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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-nitropyrene
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Accession:CHEBI:34107 term browser browse the term
Definition:A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine.
Synonyms:related_synonym: 3-Nitropyrene;   Formula=C16H9NO2;   InChI=1S/C16H9NO2/c18-17(19)14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9H;   InChIKey=ALRLPDGCPYIVHP-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2ccc3cccc4ccc1c2c34
 alt_id: CHEBI:76262
 xref: Beilstein:1882811;   CAS:5522-43-0;   KEGG:C14421
 xref_mesh: MESH:C032668
 xref: PMID:21861515;   PMID:21872649;   PMID:22458822;   PMID:23348104;   Reaxys:1882811;   Wikipedia:1-Nitropyrene



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1-nitropyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abce1 ATP binding cassette subfamily E member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCE1 mRNA CTD PMID:19041380 NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489
JBrowse link
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO 1-nitropyrene results in increased expression of ABCF1 mRNA CTD PMID:19428942 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression ISO 1-nitropyrene results in increased expression of ADAMTS1 mRNA CTD PMID:19041380 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 increases expression ISO 1-nitropyrene results in increased expression of ADGRG6 mRNA CTD PMID:19041380 NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO ADRB2 protein promotes the reaction [1-nitropyrene results in increased secretion of CXCL8 protein] CTD PMID:24904980 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Aff4 AF4/FMR2 family, member 4 increases expression ISO 1-nitropyrene results in increased expression of AFF4 mRNA CTD PMID:19041380 NCBI chr10:37,498,825...37,579,751
Ensembl chr10:37,498,825...37,579,751
JBrowse link
G Aftph aftiphilin increases expression ISO 1-nitropyrene results in increased expression of AFTPH mRNA CTD PMID:19041380 NCBI chr14:94,871,429...94,925,625
Ensembl chr14:94,871,429...94,925,376
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects response to substance
ISO 1-nitropyrene binds to and results in increased activity of AHR protein; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]
AHR affects the susceptibility to 1-nitropyrene
CTD PMID:12117779 PMID:22044530 PMID:28186253 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 1-nitropyrene results in increased phosphorylation of and results in increased activity of AKT1 protein CTD PMID:17240030 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alcam activated leukocyte cell adhesion molecule increases expression ISO 1-nitropyrene results in increased expression of ALCAM mRNA CTD PMID:19041380 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
JBrowse link
G Ang angiogenin decreases expression ISO 1-nitropyrene results in decreased expression of ANG mRNA CTD PMID:19041380 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 increases expression ISO 1-nitropyrene results in increased expression of ANTXR2 mRNA CTD PMID:19041380 NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094
JBrowse link
G Apcdd1 APC down-regulated 1 decreases expression ISO 1-nitropyrene results in decreased expression of APCDD1 mRNA CTD PMID:19041380 NCBI chr18:56,385,398...56,416,065
Ensembl chr18:56,385,264...56,416,070
JBrowse link
G Ar androgen receptor multiple interactions ISO 1-nitropyrene inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18324785 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 increases expression ISO 1-nitropyrene results in increased expression of ARFIP1 mRNA CTD PMID:19041380 NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO 1-nitropyrene results in increased expression of ASNS mRNA CTD PMID:19041380 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atg7 autophagy related 7 multiple interactions
affects response to substance
increases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
ATG7 protein affects the susceptibility to 1-nitropyrene
1-nitropyrene results in increased expression of ATG7 mRNA; 1-nitropyrene results in increased expression of ATG7 protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:29078374 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atp5pd ATP synthase peripheral stalk subunit d decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of ATP5H mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5H mRNA]
CTD PMID:29078374 NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 increases expression ISO 1-nitropyrene results in increased expression of ATP8B1 mRNA CTD PMID:19041380 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Bad BCL2-associated agonist of cell death increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of BAD protein CTD PMID:17240030 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of BAX mRNA
TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]
CTD PMID:10837373 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2a1 BCL2-related protein A1 increases expression ISO 1-nitropyrene results in increased expression of BCL2A1 mRNA CTD PMID:21540303 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 1-nitropyrene results in decreased expression of BCL2L1 protein CTD PMID:17240030 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bid BH3 interacting domain death agonist increases expression ISO 1-nitropyrene results in increased expression of BID protein CTD PMID:17240030 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO 1-nitropyrene results in increased expression of BIRC3 mRNA CTD PMID:21540303 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO 1-nitropyrene results in increased expression of BMP2 mRNA CTD PMID:21540303 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bmper BMP-binding endothelial regulator increases expression ISO 1-nitropyrene results in increased expression of BMPER mRNA CTD PMID:19041380 NCBI chr 8:21,732,225...21,977,261
Ensembl chr 8:21,732,225...21,977,256
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO 1-nitropyrene results in decreased expression of BRCA1 mRNA CTD PMID:21540303 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G C1qtnf2 C1q and TNF related 2 decreases expression ISO 1-nitropyrene results in decreased expression of C1QTNF2 mRNA CTD PMID:19041380 NCBI chr10:27,941,948...27,958,926
