein CTD PMID:25654323 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ar androgen receptor multiple interactions ISO 2,2',4,5'-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]; 2,4,4',5-tetrachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Casp3 caspase 3 affects activity ISO 2,4,4',5-tetrachlorobiphenyl affects the activity of CASP3 protein CTD PMID:19362103 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 affects activity ISO 2,4,4',5-tetrachlorobiphenyl affects the activity of CASP7 protein CTD PMID:19362103 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 increases activity ISO 2,4,4',5-tetrachlorobiphenyl results in increased activity of CASP9 protein CTD PMID:19362103 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 2,4,4',5-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA CTD PMID:25654323 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression EXP 2,4,4',5-tetrachlorobiphenyl results in increased expression of CYP1B1 mRNA CTD PMID:25654323 PMID:29738842 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl CTD PMID:27913846 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 affects expression
multiple interactions 		ISO 2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein
[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with 2,4,4',5-tetrachlorobiphenyl co-treated with 2,3',4,4',5-pentachlorobiphenyl] affects the expression of GNRH1 protein; fulvestrant affects the reaction [2,4,4',5-tetrachlorobiphenyl affects the expression of GNRH1 protein] 		CTD PMID:19362103 NCBI chr15:46,147,878...46,152,086
Ensembl chr15:46,148,301...46,148,977
Ensembl chr15:46,148,301...46,148,977 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene CTD PMID:27913846 NCBI chr  X:137,655,744...137,687,718
Ensembl chr  X:137,655,680...137,687,712 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein CTD PMID:19751709 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein CTD PMID:19751709 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation ISO 2,4,4',5-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791 		JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO 2,4,4',5-tetrachlorobiphenyl results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:107,452,044...107,510,958
Ensembl chr  X:107,452,044...107,457,681 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 multiple interactions ISO [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl] which results in increased mutagenesis of HPRT1 gene; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to 2,4,4',5-tetrachlorobiphenyl CTD PMID:27913846 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 2,4,4',5-tetrachlorobiphenyl affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        environmental contaminant 19676
          persistent organic pollutant 17035
            polychlorobiphenyl 6093
              tetrachlorobiphenyl 2434
                2,2',4,5-tetrachlorobiphenyl 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20574
                        hydrogen molecular entity 20558
                          hydrides 19693
                            organic hydride 19079
                              organic fundamental parent 19079
                                hydrocarbon 18731
                                  halohydrocarbon 16109
                                    haloarene 6492
                                      chloroarene 6095
                                        chlorobiphenyl 6095
                                          polychlorobiphenyl 6093
                                            tetrachlorobiphenyl 2434
                                              2,2',4,5-tetrachlorobiphenyl 16
paths to the root