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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carisoprodol
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Accession:CHEBI:3419 term browser browse the term
Definition:A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
Synonyms:exact_synonym: 2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate
 related_synonym: (1-methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester;   2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate;   2-methyl-2-propyltrimethylene carbamate isopropylcarbamate;   Formula=C12H24N2O4;   InChI=1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16);   InChIKey=OFZCIYFFPZCNJE-UHFFFAOYSA-N;   N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate;   SMILES=CCCC(C)(COC(N)=O)COC(=O)NC(C)C;   carbamic acid 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester;   carisoprodolum;   isopropyl meprobamate
 alt_id: CHEBI:330249
 xref: Beilstein:1791537;   CAS:78-44-4;   DrugBank:DB00395;   Drug_Central:509;   HMDB:HMDB0014539;   KEGG:C07927;   KEGG:D00768;   LINCS:LSM-5197
 xref_mesh: MESH:D002328
 xref: PMID:14521410;   PMID:17725338;   Patent:US2937119;   Reaxys:1791537;   Wikipedia:Carisoprodol


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carisoprodol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions EXP [CYP2C19 gene polymorphism affects the metabolism of Carisoprodol] which affects the chemical synthesis of Meprobamate; [CYP2C19 protein results in increased metabolism of Carisoprodol] which results in increased chemical synthesis of Meprobamate CTD PMID:12835613 PMID:22527345 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions EXP Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 multiple interactions EXP Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 multiple interactions EXP Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        pharmaceutical 24553
          drug 24550
            neuromuscular agent 1309
              muscle relaxant 1304
                carisoprodol 4
                  (R)-carisoprodol 0
                  (S)-carisoprodol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbon oxoacid 22757
                                    carbamic acid 19659
                                      carbamate ester 7988
                                        carisoprodol 4
                                          (R)-carisoprodol 0
                                          (S)-carisoprodol 0
paths to the root