Ensembl chr10:27,941,948...27,959,185
JBrowse link
G C1rl complement C1r subcomponent like decreases expression ISO 1-nitropyrene results in decreased expression of C1RL mRNA CTD PMID:19041380 NCBI chr 4:157,394,183...157,410,771
Ensembl chr 4:157,394,200...157,410,134
JBrowse link
G Ca6 carbonic anhydrase 6 decreases expression ISO 1-nitropyrene results in decreased expression of CA6 mRNA CTD PMID:19041380 NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
JBrowse link
G Casp2 caspase 2 increases activity ISO 1-nitropyrene results in increased activity of CASP2 protein CTD PMID:21872649 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP3 protein; methyl-beta-cyclodextrin inhibits the reaction [1-nitropyrene results in increased activity of CASP3 protein] CTD PMID:17240030 PMID:21872649 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 1-nitropyrene results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17240030 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cbs cystathionine beta synthase increases expression ISO 1-nitropyrene results in increased expression of CBS mRNA CTD PMID:19041380 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccdc18 coiled-coil domain containing 18 increases expression ISO 1-nitropyrene results in increased expression of CCDC18 mRNA CTD PMID:19041380 NCBI chr14:1,501,749...1,607,672
Ensembl chr14:1,501,784...1,607,711
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 decreases expression ISO 1-nitropyrene results in decreased expression of CCL17 mRNA CTD PMID:19428942 NCBI chr19:10,202,317...10,203,768
Ensembl chr19:10,202,128...10,203,819
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 decreases expression ISO 1-nitropyrene results in decreased expression of CCL19 mRNA CTD PMID:19428942 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO 1-nitropyrene results in increased expression of CCL20 mRNA CTD PMID:19428942 PMID:19879285 PMID:21540303 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 decreases expression ISO 1-nitropyrene results in decreased expression of CCL21 mRNA CTD PMID:19428942 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 decreases expression ISO 1-nitropyrene results in decreased expression of CCL24 mRNA CTD PMID:19428942 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
JBrowse link
G Ccl26 C-C motif chemokine ligand 26 decreases expression ISO 1-nitropyrene results in decreased expression of CCL26 mRNA CTD PMID:19428942 NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO 1-nitropyrene results in increased expression of CCL5 mRNA CTD PMID:19879285 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccl6 C-C motif chemokine ligand 6 decreases expression ISO 1-nitropyrene results in decreased expression of CCL15 mRNA CTD PMID:19428942 NCBI chr10:68,381,179...68,385,811
Ensembl chr10:68,380,188...68,384,001
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO 1-nitropyrene results in increased expression of CCN2 mRNA CTD PMID:19041380 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO 1-nitropyrene results in increased expression of CCND1 mRNA CTD PMID:19041380 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO 1-nitropyrene results in increased expression of CCR4 mRNA CTD PMID:19428942 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Ccr6 C-C motif chemokine receptor 6 decreases expression ISO 1-nitropyrene results in decreased expression of CCR6 mRNA CTD PMID:19428942 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO 1-nitropyrene results in decreased expression of CCR7 mRNA CTD PMID:19428942 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Ccr8 C-C motif chemokine receptor 8 decreases expression ISO 1-nitropyrene results in decreased expression of CCR8 mRNA CTD PMID:19428942 NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629
JBrowse link
G Cd14 CD14 molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD14 mRNA CTD PMID:19041380 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd8b CD8b molecule decreases expression ISO 1-nitropyrene results in decreased expression of CD8B1 mRNA CTD PMID:19041380 NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO 1-nitropyrene results in decreased expression of CDH1 mRNA CTD PMID:19041380 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh13 cadherin 13 increases expression ISO 1-nitropyrene results in increased expression of CDH13 mRNA CTD PMID:19041380 NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459
JBrowse link
G Cdh3 cadherin 3 decreases expression ISO 1-nitropyrene results in decreased expression of CDH3 mRNA CTD PMID:19041380 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
JBrowse link
G Cdk17 cyclin-dependent kinase 17 increases expression ISO 1-nitropyrene results in increased expression of CDK17 mRNA CTD PMID:19041380 NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO pifithrin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of CDKN1A protein]
1-nitropyrene results in increased expression of CDKN1A mRNA; 1-nitropyrene results in increased expression of CDKN1A protein
CTD PMID:21540303 PMID:22044530 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
decreases expression
ISO [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]; CEBPA protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein] CTD PMID:29078374 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO 1-nitropyrene results in increased expression of CEBPB mRNA CTD PMID:19428942 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO 1-nitropyrene results in decreased expression of CEBPD mRNA CTD PMID:19041380 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO 1-nitropyrene results in increased expression of CEBPG mRNA CTD PMID:19041380 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
JBrowse link
G Cenpb centromere protein B decreases expression ISO 1-nitropyrene results in decreased expression of CENPB mRNA CTD PMID:19041380 NCBI chr 3:118,396,987...118,399,788
Ensembl chr 3:118,388,546...118,400,470
JBrowse link
G Clu clusterin decreases expression ISO 1-nitropyrene results in decreased expression of CLU mRNA CTD PMID:19041380 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Commd3 COMM domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of COMMD3 mRNA CTD PMID:19041380 NCBI chr17:81,327,451...81,331,183
