alkaline earth hydroxide - Ontology Report

Calcium Hydroxide results in increased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

Col1a1

collagen type I alpha 1 chain

increases expression

Calcium Hydroxide results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

Esr1

estrogen receptor 1

increases expression

Calcium Hydroxide results in increased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

Polg

DNA polymerase gamma, catalytic subunit

affects expression

Calcium Hydroxide affects the expression of POLG mRNA

PMID:30615914

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

Polg2

DNA polymerase gamma 2, accessory subunit

affects expression

Calcium Hydroxide affects the expression of POLG2 mRNA

PMID:30615914

NCBI chr10:91,712,586...91,723,008
Ensembl chr10:91,712,586...91,723,008

Tfam

transcription factor A, mitochondrial

affects expression

Calcium Hydroxide affects the expression of TFAM mRNA

PMID:30615914

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

Trpv1

transient receptor potential cation channel, subfamily V, member 1

increases expression

Calcium Hydroxide results in increased expression of TRPV1 mRNA

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

magnesium dihydroxide

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Casp1

caspase 1

multiple interactions

[Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased activity of CASP1 protein]; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] promotes the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine results in increased expression of and results in increased secretion of CASP1 protein modified form]; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]

PMID:18604214 PMID:22075093

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

Chrna4

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]

PMID:22750351

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

Chrnb2

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Magnesium Hydroxide inhibits the reaction [Acetylcholine results in increased activity of [CHRNA4 protein co-treated with CHRNB2 protein]]

PMID:22750351

NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619

Cxcl10

C-X-C motif chemokine ligand 10

multiple interactions

[Aluminum Hydroxide co-treated with Magnesium Hydroxide] inhibits the reaction [K-12 lipopolysaccharide results in increased secretion of CXCL10 protein]

PMID:17404311

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Il1b

interleukin 1 beta

multiple interactions

[[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form; [Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; CASP1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL1B protein]
[[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine] results in increased secretion of IL1B protein; [Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein; IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]; PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]

PMID:17404311 PMID:18604214 PMID:22075093

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il1r1

interleukin 1 receptor type 1

multiple interactions

IL1R1 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]

PMID:18604214

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

Il2

interleukin 2

multiple interactions

[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein; N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]; TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]

PMID:22075093

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

Nlrp3

NLR family, pyrin domain containing 3

multiple interactions

NLRP3 protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]

PMID:18604214

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

Pycard

PYD and CARD domain containing

multiple interactions

PYCARD protein affects the reaction [[Lipopolysaccharides co-treated with [Aluminum Hydroxide co-treated with Magnesium Hydroxide]] results in increased cleavage of and results in increased secretion of IL1B protein]

PMID:18604214

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

Tlr4

toll-like receptor 4

multiple interactions

TLR4 protein affects the reaction [N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine promotes the reaction [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] results in increased secretion of IL2 protein]]; TLR4 protein affects the susceptibility to [[Aluminum Hydroxide co-treated with Magnesium Hydroxide] co-treated with N-t-butyl-n'-tetradecyl-3-tetradecylaminopropionamidine]; TLR4 protein affects the susceptibility to [Aluminum Hydroxide co-treated with Magnesium Hydroxide]