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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,2',4,4'-tetrachlorobiphenyl
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Accession:CHEBI:34204 term browser browse the term
Definition:A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.
Synonyms:related_synonym: 1,1'-Biphenyl, 2,2',4,4'-tetrachloro-;   2,2',4,4'-Tetrachlorodiphenyl;   Formula=C12H6Cl4;   InChI=1S/C12H6Cl4/c13-7-1-3-9(11(15)5-7)10-4-2-8(14)6-12(10)16/h1-6H;   InChIKey=QORAVNMWUNPXAO-UHFFFAOYSA-N;   PCB 47;   SMILES=Clc1ccc(c(Cl)c1)-c1ccc(Cl)cc1Cl
 xref: Beilstein:2052543;   CAS:2437-79-8;   KEGG:C14247
 xref_mesh: MESH:C035976


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2,2',4,4'-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
2,4,2',4'-tetrachlorobiphenyl binds to AR protein
[aroclor 1260 co-treated with Chlorodiphenyl (54% Chlorine) co-treated with 2,4,4'-trichlorobiphenyl co-treated with 2,4,2',4'-tetrachlorobiphenyl co-treated with 3,4,5,3',4'-pentachlorobiphenyl co-treated with 3,4,3',4'-tetrachlorobiphenyl] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]
CTD PMID:14565775 PMID:21295777 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:20861069 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:20861069 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; [2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:20819908 PMID:20861069 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; [2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:20819908 PMID:20861069 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [3,5-dibromo-2-(2,4-dibromophenoxy)phenol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; 2,4,4'-trichlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; 3,5-dibromo-2-(2,4-dibromophenoxy)phenol promotes the reaction [2,4,2',4'-tetrachlorobiphenyl results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; [2,4,2',4'-tetrachlorobiphenyl co-treated with gamma-Aminobutyric Acid] binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]; [3,5-dibromo-2-(2,4-dibromophenoxy)phenol co-treated with 2,4,2',4'-tetrachlorobiphenyl] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; PCB 180 inhibits the reaction [2,4,2',4'-tetrachlorobiphenyl binds to and results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:20819908 PMID:20861069 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO
EXP
2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein CTD PMID:19751709 PMID:20171977 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO
EXP
2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein CTD PMID:19751709 PMID:20171977 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation ISO 2,4,2',4'-tetrachlorobiphenyl results in increased phosphorylation of MDM2 protein CTD PMID:19751709 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mpo myeloperoxidase increases secretion ISO 2,4,2',4'-tetrachlorobiphenyl results in increased secretion of MPO protein CTD PMID:15673847 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO 2,4,2',4'-tetrachlorobiphenyl results in increased activity of NR1I2 protein CTD PMID:25680588 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 2,4,2',4'-tetrachlorobiphenyl inhibits the reaction [Budesonide results in increased activity of NR3C1 protein] CTD PMID:21782008 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO 2,4,2',4'-tetrachlorobiphenyl results in increased expression of PTGS2 mRNA
2,4,2',4'-tetrachlorobiphenyl results in increased expression of and results in increased activity of PTGS2 protein
CTD PMID:15673847 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      chemical role 19351
        environmental contaminant 18668
          persistent organic pollutant 15830
            polychlorobiphenyl 5786
              tetrachlorobiphenyl 2145
                2,2',4,4'-tetrachlorobiphenyl 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    main group molecular entity 19771
                      s-block molecular entity 19520
                        hydrogen molecular entity 19512
                          hydrides 18784
                            organic hydride 18338
                              organic fundamental parent 18338
                                hydrocarbon 18064
                                  halohydrocarbon 14060
                                    haloarene 6190
                                      chloroarene 5788
                                        chlorobiphenyl 5788
                                          polychlorobiphenyl 5786
                                            tetrachlorobiphenyl 2145
                                              2,2',4,4'-tetrachlorobiphenyl 13
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