Ensembl chr17:81,327,405...81,331,177
JBrowse link
G Coro1c coronin 1C increases expression ISO 1-nitropyrene results in increased expression of CORO1C mRNA CTD PMID:19041380 NCBI chr12:42,712,960...42,785,179
Ensembl chr12:42,712,991...42,785,179
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO 1-nitropyrene results in increased expression of CSF2 mRNA CTD PMID:21540303 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cth cystathionine gamma-lyase increases expression ISO 1-nitropyrene results in increased expression of CTH mRNA CTD PMID:19041380 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380 PMID:19428942 PMID:19879285 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO 1-nitropyrene results in increased expression of CXCL10 mRNA CTD PMID:19428942 PMID:19879285 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO 1-nitropyrene results in increased expression of CXCL11 mRNA CTD PMID:19428942 PMID:19879285 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL13 mRNA CTD PMID:19428942 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO 1-nitropyrene results in increased expression of CXCL2 mRNA CTD PMID:19041380 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO 1-nitropyrene results in increased expression of CXCL1 mRNA CTD PMID:19041380 PMID:19428942 PMID:19879285 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 decreases expression ISO 1-nitropyrene results in decreased expression of CXCL6 mRNA CTD PMID:19428942 NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO 1-nitropyrene results in decreased expression of CXCR2 mRNA CTD PMID:19428942 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases degradation
multiple interactions
increases stability
increases expression
ISO
EXP
1-nitropyrene results in increased degradation of CYP1A1 protein
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]
1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 protein
1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]
CTD PMID:12117779 PMID:16280210 PMID:17240030 PMID:18493746 PMID:19961161 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects response to substance
multiple interactions
ISO
EXP
CYP1A2 affects the susceptibility to 1-nitropyrene
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene]
CTD PMID:10727902 PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
ISO 1-nitropyrene results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of 1-nitropyrene
CTD PMID:11525925 PMID:12117779 PMID:21887816 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO 1-nitropyrene results in increased expression of DDIT3 mRNA CTD PMID:19041380 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 increases expression ISO 1-nitropyrene results in increased expression of DKK1 mRNA CTD PMID:19041380 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein increases expression ISO 1-nitropyrene results in increased expression of DLC1 mRNA CTD PMID:19041380 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dmtf1 cyclin D binding myb-like transcription factor 1 increases expression ISO 1-nitropyrene results in increased expression of DMTF1 mRNA CTD PMID:19041380 NCBI chr 4:24,909,937...24,950,786
Ensembl chr 4:24,910,534...24,950,967
JBrowse link
G Dner delta/notch-like EGF repeat containing increases expression ISO 1-nitropyrene results in increased expression of DNER mRNA CTD PMID:19041380 NCBI chr 9:85,586,985...85,902,820
Ensembl chr 9:85,586,987...85,902,637
JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO 1-nitropyrene results in increased expression of DUSP10 mRNA CTD PMID:19041380 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO 1-nitropyrene results in increased expression of DUSP6 mRNA CTD PMID:19041380 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Egr1 early growth response 1 increases expression ISO 1-nitropyrene results in increased expression of EGR1 mRNA CTD PMID:21540303 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO 1-nitropyrene results in increased expression of EHHADH mRNA CTD PMID:19041380 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of EIF4EBP1 mRNA CTD PMID:19041380 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Ereg epiregulin increases expression ISO 1-nitropyrene results in increased expression of EREG mRNA CTD PMID:21887816 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Esm1 endothelial cell-specific molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ESM1 mRNA CTD PMID:19041380 NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804
JBrowse link
G Etv5 ETS variant transcription factor 5 increases expression ISO 1-nitropyrene results in increased expression of ETV5 mRNA CTD PMID:19041380 NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO 1-nitropyrene results in increased expression of EVI2A mRNA CTD PMID:19041380 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
JBrowse link
G Exoc5 exocyst complex component 5 increases expression ISO 1-nitropyrene results in increased expression of EXOC5 mRNA CTD PMID:19041380 NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO 1-nitropyrene results in increased expression of F3 mRNA CTD PMID:19041380 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fgf5 fibroblast growth factor 5 increases expression ISO 1-nitropyrene results in increased expression of FGF5 mRNA CTD PMID:19041380 NCBI chr14:11,325,334...11,346,570
Ensembl chr14:11,325,334...11,345,997
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of FOS mRNA CTD PMID:21540303 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO 1-nitropyrene results in increased expression of G0S2 mRNA CTD PMID:19041380 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of GARS1 mRNA CTD PMID:19041380 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
JBrowse link
G Gas1 growth arrest-specific 1 decreases expression ISO 1-nitropyrene results in decreased expression of GAS1 mRNA CTD PMID:19041380 NCBI chr17:4,482,014...4,485,155 JBrowse link
G Gbp2 guanylate binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of GBP2 mRNA CTD PMID:19041380 NCBI chr 2:231,332,488...231,348,573
Ensembl chr 2:231,332,284...231,348,571
JBrowse link
