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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbinoxamine
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Accession:CHEBI:3398 term browser browse the term
Definition:An organochlorine compound that is 2-(4-chlorobenzyl)pyridine in which one of the benzylic hydrogens is substituted by 2-(dimethylamino)ethoxy group. It is an ethanolamine-type antihistamine, used as its maleate salt for treating hay fever, as well as mild cases of Parkinson's disease.
Synonyms:exact_synonym: 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine
 related_synonym: 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine;   Formula=C16H19ClN2O;   InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3;   InChIKey=OJFSXZCBGQGRNV-UHFFFAOYSA-N;   SMILES=CN(C)CCOC(c1ccc(Cl)cc1)c1ccccn1;   carbinoxamina;   carbinoxamine base;   carbinoxaminum;   paracarbinoxamine;   {2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine
 alt_id: CHEBI:166273
 xref: Beilstein:250475;   CAS:486-16-8;   DrugBank:DB00748;   Drug_Central:499;   HMDB:HMDB0014886;   KEGG:C06871;   KEGG:D07617;   LINCS:LSM-1435
 xref_mesh: MESH:C004649
 xref: PMID:6094812;   Patent:US2606195;   Patent:US2800485;   Reaxys:250475;   Wikipedia:Carbinoxamine


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carbinoxamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO carbinoxamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO carbinoxamine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      application 19717
        pharmaceutical 19544
          drug 19544
            anti-allergic agent 3933
              carbinoxamine 2
                (R)-carbinoxamine 0
                (S)-carbinoxamine + 0
                carbinoxamine maleate + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    main group molecular entity 19853
                      s-block molecular entity 19684
                        hydrogen molecular entity 19673
                          hydrides 19150
                            inorganic hydride 18129
                              pnictogen hydride 18118
                                nitrogen hydride 18024
                                  azane 17823
                                    ammonia 17822
                                      organic amino compound 17822
                                        tertiary amino compound 10136
                                          carbinoxamine 2
                                            (R)-carbinoxamine 0
                                            (S)-carbinoxamine + 0
                                            carbinoxamine maleate + 0
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