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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carisoprodol
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Accession:CHEBI:3419 term browser browse the term
Definition:A carbamate ester that is the mono-N-isopropyl derivative of meprobamate (which is a significant metabolite). Carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception. It is used as a muscle relaxant in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.
Synonyms:exact_synonym: 2-[(carbamoyloxy)methyl]-2-methylpentyl propan-2-ylcarbamate
 related_synonym: (1-methylethyl)carbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester;   2-methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate;   2-methyl-2-propyltrimethylene carbamate isopropylcarbamate;   Formula=C12H24N2O4;   InChI=1S/C12H24N2O4/c1-5-6-12(4,7-17-10(13)15)8-18-11(16)14-9(2)3/h9H,5-8H2,1-4H3,(H2,13,15)(H,14,16);   InChIKey=OFZCIYFFPZCNJE-UHFFFAOYSA-N;   N-isopropy-2-methyl-2-propyl-1,3-propanediol dicarbamate;   SMILES=CCCC(C)(COC(N)=O)COC(=O)NC(C)C;   carbamic acid 2-isopropylcarbamoyloxymethyl-2-methyl-pentyl ester;   carisoprodolum;   isopropyl meprobamate
 alt_id: CHEBI:330249
 xref: Beilstein:1791537;   CAS:78-44-4;   DrugBank:DB00395;   Drug_Central:509;   HMDB:HMDB0014539;   KEGG:C07927;   KEGG:D00768;   LINCS:LSM-5197
 xref_mesh: MESH:D002328
 xref: PMID:14521410;   PMID:17725338;   Patent:US2937119;   Reaxys:1791537;   Wikipedia:Carisoprodol


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carisoprodol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO [CYP2C19 gene polymorphism affects the metabolism of Carisoprodol] which affects the chemical synthesis of Meprobamate; [CYP2C19 protein results in increased metabolism of Carisoprodol] which results in increased chemical synthesis of Meprobamate CTD PMID:12835613 PMID:22527345 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Bemegride inhibits the reaction [Carisoprodol results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Carisoprodol binds to and affects the activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein] CTD PMID:19244096 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      application 19734
        pharmaceutical 19573
          drug 19573
            neuromuscular agent 1323
              muscle relaxant 1318
                carisoprodol 4
                  (R)-carisoprodol 0
                  (S)-carisoprodol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carbamic acid 17601
                                      carbamate ester 7511
                                        carisoprodol 4
                                          (R)-carisoprodol 0
                                          (S)-carisoprodol 0
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