G Gdap1 ganglioside-induced differentiation-associated-protein 1 increases expression ISO 1-nitropyrene results in increased expression of GDAP1 mRNA CTD PMID:19041380 NCBI chr 5:1,932,613...1,951,691
Ensembl chr 5:1,932,613...2,030,061
JBrowse link
G Glipr1 GLI pathogenesis-related 1 increases expression ISO 1-nitropyrene results in increased expression of GLIPR1 mRNA CTD PMID:19041380 NCBI chr 7:47,487,342...47,498,974
Ensembl chr 7:47,487,345...47,498,429
JBrowse link
G Golga4 golgin A4 increases expression ISO 1-nitropyrene results in increased expression of GOLGA4 mRNA CTD PMID:19041380 NCBI chr 8:118,208,200...118,285,003 JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression ISO 1-nitropyrene results in increased expression of GPT2 mRNA CTD PMID:19041380 NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO 1-nitropyrene results in increased expression of GREM1 mRNA CTD PMID:19041380 NCBI chr 3:100,512,317...100,524,001
Ensembl chr 3:100,512,313...100,524,082
JBrowse link
G Gsdmc gasdermin C decreases expression ISO 1-nitropyrene results in decreased expression of GSDMC mRNA CTD PMID:19041380 NCBI chr 7:95,594,015...95,606,106
Ensembl chr 7:95,594,015...95,611,344
JBrowse link
G Habp2 hyaluronan binding protein 2 decreases expression ISO 1-nitropyrene results in decreased expression of HABP2 mRNA CTD PMID:19041380 NCBI chr 1:255,315,870...255,350,161
Ensembl chr 1:255,315,915...255,350,160
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO 1-nitropyrene results in increased expression of HBEGF mRNA CTD PMID:19041380 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO 1-nitropyrene results in increased expression of HIF1A mRNA CTD PMID:19041380 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO 1-nitropyrene results in increased expression of HMGA2 mRNA CTD PMID:19041380 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO 1-nitropyrene results in increased expression of HMOX1 protein CTD PMID:28633978 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 multiple interactions ISO CYP1A2 affects the reaction [1-nitropyrene results in increased mutagenesis of HPRT1 gene] CTD PMID:10727902 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hras HRas proto-oncogene, GTPase affects expression
increases expression
EXP
ISO
1-nitropyrene affects the expression of HRAS mRNA
1-nitropyrene results in increased expression of HRAS mRNA
CTD PMID:9891514 PMID:11201684 PMID:11911274 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of HSPA5 protein
Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein]
CTD PMID:19460413 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of IARS1 mRNA CTD PMID:19041380 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO 1-nitropyrene results in increased expression of ICAM1 mRNA CTD PMID:21540303 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 decreases expression ISO 1-nitropyrene results in decreased expression of IFITM1 mRNA CTD PMID:19041380 NCBI chr 1:196,067,163...196,069,169
Ensembl chr 1:196,067,963...196,069,169
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO 1-nitropyrene results in increased expression of IFRD1 mRNA CTD PMID:19041380 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Il10rb interleukin 10 receptor subunit beta decreases expression ISO 1-nitropyrene results in decreased expression of IL10RB mRNA CTD PMID:19428942 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-nitropyrene results in increased expression of IL1A mRNA CTD PMID:19428942 PMID:21540303 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 1-nitropyrene results in increased secretion of IL1B protein CTD PMID:19041380 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il36rn interleukin 36 receptor antagonist decreases expression ISO 1-nitropyrene results in decreased expression of IL36RN mRNA CTD PMID:19428942 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
multiple interactions
ISO 1-nitropyrene results in increased expression of IL6 mRNA
1-nitropyrene results in increased secretion of IL6 protein
3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; ATG7 protein affects the reaction [1-nitropyrene results in increased secretion of IL6 protein]
CTD PMID:19041380 PMID:19879285 PMID:29078374 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha increases expression ISO 1-nitropyrene results in increased expression of INA mRNA CTD PMID:19041380 NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
JBrowse link
G Inhbb inhibin subunit beta B increases expression ISO 1-nitropyrene results in increased expression of INHBB mRNA CTD PMID:19041380 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B increases expression ISO 1-nitropyrene results in increased expression of INPP4B mRNA CTD PMID:19041380 NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634
JBrowse link
G Ipo7 importin 7 increases expression ISO 1-nitropyrene results in increased expression of IPO7 mRNA CTD PMID:19041380 NCBI chr 1:164,062,702...164,102,938
Ensembl chr 1:164,062,702...164,102,938
JBrowse link
G Irf1 interferon regulatory factor 1 increases expression ISO 1-nitropyrene results in increased expression of IRF1 mRNA CTD PMID:21540303 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Itgb4 integrin subunit beta 4 decreases expression ISO 1-nitropyrene results in decreased expression of ITGB4 mRNA CTD PMID:19041380 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO 1-nitropyrene results in increased expression of JUN mRNA CTD PMID:21540303 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kctd15 potassium channel tetramerization domain containing 15 increases expression ISO 1-nitropyrene results in increased expression of KCTD15 mRNA CTD PMID:19041380 NCBI chr 1:87,258,658...87,271,979
Ensembl chr 1:87,258,658...87,273,497
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions
increases mutagenesis
ISO [1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene; [1-nitropyrene co-treated with Polychlorinated Biphenyls] results in increased mutagenesis of KRAS gene; [Bleomycin co-treated with 1-nitropyrene] results in increased mutagenesis of KRAS gene
1-nitropyrene results in increased mutagenesis of KRAS gene
CTD PMID:9726818 PMID:10396879 PMID:11746253 PMID:12616606 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt34 keratin 34 increases expression ISO 1-nitropyrene results in increased expression of KRT34 mRNA CTD PMID:19041380 NCBI chr10:84,970,351...84,974,040
