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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbinoxamine
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Accession:CHEBI:3398 term browser browse the term
Definition:An organochlorine compound that is 2-(4-chlorobenzyl)pyridine in which one of the benzylic hydrogens is substituted by 2-(dimethylamino)ethoxy group. It is an ethanolamine-type antihistamine, used as its maleate salt for treating hay fever, as well as mild cases of Parkinson's disease.
Synonyms:exact_synonym: 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine
 related_synonym: 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine;   Formula=C16H19ClN2O;   InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3;   InChIKey=OJFSXZCBGQGRNV-UHFFFAOYSA-N;   SMILES=CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1;   carbinoxamina;   carbinoxamine base;   carbinoxaminum;   paracarbinoxamine;   {2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine
 alt_id: CHEBI:166273
 xref: Beilstein:250475;   CAS:486-16-8;   DrugBank:DB00748;   Drug_Central:499;   HMDB:HMDB0014886;   KEGG:C06871;   KEGG:D07617;   LINCS:LSM-1435
 xref_mesh: MESH:C004649
 xref: PMID:6094812;   Patent:US2606195;   Patent:US2800485;   Reaxys:250475;   Wikipedia:Carbinoxamine


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carbinoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO carbinoxamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
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G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            anti-allergic agent 3794
              carbinoxamine 2
                (R)-carbinoxamine 0
                (S)-carbinoxamine + 0
                carbinoxamine maleate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          carbinoxamine 2
                                            (R)-carbinoxamine 0
                                            (S)-carbinoxamine + 0
                                            carbinoxamine maleate + 0
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