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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:deoxymannose
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Accession:CHEBI:33983 term browser browse the term
Synonyms:related_synonym: deoxymannoses


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icariside II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases expression ISO
EXP		 baohuoside I results in decreased expression of ABCB11 mRNA; baohuoside I results in decreased expression of ABCB11 protein CTD PMID:35802278 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases expression ISO
EXP		 baohuoside I results in decreased expression of ABCC2 mRNA; baohuoside I results in decreased expression of ABCC2 protein CTD PMID:35802278 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 EXP baohuoside I results in decreased phosphorylation of AKT1 protein
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]		 CTD PMID:25119583 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G AKT1S1 AKT1 substrate 1 multiple interactions
decreases phosphorylation		 EXP baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]
baohuoside I results in decreased phosphorylation of AKT1S1 protein		 CTD PMID:25119583 NCBI chr19:49,869,033...49,878,356
Ensembl chr19:49,869,033...49,878,459 		JBrowse link
G ALPL alkaline phosphatase, biomineralization associated increases expression
increases secretion		 ISO baohuoside I results in increased expression of ALPL mRNA
baohuoside I results in increased secretion of ALPL protein		 CTD PMID:17764702 PMID:35802278 NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP baohuoside I results in increased expression of BAX protein CTD PMID:22687635 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP baohuoside I results in decreased expression of BCL2 protein CTD PMID:22687635 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein increases expression ISO baohuoside I results in increased expression of BGLAP mRNA CTD PMID:17764702 NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317 		JBrowse link
G BRAF B-Raf proto-oncogene, serine/threonine kinase decreases phosphorylation
multiple interactions		 EXP baohuoside I results in decreased phosphorylation of BRAF protein
baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]		 CTD PMID:25119583 NCBI chr 7:140,713,328...140,924,929
Ensembl chr 7:140,719,327...140,924,929 		JBrowse link
G CASP3 caspase 3 increases cleavage
increases activity		 EXP baohuoside I results in increased cleavage of CASP3 protein
baohuoside I results in increased activity of CASP3 protein		 CTD PMID:19289254 PMID:22687635 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity EXP baohuoside I results in increased activity of CASP8 protein CTD PMID:19289254 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
increases cleavage		 EXP baohuoside I results in increased activity of CASP9 protein
baohuoside I results in increased cleavage of CASP9 protein		 CTD PMID:19289254 PMID:22687635 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G COL1A2 collagen type I alpha 2 chain increases expression ISO baohuoside I results in increased expression of COL1A2 mRNA CTD PMID:17764702 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO
EXP		 baohuoside I results in increased expression of CYP7A1 mRNA; baohuoside I results in increased expression of CYP7A1 protein CTD PMID:35802278 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G EGF epidermal growth factor multiple interactions EXP baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of BRAF protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein] CTD PMID:25119583 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions
decreases phosphorylation		 EXP baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
baohuoside I results in decreased phosphorylation of EGFR protein		 CTD PMID:25119583 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ESR1 estrogen receptor 1 multiple interactions EXP baohuoside I binds to and results in increased degradation of ESR1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [baohuoside I results in increased degradation of ESR1 protein]; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein] CTD PMID:35802278 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 increases secretion ISO
EXP		 baohuoside I results in increased secretion of GOT1 protein CTD PMID:35802278 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GPT glutamic--pyruvic transaminase increases secretion ISO
EXP		 baohuoside I results in increased secretion of GPT protein CTD PMID:35802278 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta decreases phosphorylation EXP baohuoside I results in decreased phosphorylation of GSK3B protein CTD PMID:25119583 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation		 EXP baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]
baohuoside I results in decreased phosphorylation of MAPK1 protein		 CTD PMID:25119583 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
decreases phosphorylation		 EXP baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]
baohuoside I results in decreased phosphorylation of MAPK3 protein		 CTD PMID:25119583 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MKI67 marker of proliferation Ki-67 decreases expression EXP baohuoside I results in decreased expression of MKI67 protein CTD PMID:25119583 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 EXP baohuoside I inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein]
baohuoside I results in decreased phosphorylation of MTOR protein		 CTD PMID:25119583 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression EXP baohuoside I results in decreased expression of NOS2 CTD PMID:19289254 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases expression
multiple interactions		 ISO
EXP		 baohuoside I results in decreased expression of NR0B2 mRNA; baohuoside I results in decreased expression of NR0B2 protein
baohuoside I results in decreased expression of and results in decreased activity of and affects the localization of NR0B2 protein; ESR1 inhibits the reaction [baohuoside I results in decreased expression of and affects the localization of NR0B2 protein]		 CTD PMID:35802278 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 decreases expression EXP
ISO		 baohuoside I results in decreased expression of NR1H4 mRNA; baohuoside I results in decreased expression of NR1H4 protein CTD PMID:35802278 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 EXP baohuoside I results in increased cleavage of PARP1 protein
Dinoprostone inhibits the reaction [baohuoside I results in increased cleavage of PARP1 protein]; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]		 CTD PMID:19289254 PMID:22687635 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 decreases phosphorylation EXP baohuoside I results in decreased phosphorylation of PDPK1 protein CTD PMID:25119583 NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 EXP baohuoside I results in decreased expression of PTGS2
[baohuoside I results in decreased expression of PTGS2] which results in decreased abundance of Dinoprostone; PTGS2 mutant form promotes the reaction [baohuoside I results in increased cleavage of PARP1 protein]		 CTD PMID:19289254 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 increases expression ISO
EXP		 baohuoside I results in increased expression of SLC10A1 mRNA; baohuoside I results in increased expression of SLC10A1 protein CTD PMID:35802278 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 decreases expression EXP baohuoside I results in decreased expression of SLCO1A1 mRNA CTD PMID:35802278 NCBI chr12:21,264,600...21,419,634
Ensembl chr12:21,264,600...21,419,594 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b increases expression ISO baohuoside I results in increased expression of TNFRSF11B mRNA CTD PMID:17764702 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G TNFSF11 TNF superfamily member 11 decreases expression ISO baohuoside I results in decreased expression of TNFSF11 mRNA CTD PMID:17764702 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression EXP baohuoside I results in decreased expression of VEGFA CTD PMID:19289254 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
rhamnose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OAT ornithine aminotransferase multiple interactions ISO Rhamnose inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] CTD PMID:2827574 NCBI chr10:124,397,303...124,418,923
Ensembl chr10:124,397,303...124,418,976 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    chemical entity 26020
      atom 26016
        nonmetal atom 25505
          oxygen atom 24814
            oxygen molecular entity 24814
              organooxygen compound 24061
                carbohydrates and carbohydrate derivatives 16791
                  carbohydrate 16791
                    deoxy sugar 148
                      deoxyhexose 148
                        deoxymannose 36
                          deoxymannose derivative + 0
                          rhamnose + 36
                          tyvelose + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbohydrates and carbohydrate derivatives 16791
                                    carbohydrate 16791
                                      monosaccharide 4980
                                        aldose 3333
                                          aldohexose 2958
                                            deoxyhexose 148
                                              deoxymannose 36
                                                deoxymannose derivative + 0
                                                rhamnose + 36
                                                tyvelose + 0
paths to the root