Ensembl chr10:84,970,017...84,974,040
JBrowse link
G Lcor ligand dependent nuclear receptor corepressor increases expression ISO 1-nitropyrene results in increased expression of LCOR mRNA CTD PMID:19041380 NCBI chr 1:240,298,565...240,405,627
Ensembl chr 1:240,298,563...240,402,448
JBrowse link
G Lig4 DNA ligase 4 increases expression ISO 1-nitropyrene results in increased expression of LIG4 mRNA CTD PMID:19041380 NCBI chr16:79,518,393...79,526,956
Ensembl chr16:79,518,312...79,527,040
JBrowse link
G Lman1 lectin, mannose-binding, 1 increases expression ISO 1-nitropyrene results in increased expression of LMAN1 mRNA CTD PMID:19041380 NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851
JBrowse link
G Lrrc17 leucine rich repeat containing 17 decreases expression ISO 1-nitropyrene results in decreased expression of LRRC17 mRNA CTD PMID:19041380 NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845
JBrowse link
G Lta lymphotoxin alpha decreases expression ISO 1-nitropyrene results in decreased expression of LTA mRNA CTD PMID:19428942 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Ltb lymphotoxin beta increases expression ISO 1-nitropyrene results in increased expression of LTB mRNA CTD PMID:19428942 PMID:19879285 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like increases expression ISO 1-nitropyrene results in increased expression of LURAP1L mRNA CTD PMID:19041380 NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
JBrowse link
G Mak16 MAK16 homolog increases expression ISO 1-nitropyrene results in increased expression of MAK16 mRNA CTD PMID:19041380 NCBI chr16:60,972,699...60,981,250
Ensembl chr16:60,972,697...60,983,243
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MAP1LC3B mRNA; 1-nitropyrene results in increased expression of MAP1LC3B protein
ATG7 protein affects the reaction [1-nitropyrene results in increased expression of MAP1LC3B protein]
CTD PMID:29078374 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK1 protein CTD PMID:17240030 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK3 protein CTD PMID:17240030 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression ISO 1-nitropyrene results in increased expression of MAPK6 mRNA CTD PMID:19041380 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO 1-nitropyrene results in increased phosphorylation of MAPK8 protein CTD PMID:17240030 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of MARS1 mRNA CTD PMID:19041380 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression
multiple interactions
ISO 1-nitropyrene results in increased expression of MDM2 mRNA; 1-nitropyrene results in increased expression of MDM2 protein; 1-nitropyrene results in increased expression of MDM2 protein modified form
nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373 PMID:22044530 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mettl7a methyltransferase like 7A decreases expression ISO 1-nitropyrene results in decreased expression of METTL7A mRNA CTD PMID:19041380 NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154
JBrowse link
G Mlph melanophilin increases expression ISO 1-nitropyrene results in increased expression of MLPH mRNA CTD PMID:19041380 NCBI chr 9:91,507,410...91,542,984
Ensembl chr 9:91,507,591...91,542,983
JBrowse link
G Mob4 MOB family member 4, phocein increases expression ISO 1-nitropyrene results in increased expression of MOB4 mRNA CTD PMID:19041380 NCBI chr 9:56,617,374...56,641,336
Ensembl chr 9:56,617,368...56,641,329
JBrowse link
G Mocos molybdenum cofactor sulfurase increases expression ISO 1-nitropyrene results in increased expression of MOCOS mRNA CTD PMID:19041380 NCBI chr18:15,931,654...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mospd1 motile sperm domain containing 1 increases expression ISO 1-nitropyrene results in increased expression of MOSPD1 mRNA CTD PMID:19041380 NCBI chr  X:133,100,200...133,127,960
Ensembl chr  X:133,100,422...133,127,908
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like increases expression ISO 1-nitropyrene results in increased expression of MTHFD1L mRNA CTD PMID:19041380 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
JBrowse link
G Mtmr2 myotubularin related protein 2 increases expression ISO 1-nitropyrene results in increased expression of MTMR2 mRNA CTD PMID:19041380 NCBI chr 8:10,617,993...10,670,724
Ensembl chr 8:10,617,993...10,668,172
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO 1-nitropyrene results in increased expression of MYC mRNA CTD PMID:10928071 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFA1 mRNA
1-nitropyrene results in decreased expression of NDUFA1 mRNA; 1-nitropyrene results in decreased expression of NDUFA1 protein
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA1 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]
CTD PMID:29078374 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 multiple interactions
decreases expression
ISO 3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; NDUFA2 protein inhibits the reaction [1-nitropyrene results in increased expression of ATG7 protein]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]
1-nitropyrene results in decreased expression of NDUFA2 mRNA; 1-nitropyrene results in decreased expression of NDUFA2 protein
CTD PMID:29078374 NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 multiple interactions
decreases expression
ISO [3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA] CTD PMID:29078374 NCBI chr 1:151,711,965...151,718,188
Ensembl chr 1:151,711,901...151,718,189
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression
multiple interactions
ISO 1-nitropyrene results in decreased expression of NDUFS4 mRNA
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]
CTD PMID:29078374 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO 1-nitropyrene results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:28633978 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions
increases activity
ISO 1-nitropyrene results in increased expression of NFKB1 mRNA
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]
