Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carisoprodol
go back to main search page
Accession:CHEBI:3419 term browser browse the term
Definition:A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
Synonyms:exact_synonym: 2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate
 related_synonym: (1-methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester;   2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate;   2-methyl-2-propyltrimethylene carbamate isopropylcarbamate;   Formula=C12H24N2O4;   InChI=1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16);   InChIKey=OFZCIYFFPZCNJE-UHFFFAOYSA-N;   N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate;   SMILES=CCCC(C)(COC(N)=O)COC(=O)NC(C)C;   carbamic acid 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester;   carisoprodolum;   isopropyl meprobamate
 alt_id: CHEBI:330249
 xref: Beilstein:1791537;   CAS:78-44-4;   DrugBank:DB00395;   Drug_Central:509;   HMDB:HMDB0014539;   KEGG:C07927;   KEGG:D00768;   LINCS:LSM-5197
 xref_mesh: MESH:D002328
 xref: PMID:14521410;   PMID:17725338;   Patent:US2937119;   Reaxys:1791537;   Wikipedia:Carisoprodol



show annotations for term's descendants           Sort by:
 
carisoprodol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO [CYP2C19 gene polymorphism affects the metabolism of Carisoprodol] which affects the chemical synthesis of Meprobamate; [CYP2C19 protein results in increased metabolism of Carisoprodol] which results in increased chemical synthesis of Meprobamate CTD PMID:12835613 PMID:22527345 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            neuromuscular agent 1315
              muscle relaxant 1310
                carisoprodol 4
                  (R)-carisoprodol 0
                  (S)-carisoprodol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic ester 15883
                                        carbamate ester 7449
                                          carisoprodol 4
                                            (R)-carisoprodol 0
                                            (S)-carisoprodol 0
paths to the root