CTD PMID:12393170 PMID:21540303 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of NFKB1 protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]; NFKBIA protein inhibits the reaction [1-nitropyrene results in increased expression of CXCL8 mRNA] CTD PMID:12393170 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Noc3l NOC3-like DNA replication regulator increases expression ISO 1-nitropyrene results in increased expression of NOC3L mRNA CTD PMID:19041380 NCBI chr 1:236,556,037...236,585,372
Ensembl chr 1:236,556,789...236,585,318
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO 1-nitropyrene results in increased expression of NRG1 mRNA CTD PMID:19041380 NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884
JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO 1-nitropyrene results in increased expression of NT5E mRNA CTD PMID:19041380 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Ntn3 netrin 3 decreases expression ISO 1-nitropyrene results in decreased expression of NTN3 mRNA CTD PMID:19041380 NCBI chr10:13,236,905...13,240,001
Ensembl chr10:13,236,905...13,240,001
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO 1-nitropyrene results in decreased expression of OAS1 mRNA CTD PMID:19041380 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression ISO 1-nitropyrene results in increased expression of OASL mRNA CTD PMID:19041380 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Osbpl6 oxysterol binding protein-like 6 increases expression ISO 1-nitropyrene results in increased expression of OSBPL6 mRNA CTD PMID:19041380 NCBI chr 3:61,343,776...61,541,170
Ensembl chr 3:61,343,809...61,537,102
JBrowse link
G Oxr1 oxidation resistance 1 increases expression ISO 1-nitropyrene results in increased expression of OXR1 mRNA CTD PMID:19041380 NCBI chr 7:72,528,782...72,965,666
Ensembl chr 7:72,528,786...72,965,666
JBrowse link
G Pcdhb8 protocadherin beta 8 decreases expression ISO 1-nitropyrene results in decreased expression of PCDHB5 mRNA CTD PMID:19041380 NCBI chr18:29,065,466...29,067,805
Ensembl chr18:29,065,466...29,067,805
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO 1-nitropyrene results in increased expression of PCK2 mRNA CTD PMID:19041380 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRB mRNA CTD PMID:19041380 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pdgfrl platelet-derived growth factor receptor-like decreases expression ISO 1-nitropyrene results in decreased expression of PDGFRL mRNA CTD PMID:19041380 NCBI chr16:51,347,929...51,407,850
Ensembl chr16:51,347,948...51,407,850
JBrowse link
G Pdpn podoplanin decreases expression ISO 1-nitropyrene results in decreased expression of PDPN mRNA CTD PMID:19041380 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein increases expression ISO 1-nitropyrene results in increased expression of PICALM mRNA CTD PMID:19041380 NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha increases expression ISO 1-nitropyrene results in increased expression of PIK3C2A mRNA CTD PMID:19041380 NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
JBrowse link
G Pir pirin decreases expression ISO 1-nitropyrene results in decreased expression of PIR mRNA CTD PMID:19041380 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 decreases expression ISO 1-nitropyrene results in decreased expression of PLEKHB1 mRNA CTD PMID:19041380 NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of POLA1 mRNA CTD PMID:19041380 NCBI chr  X:58,034,617...58,348,612
Ensembl chr  X:58,034,619...58,348,536
JBrowse link
G Polr2e RNA polymerase II, I and III subunit E decreases expression ISO 1-nitropyrene results in decreased expression of POLR2E mRNA CTD PMID:19041380 NCBI chr 7:9,666,695...9,670,638
Ensembl chr 7:9,666,716...9,670,643
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO 1-nitropyrene results in increased expression of PRKAA1 mRNA CTD PMID:19041380 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha increases expression ISO 1-nitropyrene results in increased expression of PRKAR1A mRNA CTD PMID:19041380 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041
JBrowse link
G Prkch protein kinase C, eta increases expression ISO 1-nitropyrene results in increased expression of PRKCH mRNA CTD PMID:19041380 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit increases expression ISO 1-nitropyrene results in increased expression of PRKDC protein CTD PMID:28633978 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Prmt3 protein arginine methyltransferase 3 increases expression ISO 1-nitropyrene results in increased expression of PRMT3 mRNA CTD PMID:19041380 NCBI chr 1:99,492,712...99,581,774
Ensembl chr 1:99,492,724...99,579,435
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO 1-nitropyrene results in increased expression of PSAT1 mRNA CTD PMID:19041380 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression ISO 1-nitropyrene results in decreased expression of PSMB9 mRNA CTD PMID:19041380 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
JBrowse link
G Psmd5 proteasome 26S subunit, non-ATPase 5 increases expression ISO 1-nitropyrene results in increased expression of PSMD5 mRNA CTD PMID:19041380 NCBI chr 3:18,133,715...18,151,000
Ensembl chr 3:18,133,717...18,151,029
JBrowse link
G Psme4 proteasome activator subunit 4 increases expression ISO 1-nitropyrene results in increased expression of PSME4 mRNA CTD PMID:19041380 NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408
JBrowse link
G Ptcd2 pentatricopeptide repeat domain 2 increases expression ISO 1-nitropyrene results in increased expression of PTCD2 mRNA CTD PMID:19041380 NCBI chr 2:30,712,276...30,739,968
Ensembl chr 2:30,712,280...30,739,942
JBrowse link
G Pthlh parathyroid hormone-like hormone increases expression ISO 1-nitropyrene results in increased expression of PTHLH mRNA CTD PMID:19041380 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847
JBrowse link
G Ptn pleiotrophin decreases expression ISO 1-nitropyrene results in decreased expression of PTN mRNA CTD PMID:19041380 NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456
JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B increases expression ISO 1-nitropyrene results in increased expression of PTPRB mRNA CTD PMID:19041380 NCBI chr 7:51,953,375...52,034,751
Ensembl chr 7:51,930,015...52,034,748
JBrowse link
G Rab20 RAB20, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB20 mRNA CTD PMID:19041380 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529
JBrowse link
G Rab26 RAB26, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB26 mRNA CTD PMID:19041380 NCBI chr10:13,553,395...13,558,063
Ensembl chr10:13,553,395...13,558,030
JBrowse link
G Rab34 RAB34, member RAS oncogene family decreases expression ISO 1-nitropyrene results in decreased expression of RAB34 mRNA CTD PMID:19041380 NCBI chr10:63,083,319...63,087,538
Ensembl chr10:63,083,338...63,087,538
JBrowse link
G Ramp1 receptor activity modifying protein 1 decreases expression ISO 1-nitropyrene results in decreased expression of RAMP1 mRNA CTD PMID:19041380 NCBI chr 9:91,765,481...91,816,152
Ensembl chr 9:91,781,285...91,816,151
JBrowse link
G Ranbp6 RAN binding protein 6 increases expression ISO 1-nitropyrene results in increased expression of RANBP6 mRNA CTD PMID:19041380 NCBI chr 1:227,572,394...227,576,915
Ensembl chr 1:227,572,105...227,576,942
JBrowse link
G Rasa2 RAS p21 protein activator 2 increases expression ISO 1-nitropyrene results in increased expression of RASA2 mRNA CTD PMID:19041380 NCBI chr 8:97,119,983...97,236,687
Ensembl chr 8:97,118,802...97,236,671
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
ISO 1-nitropyrene results in increased activity of RELA protein
NFKBIA protein inhibits the reaction [1-nitropyrene results in increased activity of RELA protein]
CTD PMID:12393170 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RGD1306227 similar to 4833420G17Rik protein increases expression ISO 1-nitropyrene results in increased expression of C5ORF34 mRNA CTD PMID:19041380 NCBI chr 2:51,553,223...51,577,090
Ensembl chr 2:51,555,432...51,577,085
JBrowse link
G Riox2 ribosomal oxygenase 2 increases expression ISO 1-nitropyrene results in increased expression of RIOX2 mRNA CTD PMID:19041380 NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
JBrowse link
G Rnd3 Rho family GTPase 3 increases expression ISO 1-nitropyrene results in increased expression of RND3 mRNA CTD PMID:19041380 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Sacs sacsin molecular chaperone increases expression ISO 1-nitropyrene results in increased expression of SACS mRNA CTD PMID:19041380 NCBI chr15:35,285,783...35,370,335
Ensembl chr15:35,285,782...35,370,335
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression
decreases response to substance
ISO 1-nitropyrene results in decreased expression of SCD1 mRNA; 1-nitropyrene results in decreased expression of SCD1 protein
SCD1 protein results in decreased susceptibility to 1-nitropyrene
CTD PMID:21872649 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha decreases expression ISO 1-nitropyrene results in decreased expression of SCNN1A mRNA CTD PMID:19041380 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Sectm1b secreted and transmembrane 1B decreases expression ISO 1-nitropyrene results in decreased expression of SECTM1 mRNA CTD PMID:19041380 NCBI chr10:106,325,202...106,333,769
Ensembl chr10:106,325,203...106,333,769
JBrowse link
G Sele selectin E increases expression ISO 1-nitropyrene results in increased expression of SELE mRNA CTD PMID:21540303 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Serpinb8 serpin family B member 8 increases expression ISO 1-nitropyrene results in increased expression of SERPINB8 mRNA CTD PMID:19041380 NCBI chr13:23,626,945...23,650,270
Ensembl chr13:23,626,945...23,650,835
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO 1-nitropyrene results in increased expression of SERPINE1 mRNA CTD PMID:19041380 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sh3kbp1 SH3 domain-containing kinase-binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of SH3KBP1 mRNA CTD PMID:19041380 NCBI chr  X:34,877,862...35,223,013
Ensembl chr  X:34,877,866...35,222,747
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 increases expression ISO 1-nitropyrene results in increased expression of SH3RF1 mRNA CTD PMID:19041380 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Slmap sarcolemma associated protein increases expression ISO 1-nitropyrene results in increased expression of SLMAP mRNA CTD PMID:19041380 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 increases expression ISO 1-nitropyrene results in increased expression of SMURF2 mRNA CTD PMID:19041380 NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488
JBrowse link
G Snca synuclein alpha decreases expression ISO 1-nitropyrene results in decreased expression of SNCA mRNA CTD PMID:19041380 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Snx14 sorting nexin 14 increases expression ISO 1-nitropyrene results in increased expression of SNX14 mRNA CTD PMID:19041380 NCBI chr 8:89,283,673...89,390,597
Ensembl chr 8:89,298,114...89,390,580
JBrowse link
G Sox21 SRY-box transcription factor 21 decreases expression ISO 1-nitropyrene results in decreased expression of SOX21 mRNA CTD PMID:19041380 NCBI chr15:95,292,272...95,295,316 JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 1-nitropyrene results in decreased expression of SPP1 mRNA CTD PMID:19428942 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO 1-nitropyrene results in increased expression of STC2 mRNA CTD PMID:19041380 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 decreases expression ISO 1-nitropyrene results in decreased expression of TACSTD2 mRNA CTD PMID:19041380 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link
G Tagln transgelin increases expression ISO 1-nitropyrene results in increased expression of TAGLN mRNA CTD PMID:19041380 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of TARS1 mRNA CTD PMID:19041380 NCBI chr 2:60,368,251...60,387,733
Ensembl chr 2:60,367,796...60,387,717
JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression ISO 1-nitropyrene results in increased expression of TAX1BP1 mRNA CTD PMID:19041380 NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100
JBrowse link
G Thbd thrombomodulin increases expression ISO 1-nitropyrene results in increased expression of THBD mRNA CTD PMID:19041380 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene CTD PMID:23458896 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tmpo thymopoietin increases expression ISO 1-nitropyrene results in increased expression of TMPO mRNA CTD PMID:19041380 NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
ISO 1-nitropyrene results in increased expression of TNF mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; MK 2206 inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]
1-nitropyrene results in increased secretion of TNF protein
CTD PMID:19041380 PMID:19428942 PMID:19879285 PMID:21540303 PMID:28633978 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnpo1 transportin 1 increases expression ISO 1-nitropyrene results in increased expression of TNPO1 mRNA CTD PMID:19041380 NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375
JBrowse link
G Top1 DNA topoisomerase I increases expression ISO 1-nitropyrene results in increased expression of TOP1 mRNA CTD PMID:19041380 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2b DNA topoisomerase II beta increases expression ISO 1-nitropyrene results in increased expression of TOP2B mRNA CTD PMID:19041380 NCBI chr15:9,051,661...9,111,220
Ensembl chr15:9,051,341...9,112,085
JBrowse link
G Tp53 tumor protein p53 increases expression
increases phosphorylation
decreases expression
affects localization
affects response to substance
affects expression
multiple interactions
ISO
EXP
1-nitropyrene results in increased expression of TP53 protein; 1-nitropyrene results in increased expression of TP53 protein modified form
1-nitropyrene results in increased phosphorylation of TRP53 protein
1-nitropyrene results in decreased expression of TRP53 mRNA
1-nitropyrene results in increased expression of TRP53 mRNA
1-nitropyrene affects the localization of TRP53 protein
TP53 affects the susceptibility to 1-nitropyrene
1-nitropyrene affects the expression of TP53 mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; [beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [1-nitropyrene results in increased expression of BAX mRNA]; TP53 affects the reaction [1-nitropyrene results in increased expression of MDM2 mRNA]
CTD PMID:10837373 PMID:10928071 PMID:11201684 PMID:11911274 PMID:17240030 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO 1-nitropyrene results in increased expression of TRIB3 mRNA CTD PMID:19041380 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim23 tripartite motif-containing 23 increases expression ISO 1-nitropyrene results in increased expression of TRIM23 mRNA CTD PMID:19041380 NCBI chr 2:35,302,405...35,335,746
Ensembl chr 2:35,302,409...35,335,743
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 increases expression ISO 1-nitropyrene results in increased expression of TRPM7 mRNA CTD PMID:19041380 NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190
JBrowse link
G Trub1 TruB pseudouridine synthase family member 1 increases expression ISO 1-nitropyrene results in increased expression of TRUB1 mRNA CTD PMID:19041380 NCBI chr 1:256,513,418...256,554,549
Ensembl chr 1:256,515,562...256,552,814
JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing, B increases expression ISO 1-nitropyrene results in increased expression of UBASH3B mRNA CTD PMID:19041380 NCBI chr 8:41,385,419...41,532,248
Ensembl chr 8:41,388,341...41,532,201
JBrowse link
G Usp15 ubiquitin specific peptidase 15 increases expression ISO 1-nitropyrene results in increased expression of USP15 mRNA CTD PMID:19041380 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721
JBrowse link
G Vcan versican increases expression ISO 1-nitropyrene results in increased expression of VCAN mRNA CTD PMID:19041380 NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
JBrowse link
G Virma vir like m6A methyltransferase associated increases expression ISO 1-nitropyrene results in increased expression of VIRMA mRNA CTD PMID:19041380 NCBI chr 5:24,961,208...25,024,660
Ensembl chr 5:24,960,778...25,023,341
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression ISO 1-nitropyrene results in increased expression of WARS1 mRNA CTD PMID:19041380 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
JBrowse link
G Wdfy3 WD repeat and FYVE domain containing 3 increases expression ISO 1-nitropyrene results in increased expression of WDFY3 mRNA CTD PMID:19041380 NCBI chr14:7,578,245...7,810,491
Ensembl chr14:7,606,628...7,810,482
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO 1-nitropyrene results in increased expression of WNT2 mRNA CTD PMID:21540303 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
G Xcr1 X-C motif chemokine receptor 1 decreases expression ISO 1-nitropyrene results in decreased expression of XCR1 mRNA CTD PMID:19428942 NCBI chr 8:123,479,454...123,516,168
Ensembl chr 8:123,479,590...123,487,226
JBrowse link
G Xpot exportin for tRNA increases expression ISO 1-nitropyrene results in increased expression of XPOT mRNA CTD PMID:19041380 NCBI chr 7:57,111,536...57,151,847
Ensembl chr 7:57,111,536...57,152,099
JBrowse link
G Zdhhc11 zinc finger, DHHC-type containing 11 increases expression ISO 1-nitropyrene results in increased expression of ZDHHC11 mRNA CTD PMID:19041380 NCBI chr 1:29,296,216...29,327,227
Ensembl chr 1:29,296,334...29,326,898
JBrowse link
G Zeb1 zinc finger E-box binding homeobox 1 increases expression ISO 1-nitropyrene results in increased expression of ZEB1 mRNA CTD PMID:19041380 NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
JBrowse link
G Zfp62 zinc finger protein 62 increases expression ISO 1-nitropyrene results in increased expression of ZFP62 mRNA CTD PMID:19041380 NCBI chr10:33,522,618...33,539,446
Ensembl chr10:33,500,323...33,542,013
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        aetiopathogenetic role 19027
          carcinogenic agent 18362
            1-nitropyrene 249
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    main group molecular entity 19698
                      s-block molecular entity 19479
                        hydrogen molecular entity 19471
                          hydrides 18834
                            organic hydride 18348
                              organic fundamental parent 18348
                                hydrocarbon 18059
                                  cyclic hydrocarbon 17069
                                    arene 17065
                                      polycyclic arene 16885
                                        ortho- and peri-fused polycyclic arene 16177
                                          pyrene 290
                                            1-nitropyrene 249
paths to the root